IL126418A0 - Hormone-mediated methods for modulating expression of exogenous genes and pharmaceutical compositions for modulating the same - Google Patents
Hormone-mediated methods for modulating expression of exogenous genes and pharmaceutical compositions for modulating the sameInfo
- Publication number
- IL126418A0 IL126418A0 IL12641897A IL12641897A IL126418A0 IL 126418 A0 IL126418 A0 IL 126418A0 IL 12641897 A IL12641897 A IL 12641897A IL 12641897 A IL12641897 A IL 12641897A IL 126418 A0 IL126418 A0 IL 126418A0
- Authority
- IL
- Israel
- Prior art keywords
- modulating
- hormone
- pharmaceutical compositions
- same
- exogenous genes
- Prior art date
Links
- 229940088597 hormone Drugs 0.000 title 1
- 239000005556 hormone Substances 0.000 title 1
- 230000001404 mediated effect Effects 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
- C07K14/721—Steroid/thyroid hormone superfamily, e.g. GR, EcR, androgen receptor, oestrogen receptor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
- C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/75—Vector systems having a special element relevant for transcription from invertebrates
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Environmental Sciences (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Endocrinology (AREA)
- Plant Pathology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US62883096A | 1996-04-05 | 1996-04-05 | |
PCT/US1997/005330 WO1997038117A1 (en) | 1996-04-05 | 1997-03-27 | Hormone-mediated methods for modulating expression of exogenous genes in mammalian systems, and products related thereto |
Publications (1)
Publication Number | Publication Date |
---|---|
IL126418A0 true IL126418A0 (en) | 1999-05-09 |
Family
ID=24520484
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL12641897A IL126418A0 (en) | 1996-04-05 | 1997-03-27 | Hormone-mediated methods for modulating expression of exogenous genes and pharmaceutical compositions for modulating the same |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP0910652B1 (xx) |
JP (1) | JP2000508895A (xx) |
CN (1) | CN1215432A (xx) |
AU (1) | AU734051B2 (xx) |
CA (1) | CA2251466A1 (xx) |
IL (1) | IL126418A0 (xx) |
WO (1) | WO1997038117A1 (xx) |
Families Citing this family (61)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EA003423B1 (ru) | 1995-10-10 | 2003-04-24 | Новартис Аг | Штамм трансгенных растительных клеток и трансгенное растение, содержащие кассету экспрессии полипептида-мишени usp рецептора, способы получения их потомства, способы регулирования экспрессии полипептида-мишени в указанном растении с помощью ювенильного гормона или его агонистов, способы выявления и получения лиганда для полипептида usp рецептора и соответствующий лиганд |
AUPP135698A0 (en) * | 1998-01-15 | 1998-02-05 | Commonwealth Scientific And Industrial Research Organisation | Insectical modalities |
US6342596B1 (en) | 1998-05-05 | 2002-01-29 | Hsf Pharmaceuticals S.A. | Molecular regulatory circuits to achieve sustained activation of genes of interest by a single stress |
US6333318B1 (en) | 1998-05-14 | 2001-12-25 | The Salk Institute For Biological Studies | Formulations useful for modulating expression of exogenous genes in mammalian systems, and products related thereto |
US6258603B1 (en) * | 1998-06-17 | 2001-07-10 | Rohm And Haas Company | Ligands for modulating the expression of exogenous genes via an ecdysone receptor complex |
FR2782732A1 (fr) * | 1998-08-28 | 2000-03-03 | Transgene Sa | Systeme d'expression inductible |
US6117639A (en) * | 1998-08-31 | 2000-09-12 | Vertex Pharmaceuticals Incorporated | Fusion proteins, DNA molecules, vectors, and host cells useful for measuring protease activity |
AU3642601A (en) * | 1999-11-05 | 2001-05-30 | Avigen, Inc. | Ecdysone-inducible adeno-associated virus expression vectors |
EP1478750B1 (en) * | 1999-11-23 | 2012-08-08 | Mayo Foundation For Medical Education And Research | Gene expression by positive feedback activation of a cell type-specific promoter |
WO2001062780A1 (en) * | 2000-02-24 | 2001-08-30 | The Salk Institute For Biological Studies | Gene expression system based on chimeric receptors |
US20040033600A1 (en) | 2001-03-21 | 2004-02-19 | Palli Subba Reddy | Ecdysone receptor-based inducible gene expression system |
MXPA02009157A (es) | 2000-03-22 | 2004-04-05 | Rohm & Haas | Nuevo sistema de expresion genetica inducible a base del receptor de ecdisona. |
US7514239B2 (en) | 2000-03-28 | 2009-04-07 | Amgen Inc. | Nucleic acid molecules encoding beta-like glycoprotein hormone polypeptides and heterodimers thereof |
AU7026601A (en) | 2000-06-28 | 2002-01-08 | Amgen Inc | Thymic stromal lymphopoietin receptor molecules and uses thereof |
US8105825B2 (en) | 2000-10-03 | 2012-01-31 | Intrexon Corporation | Multiple inducible gene regulation system |
EP1356066A2 (en) | 2000-10-24 | 2003-10-29 | Syngenta Participations AG | Control of gene expression in plants |
EP1456346B1 (en) | 2001-02-20 | 2012-02-15 | Intrexon Corporation | Novel ecdysone receptor/invertebrate retinoid x receptor-based inducible gene expression system |
EP1373470B1 (en) | 2001-02-20 | 2013-04-24 | Intrexon Corporation | Novel substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system |
WO2002066615A2 (en) | 2001-02-20 | 2002-08-29 | Rheogene, Inc. | Novel substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system |
MXPA03007492A (es) | 2001-02-20 | 2004-10-15 | Rheogene Holdings Inc | Receptores de retinoide x quimerico y su uso en un sistema de expresion de gen inducible basado en receptor de ecdisona novedoso. |
CA2344208A1 (en) | 2001-04-30 | 2002-10-30 | Oxford Biomedica (Uk) Limited | Method |
US7919269B2 (en) | 2001-09-26 | 2011-04-05 | Intrexon Corporation | Whitefly ecdysone receptor nucleic acids, polypeptides, and uses thereof |
US7563879B2 (en) | 2001-09-26 | 2009-07-21 | Intrexon Corporation | Leafhopper ecdysone receptor nucleic acids, polypeptides, and uses thereof |
US7662924B2 (en) | 2002-02-22 | 2010-02-16 | The Board Of Trustees Of The University Of Illinois | Beta chain-associated regulator of apoptosis |
AU2003216407A1 (en) * | 2002-02-25 | 2003-09-09 | University Of Rochester | Dna construct for inducible expression of angiogenic protein and use thereof |
US7375093B2 (en) | 2002-07-05 | 2008-05-20 | Intrexon Corporation | Ketone ligands for modulating the expression of exogenous genes via an ecdysone receptor complex |
US7304161B2 (en) | 2003-02-10 | 2007-12-04 | Intrexon Corporation | Diaclhydrazine ligands for modulating the expression of exogenous genes in mammalian systems via an ecdysone receptor complex |
US7456315B2 (en) | 2003-02-28 | 2008-11-25 | Intrexon Corporation | Bioavailable diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex |
US20050164210A1 (en) * | 2004-01-23 | 2005-07-28 | Vivek Mittal | Regulated polymerase III expression systems and related methods |
US7935510B2 (en) * | 2004-04-30 | 2011-05-03 | Intrexon Corporation | Mutant receptors and their use in a nuclear receptor-based inducible gene expression system |
CN101016518B (zh) * | 2006-09-12 | 2010-07-28 | 南方医科大学 | 一种生物杀虫剂筛选模型及其制备方法和应用 |
MX363066B (es) | 2007-05-29 | 2019-03-07 | Intrexon Corp | Ligandos quirales de diacilhidrazina para modular la expresion de genes exogenos por medio de un complejo receptor de ecdisona. |
EP2179044A4 (en) | 2007-07-06 | 2012-06-06 | Temasek Life Sciences Lab Ltd | LEXA BASED INDUCIBLE GENE EXPRESSION SYSTEM FOR TRANSGENIC ANIMALS |
AU2008302504B2 (en) | 2007-09-17 | 2014-08-14 | Agrofresh Inc. | Compositions and methods for the modification of physiological responses in plants |
AU2008307643B9 (en) * | 2007-09-28 | 2014-04-17 | Intrexon Corporation | Therapeutic gene-switch constructs and bioreactors for the expression of biotherapeutic molecules, and uses thereof |
CA2718494C (en) | 2008-03-14 | 2016-05-17 | Intrexon Corporation | Steroidal ligands and their use in gene switch modulation |
ES2337973B8 (es) | 2008-05-16 | 2011-07-21 | Proyecto De Biomedicina Cima, S.L. | Adenovirus auxiliares auto-inactivantes para la produccion de adenovirus recombinantes de alta capacidad. |
ES2330826B1 (es) | 2008-06-04 | 2010-07-26 | Proyecto De Biomedicina Cima, S.L. | Sistema para empaquetamiento de adenovirus de alta capacidad. |
MX2011009239A (es) | 2009-03-05 | 2011-09-15 | Rohm & Haas | Control de rotacion apuntada de proteina de ruta de señalizacion de hormona de etileno clave para modular la sensibilidad a etileno en plantas. |
WO2010114143A1 (ja) * | 2009-03-30 | 2010-10-07 | 国立大学法人岡山大学 | 特異的プロモーターの活性を上昇させるシステム及び該システムを保持したベクター |
EP2407534A1 (en) | 2010-07-14 | 2012-01-18 | Neo Virnatech, S.L. | Methods and reagents for obtaining transcriptionally active virus-like particles and recombinant virions |
DK2626431T3 (en) | 2010-10-06 | 2015-12-21 | Fundació Inst De Recerca Biomèdica Irb Barcelona | A process for the diagnosis, prognosis and treatment of breast cancer metastasis |
US20150052625A1 (en) * | 2012-03-27 | 2015-02-19 | Trans Genic Inc. | Humanized mouse |
EP2650682A1 (en) | 2012-04-09 | 2013-10-16 | Fundació Privada Institut de Recerca Biomèdica | Method for the prognosis and treatment of cancer metastasis |
ES2705237T3 (es) | 2012-06-06 | 2019-03-22 | Fundacio Inst De Recerca Biomedica Irb Barcelona | Método para el diagnóstico y el pronóstico de metástasis del cáncer de pulmón |
EP2687852A1 (en) | 2012-07-17 | 2014-01-22 | Laboratorios Del. Dr. Esteve, S.A. | Method for diagnosing and treating chronic fatigue syndrome |
ES2906586T3 (es) | 2012-10-12 | 2022-04-19 | Inbiomotion Sl | Método para el diagnóstico, pronóstico y tratamiento de metástasis de cáncer de próstata |
WO2014144380A1 (en) | 2013-03-15 | 2014-09-18 | Intrexon Corporation | Boron-containing diacylhydrazines |
JP2016518815A (ja) | 2013-03-15 | 2016-06-30 | フンダシオ、インスティトゥト、デ、レセルカ、ビオメディカ(イエレベ、バルセロナ)Fundacio Institut De Recerca Biomedica (Irb Barcelona) | 転移性がんの診断、予後、および処置の方法 |
WO2014184679A2 (en) | 2013-03-15 | 2014-11-20 | Inbiomotion S.L. | Method for the prognosis and treatment of renal cell carcinoma metastasis |
JP6577873B2 (ja) | 2013-03-15 | 2019-09-18 | フンダシオ、インスティトゥト、デ、レセルカ、ビオメディカ(イエレベ、バルセロナ)Fundacio Institut De Recerca Biomedica (Irb Barcelona) | がんの転移の予後診断および処置のための方法 |
ES2523016B1 (es) | 2013-05-20 | 2015-09-09 | 3P Biopharmaceuticals | Vectores alfavirales y líneas celulares para la producción de proteínas recombinantes |
TR201907389T4 (tr) | 2013-10-09 | 2019-06-21 | Fundacio Inst De Recerca Biomedica Irb Barcelona | Meme kanserinden kaynaklanan metastazlı kemik kanserinin prognozu ve tedavisine yönelik yöntem. |
WO2015101666A1 (en) | 2014-01-03 | 2015-07-09 | Fundación Biofísica Bizkaia | VLPs, METHODS FOR THEIR OBTENTION AND APPLICATIONS THEREOF |
SG11201701944WA (en) | 2014-09-17 | 2017-04-27 | Intrexon Corp | Boron-containing diacylhydrazine compounds |
GB201619876D0 (en) * | 2016-11-24 | 2017-01-11 | Cambridge Entpr Ltd | Controllable transcription |
WO2018132494A1 (en) | 2017-01-10 | 2018-07-19 | Intrexon Corporation | Modulating expression of polypeptides via new gene switch expression systems |
CN110997920A (zh) | 2017-06-07 | 2020-04-10 | 英特拉克森公司 | 新型细胞标签的表达 |
EP3762010A4 (en) | 2018-03-06 | 2022-04-06 | Precigen, Inc. | HEPATITIS B VACCINES AND USES THEREOF |
EP3820888A4 (en) | 2018-07-13 | 2022-04-27 | Nanjing Legend Biotech Co., Ltd. | CO-RECEPTOR SYSTEMS FOR THE TREATMENT OF INFECTIOUS DISEASES |
EP4371569A1 (en) | 2022-11-16 | 2024-05-22 | Universidad del País Vasco/Euskal Herriko Unibertsitatea | Vlps against acute myeloid leukaemia |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6492137B1 (en) * | 1989-11-16 | 2002-12-10 | The Salk Institute For Biological Studies | Response element compositions and assays employing same |
WO1991013167A1 (en) * | 1990-02-26 | 1991-09-05 | The Board Of Trustees Of The Leland Stanford Junior University | Identification and expression of insect steroid receptor dna sequences |
DE69227589T2 (de) * | 1991-08-08 | 1999-04-08 | Genentech Inc | Ecdysteroid-abhängige gen regulierung in säugetier-zellen |
EP0804568A2 (en) * | 1992-07-02 | 1997-11-05 | The Salk Institute For Biological Studies | Multimeric forms of members of the steroid/thyroid superfamily of receptors with the ultraspiracle receptor |
-
1997
- 1997-03-27 IL IL12641897A patent/IL126418A0/xx unknown
- 1997-03-27 EP EP97917146.9A patent/EP0910652B1/en not_active Expired - Lifetime
- 1997-03-27 CN CN97193597.1A patent/CN1215432A/zh active Pending
- 1997-03-27 WO PCT/US1997/005330 patent/WO1997038117A1/en active Application Filing
- 1997-03-27 AU AU25572/97A patent/AU734051B2/en not_active Ceased
- 1997-03-27 CA CA002251466A patent/CA2251466A1/en not_active Abandoned
- 1997-03-27 JP JP9536281A patent/JP2000508895A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
AU734051B2 (en) | 2001-05-31 |
EP0910652A1 (en) | 1999-04-28 |
WO1997038117A1 (en) | 1997-10-16 |
JP2000508895A (ja) | 2000-07-18 |
CN1215432A (zh) | 1999-04-28 |
AU2557297A (en) | 1997-10-29 |
CA2251466A1 (en) | 1997-10-16 |
EP0910652B1 (en) | 2014-10-08 |
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