IL133087A0 - Conjugated peptide nucleic acids having enhanced cellular uptake - Google Patents
Conjugated peptide nucleic acids having enhanced cellular uptakeInfo
- Publication number
- IL133087A0 IL133087A0 IL13308798A IL13308798A IL133087A0 IL 133087 A0 IL133087 A0 IL 133087A0 IL 13308798 A IL13308798 A IL 13308798A IL 13308798 A IL13308798 A IL 13308798A IL 133087 A0 IL133087 A0 IL 133087A0
- Authority
- IL
- Israel
- Prior art keywords
- nucleic acids
- peptide nucleic
- cellular uptake
- enhanced cellular
- conjugated peptide
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
- C07K14/003—Peptide-nucleic acids (PNAs)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Oncology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Dispersion Chemistry (AREA)
- AIDS & HIV (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US86476597A | 1997-05-28 | 1997-05-28 | |
PCT/US1998/010804 WO1998053801A1 (en) | 1997-05-28 | 1998-05-28 | Conjugated peptide nucleic acids having enhanced cellular uptake |
Publications (1)
Publication Number | Publication Date |
---|---|
IL133087A0 true IL133087A0 (en) | 2001-03-19 |
Family
ID=25344022
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL13308798A IL133087A0 (en) | 1997-05-28 | 1998-05-28 | Conjugated peptide nucleic acids having enhanced cellular uptake |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP1003480A4 (en) |
JP (1) | JP2001501975A (en) |
AU (1) | AU745309B2 (en) |
CA (1) | CA2291839A1 (en) |
IL (1) | IL133087A0 (en) |
NZ (1) | NZ501289A (en) |
WO (1) | WO1998053801A1 (en) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6723560B2 (en) | 1998-10-08 | 2004-04-20 | Mayo Foundation For Medical Education And Research | Using polyamide nucleic acid oligomers to engender a biological response |
US6989270B1 (en) | 1997-10-17 | 2006-01-24 | Mayo Foundation For Medical Education And Research | Using polyamide nucleic acid oligomers to engender a biological response |
US6472209B1 (en) | 1997-10-17 | 2002-10-29 | Mayo Foundation For Medical Education And Research | Using polyamide nucleic acid oligomers to engender a biological response |
DE19909373A1 (en) * | 1999-03-03 | 2000-10-05 | Ugichem | New PNA monomers, resulting PNA oligomers and their use |
DE10038169A1 (en) * | 2000-08-04 | 2002-03-07 | November Ag Molekulare Medizin | Synthetic particle for marking a substance |
WO2004024757A2 (en) * | 2002-09-11 | 2004-03-25 | Santaris Pharma A/S | Modified pna molecules |
SG171914A1 (en) | 2008-12-02 | 2011-07-28 | Chiralgen Ltd | Method for the synthesis of phosphorus atom modified nucleic acids |
AU2010270714B2 (en) | 2009-07-06 | 2015-08-13 | Wave Life Sciences Ltd. | Novel nucleic acid prodrugs and methods use thereof |
US10428019B2 (en) | 2010-09-24 | 2019-10-01 | Wave Life Sciences Ltd. | Chiral auxiliaries |
DK2734208T3 (en) | 2011-07-19 | 2017-06-19 | Wave Life Sciences Ltd | PROCEDURES FOR SYNTHESIS OF FUNCTIONALIZED NUCLEIC ACIDS |
US9598458B2 (en) | 2012-07-13 | 2017-03-21 | Wave Life Sciences Japan, Inc. | Asymmetric auxiliary group |
JP6246121B2 (en) | 2012-07-13 | 2017-12-13 | 株式会社新日本科学 | Chiral nucleic acid adjuvant |
SG11201500232UA (en) | 2012-07-13 | 2015-04-29 | Wave Life Sciences Pte Ltd | Chiral control |
JPWO2015108047A1 (en) | 2014-01-15 | 2017-03-23 | 株式会社新日本科学 | Chiral nucleic acid adjuvant having immunity induction activity and immunity induction activator |
EP3095460A4 (en) | 2014-01-15 | 2017-08-23 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant having anti-allergic activity, and anti-allergic agent |
JPWO2015108048A1 (en) | 2014-01-15 | 2017-03-23 | 株式会社新日本科学 | Chiral nucleic acid adjuvant and antitumor agent having antitumor activity |
US10160969B2 (en) | 2014-01-16 | 2018-12-25 | Wave Life Sciences Ltd. | Chiral design |
DE102014007158A1 (en) * | 2014-05-16 | 2015-11-19 | Ugichem Gmbh | New peptide-nucleic acid monomers and oligomers |
ES2964588T3 (en) * | 2014-06-24 | 2024-04-08 | Translate Bio Inc | Stereochemically enriched compositions for nucleic acid delivery |
JP2022541650A (en) * | 2019-07-24 | 2022-09-26 | ザ・トラスティーズ・オブ・コロンビア・ユニバーシティ・イン・ザ・シティ・オブ・ニューヨーク | Methods and compositions for treating cancer using peptide nucleic acid-based agents |
CN114315835B (en) * | 2021-11-30 | 2023-03-03 | 华南农业大学 | 6-benzyladenine hapten, artificial antigen, antibody and preparation method and application thereof |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5539082A (en) * | 1993-04-26 | 1996-07-23 | Nielsen; Peter E. | Peptide nucleic acids |
DK51092D0 (en) * | 1991-05-24 | 1992-04-15 | Ole Buchardt | OLIGONUCLEOTIDE ANALOGUE DESCRIBED BY PEN, MONOMERIC SYNTHONES AND PROCEDURES FOR PREPARING THEREOF, AND APPLICATIONS THEREOF |
US5705333A (en) * | 1994-08-05 | 1998-01-06 | The Regents Of The University Of California | Peptide-based nucleic acid mimics(PENAMS) |
EP0804456B1 (en) * | 1994-10-06 | 2002-08-21 | Isis Pharmaceuticals, Inc. | Peptide nucleic acid conjugates |
EP0790837A1 (en) * | 1994-12-21 | 1997-08-27 | Novartis AG | Oligonucleotide-dendrimer conjugates |
DE69637086T2 (en) * | 1995-10-12 | 2008-01-10 | Lansdorp, Peter M., Vancouver | METHOD FOR DETECTING MULTIPLE COPIES OF A REPEAT SEQUENCE IN A NUCLEIC ACID MOLECULE |
-
1998
- 1998-05-28 JP JP11500871A patent/JP2001501975A/en active Pending
- 1998-05-28 EP EP98923819A patent/EP1003480A4/en not_active Withdrawn
- 1998-05-28 AU AU76021/98A patent/AU745309B2/en not_active Ceased
- 1998-05-28 NZ NZ501289A patent/NZ501289A/en not_active IP Right Cessation
- 1998-05-28 IL IL13308798A patent/IL133087A0/en unknown
- 1998-05-28 WO PCT/US1998/010804 patent/WO1998053801A1/en not_active Application Discontinuation
- 1998-05-28 CA CA002291839A patent/CA2291839A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU7602198A (en) | 1998-12-30 |
WO1998053801A1 (en) | 1998-12-03 |
EP1003480A1 (en) | 2000-05-31 |
NZ501289A (en) | 2001-06-29 |
CA2291839A1 (en) | 1998-12-03 |
AU745309B2 (en) | 2002-03-21 |
EP1003480A4 (en) | 2002-04-17 |
JP2001501975A (en) | 2001-02-13 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL133087A0 (en) | Conjugated peptide nucleic acids having enhanced cellular uptake | |
HK1036997A1 (en) | Peptides | |
SG71179A1 (en) | Improved interferon polymer conjugates | |
EP1012260A4 (en) | Interleukin-20 | |
GB9827348D0 (en) | Natriuretic peptide | |
EP0977579A4 (en) | Gastrin receptor-avid peptide conjugates | |
GB2332660B (en) | Improved deflector | |
GB9719879D0 (en) | Protein | |
GB9703681D0 (en) | Protein complemention | |
ZA98642B (en) | Immune-modulation with amino acids | |
GB9718110D0 (en) | Peptides | |
GB9825854D0 (en) | Peptide | |
EP1018551A4 (en) | Megsin protein | |
EP0961793A4 (en) | Polymers incorporating peptides | |
GB9700154D0 (en) | Peptides | |
GB9812675D0 (en) | Peptides | |
ZA984322B (en) | Sucrose-binding proteins | |
EP0996457A4 (en) | Fsh-releasing peptides | |
GB9720784D0 (en) | Protein | |
GB9807890D0 (en) | Peptides | |
GB9719486D0 (en) | Electrically propelled vehicle | |
GB9706556D0 (en) | Peptides | |
GB9701024D0 (en) | Peptides | |
GB9713146D0 (en) | Peptides | |
GB9720995D0 (en) | Nucleic acids |