IL135593A - מיקרוספרות פולימריות צבועות פלואורסצנטית במדויק ושיטות להכנתן ושמוש בהן - Google Patents

מיקרוספרות פולימריות צבועות פלואורסצנטית במדויק ושיטות להכנתן ושמוש בהן

Info

Publication number
IL135593A
IL135593A IL13559398A IL13559398A IL135593A IL 135593 A IL135593 A IL 135593A IL 13559398 A IL13559398 A IL 13559398A IL 13559398 A IL13559398 A IL 13559398A IL 135593 A IL135593 A IL 135593A
Authority
IL
Israel
Prior art keywords
microspheres
population
fluorescent dyes
polymeric microspheres
dyes
Prior art date
Application number
IL13559398A
Other languages
English (en)
Other versions
IL135593A0 (en
Original Assignee
Luminex Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26741675&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL135593(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Luminex Corp filed Critical Luminex Corp
Publication of IL135593A0 publication Critical patent/IL135593A0/xx
Publication of IL135593A publication Critical patent/IL135593A/he

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • D—TEXTILES; PAPER
    • D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
    • D06P—DYEING OR PRINTING TEXTILES; DYEING LEATHER, FURS OR SOLID MACROMOLECULAR SUBSTANCES IN ANY FORM
    • D06P1/00—General processes of dyeing or printing textiles, or general processes of dyeing leather, furs, or solid macromolecular substances in any form, classified according to the dyes, pigments, or auxiliary substances employed
    • D06P1/0004—General aspects of dyeing
    • D06P1/0012—Effecting dyeing to obtain luminescent or phosphorescent dyeings
    • D—TEXTILES; PAPER
    • D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
    • D06P—DYEING OR PRINTING TEXTILES; DYEING LEATHER, FURS OR SOLID MACROMOLECULAR SUBSTANCES IN ANY FORM
    • D06P1/00—General processes of dyeing or printing textiles, or general processes of dyeing leather, furs, or solid macromolecular substances in any form, classified according to the dyes, pigments, or auxiliary substances employed
    • D06P1/90—General processes of dyeing or printing textiles, or general processes of dyeing leather, furs, or solid macromolecular substances in any form, classified according to the dyes, pigments, or auxiliary substances employed using dyes dissolved in organic solvents or aqueous emulsions thereof
    • D06P1/92—General processes of dyeing or printing textiles, or general processes of dyeing leather, furs, or solid macromolecular substances in any form, classified according to the dyes, pigments, or auxiliary substances employed using dyes dissolved in organic solvents or aqueous emulsions thereof in organic solvents
    • D06P1/922—General processes of dyeing or printing textiles, or general processes of dyeing leather, furs, or solid macromolecular substances in any form, classified according to the dyes, pigments, or auxiliary substances employed using dyes dissolved in organic solvents or aqueous emulsions thereof in organic solvents hydrocarbons
    • D—TEXTILES; PAPER
    • D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
    • D06P—DYEING OR PRINTING TEXTILES; DYEING LEATHER, FURS OR SOLID MACROMOLECULAR SUBSTANCES IN ANY FORM
    • D06P1/00—General processes of dyeing or printing textiles, or general processes of dyeing leather, furs, or solid macromolecular substances in any form, classified according to the dyes, pigments, or auxiliary substances employed
    • D06P1/90—General processes of dyeing or printing textiles, or general processes of dyeing leather, furs, or solid macromolecular substances in any form, classified according to the dyes, pigments, or auxiliary substances employed using dyes dissolved in organic solvents or aqueous emulsions thereof
    • D06P1/92—General processes of dyeing or printing textiles, or general processes of dyeing leather, furs, or solid macromolecular substances in any form, classified according to the dyes, pigments, or auxiliary substances employed using dyes dissolved in organic solvents or aqueous emulsions thereof in organic solvents
    • D06P1/922—General processes of dyeing or printing textiles, or general processes of dyeing leather, furs, or solid macromolecular substances in any form, classified according to the dyes, pigments, or auxiliary substances employed using dyes dissolved in organic solvents or aqueous emulsions thereof in organic solvents hydrocarbons
    • D06P1/924—Halogenated hydrocarbons
    • D—TEXTILES; PAPER
    • D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
    • D06P—DYEING OR PRINTING TEXTILES; DYEING LEATHER, FURS OR SOLID MACROMOLECULAR SUBSTANCES IN ANY FORM
    • D06P1/00—General processes of dyeing or printing textiles, or general processes of dyeing leather, furs, or solid macromolecular substances in any form, classified according to the dyes, pigments, or auxiliary substances employed
    • D06P1/90—General processes of dyeing or printing textiles, or general processes of dyeing leather, furs, or solid macromolecular substances in any form, classified according to the dyes, pigments, or auxiliary substances employed using dyes dissolved in organic solvents or aqueous emulsions thereof
    • D06P1/92—General processes of dyeing or printing textiles, or general processes of dyeing leather, furs, or solid macromolecular substances in any form, classified according to the dyes, pigments, or auxiliary substances employed using dyes dissolved in organic solvents or aqueous emulsions thereof in organic solvents
    • D06P1/922—General processes of dyeing or printing textiles, or general processes of dyeing leather, furs, or solid macromolecular substances in any form, classified according to the dyes, pigments, or auxiliary substances employed using dyes dissolved in organic solvents or aqueous emulsions thereof in organic solvents hydrocarbons
    • D06P1/926—Non-halogenated hydrocarbons
    • D—TEXTILES; PAPER
    • D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
    • D06P—DYEING OR PRINTING TEXTILES; DYEING LEATHER, FURS OR SOLID MACROMOLECULAR SUBSTANCES IN ANY FORM
    • D06P1/00—General processes of dyeing or printing textiles, or general processes of dyeing leather, furs, or solid macromolecular substances in any form, classified according to the dyes, pigments, or auxiliary substances employed
    • D06P1/90—General processes of dyeing or printing textiles, or general processes of dyeing leather, furs, or solid macromolecular substances in any form, classified according to the dyes, pigments, or auxiliary substances employed using dyes dissolved in organic solvents or aqueous emulsions thereof
    • D06P1/92—General processes of dyeing or printing textiles, or general processes of dyeing leather, furs, or solid macromolecular substances in any form, classified according to the dyes, pigments, or auxiliary substances employed using dyes dissolved in organic solvents or aqueous emulsions thereof in organic solvents
    • D06P1/928—Solvents other than hydrocarbons
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2989—Microcapsule with solid core [includes liposome]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991—Coated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991—Coated
    • Y10T428/2998—Coated including synthetic resin or polymer

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Textile Engineering (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
IL13559398A 1997-10-14 1998-10-14 מיקרוספרות פולימריות צבועות פלואורסצנטית במדויק ושיטות להכנתן ושמוש בהן IL135593A (he)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6193897P 1997-10-14 1997-10-14
US8558498P 1998-05-15 1998-05-15
PCT/US1998/021562 WO1999019515A1 (en) 1997-10-14 1998-10-14 Precision fluorescently dyed particles and methods of making and using same

Publications (2)

Publication Number Publication Date
IL135593A0 IL135593A0 (en) 2001-05-20
IL135593A true IL135593A (he) 2004-06-01

Family

ID=26741675

Family Applications (1)

Application Number Title Priority Date Filing Date
IL13559398A IL135593A (he) 1997-10-14 1998-10-14 מיקרוספרות פולימריות צבועות פלואורסצנטית במדויק ושיטות להכנתן ושמוש בהן

Country Status (9)

Country Link
US (5) US6632526B1 (he)
EP (1) EP1023464B1 (he)
JP (1) JP4357112B2 (he)
KR (1) KR20010031140A (he)
AU (1) AU1080999A (he)
CA (1) CA2306501C (he)
HU (1) HUP0003986A3 (he)
IL (1) IL135593A (he)
WO (1) WO1999019515A1 (he)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2982963A1 (en) 2006-11-02 2016-02-10 Fluidigm Canada Inc. Particles containing detectable elemental code

Families Citing this family (294)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7041510B2 (en) * 1996-04-25 2006-05-09 Bioarray Solutions Ltd. System and method for programmable illumination pattern generation
ES2288760T3 (es) 1996-04-25 2008-01-16 Bioarray Solutions Ltd. Ensamblaje electrocinetico controlado por luz de particulas proximas a superficies.
US6387707B1 (en) 1996-04-25 2002-05-14 Bioarray Solutions Array Cytometry
US20030027126A1 (en) 1997-03-14 2003-02-06 Walt David R. Methods for detecting target analytes and enzymatic reactions
US7622294B2 (en) 1997-03-14 2009-11-24 Trustees Of Tufts College Methods for detecting target analytes and enzymatic reactions
JP4302780B2 (ja) 1997-05-23 2009-07-29 バイオアレイ ソリューションズ エルエルシー マトリックスで結合された化合物の色別コード化とインシトゥ探索
JP4357112B2 (ja) * 1997-10-14 2009-11-04 ルミネックス コーポレイション 精密蛍光染色された粒子及びその製造及び使用方法
US6607829B1 (en) 1997-11-13 2003-08-19 Massachusetts Institute Of Technology Tellurium-containing nanocrystalline materials
US5990479A (en) 1997-11-25 1999-11-23 Regents Of The University Of California Organo Luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes
US6207392B1 (en) 1997-11-25 2001-03-27 The Regents Of The University Of California Semiconductor nanocrystal probes for biological applications and process for making and using such probes
US6699723B1 (en) 1997-11-25 2004-03-02 The Regents Of The University Of California Organo luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes
JP3468750B2 (ja) * 1998-01-22 2003-11-17 ルミネックス コーポレイション 多数の蛍光シグナルを有する微小粒子
AU3555599A (en) * 1998-04-13 1999-11-01 Luminex Corporation Liquid labeling with fluorescent microparticles
US6642062B2 (en) 1998-09-03 2003-11-04 Trellis Bioinformatics, Inc. Multihued labels
EP1110090B1 (en) * 1998-09-03 2009-03-25 Trellis Bioscience, Inc. Multihued labels
US6306610B1 (en) 1998-09-18 2001-10-23 Massachusetts Institute Of Technology Biological applications of quantum dots
US6251303B1 (en) 1998-09-18 2001-06-26 Massachusetts Institute Of Technology Water-soluble fluorescent nanocrystals
US6617583B1 (en) 1998-09-18 2003-09-09 Massachusetts Institute Of Technology Inventory control
US6696304B1 (en) 1999-02-24 2004-02-24 Luminex Corporation Particulate solid phase immobilized protein quantitation
GB9905807D0 (en) * 1999-03-12 1999-05-05 Amersham Pharm Biotech Uk Ltd Analysis of differential gene expression
JP2002540802A (ja) 1999-04-06 2002-12-03 イェール ユニバーシティ 配列標識の固定されたアドレス分析
US7253435B2 (en) 1999-04-15 2007-08-07 Millipore Corporation Particles with light-polarizing codes
US6908737B2 (en) 1999-04-15 2005-06-21 Vitra Bioscience, Inc. Systems and methods of conducting multiplexed experiments
CN1271410C (zh) 1999-04-16 2006-08-23 泰博特克有限公司 微载体的编码
US6383740B2 (en) 1999-07-30 2002-05-07 Bioergonomics, Inc. Methods for simultaneously detecting both members of a binding pair
WO2001012855A2 (en) 1999-08-13 2001-02-22 Yale University Binary encoded sequence tags
AU6779200A (en) * 1999-08-17 2001-03-13 Luminex Corporation Encapsulation of fluorescent particles
US6649414B1 (en) * 1999-08-17 2003-11-18 Luminex Corporation Microparticles with multiple fluorescent signals and methods of using same
EP1248853A2 (en) * 1999-08-20 2002-10-16 Luminex Corporation Liquid array technology
EP1250675A2 (en) * 1999-09-15 2002-10-23 Luminex Corporation Creation of a database of biochemical data and methods of use
CA2406983A1 (en) 2000-03-14 2001-09-27 Massachusetts Institute Of Technology A gain medium and lasers based on close-packed semiconductor nanocrystals
JP4951184B2 (ja) 2000-03-20 2012-06-13 マサチューセッツ インスティテュート オブ テクノロジー 無機粒子結合体
EP1268858A1 (de) * 2000-03-31 2003-01-02 Memorec Stoffel GmbH Medizinisch-Molekulare Entwicklung Verwendung von partikeln, die signalgebende eigenschaften und mindestens eine affinitätsgruppierung für markierte nukleinsäuren besitzen
US9709559B2 (en) 2000-06-21 2017-07-18 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
US6586190B2 (en) 2000-08-18 2003-07-01 Syngenta Participations Ag Parallel high throughput method and kit
US7057704B2 (en) * 2000-09-17 2006-06-06 Bioarray Solutions Ltd. System and method for programmable illumination pattern generation
US7465540B2 (en) 2000-09-21 2008-12-16 Luminex Corporation Multiple reporter read-out for bioassays
US20030045005A1 (en) * 2000-10-17 2003-03-06 Michael Seul Light-controlled electrokinetic assembly of particles near surfaces
RU2285265C2 (ru) 2000-10-19 2006-10-10 Тиботек Бвба Способ и устройство манипулирования микроносителями для их идентификации
US20020110180A1 (en) 2001-02-09 2002-08-15 Barney Alfred A. Temperature-sensing composition
US7972818B2 (en) * 2001-02-14 2011-07-05 Lawrence Livermore National Security, Llc Flow cytometric detection method for DNA samples
US7262063B2 (en) 2001-06-21 2007-08-28 Bio Array Solutions, Ltd. Directed assembly of functional heterostructures
US7473767B2 (en) 2001-07-03 2009-01-06 The Institute For Systems Biology Methods for detection and quantification of analytes in complex mixtures
US7479630B2 (en) 2004-03-25 2009-01-20 Bandura Dmitry R Method and apparatus for flow cytometry linked with elemental analysis
ATE431567T1 (de) 2001-09-17 2009-05-15 Massachusetts Inst Technology Halbleiternanokristall-verbundstoff
CN100399025C (zh) * 2001-09-27 2008-07-02 北京源德生物医学工程有限公司 多标记连续注射免疫及基因分析***
US8148171B2 (en) 2001-10-09 2012-04-03 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and methods
US20050164261A1 (en) * 2001-10-09 2005-07-28 Chandler Don J. Multiplexed analysis of clinical specimens apparatus and methods
EP2722395B1 (en) 2001-10-15 2018-12-19 Bioarray Solutions Ltd Multiplexed analysis of polymorphic loci by concurrent interrogation and enzyme-mediated detection
US6838289B2 (en) 2001-11-14 2005-01-04 Beckman Coulter, Inc. Analyte detection system
US7150910B2 (en) 2001-11-16 2006-12-19 Massachusetts Institute Of Technology Nanocrystal structures
US20050118589A1 (en) 2001-11-21 2005-06-02 Vann Charles S. Digital array
US7241629B2 (en) * 2001-12-20 2007-07-10 Corning Incorporated Detectable labels, methods of manufacture and use
US20040171076A1 (en) * 2001-12-20 2004-09-02 Dejneka Matthew J. Detectable micro to nano sized structures, methods of manufacture and use
US7335153B2 (en) 2001-12-28 2008-02-26 Bio Array Solutions Ltd. Arrays of microparticles and methods of preparation thereof
US7319709B2 (en) 2002-07-23 2008-01-15 Massachusetts Institute Of Technology Creating photon atoms
US20040157238A1 (en) * 2002-09-20 2004-08-12 Quinn John J. Method for detection of multiple nucleic acid sequence variations
US20040157242A1 (en) * 2002-11-12 2004-08-12 Becton, Dickinson And Company Diagnosis of sepsis or SIRS using biomarker profiles
EP1573054A4 (en) * 2002-11-12 2005-12-28 Becton Dickinson Co DIAGNOSIS FOR SEPTICEMIA OR SIRS USING BIOMARKER PROFILES
JP2006506069A (ja) * 2002-11-12 2006-02-23 ベクトン，ディッキンソン アンド カンパニー バイオマーカープロフィールを用いた敗血症またはｓｉｒｓの診断
AU2003298655A1 (en) 2002-11-15 2004-06-15 Bioarray Solutions, Ltd. Analysis, secure access to, and transmission of array images
US7255895B2 (en) 2003-01-21 2007-08-14 Bioarray Solutions, Ltd. Method for controlling solute loading of polymer microparticles
US6964747B2 (en) 2003-01-21 2005-11-15 Bioarray Solutions, Ltd. Production of dyed polymer microparticles
ITMI20030339A1 (it) * 2003-02-26 2004-08-27 Pranha 50 Ltda Metodo, apparato e dispositivi per il risanamento di condotte mediante introduzione di tubi in materiale plastico.
FI20030615A0 (fi) * 2003-04-24 2003-04-24 Marko Virta Nanopartikkeli bioaffiniteettimäärityksiin
JP4145705B2 (ja) * 2003-04-15 2008-09-03 大成化工株式会社 着色剤（カララント）の製造方法
US7917298B1 (en) 2003-04-17 2011-03-29 Nanosys, Inc. Nanocrystal taggants
EP1480041A1 (en) * 2003-05-22 2004-11-24 Innogenetics N.V. Method for the prediction, diagnosis and differential diagnosis of Alzheimer's disease
FR2855613B1 (fr) * 2003-05-26 2005-08-19 Biocytex Procede de detection et de quantification multiplex d'analytes dans un echantillon a l'aide de microspheres
AU2003903417A0 (en) * 2003-07-04 2003-07-17 Genera Biosystems Pty Ltd Multiplex detection
US8796030B2 (en) * 2003-07-12 2014-08-05 Parallel Synthesis Technologies, Inc. Methods for optically encoding an object with upconverting materials and compositions used therein
US8012768B2 (en) * 2003-07-18 2011-09-06 Bio-Rad Laboratories, Inc. System and method for multi-analyte detection
US7220385B2 (en) * 2003-07-18 2007-05-22 Bio-Rad Laboratories, Inc. System and method for multi-analyte detection
US7260485B2 (en) * 2003-07-18 2007-08-21 Luminex Corporation Method and systems for distinguishing between materials having similar spectra
US20050176023A1 (en) * 2003-08-01 2005-08-11 Dynal Biotech Inc. Self-hybridizing multiple target nucleic acid probes and methods of use
CA2534402C (en) 2003-08-04 2013-06-25 Emory University Porous materials embedded with nanospecies, methods of fabrication thereof, and methods of use thereof
US7692773B2 (en) * 2003-08-05 2010-04-06 Luminex Corporation Light emitting diode based measurement systems
US7069191B1 (en) 2003-08-06 2006-06-27 Luminex Corporation Methods for reducing the susceptibility of a peak search to signal noise
KR101166180B1 (ko) * 2003-08-13 2012-07-18 루미넥스 코포레이션 유세포 분석기식 측정 시스템의 하나 이상의 파라미터의 제어 방법
CA2539824C (en) 2003-09-22 2015-02-03 Xinwen Wang Surface immobilized polyelectrolyte with multiple functional groups capable of covalently bonding to biomolecules
EP1692298A4 (en) 2003-10-28 2008-08-13 Bioarray Solutions Ltd OPTIMIZATION OF GENE EXPRESSION ANALYSIS USING IMMOBILIZED CATCHES
US20050106712A1 (en) * 2003-11-14 2005-05-19 Eastman Kodak Company Yellow low fluorescence dye for coated optical bead random array DNA analysis
WO2005071412A2 (en) 2004-01-09 2005-08-04 Applera Corporation Phosphor particle coded beads
KR20060123539A (ko) * 2004-01-14 2006-12-01 루미넥스 코포레이션 측정시스템의 하나 이상의 매개변수를 변경하는 방법
CN101187621B (zh) * 2004-01-14 2012-02-15 卢米尼克斯股份有限公司 用于动态范围扩展的方法和***
US7229778B2 (en) * 2004-02-26 2007-06-12 The Procter & Gamble Company Methods for determining the relative benefits and/or evaluating quantitative changes of products on epithelial tissue
WO2005094381A2 (en) * 2004-04-01 2005-10-13 Rules-Based Medicine, Inc. Universal shotgun assay
US7407816B2 (en) * 2004-05-07 2008-08-05 Gentius, Inc Isoelectric particles and uses thereof
US7465543B1 (en) 2004-05-21 2008-12-16 The United States Of America, As Represented By The Secretary Of Agriculture Multiplex DNA identification of clinical yeasts using flow cytometry
US7858323B2 (en) 2004-06-09 2010-12-28 The Regents Of The University Of Michigan Phage microarray profiling of the humoral response to disease
US7635563B2 (en) * 2004-06-30 2009-12-22 Massachusetts Institute Of Technology High throughput methods relating to microRNA expression analysis
US7229690B2 (en) 2004-07-26 2007-06-12 Massachusetts Institute Of Technology Microspheres including nanoparticles
US7848889B2 (en) 2004-08-02 2010-12-07 Bioarray Solutions, Ltd. Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification
US20060045814A1 (en) * 2004-09-01 2006-03-02 Zhang Yu-Zhong Microplates containing microsphere fluorescence standards, microsphere standards, and methods for their use
US8088629B1 (en) 2004-10-12 2012-01-03 Luminex Corporation Methods for forming dyed microspheres and populations of microspheres
US7867774B2 (en) * 2004-10-12 2011-01-11 Luminex Corporation Methods for altering surface characteristics of microspheres
CN101044213B (zh) 2004-10-12 2014-04-02 卢米尼克斯股份有限公司 形成染色的微球体和染色的微球体群的方法
US8927892B2 (en) * 2004-10-22 2015-01-06 Parallel Synthesis Technologies Rare earth downconverting phosphor compositions for optically encoding objects and methods and apparatus relating to same
CN101084429A (zh) * 2004-12-17 2007-12-05 卢米尼克斯股份有限公司 用于增加由荧光团发射的荧光的***、照明子***和方法
JP4452188B2 (ja) * 2005-01-17 2010-04-21 凸版印刷株式会社 カラービーズ製造装置、カラービーズ製造方法及びバイオ分析装置
US20060157647A1 (en) * 2005-01-18 2006-07-20 Becton, Dickinson And Company Multidimensional liquid chromatography/spectrometry
EP2244270B1 (en) * 2005-01-20 2012-06-06 Luminex Corporation Microspheres having fluorescent and magnetic properties
CA2495138C (en) * 2005-01-20 2012-10-23 Alison Jane Basile Multiplexed analysis for determining a serodiagnosis of viral infection
EP1869463A4 (en) * 2005-04-15 2010-05-05 Becton Dickinson Co SEPSIS DIAGNOSIS
JP2008538609A (ja) * 2005-04-20 2008-10-30 ベクトン・ディキンソン・アンド・カンパニー マルチプレックスマイクロ粒子システム
US7874489B2 (en) * 2005-06-20 2011-01-25 Authentiform Technologies, Llc Product authentication
US8247018B2 (en) * 2005-06-20 2012-08-21 Authentiform Technologies, Llc Methods for quality control
EP1907988B1 (en) * 2005-06-20 2013-11-06 AuthentiForm Technologies, L.L.C. Systems and methods for product authentication
WO2007005426A2 (en) * 2005-06-29 2007-01-11 Rules-Based Medicine, Inc. Methods and kits for the diagnosis of acute coronary syndrome
NO20053373D0 (no) * 2005-07-11 2005-07-11 Rikshospitalet Radiumhospitale Multicolored Particles.
US7781224B2 (en) * 2005-08-10 2010-08-24 Lawrence Livermore National Security, Llc Safe biodegradable fluorescent particles
US20070043510A1 (en) * 2005-08-19 2007-02-22 Beckman Coulter, Inc. Assay system
CN102621053B (zh) 2005-09-21 2015-05-06 卢米尼克斯股份有限公司 图像数据处理的方法和***
US20090117560A1 (en) * 2005-09-27 2009-05-07 Toshihiko Fujikawa Method of Forming Self Assembly Substance on Microsphere and Method of Detecting Target Analyte
CN101321686A (zh) * 2005-10-07 2008-12-10 佛罗里达大学研究基金会有限公司 用于多路信号传递和光编码的多组分纳米颗粒
WO2007051035A1 (en) * 2005-10-28 2007-05-03 Parallel Synthesis Technologies, Inc. Methods for fabricating optically encoded particles and methods for optically encoding objects with such particles
GB2432419A (en) 2005-11-16 2007-05-23 Agency Science Tech & Res Influenza A virus detection method
US20100015607A1 (en) 2005-12-23 2010-01-21 Nanostring Technologies, Inc. Nanoreporters and methods of manufacturing and use thereof
US20070239483A1 (en) * 2006-01-09 2007-10-11 Biophysical Corporation Methods for individualized health assessment service
US8309025B1 (en) 2006-01-26 2012-11-13 Luminex Corporation Methods and systems for determining composition and completion of an experiment
AU2007211085A1 (en) 2006-01-27 2007-08-09 Tripath Imaging, Inc. Methods for identifying patients with an increased likelihood of having ovarian cancer and compositions therefor
US20080038761A1 (en) * 2006-01-30 2008-02-14 Invitrogen Corporation Compositions and methods for detecting and quantifying toxic substances in disease states
WO2007099289A1 (en) * 2006-02-28 2007-09-07 Medical Research Council Targeted iron oxide nanoparticles
US20070207513A1 (en) * 2006-03-03 2007-09-06 Luminex Corporation Methods, Products, and Kits for Identifying an Analyte in a Sample
US8124943B1 (en) 2006-04-06 2012-02-28 Lugade Ananda G Methods and systems for altering fluorescent intensities of a plurality of particles
CN101421414A (zh) * 2006-04-17 2009-04-29 卢米尼克斯股份有限公司 用来测定激酶的活性的方法、颗粒和试剂盒
WO2007131171A1 (en) * 2006-05-05 2007-11-15 Rules-Based Medicine, Inc. Methods and kits for the diagnosis of hypothyroidism
CA2657970A1 (en) * 2006-05-17 2007-11-29 Luminex Corporation Chip-based flow cytometer type systems for analyzing fluorescently tagged particles
US7846391B2 (en) 2006-05-22 2010-12-07 Lumencor, Inc. Bioanalytical instrumentation using a light source subsystem
EP2765423B1 (en) 2006-06-02 2016-11-02 Luminex Corporation Systems and methods for performing measurements of one or more analytes comprising using magnetic particles and applying a magnetic field
US8296088B2 (en) 2006-06-02 2012-10-23 Luminex Corporation Systems and methods for performing measurements of one or more materials
US8062609B2 (en) * 2006-11-10 2011-11-22 Luminex Corporation Flow cytometer and fluidic line assembly with multiple injection needles
JP5156944B2 (ja) * 2006-11-20 2013-03-06 国立大学法人東京工業大学 蛍光機能具備磁性ポリマー粒子とその製造方法
WO2008064336A2 (en) 2006-11-22 2008-05-29 Inivitrogen Corporation Autoimmune disease biomarkers
SG143090A1 (en) * 2006-11-27 2008-06-27 Agency Science Tech & Res Influenza b virus detection method and kit therefor
US7955802B2 (en) 2006-12-13 2011-06-07 Luminex Corporation Systems and methods for multiplex analysis of PCR in real time
US20080261253A1 (en) * 2007-01-12 2008-10-23 Rules-Based Medicine, Inc. Methods and kits for the diagnosis of galactosemia
WO2008100791A1 (en) * 2007-02-16 2008-08-21 Rules-Based Medicine, Inc. Methods and kits for the diagnosis of sickle cell
EP1961825A1 (en) 2007-02-26 2008-08-27 INSERM (Institut National de la Santé et de la Recherche Medicale) Method for predicting the occurrence of metastasis in breast cancer patients
DE102007010860B4 (de) * 2007-03-01 2014-05-15 PolyAn Gesellschaft zur Herstellung von Polymeren für spezielle Anwendungen und Analytik mbH Verfahren zur Identifikation eines Partikels mit zwei oder mehr monodispers eingebetteten Fluorophoren
WO2008109176A2 (en) 2007-03-07 2008-09-12 President And Fellows Of Harvard College Assays and other reactions involving droplets
WO2008109797A1 (en) * 2007-03-08 2008-09-12 Rules-Based Medicine, Inc. Methods for rapid disease screening
CN101801992A (zh) * 2007-05-31 2010-08-11 孟山都技术公司 大豆多态性与基因分型方法
US20090047689A1 (en) * 2007-06-20 2009-02-19 John Kolman Autoantigen biomarkers for early diagnosis of lung adenocarcinoma
US7709811B2 (en) * 2007-07-03 2010-05-04 Conner Arlie R Light emitting diode illumination system
US8098375B2 (en) 2007-08-06 2012-01-17 Lumencor, Inc. Light emitting diode illumination system
KR20100087104A (ko) 2007-09-17 2010-08-03 루미넥스 코포레이션 유동 입자를 식별하는 시스템과 저장매체 및 방법
JP5286726B2 (ja) * 2007-09-25 2013-09-11 富士ゼロックス株式会社 黒色色材及びトナー
WO2009042423A1 (en) * 2007-09-27 2009-04-02 Cellatope Corporation Methods and compositions for improved diagnostic assays
US8871687B2 (en) * 2007-09-28 2014-10-28 Quest Diagnostics Investments Incorporated Nucleic acid sequencing by single-base primer extension
CN101946010B (zh) 2007-12-21 2014-08-20 哈佛大学 用于核酸测序的***和方法
US20090170214A1 (en) * 2007-12-27 2009-07-02 Luminex Corporation Luminescent Reporter Modality for Analyzing an Assay
CA2711373C (en) * 2008-01-07 2014-10-28 Luminex Corporation Isolation and enumeration of cells from a complex sample matrix
US8318445B2 (en) * 2008-01-07 2012-11-27 Luminex Corporation Immunomagnetic capture and imaging of biological targets
US20100279272A1 (en) * 2008-02-13 2010-11-04 Michael Craig Burrell Multiplexed analysis methods using sers-active nanoparticles
WO2009123737A2 (en) 2008-04-03 2009-10-08 Becton, Dickinson And Company Advanced detection of sepsis
US7777176B2 (en) * 2008-08-14 2010-08-17 Energy Materials Corporation Composition and method to characterize membranes' defects
ES2684317T3 (es) 2008-08-14 2018-10-02 Nanostring Technologies, Inc Nanoinformadores estables
WO2010019125A1 (en) * 2008-08-15 2010-02-18 Energy Materials Corporation Composition and method to characterize membranes' defects
US9494580B2 (en) * 2008-09-11 2016-11-15 Tokyo Institute Of Technology Polymer particle containing fluorescent molecule and method for producing the same
US20100068729A1 (en) * 2008-09-12 2010-03-18 Rules-Based Medicine, Inc. Method and kits for the diagnosis of diabetes
US20110218123A1 (en) 2008-09-19 2011-09-08 President And Fellows Of Harvard College Creation of libraries of droplets and related species
US20100076302A1 (en) * 2008-09-25 2010-03-25 Jeff Gray Invisible Power Port ID Tattoo
CN102265155B (zh) 2008-11-10 2014-08-13 卢米耐克斯公司 用于制备和使用多重检测中的大孔珠粒的方法和体系
US8415161B2 (en) 2008-11-13 2013-04-09 Becton, Dickinson And Company Instrument setup system for a fluorescence analyzer
EP3290531B1 (en) 2008-12-19 2019-07-24 President and Fellows of Harvard College Particle-assisted nucleic acid sequencing
US8242462B2 (en) 2009-01-23 2012-08-14 Lumencor, Inc. Lighting design of high quality biomedical devices
EP2290102A1 (en) 2009-07-08 2011-03-02 Administración General De La Communidad Autónoma De Euskadi Methods for the diagnosis of multiple sclerosis based on its microRNA expression profiling
US20110097723A1 (en) * 2009-09-19 2011-04-28 Qun Liu Methods and reagents for analyte detection
JP5954876B2 (ja) 2009-10-13 2016-07-20 ナノストリング テクノロジーズ， インコーポレイテッド ナノレポーターによるタンパク質の検出
AU2010315580B2 (en) 2009-10-27 2014-11-06 President And Fellows Of Harvard College Droplet creation techniques
GB2475226A (en) 2009-11-03 2011-05-18 Genetic Analysis As Universal Prokaryote 16S ribosome PCR primer pair
CA2785529C (en) 2010-02-11 2019-01-08 Nanostring Technologies, Inc. Compositions and methods for the detection of small rnas
US9500644B2 (en) * 2010-02-23 2016-11-22 Luminex Corporation Particle populations and assays having varying amounts of magnetic material and particle concentrations among different subsets of particles and methods for processing assays having such particle populations
US8236574B2 (en) 2010-03-01 2012-08-07 Quanterix Corporation Ultra-sensitive detection of molecules or particles using beads or other capture objects
WO2011109379A1 (en) 2010-03-01 2011-09-09 Quanterix Corporation Methods and systems for extending dynamic range in assays for the detection of molecules or particles
CA2791905A1 (en) 2010-03-01 2011-09-09 Caris Life Sciences Luxembourg Holdings, S.A.R.L. Biomarkers for theranostics
EP2548025A4 (en) 2010-03-17 2013-09-25 Univ Michigan USE OF PHOTOEPITOPES FOR PROFILING AN IMMUNE REACTION
US20110237457A1 (en) * 2010-03-26 2011-09-29 Armune Biosciences, Inc. Method and system of particle-coupled phage epitope
US9469876B2 (en) 2010-04-06 2016-10-18 Caris Life Sciences Switzerland Holdings Gmbh Circulating biomarkers for metastatic prostate cancer
WO2011127390A2 (en) 2010-04-09 2011-10-13 Luminex Corporation Magnetic separation device
JP5985140B2 (ja) 2010-04-28 2016-09-06 ソニー株式会社 蛍光強度補正方法、蛍光強度算出方法及び蛍光強度算出装置
US8274656B2 (en) 2010-06-30 2012-09-25 Luminex Corporation Apparatus, system, and method for increasing measurement accuracy in a particle imaging device
US8767069B2 (en) 2010-06-30 2014-07-01 Luminex Corporation Apparatus, system, and method for increasing measurement accuracy in a particle imaging device using light distribution
US20120065092A1 (en) 2010-09-14 2012-03-15 Wai Hobert Fusion analyte cytometric bead assay, and systems and kits for performing the same
GB201021399D0 (en) 2010-12-16 2011-01-26 Genetic Analysis As Oligonucleotide probe set and methods of microbiota profiling
GB201021397D0 (en) 2010-12-16 2011-01-26 Genetic Analysis As Diagnosis of Crohn's disease
US8389957B2 (en) 2011-01-14 2013-03-05 Lumencor, Inc. System and method for metered dosage illumination in a bioanalysis or other system
US8466436B2 (en) 2011-01-14 2013-06-18 Lumencor, Inc. System and method for metered dosage illumination in a bioanalysis or other system
GB201102693D0 (en) 2011-02-16 2011-03-30 Genetic Analysis As Method for identifying neonates at risk for necrotizing enterocolitis
WO2012135340A2 (en) 2011-03-28 2012-10-04 Nanostring Technologies, Inc. Compositions and methods for diagnosing cancer
WO2012142301A2 (en) 2011-04-12 2012-10-18 Quanterix Corporation Methods of determining a treatment protocol for and/or a prognosis of a patients recovery from a brain injury
EP2546358A1 (en) 2011-07-15 2013-01-16 Laboratorios Del. Dr. Esteve, S.A. Methods and reagents for efficient control of HIV progression
CN104039978A (zh) 2011-09-29 2014-09-10 露美内克丝公司 水解探针
CN105894515B (zh) 2011-10-18 2019-03-01 卢米尼克斯股份有限公司 用于图像数据处理的方法和***
EP2788478B1 (en) 2011-12-09 2017-08-23 Institut Pasteur Multiplex immuno screening assay
US8967846B2 (en) 2012-01-20 2015-03-03 Lumencor, Inc. Solid state continuous white light source
EP4361607A3 (en) 2012-02-03 2024-07-17 California Institute of Technology Signal encoding and decoding in multiplexed biochemical assays
US9404923B2 (en) 2012-02-07 2016-08-02 Intuitive Biosciences, Inc. Mycobacterium tuberculosis specific peptides for detection of infection or immunization in non-human primates
EP2823311B1 (en) 2012-03-06 2016-04-27 Life Technologies Corporation Biomarkers for systemic lupus erythematosus
ES2434853B1 (es) 2012-06-12 2014-09-30 Fundación Centro Nacional De Investigaciones Cardiovasculares Carlos Iii Marcador molecular de potencia terapéutica de células madre mesenquimales humanas y sus usos
US9217561B2 (en) 2012-06-15 2015-12-22 Lumencor, Inc. Solid state light source for photocuring
WO2013188857A2 (en) 2012-06-15 2013-12-19 Luminex Corporation Apparatus, system, and method for image normalization using a gaussian residual of fit selection criteria
FR2992427A1 (fr) * 2012-06-20 2013-12-27 Assist Publ Hopitaux De Paris Methode de pronostic d'un lymphome et kit pour sa mise en oeuvre
CN104487568B (zh) 2012-07-11 2017-08-15 爱姆斯坦生物技术公司 人胚胎干细胞衍生的间充质样干细胞、方法及其应用
US9791372B2 (en) 2012-08-03 2017-10-17 California Institute Of Technology Multiplexing and quantification in PCR with reduced hardware and requirements
US10752949B2 (en) 2012-08-14 2020-08-25 10X Genomics, Inc. Methods and systems for processing polynucleotides
US9701998B2 (en) 2012-12-14 2017-07-11 10X Genomics, Inc. Methods and systems for processing polynucleotides
US11591637B2 (en) 2012-08-14 2023-02-28 10X Genomics, Inc. Compositions and methods for sample processing
US10221442B2 (en) 2012-08-14 2019-03-05 10X Genomics, Inc. Compositions and methods for sample processing
US10584381B2 (en) 2012-08-14 2020-03-10 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10273541B2 (en) 2012-08-14 2019-04-30 10X Genomics, Inc. Methods and systems for processing polynucleotides
US9951386B2 (en) 2014-06-26 2018-04-24 10X Genomics, Inc. Methods and systems for processing polynucleotides
US20140155295A1 (en) 2012-08-14 2014-06-05 10X Technologies, Inc. Capsule array devices and methods of use
US10323279B2 (en) 2012-08-14 2019-06-18 10X Genomics, Inc. Methods and systems for processing polynucleotides
WO2014031902A2 (en) 2012-08-23 2014-02-27 The Regents Of The University Of California Spectrally encoded microbeads and methods and devices for making and using same
US10942184B2 (en) 2012-10-23 2021-03-09 Caris Science, Inc. Aptamers and uses thereof
KR20150090072A (ko) 2012-10-23 2015-08-05 카리스 라이프 사이언스 스위스 홀딩스 게엠베하 압타머 및 이의 용도
EP2915098A4 (en) 2012-10-30 2016-07-06 Certirx Corp PRODUCT, IMAGE, OR DOCUMENT AUTHENTICATION AND VERIFICATION AND OBJECT IDENTIFICATION
WO2014093676A1 (en) 2012-12-14 2014-06-19 10X Technologies, Inc. Methods and systems for processing polynucleotides
US10533221B2 (en) 2012-12-14 2020-01-14 10X Genomics, Inc. Methods and systems for processing polynucleotides
EP2935628B1 (en) 2012-12-19 2018-03-21 Caris Life Sciences Switzerland Holdings GmbH Compositions and methods for aptamer screening
WO2014099933A1 (en) * 2012-12-21 2014-06-26 Janssen Biotech, Inc. Sensitive multiplex immunoassay for soluble fibroblast growth factor receptors
CN108753766A (zh) 2013-02-08 2018-11-06 10X基因组学有限公司 多核苷酸条形码生成
US20140243231A1 (en) 2013-02-28 2014-08-28 The Terasaki Family Foundation Methods and compositions for the efficient reuse of multiply dyed particles
JP6107244B2 (ja) * 2013-03-08 2017-04-05 コニカミノルタ株式会社 蛍光色素標識用樹脂粒子及びその製造方法並びに該粒子を含む組織免疫染色用キット
WO2014152775A2 (en) 2013-03-14 2014-09-25 Certirx Corporation Nucleic acid-based authentication and identification codes
WO2014145152A2 (en) 2013-03-15 2014-09-18 Gpb Scientific, Llc On-chip microfluidic processing of particles
EP2971279B1 (en) 2013-03-15 2019-11-13 The Trustees of Princeton University Methods and devices for high throughput purification
US20150064153A1 (en) 2013-03-15 2015-03-05 The Trustees Of Princeton University High efficiency microfluidic purification of stem cells to improve transplants
ES2523016B1 (es) 2013-05-20 2015-09-09 3P Biopharmaceuticals Vectores alfavirales y líneas celulares para la producción de proteínas recombinantes
WO2014205083A1 (en) 2013-06-19 2014-12-24 Luminex Corporation Real-time multiplexed hydrolysis probe assay using spectrally identifiable microspheres
KR102129506B1 (ko) 2013-08-09 2020-07-06 루미넥스 코포레이션 핵산 에세이에서의 향상된 용융 식별 및 복합화를 위한 프로브
CN105980615A (zh) 2013-08-28 2016-09-28 卡里斯生命科学瑞士控股有限公司 寡核苷酸探针及其用途
US10395758B2 (en) 2013-08-30 2019-08-27 10X Genomics, Inc. Sequencing methods
EP3065712A4 (en) 2013-11-08 2017-06-21 President and Fellows of Harvard College Microparticles, methods for their preparation and use
US9824068B2 (en) 2013-12-16 2017-11-21 10X Genomics, Inc. Methods and apparatus for sorting data
JP6409173B2 (ja) * 2014-02-20 2018-10-24 国立大学法人東京工業大学 蛍光標識セット
CN110548550B (zh) 2014-04-10 2022-03-08 10X基因组学有限公司 用于封装和分割试剂的流体装置、***和方法及其应用
AU2015249592A1 (en) 2014-04-24 2016-12-15 Immusant, Inc. Use of Interleukin-2 for diagnosis of Celiac disease
CN106575322B (zh) 2014-06-26 2019-06-18 10X基因组学有限公司 核酸序列装配的方法和***
WO2015200893A2 (en) 2014-06-26 2015-12-30 10X Genomics, Inc. Methods of analyzing nucleic acids from individual cells or cell populations
EP3967771B1 (en) 2014-08-11 2023-10-04 Luminex Corporation Probes for improved melt discrimination and multiplexing in nucleic acid assays
AU2015339148B2 (en) 2014-10-29 2022-03-10 10X Genomics, Inc. Methods and compositions for targeted nucleic acid sequencing
US9975122B2 (en) 2014-11-05 2018-05-22 10X Genomics, Inc. Instrument systems for integrated sample processing
EP3221344A2 (en) 2014-11-21 2017-09-27 Immusant Inc. Peptides for use in treatment and diagnosis of type 1 diabetes
SG11201705615UA (en) 2015-01-12 2017-08-30 10X Genomics Inc Processes and systems for preparing nucleic acid sequencing libraries and libraries prepared using same
US20180003703A1 (en) * 2015-01-13 2018-01-04 Quanterix Corporation Methods relating to improving accuracy of capture object-based assays
CA2968417A1 (en) 2015-01-13 2016-07-21 10X Genomics, Inc. Systems and methods for visualizing structural variation and phasing information
MX2017010142A (es) 2015-02-09 2017-12-11 10X Genomics Inc Sistemas y metodos para determinar variacion estructural y ajuste de fases con datos de recuperacion de variantes.
US11434264B2 (en) 2015-02-13 2022-09-06 Quanterix Corporation Immunoassays for differential detection of clostridium difficile
MX2017010857A (es) 2015-02-24 2017-12-11 10X Genomics Inc Metodos para la cobertura de secuencia de acidos nucleicos seleccionados como diana.
US10697000B2 (en) 2015-02-24 2020-06-30 10X Genomics, Inc. Partition processing methods and systems
AU2016229076B2 (en) 2015-03-09 2022-01-20 Caris Science, Inc. Oligonucleotide probes and uses thereof
AU2016287499B2 (en) 2015-06-29 2022-08-04 Caris Science, Inc. Therapeutic oligonucleotides
ES2975361T3 (es) 2015-07-17 2024-07-04 Nanostring Technologies Inc Cuantificación simultánea de una pluralidad de proteínas en una región definida por el usuario de un tejido seccionado transversalmente
AU2016295158B2 (en) 2015-07-17 2021-02-25 Bruker Spatial Biology, Inc. Simultaneous quantification of gene expression in a user-defined region of a cross-sectioned tissue
US10941176B2 (en) 2015-07-28 2021-03-09 Caris Science, Inc. Therapeutic oligonucleotides
US10976232B2 (en) 2015-08-24 2021-04-13 Gpb Scientific, Inc. Methods and devices for multi-step cell purification and concentration
AU2016338907B2 (en) 2015-10-13 2022-07-07 President And Fellows Of Harvard College Systems and methods for making and using gel microspheres
US20170137133A1 (en) * 2015-11-12 2017-05-18 Goodrich Corporation System, method, and apparatus for dye in search, rescue, and recovery
US10774370B2 (en) 2015-12-04 2020-09-15 10X Genomics, Inc. Methods and compositions for nucleic acid analysis
KR102652405B1 (ko) * 2015-12-28 2024-03-28 삼성디스플레이 주식회사 염료 비드, 이를 포함하는 컬러필터용 감광성 수지 조성물 및 컬러필터
EP3408288A2 (en) 2016-01-29 2018-12-05 Achaogen, Inc. Screening methods for identifying antibodies that bind cell surface epitopes
SG11201806757XA (en) 2016-02-11 2018-09-27 10X Genomics Inc Systems, methods, and media for de novo assembly of whole genome sequence data
KR20190008843A (ko) 2016-03-18 2019-01-25 카리스 싸이언스, 인코포레이티드 올리고뉴클레오티드 프로브 및 이의 용도
WO2017197338A1 (en) 2016-05-13 2017-11-16 10X Genomics, Inc. Microfluidic systems and methods of use
IL306052A (he) 2016-05-25 2023-11-01 Caris Science Inc פרובים אוליגונוקלאוטידים ושימושיהם
CN109642252A (zh) 2016-06-17 2019-04-16 加州理工学院 核酸反应及相关方法和组合物
JP7132233B2 (ja) 2016-11-11 2022-09-06 アセンダント ディーエックス， エルエルシー 全身型若年性特発性関節炎および川崎病を診断および識別するための組成物および方法
JP6730525B2 (ja) 2016-11-21 2020-07-29 ナノストリング テクノロジーズ，インコーポレイティド 化学組成物とそれを利用する方法
US10011872B1 (en) 2016-12-22 2018-07-03 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10550429B2 (en) 2016-12-22 2020-02-04 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10815525B2 (en) 2016-12-22 2020-10-27 10X Genomics, Inc. Methods and systems for processing polynucleotides
WO2018140827A1 (en) 2017-01-27 2018-08-02 Achaogen, Inc. Reporter microorganisms and uses thereof
WO2018140966A1 (en) 2017-01-30 2018-08-02 10X Genomics, Inc. Methods and systems for droplet-based single cell barcoding
WO2018194609A1 (en) 2017-04-20 2018-10-25 Hewlett-Packard Development Company, L.P. Build compositions
EP3625715A4 (en) 2017-05-19 2021-03-17 10X Genomics, Inc. DATA SET ANALYSIS SYSTEMS AND METHODS
US10400235B2 (en) 2017-05-26 2019-09-03 10X Genomics, Inc. Single cell analysis of transposase accessible chromatin
CN109526228B (zh) 2017-05-26 2022-11-25 10X基因组学有限公司 转座酶可接近性染色质的单细胞分析
SG11201913654QA (en) 2017-11-15 2020-01-30 10X Genomics Inc Functionalized gel beads
US10829815B2 (en) 2017-11-17 2020-11-10 10X Genomics, Inc. Methods and systems for associating physical and genetic properties of biological particles
CN108531550A (zh) * 2018-02-01 2018-09-14 武汉尚码生物科技有限公司 一种微粒载体的标记和鉴别方法及其应用
SG11202007501SA (en) 2018-02-12 2020-09-29 Nanostring Technologies Inc Biomolecular probes and methods of detecting gene and protein expression
SG11202009889VA (en) 2018-04-06 2020-11-27 10X Genomics Inc Systems and methods for quality control in single cell processing
US11549139B2 (en) 2018-05-14 2023-01-10 Nanostring Technologies, Inc. Chemical compositions and methods of using same
US11929171B2 (en) 2018-10-18 2024-03-12 The Board Of Trustees Of The Leland Stanford Junior University Methods for evaluation and treatment of glycemic dysregulation and atherosclerotic cardiovascular disease and applications thereof
US20220364147A1 (en) 2019-11-15 2022-11-17 Miltenyi Biotec B.V. & Co. KG Color and bardcoded beads for single cell indexing
CN111060683B (zh) * 2019-12-09 2023-11-21 彩科(苏州)生物科技有限公司 一种多重免疫分子检测方法及试剂盒
CN111218498A (zh) * 2019-12-09 2020-06-02 彩科(苏州)生物科技有限公司 一种无扩增的核酸分子检测试剂盒及其使用方法
CN112111268B (zh) * 2020-09-27 2021-11-23 上海交通大学 荧光编码微球和阵列及制备方法
CN113061385B (zh) * 2021-03-31 2022-04-12 福州大学 一种耐候、高硬水性环氧氨基烤漆及其制备方法
CN113281317B (zh) * 2021-05-14 2022-04-29 北京指真生物科技有限公司 一种含有花菁类化合物的编码微球及其制备方法和应用
WO2024124044A1 (en) 2022-12-07 2024-06-13 The Brigham And Women’S Hospital, Inc. Compositions and methods targeting sat1 for enhancing anti¬ tumor immunity during tumor progression

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3790492A (en) * 1971-03-11 1974-02-05 Atomic Energy Commission Method for production of uniform microspheres
US4267234A (en) 1978-03-17 1981-05-12 California Institute Of Technology Polyglutaraldehyde synthesis and protein bonding substrates
US4267235A (en) 1979-03-19 1981-05-12 California Institute Of Technology Polyglutaraldehyde microspheres
IL63220A (en) 1981-07-01 1985-09-29 Yeda Res & Dev Process for production of polyacrolein microspheres
US4717655A (en) 1982-08-30 1988-01-05 Becton, Dickinson And Company Method and apparatus for distinguishing multiple subpopulations of cells
DE3322373C2 (de) 1983-05-19 1986-12-04 Ioannis Dr. 3000 Hannover Tripatzis Testmittel und Verfahren zum Nachweis von Antigenen und/oder Antikörpern
US4677138A (en) 1983-10-19 1987-06-30 Yeda Research And Development Co., Ltd. High yield process for producing polyaldehyde microspheres
US4677045A (en) 1984-07-27 1987-06-30 International Business Machines Corporation Squarylium charge generating dye and electrophotographic photoconductor
US4774189A (en) 1984-12-24 1988-09-27 Flow Cytometry Standards Corp. Fluorescent calibration microbeads simulating stained cells
US5073498A (en) 1984-12-24 1991-12-17 Caribbean Microparticles Corporation Fluorescent alignment microbeads with broad excitation and emission spectra and its use
US4667138A (en) * 1986-03-27 1987-05-19 Rockwell International Corporation Multiplexed synchro driver
US5194300A (en) 1987-07-15 1993-03-16 Cheung Sau W Methods of making fluorescent microspheres
US5237498A (en) 1988-07-08 1993-08-17 Hitachi, Ltd. System and method for computing profits for individual entities of an entity group via use of means to retrieve and process data for specific entities
US5723218A (en) * 1990-04-16 1998-03-03 Molecular Probes, Inc. Dipyrrometheneboron difluoride labeled flourescent microparticles
US5326692B1 (en) * 1992-05-13 1996-04-30 Molecular Probes Inc Fluorescent microparticles with controllable enhanced stokes shift
US5227498A (en) * 1991-11-20 1993-07-13 Polaroid Corporation Squarylium dyes, and processes and intermediates for the preparation thereof
US5354873A (en) 1991-11-20 1994-10-11 Polaroid Corporation Squarylium dyes, and processes and intermediates for the preparation thereof
FR2707658B1 (fr) 1993-07-12 1995-11-24 Prolabo Sa Latex fluorescent comportant au moins deux fluorochromes, procédé d'obtention et application dudit latex comme marqueur, notamment en biologie.
US5747349A (en) 1996-03-20 1998-05-05 University Of Washington Fluorescent reporter beads for fluid analysis
US5945526A (en) * 1996-05-03 1999-08-31 Perkin-Elmer Corporation Energy transfer dyes with enhanced fluorescence
US5786219A (en) 1996-10-28 1998-07-28 Molecular Probes, Inc. Microspheres with fluorescent spherical zones
JP4357112B2 (ja) * 1997-10-14 2009-11-04 ルミネックス コーポレイション 精密蛍光染色された粒子及びその製造及び使用方法
JP3468750B2 (ja) * 1998-01-22 2003-11-17 ルミネックス コーポレイション 多数の蛍光シグナルを有する微小粒子
US6309701B1 (en) * 1998-11-10 2001-10-30 Bio-Pixels Ltd. Fluorescent nanocrystal-labeled microspheres for fluorescence analyses
US6649414B1 (en) * 1999-08-17 2003-11-18 Luminex Corporation Microparticles with multiple fluorescent signals and methods of using same
AU6779200A (en) * 1999-08-17 2001-03-13 Luminex Corporation Encapsulation of fluorescent particles
US6417402B1 (en) * 2001-09-26 2002-07-09 Council Of Scientific And Industrial Research Squaraine based dyes and process for preparation thereof
US6964747B2 (en) * 2003-01-21 2005-11-15 Bioarray Solutions, Ltd. Production of dyed polymer microparticles

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2982963A1 (en) 2006-11-02 2016-02-10 Fluidigm Canada Inc. Particles containing detectable elemental code

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