IE41273B1 - 7-aminoalkoxy substituted benzopyrans, benzo thiopyrans and naphthalenes - Google Patents

7-aminoalkoxy substituted benzopyrans, benzo thiopyrans and naphthalenes

Info

Publication number
IE41273B1
IE41273B1 IE1647/75A IE164775A IE41273B1 IE 41273 B1 IE41273 B1 IE 41273B1 IE 1647/75 A IE1647/75 A IE 1647/75A IE 164775 A IE164775 A IE 164775A IE 41273 B1 IE41273 B1 IE 41273B1
Authority
IE
Ireland
Prior art keywords
hydrogen atom
compound
alkyl
thiopyrans
naphthalenes
Prior art date
Application number
IE1647/75A
Other versions
IE41273L (en
Original Assignee
Beecham Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group Ltd filed Critical Beecham Group Ltd
Publication of IE41273L publication Critical patent/IE41273L/en
Publication of IE41273B1 publication Critical patent/IE41273B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/01—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis
    • C07C37/055—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pyrane Compounds (AREA)

Abstract

Compounds of the formula II are prepared <IMAGE> in which X is alkylene having 2 to 4 carbon atoms, Y is an oxygen or sulphur atom or a CH2 group; R1 is a hydrogen atom or lower alkyl; R2 is a hydrogen atom, lower alkyl, phenyl, tolyl or benzyl, or R2 is bonded to R1 with the formation of a 5-, 6- or 7-membered ring; R3 is aryl, aralkyl or a pyridyl, furyl, thienyl or pyrrolidyl radical, R4 is a hydrogen atom or C1-4-alkyl and R5 is a hydrogen atom or C1-4-alkyl, by reaction of an appropriate 7-OH compound with a compound Q1-X-NR1R2 or a compound Q1XQ2, in which Q1 and Q2 are groups which are easily removable by a nucleophile, and subsequent reaction with an amine HNR1R2. The compounds prepared according to the invention act on the central nervous system. Depending on the dose administered, they act as appetite suppressants or affect the mood of the person. [GB1486001A]
IE1647/75A 1974-07-30 1975-07-23 7-aminoalkoxy substituted benzopyrans, benzo thiopyrans and naphthalenes IE41273B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB33549/74A GB1486001A (en) 1974-07-30 1974-07-30 7-aminoalkoxy substituted benzopyrans benzo thiopyrans and naphthalenes

Publications (2)

Publication Number Publication Date
IE41273L IE41273L (en) 1976-01-30
IE41273B1 true IE41273B1 (en) 1979-11-21

Family

ID=10354390

Family Applications (1)

Application Number Title Priority Date Filing Date
IE1647/75A IE41273B1 (en) 1974-07-30 1975-07-23 7-aminoalkoxy substituted benzopyrans, benzo thiopyrans and naphthalenes

Country Status (17)

Country Link
US (1) USRE30739E (en)
JP (1) JPS51125055A (en)
AR (1) AR210500A1 (en)
AT (1) AT345283B (en)
AU (1) AU500006B2 (en)
BE (1) BE831939A (en)
CA (1) CA1077478A (en)
CH (3) CH622789A5 (en)
DE (1) DE2533885A1 (en)
DK (1) DK344175A (en)
ES (1) ES439856A1 (en)
FR (2) FR2280368A1 (en)
GB (1) GB1486001A (en)
IE (1) IE41273B1 (en)
IL (1) IL47826A (en)
SE (1) SE420490B (en)
ZA (1) ZA754821B (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2408600A1 (en) * 1977-10-11 1979-06-08 Beecham Group Ltd 7-Amino-alkoxy-3-phenyl-2,2-di:methyl-chroman derivs. - are optically active and have antidepressant and appetite suppressant activity
JPS5832847A (en) * 1981-08-20 1983-02-25 Mitsubishi Chem Ind Ltd (3-aminopropoxy)bibenzyl compound
FR2639227A1 (en) * 1988-11-23 1990-05-25 Sanofi Sa USE OF CHROMANE DERIVATIVES FOR THE TREATMENT OF DEPRESSIVE STATES
US5166367A (en) * 1991-06-21 1992-11-24 American Home Products Corporation Antipsychotic benzodioxan derivatives
GB2271566A (en) * 1992-10-14 1994-04-20 Merck & Co Inc HIV integrase inhibitors
US6017768A (en) * 1994-05-06 2000-01-25 Pharmacopeia, Inc. Combinatorial dihydrobenzopyran library
CA2190708A1 (en) * 1995-12-08 1997-06-09 Johannes Aebi Aminoalkyl substituted benzo-heterocyclic compounds
EP2725026B1 (en) * 2012-10-29 2017-09-06 Symrise AG Heterocyclic neoflavonoids with taste masking properties

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3476767A (en) * 1965-10-11 1969-11-04 Ciba Geigy Corp 1,2-diaryl - 6 - tertiary amino lower-alkoxy-3,4-dihydro naphthalenes
GB1357633A (en) * 1971-03-02 1974-06-26 Beecham Group Ltd Chromanone basic ether derivatives

Also Published As

Publication number Publication date
AU500006B2 (en) 1979-05-10
SE7508414L (en) 1976-02-02
USRE30739E (en) 1981-09-08
DE2533885A1 (en) 1976-02-19
CH622789A5 (en) 1981-04-30
IL47826A (en) 1979-05-31
IE41273L (en) 1976-01-30
FR2313025B1 (en) 1979-10-05
SE420490B (en) 1981-10-12
BE831939A (en) 1976-01-30
IL47826A0 (en) 1975-10-15
AR210500A1 (en) 1977-08-15
CH624111A5 (en) 1981-07-15
FR2280368A1 (en) 1976-02-27
ZA754821B (en) 1976-07-28
GB1486001A (en) 1977-09-14
AU8353675A (en) 1977-02-03
FR2280368B1 (en) 1979-08-10
AT345283B (en) 1978-09-11
CH624110A5 (en) 1981-07-15
DK344175A (en) 1976-01-31
CA1077478A (en) 1980-05-13
ATA582775A (en) 1978-01-15
FR2313025A1 (en) 1976-12-31
ES439856A1 (en) 1977-06-16
JPS51125055A (en) 1976-11-01

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