IL124803A0 - Coralyne analogs as topoisomerase inhibitors - Google Patents
Coralyne analogs as topoisomerase inhibitorsInfo
- Publication number
- IL124803A0 IL124803A0 IL12480397A IL12480397A IL124803A0 IL 124803 A0 IL124803 A0 IL 124803A0 IL 12480397 A IL12480397 A IL 12480397A IL 12480397 A IL12480397 A IL 12480397A IL 124803 A0 IL124803 A0 IL 124803A0
- Authority
- IL
- Israel
- Prior art keywords
- coralyne
- analogs
- topoisomerase inhibitors
- topoisomerase
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
- C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1145296P | 1996-02-12 | 1996-02-12 | |
| US3216196P | 1996-10-01 | 1996-10-01 | |
| PCT/US1997/001676 WO1997029106A1 (en) | 1996-02-12 | 1997-02-11 | Coralyne analogs as topoisomerase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL124803A0 true IL124803A0 (en) | 1999-01-26 |
Family
ID=26682407
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL12480397A IL124803A0 (en) | 1996-02-12 | 1997-02-11 | Coralyne analogs as topoisomerase inhibitors |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP0888346B1 (pt) |
| JP (1) | JP2000504687A (pt) |
| KR (1) | KR19990082488A (pt) |
| CN (1) | CN1067070C (pt) |
| AU (1) | AU710070C (pt) |
| BR (1) | BR9707425A (pt) |
| CA (1) | CA2241551A1 (pt) |
| CZ (1) | CZ254498A3 (pt) |
| DE (1) | DE69705112T2 (pt) |
| ES (1) | ES2161442T3 (pt) |
| HU (1) | HUP9900413A3 (pt) |
| IL (1) | IL124803A0 (pt) |
| NO (1) | NO983669L (pt) |
| NZ (1) | NZ330705A (pt) |
| PL (1) | PL328402A1 (pt) |
| PT (1) | PT888346E (pt) |
| TR (1) | TR199801555T2 (pt) |
| WO (1) | WO1997029106A1 (pt) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW460464B (en) * | 1996-11-25 | 2001-10-21 | Nippon Kayaku Kk | Novel phenanthridinium derivative having an anti-tumor activity and pharmaceutical composition containing the same |
| US6140328A (en) * | 1997-12-12 | 2000-10-31 | Rutgers, The State University Of New Jersey | Heterocyclic cytotoxic agents |
| US6063801A (en) | 1998-02-12 | 2000-05-16 | Rutgers, The State University Of New Jersey | Heterocyclic topoisomerase poisons |
| US6833373B1 (en) | 1998-12-23 | 2004-12-21 | G.D. Searle & Co. | Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia |
| CN1093129C (zh) * | 1999-08-19 | 2002-10-23 | 广州市海科生物技术有限公司 | 一种具有抗肿瘤生理活性的尖叶唐松草阿原碱及其提取方法 |
| US6740650B2 (en) | 1999-10-29 | 2004-05-25 | Rutgers, The State University Of New Jersey | Heterocyclic cytotoxic agents |
| DE60231426D1 (de) | 2001-11-14 | 2009-04-16 | Univ Rutgers | Solubilisierte topoisomerase-gift-mittel |
| DE60235287D1 (de) | 2001-11-14 | 2010-03-25 | Univ Rutgers | Löslich gemachte topoisomerase-gifte |
| EP1453506B1 (en) | 2001-11-14 | 2008-04-02 | Rutgers, The State University | Topoisomerase poison agents |
| AU2003268075A1 (en) | 2002-08-09 | 2004-02-25 | Edmond J. Lavoie | Nitro and amino substituted dibenzonaphthyridines as topoisomerase agents |
| WO2004014862A1 (en) | 2002-08-09 | 2004-02-19 | Rutgers, The State University | Nitro and amino substituted heterocycles as topoisomerase i targeting agents |
| AU2003265406A1 (en) | 2002-08-09 | 2004-02-25 | Edmond J. Lavoie | Nitro and amino substituted topoisomerase agents |
| WO2004044174A2 (en) | 2002-11-12 | 2004-05-27 | Rutgers, The State University | Topoisomerase-targeting agents |
| KR101431279B1 (ko) | 2005-07-29 | 2014-08-20 | 리스버로직스 코퍼레이션 | 복합 질환의 예방 및 치료용 약학적 조성물 및 삽입가능한의료 장치에 의한 이의 전달 |
| MX2009008099A (es) | 2007-02-01 | 2009-12-14 | Resverlogix Corp | Compuestos para la prevencion y tratamiento de enfermedades cardiovasculares. |
| EP2014651A1 (en) * | 2007-07-12 | 2009-01-14 | Exonhit Therapeutics SA | Compounds and methods for modulating Rho GTPases |
| JP5602728B2 (ja) | 2008-06-26 | 2014-10-08 | レスバーロジックス コーポレイション | キナゾリノン誘導体の製造方法 |
| EP2382194B1 (en) | 2009-01-08 | 2014-03-12 | Resverlogix Corp. | Compounds for the prevention and treatment of cardiovascular disease |
| JP5773888B2 (ja) | 2009-03-06 | 2015-09-02 | ラットガーズ，ザ・ステート・ユニバーシティ・オブ・ニュージャージー | 癌治療に用いられるメチレンジオキシベンゾ［ｉ］フェナントリジン誘導体 |
| WO2010106436A2 (en) | 2009-03-18 | 2010-09-23 | Resverlogix Corp. | Novel anti-inflammatory agents |
| SI2421533T1 (sl) | 2009-04-22 | 2019-01-31 | Resverlogix Corp. | Nova protivnetna sredstva |
| WO2010127363A1 (en) | 2009-05-01 | 2010-11-04 | Rutgers, The State University Of New Jersey | Toposiomerase inhibitors |
| US8188109B2 (en) * | 2009-07-20 | 2012-05-29 | Naxospharma S.R.L. | Benzoquinolizinium salt derivatives as anticancer agents |
| CN102746292B (zh) * | 2011-04-18 | 2015-03-18 | 中国医学科学院医药生物技术研究所 | 环化的小檗碱衍生物及其制备方法和用途 |
| DK2773354T3 (da) | 2011-11-01 | 2019-08-05 | Resverlogix Corp | Oralformuleringer med øjeblikkelig frigivelse for substituerede quinazolinoner |
| WO2014080291A2 (en) | 2012-11-21 | 2014-05-30 | Rvx Therapeutics Inc. | Biaryl derivatives as bromodomain inhibitors |
| WO2014080290A2 (en) | 2012-11-21 | 2014-05-30 | Rvx Therapeutics Inc. | Cyclic amines as bromodomain inhibitors |
| CA2895905A1 (en) | 2012-12-21 | 2014-06-26 | Zenith Epigenetics Corp. | Novel heterocyclic compounds as bromodomain inhibitors |
| US9642846B2 (en) | 2013-03-15 | 2017-05-09 | Georgetown University | Antifungal drugs |
| CN109851617B (zh) | 2013-08-23 | 2022-08-16 | 润新生物公司 | 化学实体、组合物和方法 |
| WO2016133935A1 (en) * | 2015-02-17 | 2016-08-25 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
| EP3268007B1 (en) | 2015-03-13 | 2022-11-09 | Resverlogix Corp. | Compositions and therapeutic methods for the treatment of complement-associated diseases |
| CN105541714A (zh) * | 2015-12-16 | 2016-05-04 | 浙江普洛康裕制药有限公司 | 一种罂粟碱及盐酸罂粟碱的制备方法 |
| CN109219610A (zh) | 2016-04-04 | 2019-01-15 | 新泽西州立拉特格斯大学 | 拓扑异构酶毒物 |
| US10544106B2 (en) | 2016-08-15 | 2020-01-28 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
| CN110759963A (zh) * | 2018-07-25 | 2020-02-07 | 中山大学 | 一种稠环类化合物及其制备方法和用途 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5126351A (en) * | 1991-01-24 | 1992-06-30 | Glaxo Inc. | Antitumor compounds |
| US5223506A (en) * | 1991-06-04 | 1993-06-29 | Glaxo Inc. | Cyclic antitumor compounds |
-
1997
- 1997-02-11 PT PT97906466T patent/PT888346E/pt unknown
- 1997-02-11 NZ NZ330705A patent/NZ330705A/en unknown
- 1997-02-11 HU HU9900413A patent/HUP9900413A3/hu unknown
- 1997-02-11 IL IL12480397A patent/IL124803A0/xx unknown
- 1997-02-11 AU AU21155/97A patent/AU710070C/en not_active Ceased
- 1997-02-11 BR BR9707425A patent/BR9707425A/pt unknown
- 1997-02-11 CN CN97192211A patent/CN1067070C/zh not_active Expired - Fee Related
- 1997-02-11 CA CA002241551A patent/CA2241551A1/en not_active Abandoned
- 1997-02-11 DE DE69705112T patent/DE69705112T2/de not_active Expired - Fee Related
- 1997-02-11 WO PCT/US1997/001676 patent/WO1997029106A1/en not_active Application Discontinuation
- 1997-02-11 TR TR1998/01555T patent/TR199801555T2/xx unknown
- 1997-02-11 ES ES97906466T patent/ES2161442T3/es not_active Expired - Lifetime
- 1997-02-11 PL PL97328402A patent/PL328402A1/xx unknown
- 1997-02-11 CZ CZ982544A patent/CZ254498A3/cs unknown
- 1997-02-11 KR KR1019980706221A patent/KR19990082488A/ko not_active Application Discontinuation
- 1997-02-11 JP JP9528606A patent/JP2000504687A/ja active Pending
- 1997-02-11 EP EP97906466A patent/EP0888346B1/en not_active Expired - Lifetime
-
1998
- 1998-08-11 NO NO983669A patent/NO983669L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| TR199801555T2 (xx) | 1998-11-23 |
| CN1067070C (zh) | 2001-06-13 |
| BR9707425A (pt) | 1999-07-20 |
| PT888346E (pt) | 2001-10-31 |
| JP2000504687A (ja) | 2000-04-18 |
| NZ330705A (en) | 2000-03-27 |
| DE69705112D1 (en) | 2001-07-12 |
| KR19990082488A (ko) | 1999-11-25 |
| AU710070C (en) | 2001-08-30 |
| AU2115597A (en) | 1997-08-28 |
| NO983669D0 (no) | 1998-08-11 |
| CA2241551A1 (en) | 1997-08-14 |
| NO983669L (no) | 1998-09-23 |
| CZ254498A3 (cs) | 1998-12-16 |
| DE69705112T2 (de) | 2002-03-21 |
| EP0888346B1 (en) | 2001-06-06 |
| AU710070B2 (en) | 1999-09-16 |
| EP0888346A1 (en) | 1999-01-07 |
| HUP9900413A2 (hu) | 1999-05-28 |
| PL328402A1 (en) | 1999-01-18 |
| CN1211252A (zh) | 1999-03-17 |
| WO1997029106A1 (en) | 1997-08-14 |
| ES2161442T3 (es) | 2001-12-01 |
| HUP9900413A3 (en) | 2002-02-28 |
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