IL132304A0 - Osteoprotegerin binding proteins and receptors - Google Patents

Osteoprotegerin binding proteins and receptors

Info

Publication number
IL132304A0
IL132304A0 IL13230498A IL13230498A IL132304A0 IL 132304 A0 IL132304 A0 IL 132304A0 IL 13230498 A IL13230498 A IL 13230498A IL 13230498 A IL13230498 A IL 13230498A IL 132304 A0 IL132304 A0 IL 132304A0
Authority
IL
Israel
Prior art keywords
fragments
encoding
sequence
nucleic acid
receptors
Prior art date
Application number
IL13230498A
Other languages
English (en)
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27368158&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL132304(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US08/842,842 external-priority patent/US5843678A/en
Priority claimed from US09/052,521 external-priority patent/US6316408B1/en
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of IL132304A0 publication Critical patent/IL132304A0/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70575NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/12Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Steroid Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
IL13230498A 1997-04-16 1998-04-15 Osteoprotegerin binding proteins and receptors IL132304A0 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US08/842,842 US5843678A (en) 1997-04-16 1997-04-16 Osteoprotegerin binding proteins
US88085597A 1997-06-23 1997-06-23
US09/052,521 US6316408B1 (en) 1997-04-16 1998-03-30 Methods of use for osetoprotegerin binding protein receptors
PCT/US1998/007584 WO1998046751A1 (fr) 1997-04-16 1998-04-15 Proteines de liaison et recepteurs d'osteoprotegerine

Publications (1)

Publication Number Publication Date
IL132304A0 true IL132304A0 (en) 2001-03-19

Family

ID=27368158

Family Applications (1)

Application Number Title Priority Date Filing Date
IL13230498A IL132304A0 (en) 1997-04-16 1998-04-15 Osteoprotegerin binding proteins and receptors

Country Status (28)

Country Link
US (1) US7923008B2 (fr)
EP (2) EP1717315A3 (fr)
JP (2) JP2001526532A (fr)
CN (1) CN1264427A (fr)
AT (1) ATE363533T1 (fr)
AU (4) AU743257B2 (fr)
BG (1) BG65242B1 (fr)
BR (1) BR9808545A (fr)
CA (1) CA2285746C (fr)
CZ (1) CZ302262B6 (fr)
DE (1) DE69837845T3 (fr)
DK (1) DK0975754T4 (fr)
EA (1) EA003636B1 (fr)
EE (1) EE05496B1 (fr)
ES (1) ES2284203T5 (fr)
HK (1) HK1022330A1 (fr)
HU (1) HU230547B1 (fr)
ID (1) ID23855A (fr)
IL (1) IL132304A0 (fr)
NO (1) NO325175B1 (fr)
NZ (1) NZ500253A (fr)
PL (1) PL190092B1 (fr)
RO (1) RO128635A2 (fr)
SI (1) SI0975754T2 (fr)
SK (1) SK288559B6 (fr)
TR (1) TR199902512T2 (fr)
TW (1) TW589376B (fr)
WO (1) WO1998046751A1 (fr)

Families Citing this family (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL117175A (en) 1995-02-20 2005-11-20 Sankyo Co Osteoclastogenesis inhibitory factor protein
PT1114864E (pt) * 1996-12-13 2008-10-08 Schering Corp Antigénios de superfície de células de mamífero, reagentes relacionados
US6271349B1 (en) 1996-12-23 2001-08-07 Immunex Corporation Receptor activator of NF-κB
DE69738841D1 (de) 1996-12-23 2008-08-28 Immunex Corp Ligand für rezeptor aktivator of nf-kappa b, ligand ist mitglied der tnf superfamilie
KR100496063B1 (ko) 1997-04-15 2005-06-21 산쿄 가부시키가이샤 신규단백질 및 그 제조방법
AU2008200700C1 (en) * 1997-04-15 2013-04-04 Daiichi Sankyo Co., Ltd Novel Protein and Process for Producing The Same
US6316408B1 (en) 1997-04-16 2001-11-13 Amgen Inc. Methods of use for osetoprotegerin binding protein receptors
DK0975754T4 (en) 1997-04-16 2016-03-21 Amgen Inc Osteoprotegerin binding proteins and their receptors
EP2009025B1 (fr) 1998-05-14 2011-07-27 Immunex Corporation Procédé d'inhibition de l'activité des ostéoclastes
US20020106728A1 (en) * 2000-06-20 2002-08-08 Genentech, Inc. NS4 nucleic acids and polypeptides and methods of use for the treatment of body weight disorders
DK1114166T3 (da) * 1998-09-15 2005-08-01 Pharmexa As Fremgangsmåde til nedregulering af osteoprotegerinligandaktivitet
AU754971B2 (en) 1998-09-15 2002-11-28 Pharmexa A/S Method for down-regulating osteoprotegerin ligand activity
SI2319928T1 (sl) 1998-10-23 2013-08-30 Kirin-Amgen, Inc. Dimerni trombopoietinski peptidni mimetiki, ki se veĺ˝ejo na receptor mp1 in imajo trombopoietinsko aktivnost
EP2339003A3 (fr) 1999-06-28 2011-10-19 Genentech, Inc. Polypeptides variants substitutionnels du ligand Apo-2
EE05673B1 (et) 1999-08-17 2013-08-15 Biogen, Inc. BAFF-retseptor (BCMA), immunoregulatoorne agens
AU7615600A (en) * 1999-09-27 2001-04-30 Eli Lilly And Company Osteoclast differentiation factor regulatory region
AUPQ314799A0 (en) * 1999-09-29 1999-10-21 University Of Western Australia, The Bone cell factor
DE60028830T2 (de) 2000-02-16 2007-01-18 Genentech, Inc., South San Francisco Anti-april antikörper und hybridomazellen
US20030103978A1 (en) 2000-02-23 2003-06-05 Amgen Inc. Selective binding agents of osteoprotegerin binding protein
MXPA02008144A (es) * 2000-02-23 2002-11-29 Amgen Inc Agentes de enlace selectivos antagonistas de la proteina de enlace de osteoprotegerina.
US6600018B1 (en) 2000-04-10 2003-07-29 The United States Of America As Represented By The Department Of Health And Human Services Secreted frizzled related protein, sFRP, fragments and methods of use thereof
CN101289511A (zh) 2000-04-11 2008-10-22 杰南技术公司 多价抗体及其应用
ATE415978T1 (de) 2000-07-27 2008-12-15 Genentech Inc Sequentielle verabreichung von cpt-11 und apo-2l polypeptid
AU2001286586A1 (en) * 2000-08-18 2002-03-04 University Of Massachusetts Medical Center Trance regulation of chondrocyte differentiation
US6884598B2 (en) 2000-09-22 2005-04-26 Immunex Corporation Screening assays for agonists and antagonists of receptor activator of NF-κB
PT1387854E (pt) 2001-01-10 2012-06-26 Us Dept Health Sfrp e motivos de peptídeos que interagem com a sfrp e respectivos métodos de utilização
US7128911B2 (en) 2001-01-19 2006-10-31 Cytos Biotechnology Ag Antigen arrays for treatment of bone disease
JP4212470B2 (ja) * 2001-06-26 2009-01-21 アムジェン フレモント インク. Opglへの抗体
PT1409544E (pt) 2001-07-03 2009-09-16 Genentech Inc Anticorpos de dr4 humanos e suas utilizações
JP2005508162A (ja) 2001-10-02 2005-03-31 ジェネンテック・インコーポレーテッド Apo−2リガンド変異体とその使用法
EP2322165A1 (fr) 2001-11-13 2011-05-18 Genentech, Inc. Compositions à base de Apo2 ligand/TRAIL
US7842668B1 (en) 2001-11-13 2010-11-30 Genentech, Inc. Apo-2 ligand/trail formulations
US7741285B2 (en) 2001-11-13 2010-06-22 Genentech, Inc. APO-2 ligand/trail formulations
JP4761710B2 (ja) 2002-04-05 2011-08-31 アムジェン インコーポレイテッド 選択的opgl経路インヒビターとしてのヒト抗opgl中和抗体
AU2011265413B2 (en) * 2002-04-05 2014-04-10 Amgen Inc. Human Anti-OPGL Neutralizing Antibodies as Selective OPGL, Pathway Inhibitors
EP1556076A4 (fr) 2002-06-24 2009-07-08 Genentech Inc Variants du ligand apo-2/trail et utilisations de ceux-ci
JP2006521084A (ja) 2002-12-10 2006-09-21 シェーリング−プラウ・リミテッド イヌranklならびにイヌranklを調製および使用するための方法
EP1773400A2 (fr) 2004-07-08 2007-04-18 Amgen Inc. Peptides therapeutiques
AU2005271249A1 (en) 2004-08-06 2006-02-16 Genentech, Inc. Assays and methods using biomarkers
CN101035912A (zh) 2004-08-06 2007-09-12 健泰科生物技术公司 使用生物标志的测定法和方法
JO3000B1 (ar) 2004-10-20 2016-09-05 Genentech Inc مركبات أجسام مضادة .
US8029783B2 (en) 2005-02-02 2011-10-04 Genentech, Inc. DR5 antibodies and articles of manufacture containing same
ZA200800974B (en) 2005-08-16 2009-11-25 Genentech Inc Apoptosis sensitivity to Apo2L/TRAIL by testing for 'GalNac-T14 expression in cells/tissues
PE20070684A1 (es) 2005-11-14 2007-08-06 Amgen Inc MOLECULAS QUIMERICAS DE ANTICUERPO RANKL-PTH/PTHrP
JP6088723B2 (ja) 2005-11-23 2017-03-01 ジェネンテック, インコーポレイテッド B細胞アッセイに関する組成物及び方法。
JO3324B1 (ar) 2006-04-21 2019-03-13 Amgen Inc مركبات علاجية مجففة بالتبريد تتعلق بالعصارة الهضمية
WO2008080112A2 (fr) * 2006-12-22 2008-07-03 The Regents Of The University Of California Nouvelle molécule de fusion basée sur un nouveau variant taa
CA2840407A1 (fr) 2007-05-22 2008-12-18 Amgen Inc. Compositions et procedes pour produire des proteines de fusion bioactives
JP2008307007A (ja) 2007-06-15 2008-12-25 Bayer Schering Pharma Ag 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞
US8637257B2 (en) 2007-06-20 2014-01-28 Galapagos Nv Molecular targets and compounds, and methods to identify the same, useful in the treatment of bone and joint degenerative diseases
JP5346925B2 (ja) * 2008-05-02 2013-11-20 国立大学法人京都大学 核初期化方法
WO2010062904A2 (fr) 2008-11-25 2010-06-03 Biogen Idec Ma Inc. Utilisation d'antagonistes dr6 et p75 pour favoriser la survie de cellules du systeme nerveux
EP2433644A1 (fr) 2010-09-22 2012-03-28 IMBA-Institut für Molekulare Biotechnologie GmbH Traitement du cancer du sein
EP2434285A1 (fr) 2010-09-22 2012-03-28 IMBA-Institut für Molekulare Biotechnologie GmbH Diagnostic du cancer du sein
US20150025077A1 (en) 2012-02-29 2015-01-22 Coyote Pharmaceuticals, Inc. Gga and gga derivatives compositions thereof and methods for treating neurodegenerative diseases including paralysis including them
US9119808B1 (en) 2012-10-08 2015-09-01 Coyote Pharmaceuticals, Inc. Treating neurodegenerative diseases with GGA or a derivative thereof
UY35148A (es) 2012-11-21 2014-05-30 Amgen Inc Immunoglobulinas heterodiméricas
WO2014144817A2 (fr) 2013-03-15 2014-09-18 Amgen Inc. Polypeptides inhibiteurs spécifiques à des inhibiteurs wnt
JP6668241B2 (ja) 2013-09-05 2020-03-18 アムジエン・インコーポレーテツド 予測可能で、一貫性のある、且つ再現可能な糖型特性を示すFc含有分子
WO2015175861A1 (fr) 2014-05-16 2015-11-19 Amgen Inc. Dosage pour la détection de populations de cellules th1 et th2
US11680101B2 (en) 2017-01-27 2023-06-20 Kymab Limited Anti-OPG antibodies
CA3056011A1 (fr) 2017-03-14 2018-09-20 Amgen Inc. Controle des glycoformes afucosylees totales d'anticorps produits en culture cellulaire
EP3713581A1 (fr) 2017-11-22 2020-09-30 Inbiomotion S.L. Traitement thérapeutique du cancer du sein basé sur le c-maf
SG11202009216YA (en) 2018-03-26 2020-10-29 Amgen Inc Total afucosylated glycoforms of antibodies produced in cell culture
KR20220069982A (ko) 2019-09-26 2022-05-27 암젠 인크 항체 조성물의 생산 방법
CN113621060B (zh) * 2020-05-07 2023-07-04 浙江瑞硕生物技术有限公司 一种opg抗体对及其应用
WO2021247892A1 (fr) 2020-06-04 2021-12-09 Amgen Inc. Évaluation de procédures de nettoyage d'un procédé de fabrication biothérapeutique
JP2023548767A (ja) 2020-10-15 2023-11-21 アムジエン・インコーポレーテツド 抗体製造方法における相対不対グリカン
AR126089A1 (es) 2021-06-07 2023-09-13 Amgen Inc Uso de fucosidasa para controlar el nivel de afucosilación de proteínas glucosiladas
WO2023059607A1 (fr) 2021-10-05 2023-04-13 Amgen Inc. Liaison de récepteur fc-gamma et teneur en glycane
WO2023215725A1 (fr) 2022-05-02 2023-11-09 Fred Hutchinson Cancer Center Compositions et méthodes pour l'immunothérapie cellulaire

Family Cites Families (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4179337A (en) * 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4710457A (en) 1983-06-29 1987-12-01 Sloan-Kettering Institute For Cancer Research Monoclonal antibody for human hematopoietic glycoproteins and method
US4710473A (en) 1983-08-10 1987-12-01 Amgen, Inc. DNA plasmids
US4959314A (en) 1984-11-09 1990-09-25 Cetus Corporation Cysteine-depleted muteins of biologically active proteins
US6410516B1 (en) * 1986-01-09 2002-06-25 President & Fellows Of Harvard College Nuclear factors associated with transcriptional regulation
US5846534A (en) 1988-02-12 1998-12-08 British Technology Group Limited Antibodies to the antigen campath-1
AU651421B2 (en) 1990-11-30 1994-07-21 Celtrix Pharmaceuticals, Inc. Use of a bone morphogenetic protein in synergistic combination with TGF-beta for bone repair
US5118667A (en) 1991-05-03 1992-06-02 Celtrix Pharmaceuticals, Inc. Bone growth factors and inhibitors of bone resorption for promoting bone formation
CA2068389A1 (fr) 1991-05-13 1992-11-14 Masahiko Sato Methode d'inhibition de la resorption osseuse
MX9204303A (es) 1991-07-23 1993-11-01 Rhone Poulenc Rorer Int Factor regulador del crecimiento de osteoclasto.
IL99120A0 (en) 1991-08-07 1992-07-15 Yeda Res & Dev Multimers of the soluble forms of tnf receptors,their preparation and pharmaceutical compositions containing them
US5961974A (en) * 1991-10-25 1999-10-05 Immunex Corporation Monoclonal antibodies to CD40 ligand, pharmaceutical composition comprising the same and hybridomas producing the same
US5447851B1 (en) 1992-04-02 1999-07-06 Univ Texas System Board Of Dna encoding a chimeric polypeptide comprising the extracellular domain of tnf receptor fused to igg vectors and host cells
EP0639079B1 (fr) 1992-04-30 2000-01-12 Amgen Inc. Methodes de traitement des maladies induites par l'interleukine-1 et le facteur de necrose tumorale
US5585479A (en) 1992-07-24 1996-12-17 The United States Of America As Represented By The Secretary Of The Navy Antisense oligonucleotides directed against human ELAM-I RNA
US5578569A (en) 1993-03-12 1996-11-26 Tam; Cherk S. Method of increasing bone growth
US5457035A (en) 1993-07-23 1995-10-10 Immunex Corporation Cytokine which is a ligand for OX40
JPH09502614A (ja) 1993-09-14 1997-03-18 メルク エンド カンパニー インコーポレーテッド 新規ヒト蛋白質チロシンホスファターゼをコードするcDNA
US6268212B1 (en) 1993-10-18 2001-07-31 Amgen Inc. Tissue specific transgene expression
US5641747A (en) 1994-07-25 1997-06-24 Temple University-Of The Commonwealth System Of Higher Education Treatment of osteopetrotic diseases
EP0792278B1 (fr) * 1994-11-07 2007-06-13 Human Genome Sciences, Inc. Polypeptide gamma appartenant a la famille des facteurs de necrose tumorale (fnt)
EP0727211A1 (fr) 1995-02-10 1996-08-21 Smithkline Beecham Corporation Emploi de composés spécifiques src SH2 dans le traitement de maladies de résorption osseuse
IL117175A (en) 1995-02-20 2005-11-20 Sankyo Co Osteoclastogenesis inhibitory factor protein
US20030166097A1 (en) * 1995-03-15 2003-09-04 Human Genome Sciences, Inc. Human tumor necrosis factor receptor
US7094564B1 (en) 1995-03-15 2006-08-22 Human Genome Sciences, Inc. Human tumor necrosis factor receptor
WO1996028546A1 (fr) 1995-03-15 1996-09-19 Human Genome Sciences, Inc. Recepteur humain du facteur de necrose tumorale
AU5985996A (en) 1995-06-07 1997-01-15 Osteosa Inc. Osteoclast growth regulatory factor
AU6090896A (en) 1995-06-07 1997-01-15 Osteosa Inc. Osteoclast growth regulatory factor
US5843901A (en) 1995-06-07 1998-12-01 Advanced Research & Technology Institute LHRH antagonist peptides
DK0835305T3 (da) * 1995-06-29 2006-02-13 Immunex Corp Cytokin som inducerer apoptose
US6369027B1 (en) 1995-12-22 2002-04-09 Amgen Inc. Osteoprotegerin
US6613544B1 (en) 1995-12-22 2003-09-02 Amgen Inc. Osteoprotegerin
US6046048A (en) 1996-01-09 2000-04-04 Genetech, Inc. Apo-2 ligand
US5981220A (en) * 1996-03-27 1999-11-09 Human Genome Sciences, Inc. Epidermal differentiation factor
TW555765B (en) * 1996-07-09 2003-10-01 Amgen Inc Low molecular weight soluble tumor necrosis factor type-I and type-II proteins
JPH1057071A (ja) 1996-08-19 1998-03-03 Snow Brand Milk Prod Co Ltd 新規dna及びそれを用いた蛋白質の製造方法
PT1114864E (pt) 1996-12-13 2008-10-08 Schering Corp Antigénios de superfície de células de mamífero, reagentes relacionados
FR2757507B1 (fr) 1996-12-20 1999-01-29 Inst Francais Du Petrole Procede de separation de paraxylene comprenant une adsorption avec injection d'eau et une cristallisation
AU5901598A (en) 1996-12-20 1998-07-17 Board Of Regents, The University Of Texas System Compositions and methods of use for osteoclast inhibitory factors
US6271349B1 (en) 1996-12-23 2001-08-07 Immunex Corporation Receptor activator of NF-κB
DE69738841D1 (de) 1996-12-23 2008-08-28 Immunex Corp Ligand für rezeptor aktivator of nf-kappa b, ligand ist mitglied der tnf superfamilie
KR100496063B1 (ko) * 1997-04-15 2005-06-21 산쿄 가부시키가이샤 신규단백질 및 그 제조방법
DK0975754T4 (en) 1997-04-16 2016-03-21 Amgen Inc Osteoprotegerin binding proteins and their receptors
US5843678A (en) * 1997-04-16 1998-12-01 Amgen Inc. Osteoprotegerin binding proteins
US6316408B1 (en) * 1997-04-16 2001-11-13 Amgen Inc. Methods of use for osetoprotegerin binding protein receptors
CA2229449A1 (fr) * 1997-04-25 1998-10-25 Takeda Chemical Industries, Ltd. Proteine receptrice nouvelle et son utilisation
AU7469998A (en) 1997-05-01 1998-11-24 Amgen, Inc. Chimeric opg polypeptides
WO1998054201A1 (fr) 1997-05-29 1998-12-03 Human Genome Sciences, Inc. Proteine 8 apparentee au recepteur du facteur de necrose tumorale humain
US6087555A (en) 1997-10-15 2000-07-11 Amgen Inc. Mice lacking expression of osteoprotegerin
US6790823B1 (en) 1998-04-23 2004-09-14 Amgen Inc. Compositions and methods for the prevention and treatment of cardiovascular diseases
EP2009025B1 (fr) * 1998-05-14 2011-07-27 Immunex Corporation Procédé d'inhibition de l'activité des ostéoclastes
AU754971B2 (en) * 1998-09-15 2002-11-28 Pharmexa A/S Method for down-regulating osteoprotegerin ligand activity
AU6078500A (en) 1999-07-09 2001-01-30 Amgen, Inc. Combination therapy for conditions leading to bone loss
EP1140136B1 (fr) 1999-09-03 2007-05-16 Amgen Inc. Compositions et procedes permettant la prevention ou le traitement du cancer et de la perte osseuse associee au cancer
US20030144187A1 (en) 1999-09-03 2003-07-31 Colin R. Dunstan Opg fusion protein compositions and methods
US20030103978A1 (en) * 2000-02-23 2003-06-05 Amgen Inc. Selective binding agents of osteoprotegerin binding protein
MXPA02008144A (es) 2000-02-23 2002-11-29 Amgen Inc Agentes de enlace selectivos antagonistas de la proteina de enlace de osteoprotegerina.
AU2001286586A1 (en) 2000-08-18 2002-03-04 University Of Massachusetts Medical Center Trance regulation of chondrocyte differentiation
US6884598B2 (en) * 2000-09-22 2005-04-26 Immunex Corporation Screening assays for agonists and antagonists of receptor activator of NF-κB
ES2212930T1 (es) 2001-05-17 2004-08-16 Immunex Corporation Uso terapeutico de antagonistas de rank.
CA2449658A1 (fr) * 2001-06-06 2002-12-12 Immunex Corporation Utilisation d'antagonistes rank dans le traitement du cancer
JP4212470B2 (ja) 2001-06-26 2009-01-21 アムジェン フレモント インク. Opglへの抗体
US6753755B2 (en) * 2001-06-28 2004-06-22 Safer Home, Inc. Electrical safety connector fuse
US7084257B2 (en) * 2001-10-05 2006-08-01 Amgen Inc. Fully human antibody Fab fragments with human interferon-gamma neutralizing activity
US6592001B2 (en) * 2001-12-18 2003-07-15 Kimberly-Clark Worldwide Dispenser for sheet material containing a dispensing port incrementally variable within a range
JP4761710B2 (ja) 2002-04-05 2011-08-31 アムジェン インコーポレイテッド 選択的opgl経路インヒビターとしてのヒト抗opgl中和抗体
US7706431B2 (en) * 2005-06-30 2010-04-27 Nokia Corporation System and method for providing optimized receiver architectures for combined pilot and data signal tracking

Also Published As

Publication number Publication date
HU230547B1 (hu) 2016-11-28
DK0975754T3 (da) 2007-10-01
BG65242B1 (bg) 2007-09-28
CA2285746A1 (fr) 1998-10-22
EP0975754B2 (fr) 2016-01-06
EA003636B1 (ru) 2003-08-28
CZ302262B6 (cs) 2011-01-19
HUP0001400A3 (en) 2001-12-28
AU2008202516A1 (en) 2008-06-26
SK288559B6 (sk) 2018-05-02
NO325175B1 (no) 2008-02-11
DE69837845T3 (de) 2016-06-23
US7923008B2 (en) 2011-04-12
AU779461C (en) 2005-10-13
CA2285746C (fr) 2010-09-28
AU2005201799A1 (en) 2005-05-26
EA199900939A1 (ru) 2000-08-28
BG103824A (en) 2000-05-31
DE69837845D1 (de) 2007-07-12
JP2001526532A (ja) 2001-12-18
US20060246064A1 (en) 2006-11-02
SI0975754T1 (sl) 2007-10-31
EP1717315A3 (fr) 2007-06-20
WO1998046751A1 (fr) 1998-10-22
PL336311A1 (en) 2000-06-19
BR9808545A (pt) 2000-05-23
HUP0001400A2 (en) 2000-07-28
SK141999A3 (en) 2000-05-16
NO995044L (no) 1999-12-15
SI0975754T2 (sl) 2016-04-29
EP0975754B1 (fr) 2007-05-30
ES2284203T5 (es) 2016-03-11
JP5001758B2 (ja) 2012-08-15
AU7120598A (en) 1998-11-11
DK0975754T4 (en) 2016-03-21
NO995044D0 (no) 1999-10-15
EP0975754A1 (fr) 2000-02-02
TR199902512T2 (xx) 2000-06-21
DE69837845T2 (de) 2008-01-31
ES2284203T3 (es) 2007-11-01
ID23855A (id) 2000-05-25
RO128635A2 (ro) 2013-07-30
JP2008054682A (ja) 2008-03-13
TW589376B (en) 2004-06-01
CZ359899A3 (cs) 2000-02-16
NZ500253A (en) 2002-09-27
HK1022330A1 (en) 2000-08-04
AU2005201799B2 (en) 2008-06-12
AU743257B2 (en) 2002-01-24
CN1264427A (zh) 2000-08-23
EE9900611A (et) 2000-08-15
ATE363533T1 (de) 2007-06-15
PL190092B1 (pl) 2005-10-31
AU9523401A (en) 2002-01-24
EE05496B1 (et) 2011-12-15
EP1717315A2 (fr) 2006-11-02
AU779461B2 (en) 2005-01-27

Similar Documents

Publication Publication Date Title
AU779461C (en) Osteoprotegerin binding proteins and receptors
Kasugai et al. Differential regulation of the 55 and 44 kDa forms of secreted phosphoprotein 1 (SPP-1, osteopontin) in normal and transformed rat bone cells by osteotropic hormones, growth factors and a tumor promoter
HU9600692D0 (en) Human metabotropic glutamate receptor subtypes (hmr4, hmr6, hmr7) and related dna compounds
EP2325316B8 (fr) Protéine réceptrice d'hémopoïétine, NR10
WO1995030003A3 (fr) Recepteurs de surface de cellule morphogenes specifiques d'une proteine et leurs usages
BR9814335A (pt) Proteìna, exceto as existentes ao natural, polinucleotìdeo substancialmente puro, anticorpo elaborado por um processo que compreende a etapa de injetar uma preparação farmaceuticamente aceitável, vetor para expressar o drr-1 de rato, vetor, célula hospedeira drr-1 de rato, drr-1 de ser humano, drr-2 de ser humano, drr-3 de ser humano, drr-4 de ser humano, drr-5 de ser humano, drr-6 de ser humano recombinantes, e, processo para ensaiar um composto de teste quanto à sua capacidade para ligar-se a ou para ativar um receptor especìfico de gânglios da raiz dorsal ligado à proteìna g (drr)
NZ508381A (en) Antibodies, antagonists and agonists of the death domain containing receptor 5 (DR5)
EA199700143A1 (ru) Способ и композиция ждя липидизации гидрофильных молекул
EP0679093A1 (fr) Procede d'apport d'agents a des cellules cibles.
ES2009590A6 (es) Metodo de preparacion de proteina de cadena pesada del factor tisular humano.
WO1995009872B1 (fr) Adn codant pour un recepteur ip de prostaglandine
DE69738370D1 (de) Modulatoren des tnf-rezeptor-assoziierten faktors, deren herstellung und verwendungen
EP0861896A3 (fr) Kinase humaine regulé par le volume de cellule (h-sgk)
NZ333203A (en) Tumour antigen proteins, genes thereof, and tumour antigen peptides
WO1997007135A3 (fr) Liaison de la proteine oestrogene 1 (op-1) et de ses analogues avec le recepteur alk-1 de surface de cellule et ses analogues
BR0013043A (pt) Proteìna isolada, anticorpo isolado, composição, método de regulação de reação imunológica em animais, método de tratamento de câncer em animais, molécula de ácido nucleico isolado, molécula de ácido nucleico recombinante, célula recombinante e vìrus recombinante
CA2312274A1 (fr) Adn isole codant pour un recepteur h3 d'histamine humain
WO1999063094A3 (fr) Sequences nucleotidiques et proteiques gpr1 et methodes y relatives
WO1999019480A3 (fr) Proteines receptrices humaines et reactifs et methodes associes
GEP20002244B (en) Osteoprotegerin
MX9701267A (es) Receptor de glutamato.
HUP0001774A3 (en) Fragments of leptin (ob protein)