IL113480A - Benzocycloalkyl-azolethione derivatives their preparation and pharmaceutical compositions containing them - Google Patents
Benzocycloalkyl-azolethione derivatives their preparation and pharmaceutical compositions containing themInfo
- Publication number
- IL113480A IL113480A IL11348095A IL11348095A IL113480A IL 113480 A IL113480 A IL 113480A IL 11348095 A IL11348095 A IL 11348095A IL 11348095 A IL11348095 A IL 11348095A IL 113480 A IL113480 A IL 113480A
- Authority
- IL
- Israel
- Prior art keywords
- azolethione
- benzocycloalkyl
- thioxo
- dihydro
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
- C07D233/32—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
- C07D233/32—One oxygen atom
- C07D233/36—One oxygen atom with hydrocarbon radicals, substituted by nitrogen atoms, attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
- C07D233/42—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/84—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/12—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IL12556198A IL125561A0 (en) | 1994-04-26 | 1995-04-25 | (s)-5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2-ylamine and its preparation |
IL12556195A IL125561A (en) | 1994-04-26 | 1995-04-25 | (S)-5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2-ylamine and the preparation of a S-enantiomer of 1,2,3,4-tetrahydronaphthalen-2-ylamine derivatives |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US23383594A | 1994-04-26 | 1994-04-26 | |
US08/233,655 US5438150A (en) | 1994-04-26 | 1994-04-26 | Process for making 1-benzocycloalkyl-1,3-dihydroimidazole-2-thione derivatives |
US08/403,209 US5538988A (en) | 1994-04-26 | 1995-03-17 | Benzocycloalkylazolethione derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
IL113480A0 IL113480A0 (en) | 1995-07-31 |
IL113480A true IL113480A (en) | 2000-06-29 |
Family
ID=27398461
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL11348095A IL113480A (en) | 1994-04-26 | 1995-04-25 | Benzocycloalkyl-azolethione derivatives their preparation and pharmaceutical compositions containing them |
Country Status (21)
Country | Link |
---|---|
EP (1) | EP0757677B1 (zh) |
JP (1) | JPH09512269A (zh) |
CN (1) | CN1113874C (zh) |
AT (1) | ATE243199T1 (zh) |
AU (1) | AU687192B2 (zh) |
BR (1) | BR9507517A (zh) |
CA (1) | CA2188748A1 (zh) |
CZ (1) | CZ290082B6 (zh) |
DE (1) | DE69531102T2 (zh) |
DK (1) | DK0757677T3 (zh) |
ES (1) | ES2201104T3 (zh) |
FI (1) | FI964312A (zh) |
HU (1) | HUT76295A (zh) |
IL (1) | IL113480A (zh) |
MX (1) | MX9605145A (zh) |
NO (1) | NO311720B1 (zh) |
NZ (1) | NZ284356A (zh) |
PL (1) | PL185959B1 (zh) |
PT (1) | PT757677E (zh) |
RU (1) | RU2145321C1 (zh) |
WO (1) | WO1995029165A2 (zh) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2201944B1 (en) | 1997-11-21 | 2012-05-23 | Purdue Neuroscience Company | Use of substituted 2-aminoacetamides for treating, preventing or ameliorating manic depression |
AU2298399A (en) * | 1998-02-06 | 1999-08-23 | Yoshitomi Pharmaceutical Industries, Ltd. | Novel azapeptide type hydroxamic acid derivatives |
JP4978762B2 (ja) * | 2001-03-30 | 2012-07-18 | Dic株式会社 | シクロヘキサ−3−エン−1−オール誘導体の製造方法 |
GB2393958A (en) * | 2002-10-11 | 2004-04-14 | Portela & Ca Sa | Peripherally-selective imidazole inhibitors of dopamine-beta-hydroxylase |
US7125904B2 (en) * | 2002-10-11 | 2006-10-24 | Portela & C.A., S.A. | Peripherally-selective inhibitors of dopamine-β-hydroxylase and method of their preparation |
GB0600709D0 (en) * | 2006-01-13 | 2006-02-22 | Portela & Ca Sa | Drug combinations |
RU2009126571A (ru) | 2006-12-12 | 2011-01-20 | Биал-Портела Энд Ка, С.А. (Pt) | Каталитический способ асимметричной гидрогенизации |
US20100093817A1 (en) * | 2007-02-01 | 2010-04-15 | Bial - Portela & Ca S.A. | Compounds |
EP1977646A1 (en) * | 2007-04-03 | 2008-10-08 | Bayer CropScience AG | Insecticidal hydroxyethyl thlourea derivatives |
GB0708818D0 (en) * | 2007-05-08 | 2007-06-13 | Portela & Ca Sa | Compounds |
GB0709695D0 (en) * | 2007-05-21 | 2007-06-27 | Portela & Ca Sa | Process |
TW200927740A (en) * | 2007-11-13 | 2009-07-01 | Bial Portela & Ca Sa | Process |
EP2726454B1 (en) | 2011-06-29 | 2018-01-24 | Bial-Portela & CA, S.A. | Process |
TR201815850T4 (tr) * | 2012-11-14 | 2018-11-21 | Bial Portela & Ca Sa | Pulmoner arteryel hipertansiyonun ve akciğer hasarının tedavisinde kullanım için 1,3-dihidroimidazol-2-tion türevleri. |
EP3490554B1 (en) * | 2016-07-28 | 2023-07-05 | Jiangsu Yahong Meditech Co., Ltd. | Uses of dopamine beta-hydroxylase (dbh) inhibitors for the treatment of cancer |
JOP20190050A1 (ar) | 2016-09-23 | 2019-03-20 | Bial Portela & C? S A | مثبطات دوبامين-b-هيدروكسيلاز تخترق حاجز المخ الدموي |
US11434242B2 (en) | 2017-12-04 | 2022-09-06 | Bial—Portela & Ca, S.A. | Dopamine-b-hydroxylase inhibitors |
GB201908044D0 (en) | 2019-06-05 | 2019-07-17 | Bial Portela & Ca Sa | Dopamine-B-Hydroxylase inhibitors |
MX2023008573A (es) | 2021-01-26 | 2023-08-08 | Jiangsu Yahong Meditech Co Ltd | Modulador de via, composicion farmaceutica que tiene la misma, uso y metodo terapeutico que utiliza la misma. |
CN113527108B (zh) * | 2021-09-16 | 2022-10-25 | 斯芬克司药物研发(天津)股份有限公司 | 一种制备光学纯的5,7-二氟-1,2,3,4-四氢化萘-2-胺及其盐的方法 |
CN114920906B (zh) * | 2022-05-23 | 2023-03-21 | 华南理工大学 | 一种含咪唑硫酮单元的聚氨酯及其制备方法和应用 |
WO2024056079A1 (zh) * | 2022-09-16 | 2024-03-21 | 江苏亚虹医药科技股份有限公司 | 内匹司他酸加成盐的多晶型及其制备方法和用途 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3485917A (en) * | 1966-04-14 | 1969-12-23 | Janssen Pharmaceutica Nv | Composition and method for combating fungus with imidazole carboxylates |
GB8516573D0 (en) * | 1985-07-01 | 1985-08-07 | Janssen Pharmaceuticaa Nv | Controlling weeds |
EP0277384A3 (en) * | 1986-12-24 | 1990-05-23 | Janssen Pharmaceutica N.V. | 1h-imidazole-5-carboxylic acid derivatives |
-
1995
- 1995-04-25 DE DE69531102T patent/DE69531102T2/de not_active Expired - Fee Related
- 1995-04-25 DK DK95916449T patent/DK0757677T3/da active
- 1995-04-25 IL IL11348095A patent/IL113480A/xx not_active IP Right Cessation
- 1995-04-25 PL PL95316856A patent/PL185959B1/pl not_active IP Right Cessation
- 1995-04-25 AT AT95916449T patent/ATE243199T1/de not_active IP Right Cessation
- 1995-04-25 PT PT95916449T patent/PT757677E/pt unknown
- 1995-04-25 RU RU96122779/04A patent/RU2145321C1/ru not_active IP Right Cessation
- 1995-04-25 EP EP95916449A patent/EP0757677B1/en not_active Expired - Lifetime
- 1995-04-25 HU HU9602946A patent/HUT76295A/hu unknown
- 1995-04-25 WO PCT/US1995/004783 patent/WO1995029165A2/en active Application Filing
- 1995-04-25 BR BR9507517A patent/BR9507517A/pt not_active IP Right Cessation
- 1995-04-25 CZ CZ19963109A patent/CZ290082B6/cs not_active IP Right Cessation
- 1995-04-25 CA CA002188748A patent/CA2188748A1/en not_active Abandoned
- 1995-04-25 MX MX9605145A patent/MX9605145A/es unknown
- 1995-04-25 ES ES95916449T patent/ES2201104T3/es not_active Expired - Lifetime
- 1995-04-25 AU AU22947/95A patent/AU687192B2/en not_active Ceased
- 1995-04-25 CN CN95193567A patent/CN1113874C/zh not_active Expired - Fee Related
- 1995-04-25 JP JP7527727A patent/JPH09512269A/ja not_active Ceased
- 1995-04-25 NZ NZ284356A patent/NZ284356A/en unknown
-
1996
- 1996-10-25 NO NO19964552A patent/NO311720B1/no not_active IP Right Cessation
- 1996-10-25 FI FI964312A patent/FI964312A/fi not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
WO1995029165A3 (en) | 1995-12-07 |
MX9605145A (es) | 1997-12-31 |
NO311720B1 (no) | 2002-01-14 |
RU2145321C1 (ru) | 2000-02-10 |
HUT76295A (en) | 1997-07-28 |
DE69531102D1 (de) | 2003-07-24 |
FI964312A (fi) | 1996-12-20 |
BR9507517A (pt) | 1997-09-16 |
DK0757677T3 (da) | 2003-10-13 |
FI964312A0 (fi) | 1996-10-25 |
AU2294795A (en) | 1995-11-16 |
WO1995029165A2 (en) | 1995-11-02 |
NO964552D0 (no) | 1996-10-25 |
PL316856A1 (en) | 1997-02-17 |
PT757677E (pt) | 2003-11-28 |
ES2201104T3 (es) | 2004-03-16 |
CZ290082B6 (cs) | 2002-05-15 |
NZ284356A (en) | 1997-12-19 |
EP0757677A1 (en) | 1997-02-12 |
DE69531102T2 (de) | 2004-04-29 |
PL185959B1 (pl) | 2003-09-30 |
CZ310996A3 (en) | 1997-06-11 |
JPH09512269A (ja) | 1997-12-09 |
CN1113874C (zh) | 2003-07-09 |
CN1151735A (zh) | 1997-06-11 |
HU9602946D0 (en) | 1996-12-30 |
ATE243199T1 (de) | 2003-07-15 |
CA2188748A1 (en) | 1995-11-02 |
AU687192B2 (en) | 1998-02-19 |
IL113480A0 (en) | 1995-07-31 |
EP0757677B1 (en) | 2003-06-18 |
NO964552L (no) | 1996-12-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FF | Patent granted | ||
KB | Patent renewed | ||
MM9K | Patent not in force due to non-payment of renewal fees |