IE38671B1 - Chromane derivatives - Google Patents

Chromane derivatives

Info

Publication number
IE38671B1
IE38671B1 IE2317/73A IE231773A IE38671B1 IE 38671 B1 IE38671 B1 IE 38671B1 IE 2317/73 A IE2317/73 A IE 2317/73A IE 231773 A IE231773 A IE 231773A IE 38671 B1 IE38671 B1 IE 38671B1
Authority
IE
Ireland
Prior art keywords
hydroxyl
hydrolysis
converted
preparation
chromane derivatives
Prior art date
Application number
IE2317/73A
Other versions
IE38671L (en
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of IE38671L publication Critical patent/IE38671L/en
Publication of IE38671B1 publication Critical patent/IE38671B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
    • C11B5/00—Preserving by using additives, e.g. anti-oxidants
    • C11B5/0021—Preserving by using additives, e.g. anti-oxidants containing oxygen
    • C11B5/0035—Phenols; Their halogenated and aminated derivates, their salts, their esters with carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
    • C07C17/16—Preparation of halogenated hydrocarbons by replacement by halogens of hydroxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/14—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of a —CHO group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/74—Separation; Purification; Use of additives, e.g. for stabilisation
    • C07C29/76—Separation; Purification; Use of additives, e.g. for stabilisation by physical treatment
    • C07C29/80—Separation; Purification; Use of additives, e.g. for stabilisation by physical treatment by distillation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/52—Unsaturated compounds containing hydroxy or O-metal groups a hydroxy or O-metal group being bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
    • C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K15/00—Anti-oxidant compositions; Compositions inhibiting chemical change
    • C09K15/04—Anti-oxidant compositions; Compositions inhibiting chemical change containing organic compounds
    • C09K15/06—Anti-oxidant compositions; Compositions inhibiting chemical change containing organic compounds containing oxygen
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K15/00—Anti-oxidant compositions; Compositions inhibiting chemical change
    • C09K15/04—Anti-oxidant compositions; Compositions inhibiting chemical change containing organic compounds
    • C09K15/06—Anti-oxidant compositions; Compositions inhibiting chemical change containing organic compounds containing oxygen
    • C09K15/08—Anti-oxidant compositions; Compositions inhibiting chemical change containing organic compounds containing oxygen containing a phenol or quinone moiety
    • C—CHEMISTRY; METALLURGY
    • C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
    • C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
    • C10M1/00—Liquid compositions essentially based on mineral lubricating oils or fatty oils; Their use as lubricants
    • C10M1/08—Liquid compositions essentially based on mineral lubricating oils or fatty oils; Their use as lubricants with additives
    • C—CHEMISTRY; METALLURGY
    • C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
    • C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
    • C10M2207/00—Organic non-macromolecular hydrocarbon compounds containing hydrogen, carbon and oxygen as ingredients in lubricant compositions
    • C10M2207/28—Esters

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Materials Engineering (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Emergency Medicine (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pyrane Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • Edible Oils And Fats (AREA)
  • Anti-Oxidant Or Stabilizer Compositions (AREA)
  • Fats And Perfumes (AREA)

Abstract

The preparation of chroman aldehydes of the formula <IMAGE> in which R represents hydroxyl, an ether group which can be converted to hydroxyl by hydrolysis or hydrogenolysis or an ester group which can be converted to hydroxyl by hydrolysis, is described. These compounds are useful intermediates for the preparation of natural optically active alpha -tocopherol and its isomers. [GB1456827A]
IE2317/73A 1972-12-22 1973-12-21 Chromane derivatives IE38671B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US31756672A 1972-12-22 1972-12-22

Publications (2)

Publication Number Publication Date
IE38671L IE38671L (en) 1974-06-22
IE38671B1 true IE38671B1 (en) 1978-05-10

Family

ID=23234257

Family Applications (1)

Application Number Title Priority Date Filing Date
IE2317/73A IE38671B1 (en) 1972-12-22 1973-12-21 Chromane derivatives

Country Status (21)

Country Link
JP (3) JPS4988876A (en)
KR (1) KR780000008B1 (en)
AR (1) AR200751A1 (en)
AT (1) AT333755B (en)
BE (2) BE808943A (en)
CA (1) CA1022562A (en)
CH (3) CH605892A5 (en)
DD (1) DD109624A5 (en)
DE (2) DE2364165A1 (en)
ES (1) ES421683A1 (en)
FR (2) FR2255299B1 (en)
GB (4) GB1456828A (en)
HU (1) HU168043B (en)
IE (1) IE38671B1 (en)
IL (1) IL43888A (en)
LU (1) LU69067A1 (en)
NL (2) NL178968C (en)
PH (1) PH11133A (en)
SE (1) SE406912B (en)
SU (1) SU518135A3 (en)
ZA (1) ZA739471B (en)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH618695A5 (en) * 1975-01-27 1980-08-15 Hoffmann La Roche Process for the preparation of chromane derivatives
NL7805217A (en) * 1977-05-16 1978-11-20 Hoffmann La Roche PROCESS FOR THE PREPARATION OF INTERMEDIATE COMPOUNDS FOR THE PREPARATION OF VITAMIN E.
EP0003484B1 (en) * 1978-01-30 1981-10-14 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Process for the preparation of chromane derivatives
US4150050A (en) * 1978-01-30 1979-04-17 Hoffmann-La Roche Inc. 3,6-Dioxo-1,4-cyclohexadien-1-yl-butandate esters
DE2909601A1 (en) * 1979-03-12 1980-09-25 Basf Ag METHOD FOR PRODUCING CHROME DERIVATIVES
DE3010505A1 (en) * 1980-03-19 1981-10-01 Basf Ag, 6700 Ludwigshafen CHROME DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS STABILIZERS OF ORGANIC MATERIALS AND ORGANIC MATERIALS CONTAINING THESE STABILIZERS
DE3010504A1 (en) * 1980-03-19 1981-10-01 Basf Ag, 6700 Ludwigshafen METHOD FOR THE PRODUCTION OF 2-HYDROXYALKYLCHROMANS
DE3103707A1 (en) * 1981-02-04 1982-08-19 Basf Ag, 6700 Ludwigshafen CHROME DERIVATIVES
DE3103740A1 (en) * 1981-02-04 1982-08-19 Basf Ag, 6700 Ludwigshafen CHROME DERIVATIVES
JPS57136582A (en) * 1981-02-19 1982-08-23 Eisai Co Ltd Preparation of optically active alpha-tocopherol
JPS57145871A (en) * 1981-03-05 1982-09-09 Eisai Co Ltd Chromanolcarboxylic derivative
DE3139238A1 (en) * 1981-10-02 1983-04-21 Basf Ag, 6700 Ludwigshafen OPTICALLY ACTIVE COMPONENTS FOR THE SYNTHESIS OF THE SIDE CHAIN OF (R, R, R) - (ALPHA) -TOCOPHEROL AND METHOD FOR THE PRODUCTION THEREOF
EP0115142B1 (en) * 1982-12-23 1986-11-05 Ici Americas Inc. Chroman compounds
ZA844519B (en) * 1983-06-24 1985-02-27 Hoffmann La Roche Dihydrobenzopyran derivatives
ATE41151T1 (en) * 1986-01-23 1989-03-15 Hoffmann La Roche 3,4-DIHYDRO-2,5,7,8-TETRAMETHYL-2H-1BENZOPYRANE DERIVATIVES AND PROCESS FOR THEIR PRODUCTION.
US4987231A (en) * 1989-08-04 1991-01-22 Pfizer Inc. Optical resolution method for 3R-(3-carboxybenzyl)-6-(5-fluoro-2-benzothiazolyl)methoxy-4R-chromanol
CA2082004A1 (en) * 1991-11-20 1993-05-21 David Laffan Substituted pentaalkylchromans
DE19859251A1 (en) * 1998-12-22 2000-06-29 Basf Ag Process for the preparation of substituted chroman derivatives
WO2002012221A1 (en) * 2000-08-03 2002-02-14 Kuraray Co., Ltd. Method for optical resolution of (±)-6-hydroxy-2,5,7,8-tetramethylcoumarone-2-carboxylic acid
WO2005073212A1 (en) * 2004-01-30 2005-08-11 Mitsubishi Gas Chemical Company, Inc. Process for producing chroman compound
KR101233223B1 (en) * 2004-12-21 2013-02-14 제이엔씨 석유 화학 주식회사 Liquid crystal compound having a chroman ring, liquid crystal composition, and liquid crystal display device comprising the liquid crystal composition
EP2522647B1 (en) * 2011-05-10 2014-04-30 DSM IP Assets B.V. Process of separating chiral isomers of chroman compounds and their derivatives and precursors
NL2010010C2 (en) 2012-12-19 2014-06-23 Sulfateq B V Compounds for protection of cells.
KR20220143897A (en) * 2020-02-21 2022-10-25 스미토모 파마 가부시키가이샤 Optically resolved Trolox intermediate and method for preparing the same

Also Published As

Publication number Publication date
FR2284604A1 (en) 1976-04-09
IL43888A (en) 1977-02-28
GB1456828A (en) 1976-11-24
JPS4988876A (en) 1974-08-24
AR200751A1 (en) 1974-12-13
BE808943A (en) 1974-06-21
FR2255299A1 (en) 1975-07-18
GB1456829A (en) 1976-11-24
DD109624A5 (en) 1974-11-12
DE2364165A1 (en) 1974-06-27
CA1022562A (en) 1977-12-13
HU168043B (en) 1976-02-28
LU69067A1 (en) 1975-08-20
SU518135A3 (en) 1976-06-15
GB1456830A (en) 1976-11-24
JPS4988877A (en) 1974-08-24
ES421683A1 (en) 1976-04-01
AT333755B (en) 1976-12-10
CH622257A5 (en) 1981-03-31
NL178968C (en) 1986-06-16
CH605892A5 (en) 1978-10-13
DE2364141A1 (en) 1974-06-27
GB1456827A (en) 1976-11-24
KR780000008B1 (en) 1978-03-04
BE808942A (en) 1974-06-21
JPS5946233B2 (en) 1984-11-10
IL43888A0 (en) 1974-03-14
NL7317587A (en) 1974-06-25
PH11133A (en) 1977-10-27
IE38671L (en) 1974-06-22
ATA1076973A (en) 1976-04-15
CH603617A5 (en) 1978-08-31
FR2284604B1 (en) 1979-05-11
SE406912B (en) 1979-03-05
JPS6026795B2 (en) 1985-06-25
JPS59144780A (en) 1984-08-18
AU6400973A (en) 1975-07-03
NL7317590A (en) 1974-06-25
ZA739471B (en) 1974-08-28
FR2255299B1 (en) 1977-06-10

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