IL110727A - History 3) Azabicycloalkyl (1,2,5 thiaziazole and oxadiazole for the treatment of schizophrenia and schizophreniform diseases - Google Patents

History 3) Azabicycloalkyl (1,2,5 thiaziazole and oxadiazole for the treatment of schizophrenia and schizophreniform diseases

Info

Publication number
IL110727A
IL110727A IL11072794A IL11072794A IL110727A IL 110727 A IL110727 A IL 110727A IL 11072794 A IL11072794 A IL 11072794A IL 11072794 A IL11072794 A IL 11072794A IL 110727 A IL110727 A IL 110727A
Authority
IL
Israel
Prior art keywords
thiadiazol
octane
azabicyclo
exo
endo
Prior art date
Application number
IL11072794A
Other languages
English (en)
Hebrew (he)
Other versions
IL110727A0 (en
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of IL110727A0 publication Critical patent/IL110727A0/xx
Publication of IL110727A publication Critical patent/IL110727A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Cosmetics (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Epoxy Resins (AREA)
IL11072794A 1993-08-19 1994-08-19 History 3) Azabicycloalkyl (1,2,5 thiaziazole and oxadiazole for the treatment of schizophrenia and schizophreniform diseases IL110727A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10928593A 1993-08-19 1993-08-19

Publications (2)

Publication Number Publication Date
IL110727A0 IL110727A0 (en) 1994-11-11
IL110727A true IL110727A (en) 1998-08-16

Family

ID=22326851

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11072794A IL110727A (en) 1993-08-19 1994-08-19 History 3) Azabicycloalkyl (1,2,5 thiaziazole and oxadiazole for the treatment of schizophrenia and schizophreniform diseases

Country Status (23)

Country Link
US (3) US5679686A (zh)
EP (1) EP0714394B1 (zh)
JP (1) JP3474575B2 (zh)
KR (1) KR960703908A (zh)
CN (1) CN1040979C (zh)
AT (1) ATE202353T1 (zh)
CA (1) CA2169838C (zh)
CZ (1) CZ42796A3 (zh)
DE (1) DE69427537T2 (zh)
DK (1) DK0714394T3 (zh)
ES (1) ES2160127T3 (zh)
FI (1) FI960748A (zh)
GR (1) GR3036587T3 (zh)
HU (1) HU222116B1 (zh)
IL (1) IL110727A (zh)
NO (1) NO310597B1 (zh)
NZ (2) NZ271313A (zh)
PT (1) PT714394E (zh)
SG (1) SG55072A1 (zh)
TW (1) TW442285B (zh)
UA (1) UA43347C2 (zh)
WO (1) WO1995005379A1 (zh)
ZA (1) ZA946321B (zh)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA43347C2 (uk) * 1993-08-19 2001-12-17 Ново Нордіск А/С Спосіб лікування психічних захворювань
US5605908A (en) * 1994-10-24 1997-02-25 Eli Lilly And Company Heterocyclic compounds and their use
US5821370A (en) * 1994-10-24 1998-10-13 Eli Lilly And Company Heterocyclic compounds and their preparation and use
US5998404A (en) * 1994-10-24 1999-12-07 Eli Lilly And Company Heterocyclic compounds and their use
US5574028A (en) * 1994-10-31 1996-11-12 Eli Lilly And Company Method for treating anxiety
US5726193A (en) * 1994-10-31 1998-03-10 Eli Lilly And Company Method for treating anxiety
US5488056A (en) * 1994-10-31 1996-01-30 Eli Lilly And Company Method for treating anxiety
PE17897A1 (es) * 1995-02-17 1997-06-12 Lilly Co Eli Formulacion transdermica en parche del 3-(4-butiltio)-1,2,5-tiadiazol-3-il)-1-azabiciclo (2,2,2) octano
US5763457A (en) * 1995-11-13 1998-06-09 Eli Lilly And Company Method for treating anxiety
US5852037A (en) * 1995-11-13 1998-12-22 Eli Lilly And Company Method for treating anxiety
AU1128297A (en) * 1995-12-06 1997-06-27 Eli Lilly And Company Composition for treating pain
US20020022056A1 (en) 1997-02-14 2002-02-21 Burkhard Schlutermann Oxacarbazepine film-coated tablets
JP2002503224A (ja) * 1997-04-11 2002-01-29 エリ リリー アンド カンパニー 疼痛を処置するための組成物
JP2001520653A (ja) * 1997-04-11 2001-10-30 エリ リリー アンド カンパニー 精神***病の治療法
US20040023951A1 (en) * 2001-06-18 2004-02-05 Bymaster Franklin Porter Combination therapy for treatment of psychoses
AU2008326360A1 (en) * 2007-11-21 2009-05-28 Abbott Laboratories Biaryl substituted azabicyclic alkane derivatives as nicotinic acetylcholine receptor activity modulators
US20110294835A1 (en) 2008-05-15 2011-12-01 The Board Of Trustees Of The University Of Illinois Muscarinic Agonists as Cognitive Enhancers
WO2012149524A1 (en) 2011-04-29 2012-11-01 The University Of Toledo Muscarinic agonists as enhancers of working memory and cognitive flexibility

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0261763B1 (en) * 1986-06-27 1994-02-09 Beecham Group Plc Novel bridged bicyclic N-heterocycles
US4977176A (en) * 1987-01-31 1990-12-11 Sandoz Ltd. Pilocarpine compounds which are used as pharmaceutical agents
NZ227841A (en) * 1988-02-12 1991-08-27 Merck Sharp & Dohme Heterocyclic compounds with at least two non-condensed five membered rings and pharmaceutical compositions
US5418240A (en) * 1990-08-21 1995-05-23 Novo Nordisk A/S Heterocyclic compounds and their preparation and use
DK198590D0 (da) * 1990-08-21 1990-08-21 Novo Nordisk As Heterocykliske forbindelser, deres fremstilling og anvendelse
UA43347C2 (uk) * 1993-08-19 2001-12-17 Ново Нордіск А/С Спосіб лікування психічних захворювань

Also Published As

Publication number Publication date
DE69427537D1 (de) 2001-07-26
EP0714394B1 (en) 2001-06-20
WO1995005379A1 (en) 1995-02-23
US5679686A (en) 1997-10-21
CA2169838C (en) 2002-06-11
ATE202353T1 (de) 2001-07-15
DE69427537T2 (de) 2002-04-04
KR960703908A (ko) 1996-08-31
NZ336596A (en) 2001-02-23
HU222116B1 (hu) 2003-04-28
ES2160127T3 (es) 2001-11-01
SG55072A1 (en) 1998-12-21
AU7490494A (en) 1995-03-14
IL110727A0 (en) 1994-11-11
CA2169838A1 (en) 1995-02-23
AU697529B2 (en) 1998-10-08
UA43347C2 (uk) 2001-12-17
DK0714394T3 (da) 2001-10-01
FI960748A0 (fi) 1996-02-19
HUT73854A (en) 1996-09-30
US5677313A (en) 1997-10-14
HU9600363D0 (en) 1996-04-29
FI960748A (fi) 1996-04-18
TW442285B (en) 2001-06-23
CN1133044A (zh) 1996-10-09
NO960620D0 (no) 1996-02-16
NO310597B1 (no) 2001-07-30
CN1040979C (zh) 1998-12-02
JPH09501659A (ja) 1997-02-18
US5968926A (en) 1999-10-19
NO960620L (no) 1996-04-18
EP0714394A1 (en) 1996-06-05
ZA946321B (en) 1996-02-19
PT714394E (pt) 2001-12-28
GR3036587T3 (en) 2001-12-31
CZ42796A3 (en) 1996-12-11
NZ271313A (en) 1999-09-29
JP3474575B2 (ja) 2003-12-08

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Legal Events

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KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees