IL129315A0 - Oxadiazoles process for their preparation and their use as medicaments - Google Patents

Oxadiazoles process for their preparation and their use as medicaments

Info

Publication number
IL129315A0
IL129315A0 IL12931597A IL12931597A IL129315A0 IL 129315 A0 IL129315 A0 IL 129315A0 IL 12931597 A IL12931597 A IL 12931597A IL 12931597 A IL12931597 A IL 12931597A IL 129315 A0 IL129315 A0 IL 129315A0
Authority
IL
Israel
Prior art keywords
oxadiazoles
medicaments
preparation
oxadiazoles process
Prior art date
Application number
IL12931597A
Other languages
English (en)
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of IL129315A0 publication Critical patent/IL129315A0/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D271/00Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/061,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
IL12931597A 1996-10-18 1997-10-15 Oxadiazoles process for their preparation and their use as medicaments IL129315A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19643037A DE19643037A1 (de) 1996-10-18 1996-10-18 Neue Oxadiazole, Verfahren zu ihrer Herstellung sowie deren Verwendung als Arzneimittel
PCT/EP1997/005693 WO1998017652A1 (de) 1996-10-18 1997-10-15 Oxadiazole, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel

Publications (1)

Publication Number Publication Date
IL129315A0 true IL129315A0 (en) 2000-02-17

Family

ID=7809114

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12931597A IL129315A0 (en) 1996-10-18 1997-10-15 Oxadiazoles process for their preparation and their use as medicaments

Country Status (32)

Country Link
US (1) US6277872B1 (xx)
EP (1) EP0934288B1 (xx)
JP (1) JP3333523B2 (xx)
KR (1) KR20000049253A (xx)
CN (1) CN1086698C (xx)
AR (1) AR008496A1 (xx)
AT (1) ATE315034T1 (xx)
AU (1) AU737552B2 (xx)
BG (1) BG103251A (xx)
BR (1) BR9714354A (xx)
CA (1) CA2268954C (xx)
CO (1) CO4920253A1 (xx)
CZ (1) CZ138099A3 (xx)
DE (2) DE19643037A1 (xx)
EE (1) EE9900147A (xx)
ES (1) ES2256880T3 (xx)
HK (1) HK1020956A1 (xx)
HR (1) HRP970553A2 (xx)
HU (1) HUP0001652A3 (xx)
ID (1) ID18613A (xx)
IL (1) IL129315A0 (xx)
NO (1) NO312512B1 (xx)
NZ (1) NZ335598A (xx)
PE (1) PE11199A1 (xx)
PL (1) PL332432A1 (xx)
RU (1) RU2182905C2 (xx)
SK (1) SK49999A3 (xx)
TR (1) TR199900848T2 (xx)
TW (1) TW413678B (xx)
WO (1) WO1998017652A1 (xx)
YU (1) YU40997A (xx)
ZA (1) ZA979220B (xx)

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DE19816880A1 (de) 1998-04-17 1999-10-21 Boehringer Ingelheim Pharma Neue Diphenyl-substituierte 5-Ring-Heterocyclen, Verfahren zu ihrer Herstellung sowie deren Verwendung als Arzneimittel
IT1300056B1 (it) * 1998-04-17 2000-04-05 Boehringer Ingelheim Italia Eterocicli con anello a 6 termini difenil-sostituiti loro procedimento di preparazione e loro impiego come farmaci
US6107313A (en) * 1998-10-02 2000-08-22 Combichem, Inc. Dopamine receptor antagonists
AU767849B2 (en) 1999-02-15 2003-11-27 Eisai R&D Management Co., Ltd. Heterodiazinone derivatives
ATE257827T1 (de) 1999-07-21 2004-01-15 Hoffmann La Roche Triazolderivate
US6660753B2 (en) 1999-08-19 2003-12-09 Nps Pharmaceuticals, Inc. Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
EP1582519A3 (en) * 1999-08-19 2005-12-21 Nps Pharmaceuticals, Inc. Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
UA75871C2 (en) * 1999-08-19 2006-06-15 Nps Pharma Inc 1,2,4-oxadiazole derivatives and use thereof as antagonists at metabotropic glutamate receptors
US6579880B2 (en) * 2000-06-06 2003-06-17 Ortho-Mcneil Pharmaceutical, Inc. Isoxazoles and oxadiazoles as anti-inflammatory inhibitors of IL-8
IL152848A0 (en) 2000-06-12 2003-06-24 Eisai Co Ltd 1,2-dihydropyridine derivatives, pharmaceutical compositions containing the same and methods for the production thereof
NZ524745A (en) * 2000-09-18 2006-01-27 Eisai Co Ltd Pyridazinones and triazinones and medicinal use thereof
RU2319701C2 (ru) * 2001-02-21 2008-03-20 Астразенека Аб ГЕТЕРОПОЛИЦИКЛИЧЕСКОЕ СОЕДИНЕНИЕ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, ОБЛАДАЮЩАЯ АНТАГОНИСТИЧЕСКОЙ АКТИВНОСТЬЮ В ОТНОШЕНИИ МЕТАБОТРОПНЫХ ГЛЮТАМАТНЫХ РЕЦЕПТОРОВ mGluR ГРУППЫ I
US7253190B2 (en) * 2001-10-04 2007-08-07 Merck & Co., Inc. Heteroaryl substituted tetrazole modulators of metabotrophic glutamate receptor-5
MY151199A (en) 2001-11-02 2014-04-30 Rigel Pharmaceuticals Inc Substituted diphenyl heterocycles useful for treating hcv infection
GB0129260D0 (en) 2001-12-06 2002-01-23 Eisai London Res Lab Ltd Pharmaceutical compositions and their uses
AU2003262831A1 (en) 2002-08-23 2004-03-11 Rigel Pharmaceuticals, Inc. Pyridyl substituted heterocycles useful for treating or preventing hcv infection
GB0303503D0 (en) * 2003-02-14 2003-03-19 Novartis Ag Organic compounds
WO2004099164A1 (en) * 2003-05-02 2004-11-18 Rigel Pharmaceuticals, Inc. Substituted diphenyl isoxazoles, pyrazoles and oxadiazoles useful for treating hcv infection
WO2004099165A2 (en) 2003-05-02 2004-11-18 Rigel Pharmaceuticals, Inc. Heterocyclic compounds and hydro isomers thereof
US7220745B2 (en) 2003-05-15 2007-05-22 Rigel Pharmaceuticals Heterocyclic compounds useful to treat HCV
WO2005049065A2 (en) 2003-11-19 2005-06-02 Rigel Pharmaceuticals, Inc. Synergistic combinations of dihaloacetamide with interferon or ribavirin for treatment hcv infections
JP4958560B2 (ja) * 2003-12-24 2012-06-20 プロシディオン・リミテッド Gpcr受容体作動薬としてのヘテロ環誘導体
US7514434B2 (en) 2004-02-23 2009-04-07 Rigel Pharmaceuticals, Inc. Heterocyclic compounds having an oxadiazole moiety and hydro isomers thereof
MY148809A (en) 2004-07-06 2013-05-31 Eisai R&D Man Co Ltd Crystals of 1,2-dihydropyridine compound and their production process
WO2006109876A1 (ja) * 2005-04-08 2006-10-19 Eisai R & D Management Co., Ltd. 不随意運動治療剤
WO2007027230A2 (en) 2005-05-02 2007-03-08 Rigel Pharmaceuticals, Inc. Heterocyclic anti-viral compounds comprising metabolizable moieties and their uses
GB0510142D0 (en) * 2005-05-18 2005-06-22 Addex Pharmaceuticals Sa Novel compounds A1
HUP0500920A2 (en) * 2005-10-05 2007-07-30 Richter Gedeon Nyrt Oxadiazole derivatives, process for their preparation and their use
MX2009006304A (es) * 2006-12-15 2009-06-23 Abbott Lab Nuevos compuestos de oxadiazol.
US20110207704A1 (en) * 2006-12-15 2011-08-25 Abbott Laboratories Novel Oxadiazole Compounds
JO2701B1 (en) 2006-12-21 2013-03-03 جلاكسو جروب ليميتد Vehicles
ES2547877T3 (es) * 2007-10-04 2015-10-09 Merck Serono S.A. Compuestos diaril-oxadiazol
US9045442B2 (en) * 2007-12-21 2015-06-02 University Of Notre Dame Du Lac Antibacterial compounds and methods of using same
PL2684873T3 (pl) 2008-06-09 2019-07-31 Ludwig-Maximilians-Universität München Leki do hamowania agregacji białek związanych z chorobami związanymi z agregacją białka i/lub chorobami neurodegeneracyjnymi
US9095596B2 (en) * 2009-10-15 2015-08-04 Southern Research Institute Treatment of neurodegenerative diseases, causation of memory enhancement, and assay for screening compounds for such
MX365851B (es) * 2012-08-24 2019-06-17 Treventis Corp Compuestos de benzofurazano anti-amiloides y metodos.
PT3110812T (pt) 2014-02-27 2019-07-10 Treventis Corp Compostos antiamiloide contendo benzofurazano
CN106231905B (zh) 2014-04-24 2019-04-09 住友化学株式会社 二芳基-唑化合物
AU2015319834A1 (en) * 2014-09-25 2017-04-20 University Of Notre Dame Du Lac Non-beta lactam antibiotics
CN107286174B (zh) * 2016-04-11 2020-08-18 上海勋和医药科技有限公司 取代2,4-(1h,3h)嘧啶二酮作为parp抑制剂及其应用
US11168062B2 (en) 2016-09-12 2021-11-09 University Of Notre Dame Du Lac Compounds for the treatment of Clostridium difficile infection
WO2018206778A1 (en) 2017-05-12 2018-11-15 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Phenyl-heterocycle-phenyl derivatives for use in the treatment or prevention of melanoma
US10676467B2 (en) 2017-06-30 2020-06-09 Washington University Compositions for binding sphingosine-1-phosphate receptor 1 (S1P1), imaging of S1P1, and methods of use thereof
BR112021010953A2 (pt) 2018-12-14 2021-08-24 Eisai R&D Management Co., Ltd. Formulações farmacêuticas de base aquosa de compostos de 1,2-di-hidropiridina
WO2023042887A1 (ja) 2021-09-15 2023-03-23 国立大学法人 琉球大学 認知機能低下、または過体重もしくは肥満症を処置することに用いるための医薬組成物
JPWO2023042888A1 (xx) 2021-09-15 2023-03-23
EP4173485A1 (en) 2021-10-27 2023-05-03 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Protein aggregation inhibiting compounds for plant disease control

Family Cites Families (14)

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US4003909A (en) * 1974-07-22 1977-01-18 E. R. Squibb & Sons, Inc. [(1,2,4-Oxadiazol-3-yl)phenyl]carbamic or thiocarbamic acid esters
JPS52272A (en) * 1975-10-17 1977-01-05 Takeda Chem Ind Ltd Process for preparing 1,2,4-oxadiazole derivatives
DE2801509A1 (de) * 1978-01-12 1979-07-19 Schering Ag 1,2,4-oxadiazolderivate, verfahren zur herstellung dieser verbindungen sowie diese enthaltende selektive herbizide mittel
JPS58150576A (ja) * 1982-03-03 1983-09-07 Sumitomo Chem Co Ltd 新規な1,2,4−オキサジアゾ−ル誘導体
EP0276432A3 (de) * 1986-12-12 1988-10-26 Ciba-Geigy Ag Schädlingsbekämpfungsmittel
DE3905242A1 (de) * 1989-02-21 1990-08-23 Basf Ag Verfahren zur herstellung von phenyloxdiazolylanilinen
JPH02250873A (ja) * 1989-03-24 1990-10-08 Mitsubishi Petrochem Co Ltd 1,2,4―オキサジアゾール誘導体及びそれを有効成分とする除草剤
NZ234760A (en) * 1989-08-18 1991-09-25 Sterling Drug Inc Antiviral oxazole compounds and compositions
DK443489D0 (da) * 1989-09-08 1989-09-08 Ferrosan As Substituerede urinstofforbindelser, deres fremstilling og anvendelse
JPH04295470A (ja) * 1991-03-22 1992-10-20 Wakamoto Pharmaceut Co Ltd モノアミンオキシダーゼ−b酵素阻害活性を有する1,2,4−オキサジアゾール誘導体及びその製造法
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DE4401108A1 (de) * 1994-01-17 1995-07-20 Bayer Ag 1,2,4-Oxadiazol-Derivate
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DE19528189A1 (de) * 1995-08-01 1997-02-06 Basf Ag Benzolderivate mit einem heterocyclischen Rest

Also Published As

Publication number Publication date
DE59712543D1 (de) 2006-03-30
NO991815L (no) 1999-04-16
KR20000049253A (ko) 2000-07-25
JP2000505089A (ja) 2000-04-25
BG103251A (en) 2000-02-29
ES2256880T3 (es) 2006-07-16
AU737552B2 (en) 2001-08-23
CA2268954A1 (en) 1998-04-30
CN1086698C (zh) 2002-06-26
US6277872B1 (en) 2001-08-21
EP0934288B1 (de) 2006-01-04
HRP970553A2 (en) 1998-08-31
NZ335598A (en) 2001-06-29
PL332432A1 (en) 1999-09-13
CN1233245A (zh) 1999-10-27
JP3333523B2 (ja) 2002-10-15
TR199900848T2 (xx) 1999-06-21
CO4920253A1 (es) 2000-05-29
AR008496A1 (es) 2000-01-19
HUP0001652A2 (hu) 2001-01-29
HK1020956A1 (en) 2000-05-26
CZ138099A3 (cs) 1999-11-17
NO991815D0 (no) 1999-04-16
BR9714354A (pt) 2000-04-11
ZA979220B (en) 1998-04-20
YU40997A (sh) 2000-10-30
AU4867697A (en) 1998-05-15
ATE315034T1 (de) 2006-02-15
CA2268954C (en) 2006-06-13
DE19643037A1 (de) 1998-04-23
PE11199A1 (es) 1999-03-03
HUP0001652A3 (en) 2002-12-28
EE9900147A (et) 1999-12-15
EP0934288A1 (de) 1999-08-11
TW413678B (en) 2000-12-01
NO312512B1 (no) 2002-05-21
SK49999A3 (en) 1999-11-08
RU2182905C2 (ru) 2002-05-27
ID18613A (id) 1998-04-23
WO1998017652A1 (de) 1998-04-30

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