IL101819A - Amidinophenylalanine derivatives, a process for the preparation thereof, and pharmaceutical compositions containing these as anticoagulants - Google Patents

Amidinophenylalanine derivatives, a process for the preparation thereof, and pharmaceutical compositions containing these as anticoagulants

Info

Publication number
IL101819A
IL101819A IL101819A IL10181992A IL101819A IL 101819 A IL101819 A IL 101819A IL 101819 A IL101819 A IL 101819A IL 10181992 A IL10181992 A IL 10181992A IL 101819 A IL101819 A IL 101819A
Authority
IL
Israel
Prior art keywords
carbon atoms
group
alkyl groups
ring
derivatized
Prior art date
Application number
IL101819A
Other languages
English (en)
Other versions
IL101819A0 (en
Inventor
Werner Dr Stueber
Gerhard Dr Dickneite
Rainer Koschinsky
Original Assignee
Behringwerke Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Behringwerke Ag filed Critical Behringwerke Ag
Publication of IL101819A0 publication Critical patent/IL101819A0/xx
Publication of IL101819A publication Critical patent/IL101819A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Plant Substances (AREA)
IL101819A 1991-05-11 1992-05-10 Amidinophenylalanine derivatives, a process for the preparation thereof, and pharmaceutical compositions containing these as anticoagulants IL101819A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4115468A DE4115468A1 (de) 1991-05-11 1991-05-11 Amidinophenylalaninderivate, verfahren zu deren herstellung, deren verwendung und diese enthaltende mittel als antikoagulantien

Publications (2)

Publication Number Publication Date
IL101819A0 IL101819A0 (en) 1992-12-30
IL101819A true IL101819A (en) 1997-04-15

Family

ID=6431497

Family Applications (1)

Application Number Title Priority Date Filing Date
IL101819A IL101819A (en) 1991-05-11 1992-05-10 Amidinophenylalanine derivatives, a process for the preparation thereof, and pharmaceutical compositions containing these as anticoagulants

Country Status (20)

Country Link
US (2) US5457114A (xx)
EP (1) EP0513543B1 (xx)
JP (1) JPH089634B2 (xx)
KR (1) KR920021503A (xx)
CN (1) CN1039125C (xx)
AT (1) ATE129503T1 (xx)
AU (1) AU651196B2 (xx)
CA (1) CA2068263A1 (xx)
CY (1) CY2121B1 (xx)
DE (2) DE4115468A1 (xx)
DK (1) DK0513543T3 (xx)
ES (1) ES2079719T3 (xx)
GR (1) GR3018182T3 (xx)
HK (1) HK1006717A1 (xx)
IE (1) IE68884B1 (xx)
IL (1) IL101819A (xx)
MX (1) MX9202166A (xx)
NO (1) NO921835L (xx)
NZ (1) NZ242668A (xx)
RU (1) RU2088591C1 (xx)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4206858A1 (de) * 1992-03-05 1993-09-09 Behringwerke Ag Glycopeptid-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische mittel
AU675981B2 (en) * 1992-12-02 1997-02-27 Bristol-Myers Squibb Company Guanidinyl-substituted heterocyclic thrombin inhibitors
US6984627B1 (en) 1993-06-03 2006-01-10 Astrazeneca Ab Peptide derivatives
US5783563A (en) * 1993-06-03 1998-07-21 Astra Aktiebolag Method for treatment or prophylaxis of venous thrombosis
SE9301916D0 (sv) * 1993-06-03 1993-06-03 Ab Astra New peptides derivatives
DE4342154A1 (de) * 1993-12-10 1995-06-14 Behringwerke Ag Amidinophenylalaninderivate, Verfahren zu deren Herstellung, deren Verwendung und diese enthaltende Mittel als Antikoagulantien
DE4344919A1 (de) * 1993-12-30 1995-07-06 Behringwerke Ag Verfahren zur Bestimmung der Thrombozytenaggregation
DE4421052A1 (de) * 1994-06-17 1995-12-21 Basf Ag Neue Thrombininhibitoren, ihre Herstellung und Verwendung
SE9404196D0 (sv) * 1994-12-02 1994-12-02 Astra Ab New antithrombotic formulation
DE19514104C2 (de) * 1995-04-13 1997-05-28 Behringwerke Ag Beschichtung für in den Blutstrom oder in das Gewebe des menschlichen Körpers einbringbares Biomaterial
KR0173034B1 (ko) * 1995-04-28 1999-03-30 성재갑 선택적 트롬빈 억제제
US6107329A (en) * 1995-06-06 2000-08-22 Pfizer, Inc. Substituted n-(indole-2-carbonyl)-glycinamides and derivatives as glycogen phosphorylase inhibitors
US5766932A (en) * 1995-12-20 1998-06-16 Hoechst Marion Roussel, Inc. Process for preparing N-acetyl(L)-4-cyanophenylalanine from a mixture of the corresponding D,L ethyl esters using subtilisin
UA48993C2 (uk) * 1995-12-20 2002-09-16 Авентіс Фармасьютікалз, Інк СПОСІБ ОТРИМАННЯ N-АЦЕТИЛ-(L)-4-ЦІАНОФЕНІЛАЛАНІНУ Аc-(L)-Phe(4-CN)-OH І N-АЦЕТИЛ-(L)-П-АМІДИНФЕНІЛАЛАНІН-ЦИКЛОГЕКСИЛГЛІЦИН-<font face="Symbol">b</font>-(3-N-МЕТИЛПІРИДИН)-АЛАНІНУ Аc-(L)-pАph-Сhg-PalMe(3)-NH<sub>2</sub>
TW541316B (en) * 1995-12-21 2003-07-11 Astrazeneca Ab Prodrugs of thrombin inhibitors
US5840733A (en) 1996-07-01 1998-11-24 Redcell, Canada, Inc. Methods and compositions for producing novel conjugates of thrombin inhibitors and endogenous carriers resulting in anti-thrombins with extended lifetimes
KR19990074598A (ko) * 1998-03-12 1999-10-05 성재갑 고체상 반응을 이용한 벤즈아미딘 유도체의 신규한 제조방법
ES2312210T3 (es) 1998-06-17 2009-02-16 N.V. Organon Composiciones antitromboticas.
US6307090B1 (en) 1999-01-22 2001-10-23 The United States Of America As Represented By The Department Of Health And Human Services Acylated oligopeptide derivatives having cell signal inhibiting activity
AU770920C (en) * 1999-03-23 2004-10-07 Georgetown University Phenylalanine derivatives
US7226991B1 (en) * 1999-03-23 2007-06-05 United States Of America, Represented By The Secretary, Department Of Health And Human Services Phenylalanine derivatives
US7871981B2 (en) * 1999-10-22 2011-01-18 The United States Of America As Represented By The Department Of Health And Human Services Inhibition of cell motility, angiogenesis, and metastasis
WO2001028577A2 (en) 1999-10-22 2001-04-26 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Inhibition of cell motility and angiogenesis by inhibitors of the grb2 sh2-domain
TWI289566B (en) * 1999-12-07 2007-11-11 N.V.Organon Antithrombotic compound
US6277877B1 (en) 2000-08-15 2001-08-21 Pfizer, Inc. Substituted n-(indole-2-carbonyl)glycinamides and derivates as glycogen phosphorylase inhibitors
US7425537B2 (en) * 2000-08-22 2008-09-16 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services SH2 domain binding inhibitors
WO2002016407A2 (en) * 2000-08-22 2002-02-28 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Sh2 domain binding inhibitors
DE10049937A1 (de) * 2000-10-06 2002-04-11 Knoll Ag Niedermolekulare Inhibitoren von Serinproteasen mit Polyhydroxyalkyl- und Polyhydroxycycloalkylresten
US20040138104A1 (en) * 2003-01-14 2004-07-15 The Government Of The United States Of America Represented By The Secretary, Peptides
WO2004091598A1 (en) * 2003-04-18 2004-10-28 Institut National De La Sante Et De La Recherche Medicale (Inserm) Use of beta-aminoisobutyric acid for the treatment of diseases linked to the accumulation of triglycerides and cholesterol
DE10330900B4 (de) † 2003-07-01 2006-09-14 Leibniz-Institut Für Polymerforschung Dresden E.V. Biomaterial mit einem modularen Beschichtungssystem zur Anwendung in Medizinprodukten mit direktem Blutkontakt
US20050119163A1 (en) * 2003-09-18 2005-06-02 The Government Of The United States Of America, As Represented By The Secretary, SH2 domain binding inhibitors
GB0507577D0 (en) 2005-04-14 2005-05-18 Novartis Ag Organic compounds
TWI389899B (zh) * 2006-08-08 2013-03-21 Msd Oss Bv 具口服活性之凝血酶抑制劑

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE155954C (xx) *
DE235866C (xx) *
SE8203887D0 (sv) * 1982-06-23 1982-06-23 Kabivitrum Ab Nya trombininhiberande foreningar
PT84171B (pt) * 1986-01-24 1989-03-30 Sanofi Sa Processo para a preparacao de derivados das n alfa-aril-sulfonilamiminoacil-p- -amidinofenil-alaninamidas, bem como dos seus derivados de sintese e das composicoes farmaceuticas que os contem
PT84170B (pt) * 1986-01-24 1989-03-30 Sanofi Sa Processo para a preparacao de derivados n alfa-substituidos das n alfa-aril-sulfonilaminoacil d-amidinofenil-alaninamidas
DE4111394A1 (de) * 1991-04-09 1992-10-15 Behringwerke Ag Amidinophenylalaninderivate, verfahren zu deren herstellung, deren verwendung und diese enthaltende mittel
US5220050A (en) * 1991-05-17 1993-06-15 G. D. Searle & Co. Peptide mimetic compounds useful as platelet aggregation inhibitors

Also Published As

Publication number Publication date
ES2079719T3 (es) 1996-01-16
NO921835L (no) 1992-11-12
DK0513543T3 (da) 1996-02-26
JPH05155898A (ja) 1993-06-22
US5457114A (en) 1995-10-10
NO921835D0 (no) 1992-05-08
JPH089634B2 (ja) 1996-01-31
HK1006717A1 (en) 1999-03-12
EP0513543A1 (de) 1992-11-19
US5627283A (en) 1997-05-06
IL101819A0 (en) 1992-12-30
CY2121B1 (en) 2002-04-26
GR3018182T3 (en) 1996-02-29
KR920021503A (ko) 1992-12-18
AU1608692A (en) 1992-11-12
CN1039125C (zh) 1998-07-15
NZ242668A (en) 1994-06-27
AU651196B2 (en) 1994-07-14
ATE129503T1 (de) 1995-11-15
RU2088591C1 (ru) 1997-08-27
CN1067249A (zh) 1992-12-23
MX9202166A (es) 1992-11-01
DE4115468A1 (de) 1992-11-12
IE921491A1 (en) 1992-11-18
CA2068263A1 (en) 1992-11-12
EP0513543B1 (de) 1995-10-25
DE59204094D1 (de) 1995-11-30
IE68884B1 (en) 1996-07-24

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Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees