IL132304A0 - Osteoprotegerin binding proteins and receptors - Google Patents
Osteoprotegerin binding proteins and receptorsInfo
- Publication number
- IL132304A0 IL132304A0 IL13230498A IL13230498A IL132304A0 IL 132304 A0 IL132304 A0 IL 132304A0 IL 13230498 A IL13230498 A IL 13230498A IL 13230498 A IL13230498 A IL 13230498A IL 132304 A0 IL132304 A0 IL 132304A0
- Authority
- IL
- Israel
- Prior art keywords
- fragments
- encoding
- sequence
- nucleic acid
- receptors
- Prior art date
Links
- 102000014914 Carrier Proteins Human genes 0.000 title abstract 2
- 108091008324 binding proteins Proteins 0.000 title abstract 2
- 102000008108 Osteoprotegerin Human genes 0.000 title 1
- 108010035042 Osteoprotegerin Proteins 0.000 title 1
- XXUPLYBCNPLTIW-UHFFFAOYSA-N octadec-7-ynoic acid Chemical compound CCCCCCCCCCC#CCCCCCC(O)=O XXUPLYBCNPLTIW-UHFFFAOYSA-N 0.000 title 1
- 102000005962 receptors Human genes 0.000 title 1
- 108020003175 receptors Proteins 0.000 title 1
- 239000012634 fragment Substances 0.000 abstract 3
- 150000007523 nucleic acids Chemical class 0.000 abstract 3
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 208000020084 Bone disease Diseases 0.000 abstract 1
- 230000004913 activation Effects 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 230000004069 differentiation Effects 0.000 abstract 1
- 239000013604 expression vector Substances 0.000 abstract 1
- 210000002997 osteoclast Anatomy 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Steroid Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/842,842 US5843678A (en) | 1997-04-16 | 1997-04-16 | Osteoprotegerin binding proteins |
US88085597A | 1997-06-23 | 1997-06-23 | |
US09/052,521 US6316408B1 (en) | 1997-04-16 | 1998-03-30 | Methods of use for osetoprotegerin binding protein receptors |
PCT/US1998/007584 WO1998046751A1 (fr) | 1997-04-16 | 1998-04-15 | Proteines de liaison et recepteurs d'osteoprotegerine |
Publications (1)
Publication Number | Publication Date |
---|---|
IL132304A0 true IL132304A0 (en) | 2001-03-19 |
Family
ID=27368158
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL13230498A IL132304A0 (en) | 1997-04-16 | 1998-04-15 | Osteoprotegerin binding proteins and receptors |
Country Status (28)
Country | Link |
---|---|
US (1) | US7923008B2 (fr) |
EP (2) | EP1717315A3 (fr) |
JP (2) | JP2001526532A (fr) |
CN (1) | CN1264427A (fr) |
AT (1) | ATE363533T1 (fr) |
AU (4) | AU743257B2 (fr) |
BG (1) | BG65242B1 (fr) |
BR (1) | BR9808545A (fr) |
CA (1) | CA2285746C (fr) |
CZ (1) | CZ302262B6 (fr) |
DE (1) | DE69837845T3 (fr) |
DK (1) | DK0975754T4 (fr) |
EA (1) | EA003636B1 (fr) |
EE (1) | EE05496B1 (fr) |
ES (1) | ES2284203T5 (fr) |
HK (1) | HK1022330A1 (fr) |
HU (1) | HU230547B1 (fr) |
ID (1) | ID23855A (fr) |
IL (1) | IL132304A0 (fr) |
NO (1) | NO325175B1 (fr) |
NZ (1) | NZ500253A (fr) |
PL (1) | PL190092B1 (fr) |
RO (1) | RO128635A2 (fr) |
SI (1) | SI0975754T2 (fr) |
SK (1) | SK288559B6 (fr) |
TR (1) | TR199902512T2 (fr) |
TW (1) | TW589376B (fr) |
WO (1) | WO1998046751A1 (fr) |
Families Citing this family (71)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL117175A (en) | 1995-02-20 | 2005-11-20 | Sankyo Co | Osteoclastogenesis inhibitory factor protein |
PT1114864E (pt) * | 1996-12-13 | 2008-10-08 | Schering Corp | Antigénios de superfície de células de mamífero, reagentes relacionados |
US6271349B1 (en) | 1996-12-23 | 2001-08-07 | Immunex Corporation | Receptor activator of NF-κB |
DE69738841D1 (de) | 1996-12-23 | 2008-08-28 | Immunex Corp | Ligand für rezeptor aktivator of nf-kappa b, ligand ist mitglied der tnf superfamilie |
KR100496063B1 (ko) | 1997-04-15 | 2005-06-21 | 산쿄 가부시키가이샤 | 신규단백질 및 그 제조방법 |
AU2008200700C1 (en) * | 1997-04-15 | 2013-04-04 | Daiichi Sankyo Co., Ltd | Novel Protein and Process for Producing The Same |
US6316408B1 (en) | 1997-04-16 | 2001-11-13 | Amgen Inc. | Methods of use for osetoprotegerin binding protein receptors |
DK0975754T4 (en) | 1997-04-16 | 2016-03-21 | Amgen Inc | Osteoprotegerin binding proteins and their receptors |
EP2009025B1 (fr) | 1998-05-14 | 2011-07-27 | Immunex Corporation | Procédé d'inhibition de l'activité des ostéoclastes |
US20020106728A1 (en) * | 2000-06-20 | 2002-08-08 | Genentech, Inc. | NS4 nucleic acids and polypeptides and methods of use for the treatment of body weight disorders |
DK1114166T3 (da) * | 1998-09-15 | 2005-08-01 | Pharmexa As | Fremgangsmåde til nedregulering af osteoprotegerinligandaktivitet |
AU754971B2 (en) | 1998-09-15 | 2002-11-28 | Pharmexa A/S | Method for down-regulating osteoprotegerin ligand activity |
SI2319928T1 (sl) | 1998-10-23 | 2013-08-30 | Kirin-Amgen, Inc. | Dimerni trombopoietinski peptidni mimetiki, ki se veĺ˝ejo na receptor mp1 in imajo trombopoietinsko aktivnost |
EP2339003A3 (fr) | 1999-06-28 | 2011-10-19 | Genentech, Inc. | Polypeptides variants substitutionnels du ligand Apo-2 |
EE05673B1 (et) | 1999-08-17 | 2013-08-15 | Biogen, Inc. | BAFF-retseptor (BCMA), immunoregulatoorne agens |
AU7615600A (en) * | 1999-09-27 | 2001-04-30 | Eli Lilly And Company | Osteoclast differentiation factor regulatory region |
AUPQ314799A0 (en) * | 1999-09-29 | 1999-10-21 | University Of Western Australia, The | Bone cell factor |
DE60028830T2 (de) | 2000-02-16 | 2007-01-18 | Genentech, Inc., South San Francisco | Anti-april antikörper und hybridomazellen |
US20030103978A1 (en) | 2000-02-23 | 2003-06-05 | Amgen Inc. | Selective binding agents of osteoprotegerin binding protein |
MXPA02008144A (es) * | 2000-02-23 | 2002-11-29 | Amgen Inc | Agentes de enlace selectivos antagonistas de la proteina de enlace de osteoprotegerina. |
US6600018B1 (en) | 2000-04-10 | 2003-07-29 | The United States Of America As Represented By The Department Of Health And Human Services | Secreted frizzled related protein, sFRP, fragments and methods of use thereof |
CN101289511A (zh) | 2000-04-11 | 2008-10-22 | 杰南技术公司 | 多价抗体及其应用 |
ATE415978T1 (de) | 2000-07-27 | 2008-12-15 | Genentech Inc | Sequentielle verabreichung von cpt-11 und apo-2l polypeptid |
AU2001286586A1 (en) * | 2000-08-18 | 2002-03-04 | University Of Massachusetts Medical Center | Trance regulation of chondrocyte differentiation |
US6884598B2 (en) | 2000-09-22 | 2005-04-26 | Immunex Corporation | Screening assays for agonists and antagonists of receptor activator of NF-κB |
PT1387854E (pt) | 2001-01-10 | 2012-06-26 | Us Dept Health | Sfrp e motivos de peptídeos que interagem com a sfrp e respectivos métodos de utilização |
US7128911B2 (en) | 2001-01-19 | 2006-10-31 | Cytos Biotechnology Ag | Antigen arrays for treatment of bone disease |
JP4212470B2 (ja) * | 2001-06-26 | 2009-01-21 | アムジェン フレモント インク. | Opglへの抗体 |
PT1409544E (pt) | 2001-07-03 | 2009-09-16 | Genentech Inc | Anticorpos de dr4 humanos e suas utilizações |
JP2005508162A (ja) | 2001-10-02 | 2005-03-31 | ジェネンテック・インコーポレーテッド | Apo−2リガンド変異体とその使用法 |
EP2322165A1 (fr) | 2001-11-13 | 2011-05-18 | Genentech, Inc. | Compositions à base de Apo2 ligand/TRAIL |
US7842668B1 (en) | 2001-11-13 | 2010-11-30 | Genentech, Inc. | Apo-2 ligand/trail formulations |
US7741285B2 (en) | 2001-11-13 | 2010-06-22 | Genentech, Inc. | APO-2 ligand/trail formulations |
JP4761710B2 (ja) | 2002-04-05 | 2011-08-31 | アムジェン インコーポレイテッド | 選択的opgl経路インヒビターとしてのヒト抗opgl中和抗体 |
AU2011265413B2 (en) * | 2002-04-05 | 2014-04-10 | Amgen Inc. | Human Anti-OPGL Neutralizing Antibodies as Selective OPGL, Pathway Inhibitors |
EP1556076A4 (fr) | 2002-06-24 | 2009-07-08 | Genentech Inc | Variants du ligand apo-2/trail et utilisations de ceux-ci |
JP2006521084A (ja) | 2002-12-10 | 2006-09-21 | シェーリング−プラウ・リミテッド | イヌranklならびにイヌranklを調製および使用するための方法 |
EP1773400A2 (fr) | 2004-07-08 | 2007-04-18 | Amgen Inc. | Peptides therapeutiques |
AU2005271249A1 (en) | 2004-08-06 | 2006-02-16 | Genentech, Inc. | Assays and methods using biomarkers |
CN101035912A (zh) | 2004-08-06 | 2007-09-12 | 健泰科生物技术公司 | 使用生物标志的测定法和方法 |
JO3000B1 (ar) | 2004-10-20 | 2016-09-05 | Genentech Inc | مركبات أجسام مضادة . |
US8029783B2 (en) | 2005-02-02 | 2011-10-04 | Genentech, Inc. | DR5 antibodies and articles of manufacture containing same |
ZA200800974B (en) | 2005-08-16 | 2009-11-25 | Genentech Inc | Apoptosis sensitivity to Apo2L/TRAIL by testing for 'GalNac-T14 expression in cells/tissues |
PE20070684A1 (es) | 2005-11-14 | 2007-08-06 | Amgen Inc | MOLECULAS QUIMERICAS DE ANTICUERPO RANKL-PTH/PTHrP |
JP6088723B2 (ja) | 2005-11-23 | 2017-03-01 | ジェネンテック, インコーポレイテッド | B細胞アッセイに関する組成物及び方法。 |
JO3324B1 (ar) | 2006-04-21 | 2019-03-13 | Amgen Inc | مركبات علاجية مجففة بالتبريد تتعلق بالعصارة الهضمية |
WO2008080112A2 (fr) * | 2006-12-22 | 2008-07-03 | The Regents Of The University Of California | Nouvelle molécule de fusion basée sur un nouveau variant taa |
CA2840407A1 (fr) | 2007-05-22 | 2008-12-18 | Amgen Inc. | Compositions et procedes pour produire des proteines de fusion bioactives |
JP2008307007A (ja) | 2007-06-15 | 2008-12-25 | Bayer Schering Pharma Ag | 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞 |
US8637257B2 (en) | 2007-06-20 | 2014-01-28 | Galapagos Nv | Molecular targets and compounds, and methods to identify the same, useful in the treatment of bone and joint degenerative diseases |
JP5346925B2 (ja) * | 2008-05-02 | 2013-11-20 | 国立大学法人京都大学 | 核初期化方法 |
WO2010062904A2 (fr) | 2008-11-25 | 2010-06-03 | Biogen Idec Ma Inc. | Utilisation d'antagonistes dr6 et p75 pour favoriser la survie de cellules du systeme nerveux |
EP2433644A1 (fr) | 2010-09-22 | 2012-03-28 | IMBA-Institut für Molekulare Biotechnologie GmbH | Traitement du cancer du sein |
EP2434285A1 (fr) | 2010-09-22 | 2012-03-28 | IMBA-Institut für Molekulare Biotechnologie GmbH | Diagnostic du cancer du sein |
US20150025077A1 (en) | 2012-02-29 | 2015-01-22 | Coyote Pharmaceuticals, Inc. | Gga and gga derivatives compositions thereof and methods for treating neurodegenerative diseases including paralysis including them |
US9119808B1 (en) | 2012-10-08 | 2015-09-01 | Coyote Pharmaceuticals, Inc. | Treating neurodegenerative diseases with GGA or a derivative thereof |
UY35148A (es) | 2012-11-21 | 2014-05-30 | Amgen Inc | Immunoglobulinas heterodiméricas |
WO2014144817A2 (fr) | 2013-03-15 | 2014-09-18 | Amgen Inc. | Polypeptides inhibiteurs spécifiques à des inhibiteurs wnt |
JP6668241B2 (ja) | 2013-09-05 | 2020-03-18 | アムジエン・インコーポレーテツド | 予測可能で、一貫性のある、且つ再現可能な糖型特性を示すFc含有分子 |
WO2015175861A1 (fr) | 2014-05-16 | 2015-11-19 | Amgen Inc. | Dosage pour la détection de populations de cellules th1 et th2 |
US11680101B2 (en) | 2017-01-27 | 2023-06-20 | Kymab Limited | Anti-OPG antibodies |
CA3056011A1 (fr) | 2017-03-14 | 2018-09-20 | Amgen Inc. | Controle des glycoformes afucosylees totales d'anticorps produits en culture cellulaire |
EP3713581A1 (fr) | 2017-11-22 | 2020-09-30 | Inbiomotion S.L. | Traitement thérapeutique du cancer du sein basé sur le c-maf |
SG11202009216YA (en) | 2018-03-26 | 2020-10-29 | Amgen Inc | Total afucosylated glycoforms of antibodies produced in cell culture |
KR20220069982A (ko) | 2019-09-26 | 2022-05-27 | 암젠 인크 | 항체 조성물의 생산 방법 |
CN113621060B (zh) * | 2020-05-07 | 2023-07-04 | 浙江瑞硕生物技术有限公司 | 一种opg抗体对及其应用 |
WO2021247892A1 (fr) | 2020-06-04 | 2021-12-09 | Amgen Inc. | Évaluation de procédures de nettoyage d'un procédé de fabrication biothérapeutique |
JP2023548767A (ja) | 2020-10-15 | 2023-11-21 | アムジエン・インコーポレーテツド | 抗体製造方法における相対不対グリカン |
AR126089A1 (es) | 2021-06-07 | 2023-09-13 | Amgen Inc | Uso de fucosidasa para controlar el nivel de afucosilación de proteínas glucosiladas |
WO2023059607A1 (fr) | 2021-10-05 | 2023-04-13 | Amgen Inc. | Liaison de récepteur fc-gamma et teneur en glycane |
WO2023215725A1 (fr) | 2022-05-02 | 2023-11-09 | Fred Hutchinson Cancer Center | Compositions et méthodes pour l'immunothérapie cellulaire |
Family Cites Families (68)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4179337A (en) * | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
US4710457A (en) | 1983-06-29 | 1987-12-01 | Sloan-Kettering Institute For Cancer Research | Monoclonal antibody for human hematopoietic glycoproteins and method |
US4710473A (en) | 1983-08-10 | 1987-12-01 | Amgen, Inc. | DNA plasmids |
US4959314A (en) | 1984-11-09 | 1990-09-25 | Cetus Corporation | Cysteine-depleted muteins of biologically active proteins |
US6410516B1 (en) * | 1986-01-09 | 2002-06-25 | President & Fellows Of Harvard College | Nuclear factors associated with transcriptional regulation |
US5846534A (en) | 1988-02-12 | 1998-12-08 | British Technology Group Limited | Antibodies to the antigen campath-1 |
AU651421B2 (en) | 1990-11-30 | 1994-07-21 | Celtrix Pharmaceuticals, Inc. | Use of a bone morphogenetic protein in synergistic combination with TGF-beta for bone repair |
US5118667A (en) | 1991-05-03 | 1992-06-02 | Celtrix Pharmaceuticals, Inc. | Bone growth factors and inhibitors of bone resorption for promoting bone formation |
CA2068389A1 (fr) | 1991-05-13 | 1992-11-14 | Masahiko Sato | Methode d'inhibition de la resorption osseuse |
MX9204303A (es) | 1991-07-23 | 1993-11-01 | Rhone Poulenc Rorer Int | Factor regulador del crecimiento de osteoclasto. |
IL99120A0 (en) | 1991-08-07 | 1992-07-15 | Yeda Res & Dev | Multimers of the soluble forms of tnf receptors,their preparation and pharmaceutical compositions containing them |
US5961974A (en) * | 1991-10-25 | 1999-10-05 | Immunex Corporation | Monoclonal antibodies to CD40 ligand, pharmaceutical composition comprising the same and hybridomas producing the same |
US5447851B1 (en) | 1992-04-02 | 1999-07-06 | Univ Texas System Board Of | Dna encoding a chimeric polypeptide comprising the extracellular domain of tnf receptor fused to igg vectors and host cells |
EP0639079B1 (fr) | 1992-04-30 | 2000-01-12 | Amgen Inc. | Methodes de traitement des maladies induites par l'interleukine-1 et le facteur de necrose tumorale |
US5585479A (en) | 1992-07-24 | 1996-12-17 | The United States Of America As Represented By The Secretary Of The Navy | Antisense oligonucleotides directed against human ELAM-I RNA |
US5578569A (en) | 1993-03-12 | 1996-11-26 | Tam; Cherk S. | Method of increasing bone growth |
US5457035A (en) | 1993-07-23 | 1995-10-10 | Immunex Corporation | Cytokine which is a ligand for OX40 |
JPH09502614A (ja) | 1993-09-14 | 1997-03-18 | メルク エンド カンパニー インコーポレーテッド | 新規ヒト蛋白質チロシンホスファターゼをコードするcDNA |
US6268212B1 (en) | 1993-10-18 | 2001-07-31 | Amgen Inc. | Tissue specific transgene expression |
US5641747A (en) | 1994-07-25 | 1997-06-24 | Temple University-Of The Commonwealth System Of Higher Education | Treatment of osteopetrotic diseases |
EP0792278B1 (fr) * | 1994-11-07 | 2007-06-13 | Human Genome Sciences, Inc. | Polypeptide gamma appartenant a la famille des facteurs de necrose tumorale (fnt) |
EP0727211A1 (fr) | 1995-02-10 | 1996-08-21 | Smithkline Beecham Corporation | Emploi de composés spécifiques src SH2 dans le traitement de maladies de résorption osseuse |
IL117175A (en) | 1995-02-20 | 2005-11-20 | Sankyo Co | Osteoclastogenesis inhibitory factor protein |
US20030166097A1 (en) * | 1995-03-15 | 2003-09-04 | Human Genome Sciences, Inc. | Human tumor necrosis factor receptor |
US7094564B1 (en) | 1995-03-15 | 2006-08-22 | Human Genome Sciences, Inc. | Human tumor necrosis factor receptor |
WO1996028546A1 (fr) | 1995-03-15 | 1996-09-19 | Human Genome Sciences, Inc. | Recepteur humain du facteur de necrose tumorale |
AU5985996A (en) | 1995-06-07 | 1997-01-15 | Osteosa Inc. | Osteoclast growth regulatory factor |
AU6090896A (en) | 1995-06-07 | 1997-01-15 | Osteosa Inc. | Osteoclast growth regulatory factor |
US5843901A (en) | 1995-06-07 | 1998-12-01 | Advanced Research & Technology Institute | LHRH antagonist peptides |
DK0835305T3 (da) * | 1995-06-29 | 2006-02-13 | Immunex Corp | Cytokin som inducerer apoptose |
US6369027B1 (en) | 1995-12-22 | 2002-04-09 | Amgen Inc. | Osteoprotegerin |
US6613544B1 (en) | 1995-12-22 | 2003-09-02 | Amgen Inc. | Osteoprotegerin |
US6046048A (en) | 1996-01-09 | 2000-04-04 | Genetech, Inc. | Apo-2 ligand |
US5981220A (en) * | 1996-03-27 | 1999-11-09 | Human Genome Sciences, Inc. | Epidermal differentiation factor |
TW555765B (en) * | 1996-07-09 | 2003-10-01 | Amgen Inc | Low molecular weight soluble tumor necrosis factor type-I and type-II proteins |
JPH1057071A (ja) | 1996-08-19 | 1998-03-03 | Snow Brand Milk Prod Co Ltd | 新規dna及びそれを用いた蛋白質の製造方法 |
PT1114864E (pt) | 1996-12-13 | 2008-10-08 | Schering Corp | Antigénios de superfície de células de mamífero, reagentes relacionados |
FR2757507B1 (fr) | 1996-12-20 | 1999-01-29 | Inst Francais Du Petrole | Procede de separation de paraxylene comprenant une adsorption avec injection d'eau et une cristallisation |
AU5901598A (en) | 1996-12-20 | 1998-07-17 | Board Of Regents, The University Of Texas System | Compositions and methods of use for osteoclast inhibitory factors |
US6271349B1 (en) | 1996-12-23 | 2001-08-07 | Immunex Corporation | Receptor activator of NF-κB |
DE69738841D1 (de) | 1996-12-23 | 2008-08-28 | Immunex Corp | Ligand für rezeptor aktivator of nf-kappa b, ligand ist mitglied der tnf superfamilie |
KR100496063B1 (ko) * | 1997-04-15 | 2005-06-21 | 산쿄 가부시키가이샤 | 신규단백질 및 그 제조방법 |
DK0975754T4 (en) | 1997-04-16 | 2016-03-21 | Amgen Inc | Osteoprotegerin binding proteins and their receptors |
US5843678A (en) * | 1997-04-16 | 1998-12-01 | Amgen Inc. | Osteoprotegerin binding proteins |
US6316408B1 (en) * | 1997-04-16 | 2001-11-13 | Amgen Inc. | Methods of use for osetoprotegerin binding protein receptors |
CA2229449A1 (fr) * | 1997-04-25 | 1998-10-25 | Takeda Chemical Industries, Ltd. | Proteine receptrice nouvelle et son utilisation |
AU7469998A (en) | 1997-05-01 | 1998-11-24 | Amgen, Inc. | Chimeric opg polypeptides |
WO1998054201A1 (fr) | 1997-05-29 | 1998-12-03 | Human Genome Sciences, Inc. | Proteine 8 apparentee au recepteur du facteur de necrose tumorale humain |
US6087555A (en) | 1997-10-15 | 2000-07-11 | Amgen Inc. | Mice lacking expression of osteoprotegerin |
US6790823B1 (en) | 1998-04-23 | 2004-09-14 | Amgen Inc. | Compositions and methods for the prevention and treatment of cardiovascular diseases |
EP2009025B1 (fr) * | 1998-05-14 | 2011-07-27 | Immunex Corporation | Procédé d'inhibition de l'activité des ostéoclastes |
AU754971B2 (en) * | 1998-09-15 | 2002-11-28 | Pharmexa A/S | Method for down-regulating osteoprotegerin ligand activity |
AU6078500A (en) | 1999-07-09 | 2001-01-30 | Amgen, Inc. | Combination therapy for conditions leading to bone loss |
EP1140136B1 (fr) | 1999-09-03 | 2007-05-16 | Amgen Inc. | Compositions et procedes permettant la prevention ou le traitement du cancer et de la perte osseuse associee au cancer |
US20030144187A1 (en) | 1999-09-03 | 2003-07-31 | Colin R. Dunstan | Opg fusion protein compositions and methods |
US20030103978A1 (en) * | 2000-02-23 | 2003-06-05 | Amgen Inc. | Selective binding agents of osteoprotegerin binding protein |
MXPA02008144A (es) | 2000-02-23 | 2002-11-29 | Amgen Inc | Agentes de enlace selectivos antagonistas de la proteina de enlace de osteoprotegerina. |
AU2001286586A1 (en) | 2000-08-18 | 2002-03-04 | University Of Massachusetts Medical Center | Trance regulation of chondrocyte differentiation |
US6884598B2 (en) * | 2000-09-22 | 2005-04-26 | Immunex Corporation | Screening assays for agonists and antagonists of receptor activator of NF-κB |
ES2212930T1 (es) | 2001-05-17 | 2004-08-16 | Immunex Corporation | Uso terapeutico de antagonistas de rank. |
CA2449658A1 (fr) * | 2001-06-06 | 2002-12-12 | Immunex Corporation | Utilisation d'antagonistes rank dans le traitement du cancer |
JP4212470B2 (ja) | 2001-06-26 | 2009-01-21 | アムジェン フレモント インク. | Opglへの抗体 |
US6753755B2 (en) * | 2001-06-28 | 2004-06-22 | Safer Home, Inc. | Electrical safety connector fuse |
US7084257B2 (en) * | 2001-10-05 | 2006-08-01 | Amgen Inc. | Fully human antibody Fab fragments with human interferon-gamma neutralizing activity |
US6592001B2 (en) * | 2001-12-18 | 2003-07-15 | Kimberly-Clark Worldwide | Dispenser for sheet material containing a dispensing port incrementally variable within a range |
JP4761710B2 (ja) | 2002-04-05 | 2011-08-31 | アムジェン インコーポレイテッド | 選択的opgl経路インヒビターとしてのヒト抗opgl中和抗体 |
US7706431B2 (en) * | 2005-06-30 | 2010-04-27 | Nokia Corporation | System and method for providing optimized receiver architectures for combined pilot and data signal tracking |
-
1998
- 1998-04-15 DK DK98918244.9T patent/DK0975754T4/en active
- 1998-04-15 PL PL98336311A patent/PL190092B1/pl unknown
- 1998-04-15 JP JP54425798A patent/JP2001526532A/ja not_active Withdrawn
- 1998-04-15 ES ES98918244.9T patent/ES2284203T5/es not_active Expired - Lifetime
- 1998-04-15 AT AT98918244T patent/ATE363533T1/de active
- 1998-04-15 AU AU71205/98A patent/AU743257B2/en not_active Ceased
- 1998-04-15 EA EA199900939A patent/EA003636B1/ru not_active IP Right Cessation
- 1998-04-15 EE EEP199900611A patent/EE05496B1/xx unknown
- 1998-04-15 SI SI9830889T patent/SI0975754T2/sl unknown
- 1998-04-15 HU HU0001400A patent/HU230547B1/hu unknown
- 1998-04-15 EP EP06015956A patent/EP1717315A3/fr not_active Withdrawn
- 1998-04-15 TR TR1999/02512T patent/TR199902512T2/xx unknown
- 1998-04-15 CZ CZ0359899A patent/CZ302262B6/cs not_active IP Right Cessation
- 1998-04-15 CA CA2285746A patent/CA2285746C/fr not_active Expired - Lifetime
- 1998-04-15 IL IL13230498A patent/IL132304A0/xx unknown
- 1998-04-15 BR BR9808545-0A patent/BR9808545A/pt not_active Application Discontinuation
- 1998-04-15 RO ROA201200577A patent/RO128635A2/ro unknown
- 1998-04-15 ID IDW991225A patent/ID23855A/id unknown
- 1998-04-15 DE DE69837845.8T patent/DE69837845T3/de not_active Expired - Lifetime
- 1998-04-15 CN CN98806073A patent/CN1264427A/zh active Pending
- 1998-04-15 NZ NZ500253A patent/NZ500253A/xx not_active IP Right Cessation
- 1998-04-15 WO PCT/US1998/007584 patent/WO1998046751A1/fr active IP Right Grant
- 1998-04-15 SK SK1419-99A patent/SK288559B6/sk active Protection Beyond IP Right Term
- 1998-04-15 EP EP98918244.9A patent/EP0975754B2/fr not_active Expired - Lifetime
- 1998-04-16 TW TW087105837A patent/TW589376B/zh not_active IP Right Cessation
-
1999
- 1999-10-15 NO NO19995044A patent/NO325175B1/no not_active IP Right Cessation
- 1999-10-21 BG BG103824A patent/BG65242B1/bg unknown
-
2000
- 2000-02-25 HK HK00101154A patent/HK1022330A1/xx not_active IP Right Cessation
-
2001
- 2001-11-30 AU AU95234/01A patent/AU779461C/en not_active Expired
-
2005
- 2005-04-27 AU AU2005201799A patent/AU2005201799B2/en not_active Expired
-
2006
- 2006-01-19 US US11/336,067 patent/US7923008B2/en not_active Expired - Fee Related
-
2007
- 2007-09-04 JP JP2007228804A patent/JP5001758B2/ja not_active Expired - Lifetime
-
2008
- 2008-06-05 AU AU2008202516A patent/AU2008202516A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AU779461C (en) | Osteoprotegerin binding proteins and receptors | |
Kasugai et al. | Differential regulation of the 55 and 44 kDa forms of secreted phosphoprotein 1 (SPP-1, osteopontin) in normal and transformed rat bone cells by osteotropic hormones, growth factors and a tumor promoter | |
HU9600692D0 (en) | Human metabotropic glutamate receptor subtypes (hmr4, hmr6, hmr7) and related dna compounds | |
EP2325316B8 (fr) | Protéine réceptrice d'hémopoïétine, NR10 | |
WO1995030003A3 (fr) | Recepteurs de surface de cellule morphogenes specifiques d'une proteine et leurs usages | |
BR9814335A (pt) | Proteìna, exceto as existentes ao natural, polinucleotìdeo substancialmente puro, anticorpo elaborado por um processo que compreende a etapa de injetar uma preparação farmaceuticamente aceitável, vetor para expressar o drr-1 de rato, vetor, célula hospedeira drr-1 de rato, drr-1 de ser humano, drr-2 de ser humano, drr-3 de ser humano, drr-4 de ser humano, drr-5 de ser humano, drr-6 de ser humano recombinantes, e, processo para ensaiar um composto de teste quanto à sua capacidade para ligar-se a ou para ativar um receptor especìfico de gânglios da raiz dorsal ligado à proteìna g (drr) | |
NZ508381A (en) | Antibodies, antagonists and agonists of the death domain containing receptor 5 (DR5) | |
EA199700143A1 (ru) | Способ и композиция ждя липидизации гидрофильных молекул | |
EP0679093A1 (fr) | Procede d'apport d'agents a des cellules cibles. | |
ES2009590A6 (es) | Metodo de preparacion de proteina de cadena pesada del factor tisular humano. | |
WO1995009872B1 (fr) | Adn codant pour un recepteur ip de prostaglandine | |
DE69738370D1 (de) | Modulatoren des tnf-rezeptor-assoziierten faktors, deren herstellung und verwendungen | |
EP0861896A3 (fr) | Kinase humaine regulé par le volume de cellule (h-sgk) | |
NZ333203A (en) | Tumour antigen proteins, genes thereof, and tumour antigen peptides | |
WO1997007135A3 (fr) | Liaison de la proteine oestrogene 1 (op-1) et de ses analogues avec le recepteur alk-1 de surface de cellule et ses analogues | |
BR0013043A (pt) | Proteìna isolada, anticorpo isolado, composição, método de regulação de reação imunológica em animais, método de tratamento de câncer em animais, molécula de ácido nucleico isolado, molécula de ácido nucleico recombinante, célula recombinante e vìrus recombinante | |
CA2312274A1 (fr) | Adn isole codant pour un recepteur h3 d'histamine humain | |
WO1999063094A3 (fr) | Sequences nucleotidiques et proteiques gpr1 et methodes y relatives | |
WO1999019480A3 (fr) | Proteines receptrices humaines et reactifs et methodes associes | |
GEP20002244B (en) | Osteoprotegerin | |
MX9701267A (es) | Receptor de glutamato. | |
HUP0001774A3 (en) | Fragments of leptin (ob protein) |