IL112622A - Iminoalkylamino or aminoalkylideneamino camptothecin derivatives, process for their preparation and pharmaceutical compositions containing them - Google Patents
Iminoalkylamino or aminoalkylideneamino camptothecin derivatives, process for their preparation and pharmaceutical compositions containing themInfo
- Publication number
- IL112622A IL112622A IL112622A IL11262295A IL112622A IL 112622 A IL112622 A IL 112622A IL 112622 A IL112622 A IL 112622A IL 11262295 A IL11262295 A IL 11262295A IL 112622 A IL112622 A IL 112622A
- Authority
- IL
- Israel
- Prior art keywords
- preparation
- pharmaceutical compositions
- compositions containing
- aminoalkylideneamino
- iminoalkylamino
- Prior art date
Links
- VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical class C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9402934A GB9402934D0 (en) | 1994-02-16 | 1994-02-16 | Camptothecin derivatives and process for their preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
IL112622A0 IL112622A0 (en) | 1995-05-26 |
IL112622A true IL112622A (en) | 1997-09-30 |
Family
ID=10750430
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL112622A IL112622A (en) | 1994-02-16 | 1995-02-13 | Iminoalkylamino or aminoalkylideneamino camptothecin derivatives, process for their preparation and pharmaceutical compositions containing them |
Country Status (20)
Country | Link |
---|---|
US (2) | US5602141A (ja) |
EP (1) | EP0694035B1 (ja) |
JP (1) | JPH08509244A (ja) |
KR (1) | KR960701878A (ja) |
CN (1) | CN1123548A (ja) |
AT (1) | ATE220681T1 (ja) |
AU (1) | AU681941B2 (ja) |
CA (1) | CA2158855C (ja) |
DE (1) | DE69527400T2 (ja) |
ES (1) | ES2180625T3 (ja) |
FI (1) | FI954898A0 (ja) |
GB (1) | GB9402934D0 (ja) |
HU (1) | HUT73423A (ja) |
IL (1) | IL112622A (ja) |
MX (1) | MX9504287A (ja) |
NO (1) | NO954072L (ja) |
NZ (1) | NZ279813A (ja) |
PL (1) | PL311122A1 (ja) |
WO (1) | WO1995022549A1 (ja) |
ZA (1) | ZA951227B (ja) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9319944D0 (en) * | 1993-09-28 | 1993-11-17 | Erba Carlo Spa | Process for the preparation of 9-amino camptothecin |
US5880131A (en) * | 1993-10-20 | 1999-03-09 | Enzon, Inc. | High molecular weight polymer-based prodrugs |
US5965566A (en) * | 1993-10-20 | 1999-10-12 | Enzon, Inc. | High molecular weight polymer-based prodrugs |
GB9402934D0 (en) * | 1994-02-16 | 1994-04-06 | Erba Carlo Spa | Camptothecin derivatives and process for their preparation |
GB9410388D0 (en) * | 1994-05-24 | 1994-07-13 | Erba Carlo Spa | Method for the preparation of 9-amino camptothecin |
GB9510716D0 (en) * | 1995-05-26 | 1995-07-19 | Pharmacia Spa | Substituted camptothecin derivatives and process for their preparation |
GB9601779D0 (en) * | 1996-01-30 | 1996-04-03 | Pharmacia Spa | 9, 10 Disubstituted camptothecin derivatives |
US6096336A (en) * | 1996-01-30 | 2000-08-01 | The Stehlin Foundation For Cancer Research | Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs |
GB9702807D0 (en) | 1997-02-12 | 1997-04-02 | Pharmacia & Upjohn Spa | Alkynyl-substituted camptothecins and process for their preparation |
GB9715821D0 (en) * | 1997-07-25 | 1997-10-01 | Pharmacia & Upjohn Spa | Amidino-camptothecin derivatives |
US6043367A (en) * | 1998-09-30 | 2000-03-28 | Roffler; Steve | Proactive antitumor compounds |
US6352996B1 (en) | 1999-08-03 | 2002-03-05 | The Stehlin Foundation For Cancer Research | Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs |
US6228855B1 (en) | 1999-08-03 | 2001-05-08 | The Stehlin Foundation For Cancer Research | Aromatic esters of camptothecins and methods to treat cancers |
EP2266607A3 (en) | 1999-10-01 | 2011-04-20 | Immunogen, Inc. | Immunoconjugates for treating cancer |
RS51051B (sr) | 2001-11-30 | 2010-10-31 | Chugai Seiyaku Kabushiki Kaisha | Heksaciklična jedinjenja |
US8034831B2 (en) | 2002-11-06 | 2011-10-11 | Celgene Corporation | Methods for the treatment and management of myeloproliferative diseases using 4-(amino)-2-(2,6-Dioxo(3-piperidyl)-isoindoline-1,3-dione in combination with other therapies |
US7563810B2 (en) | 2002-11-06 | 2009-07-21 | Celgene Corporation | Methods of using 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myeloproliferative diseases |
CZ299329B6 (cs) * | 2003-08-26 | 2008-06-18 | Pliva-Lachema A.S. | Zpusob výroby 7-ethyl-10-[ 4-(1-piperidino)-1-piperidino]karbonyloxykamptothecinu |
CZ299593B6 (cs) * | 2003-12-16 | 2008-09-10 | Pliva-Lachema A. S. | Zpusob výroby 7-ethyl-10-hydroxykamptothecinu |
EP1757609B1 (en) | 2004-04-09 | 2013-10-16 | Chugai Seiyaku Kabushiki Kaisha | Novel water-soluble prodrug |
TW200744603A (en) | 2005-08-22 | 2007-12-16 | Chugai Pharmaceutical Co Ltd | Novel anticancer concomitant drug |
JP5126900B2 (ja) * | 2009-02-24 | 2013-01-23 | 株式会社渡辺オイスター研究所 | カキ肉エキス顆粒の製造方法。 |
CN101555250B (zh) * | 2009-05-19 | 2011-05-18 | 重庆泰濠制药有限公司 | 盐酸拓扑替康的制备方法 |
AU2022282813A1 (en) * | 2021-05-27 | 2023-11-30 | Zymeworks Bc Inc. | Camptothecin analogues, conjugates and methods of use |
WO2023061393A1 (zh) | 2021-10-15 | 2023-04-20 | 昆山新蕴达生物科技有限公司 | 包含抗肿瘤药物的组合物及其制备方法和用途 |
WO2023178452A1 (en) * | 2022-03-25 | 2023-09-28 | Zymeworks Bc Inc. | Antibody-drug conjugates targeting folate receptor alpha and methods of use |
WO2024082055A1 (en) * | 2022-10-19 | 2024-04-25 | Zymeworks Bc Inc. | Antibody-drug conjugates targeting napi2b and methods of use |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4399276A (en) * | 1981-01-09 | 1983-08-16 | Kabushiki Kaisha Yakult Honsha | 7-Substituted camptothecin derivatives |
JPS6019790A (ja) * | 1983-07-14 | 1985-01-31 | Yakult Honsha Co Ltd | 新規なカンプトテシン誘導体 |
US5364858A (en) * | 1987-03-31 | 1994-11-15 | Research Triangle Institute | Camptothecin analogs as potent inhibitors of topoisomerase I |
US5227380A (en) * | 1987-03-31 | 1993-07-13 | Research Triangle Institute | Pharmaceutical compositions and methods employing camptothecins |
US4981968A (en) * | 1987-03-31 | 1991-01-01 | Research Triangle Institute | Synthesis of camptothecin and analogs thereof |
US5180722A (en) * | 1987-04-14 | 1993-01-19 | Research Triangle Institute | 10,11-methylenedioxy-20(RS)-camptothecin and 10,11-methylenedioxy-20(S)-camptothecin analogs |
US4943579A (en) * | 1987-10-06 | 1990-07-24 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Water soluble prodrugs of camptothecin |
US5004758A (en) * | 1987-12-01 | 1991-04-02 | Smithkline Beecham Corporation | Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells |
JPH0615547B2 (ja) * | 1988-01-20 | 1994-03-02 | 株式会社ヤクルト本社 | 新規なカンプトテシン誘導体 |
EP0418099B1 (en) * | 1989-09-15 | 2001-12-19 | Research Triangle Institute | Process of preparation of 10, 11-Methylenedioxy-20 (RS) camptothecin and 10, 11-methylenedioxy-20 (S) - camptothecin analog |
WO1991004260A2 (en) * | 1989-09-15 | 1991-04-04 | Research Triangle Institute | 10,11-methylenedioxy-20(rs)-camptothecin and 10,11-methylenedioxy-20(s)-camptothecin analogs |
ES2137932T3 (es) * | 1990-09-28 | 2000-01-01 | Smithkline Beecham Corp | Procedimiento para la preparacion de analogos de camptotecina solubles en agua, asi como los compuestos 10-hidroxi-11-alcoxi-6-camptotecina. |
US5162532A (en) * | 1990-12-20 | 1992-11-10 | North Carolina State University | Intermediates and method of making camptothecin and camptothecin analogs |
US5342947A (en) * | 1992-10-09 | 1994-08-30 | Glaxo Inc. | Preparation of water soluble camptothecin derivatives |
GB9402934D0 (en) * | 1994-02-16 | 1994-04-06 | Erba Carlo Spa | Camptothecin derivatives and process for their preparation |
-
1994
- 1994-02-16 GB GB9402934A patent/GB9402934D0/en active Pending
-
1995
- 1995-02-03 ES ES95908901T patent/ES2180625T3/es not_active Expired - Lifetime
- 1995-02-03 JP JP7521541A patent/JPH08509244A/ja not_active Ceased
- 1995-02-03 AT AT95908901T patent/ATE220681T1/de active
- 1995-02-03 CA CA002158855A patent/CA2158855C/en not_active Expired - Fee Related
- 1995-02-03 HU HU9503273A patent/HUT73423A/hu unknown
- 1995-02-03 KR KR1019950704455A patent/KR960701878A/ko not_active Application Discontinuation
- 1995-02-03 DE DE69527400T patent/DE69527400T2/de not_active Expired - Fee Related
- 1995-02-03 AU AU17056/95A patent/AU681941B2/en not_active Ceased
- 1995-02-03 NZ NZ279813A patent/NZ279813A/en unknown
- 1995-02-03 EP EP95908901A patent/EP0694035B1/en not_active Expired - Lifetime
- 1995-02-03 MX MX9504287A patent/MX9504287A/es unknown
- 1995-02-03 PL PL95311122A patent/PL311122A1/xx unknown
- 1995-02-03 WO PCT/EP1995/000393 patent/WO1995022549A1/en active IP Right Grant
- 1995-02-03 CN CN95190093A patent/CN1123548A/zh active Pending
- 1995-02-13 IL IL112622A patent/IL112622A/xx not_active IP Right Cessation
- 1995-02-15 US US08/389,190 patent/US5602141A/en not_active Expired - Fee Related
- 1995-02-15 ZA ZA951227A patent/ZA951227B/xx unknown
- 1995-10-13 FI FI954898A patent/FI954898A0/fi not_active Application Discontinuation
- 1995-10-13 NO NO954072A patent/NO954072L/no unknown
-
1996
- 1996-08-20 US US08/697,125 patent/US5801167A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DE69527400T2 (de) | 2003-03-06 |
DE69527400D1 (de) | 2002-08-22 |
US5602141A (en) | 1997-02-11 |
AU1705695A (en) | 1995-09-04 |
NO954072D0 (no) | 1995-10-13 |
GB9402934D0 (en) | 1994-04-06 |
EP0694035B1 (en) | 2002-07-17 |
ES2180625T3 (es) | 2003-02-16 |
KR960701878A (ko) | 1996-03-28 |
FI954898A (fi) | 1995-10-13 |
AU681941B2 (en) | 1997-09-11 |
CA2158855C (en) | 2006-01-31 |
FI954898A0 (fi) | 1995-10-13 |
HU9503273D0 (en) | 1996-01-29 |
CN1123548A (zh) | 1996-05-29 |
IL112622A0 (en) | 1995-05-26 |
ZA951227B (en) | 1996-01-19 |
ATE220681T1 (de) | 2002-08-15 |
MX9504287A (es) | 1997-05-31 |
NO954072L (no) | 1995-12-11 |
EP0694035A1 (en) | 1996-01-31 |
PL311122A1 (en) | 1996-02-05 |
CA2158855A1 (en) | 1995-08-24 |
NZ279813A (en) | 1996-10-28 |
HUT73423A (en) | 1996-07-29 |
WO1995022549A1 (en) | 1995-08-24 |
JPH08509244A (ja) | 1996-10-01 |
US5801167A (en) | 1998-09-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FF | Patent granted | ||
KB | Patent renewed | ||
MM9K | Patent not in force due to non-payment of renewal fees |