IE37834B1 - 3-amino-pyrazolones-(5),processes for their manufacture and their use as medicines - Google Patents
3-amino-pyrazolones-(5),processes for their manufacture and their use as medicinesInfo
- Publication number
- IE37834B1 IE37834B1 IE1035/73A IE103573A IE37834B1 IE 37834 B1 IE37834 B1 IE 37834B1 IE 1035/73 A IE1035/73 A IE 1035/73A IE 103573 A IE103573 A IE 103573A IE 37834 B1 IE37834 B1 IE 37834B1
- Authority
- IE
- Ireland
- Prior art keywords
- alkyl
- alkoxy
- radical carrying
- phenyl
- phenyl radical
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/44—Oxygen and nitrogen or sulfur and nitrogen atoms
- C07D231/52—Oxygen atom in position 3 and nitrogen atom in position 5, or vice versa
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
1391051 Aminopyrazolones BAYER AG 22 June 1973 [23 June 1972] 29785/73 Heading C2C The invention comprises compounds of the tautomeric formulae and their salts, wherein R is (a) a phenyl radical carrying one or two identical or different substituents selected from alkyl, phenyl, trifluoromethyl, trifluoromethoxy, nitro, nitrile, carbamoyl, sulphamoyl, alkylamino, fluorine, bromine and iodine radicals but cannot be a phenyl radical carrying trifluoromethyl only as one substituent, or (b) a phenyl radical carrying an annellated, branched or unbranched, saturated or unsaturated, five to seven-membered isocyclic or heterocyclic ring (the heterocyclic ring containing one or more oxygen and/or sulphur atoms); or (c) a phenyl radical carrying as substituent an SO n -alkyl group (n = 0, 1 or 2), an alkoxy group, or an -O-(CH 2 ) n -N(alkyl) 2 group (n = 2 or 3); or (d) a phenyl radical carrying two identical substituents selected from alkoxy and trifluoromethyl groups; or (e) a phenyl radical carrying two different substituents selected from alkyl, phenyl, halogen, alkoxy, trifluoromethyl, trifluoromethoxy, alkylamino, nitrile, carbamoyl, sulphamoyl, -SO n alkyl (n = 0, 1 or 2) and nitro radicals; or (f) a trichlorophenyl radical; or (g) a naphthyl radical carrying one or two identical or different substituents selected from halogen atoms and alkyl groups; or (h) an unsubstituted #-naphthyl, anthryl or phenanthryl radical. These compounds are prepared by reacting RCH 2 NHNH 2 with CNCH 2 COX or where X is OH, alkoxy, aralkoxy, NH 2 or alkylamino, and Y is alkoxy, aryloxy, aralkoxy, alkylmercapto, aralkylmercapto or NH 2 . Therapeutic compositions having diuretic, saluretic and antihypertensive activity comprise compounds of the above formulae, and may be administered orally, parenterally, rectally, topically or by means of a spray.
[GB1391051A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2230792A DE2230792A1 (en) | 1972-06-23 | 1972-06-23 | 3-AMINO-PYRAZOLONE- (5), METHOD FOR MANUFACTURING AND USING IT AS A MEDICINAL PRODUCT |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE37834L IE37834L (en) | 1973-12-23 |
| IE37834B1 true IE37834B1 (en) | 1977-10-26 |
Family
ID=5848604
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1035/73A IE37834B1 (en) | 1972-06-23 | 1973-06-22 | 3-amino-pyrazolones-(5),processes for their manufacture and their use as medicines |
Country Status (29)
| Country | Link |
|---|---|
| JP (1) | JPS4962463A (en) |
| KR (1) | KR780000147B1 (en) |
| AR (1) | AR205329A1 (en) |
| AT (1) | AT323735B (en) |
| BE (1) | BE801228A (en) |
| BG (1) | BG22819A3 (en) |
| CA (1) | CA1017752A (en) |
| CH (1) | CH592632A5 (en) |
| DD (1) | DD109874A5 (en) |
| DE (1) | DE2230792A1 (en) |
| DK (1) | DK133468C (en) |
| EG (1) | EG11039A (en) |
| ES (1) | ES416167A1 (en) |
| FR (1) | FR2189072B1 (en) |
| GB (1) | GB1391051A (en) |
| HK (1) | HK11276A (en) |
| HU (1) | HU168358B (en) |
| IE (1) | IE37834B1 (en) |
| IL (1) | IL42560A (en) |
| LU (1) | LU67854A1 (en) |
| NL (1) | NL7308575A (en) |
| NO (1) | NO137196C (en) |
| OA (1) | OA04432A (en) |
| PH (1) | PH11606A (en) |
| PL (1) | PL87665B1 (en) |
| RO (1) | RO71819A (en) |
| SE (1) | SE401181B (en) |
| SU (1) | SU472503A3 (en) |
| ZA (1) | ZA734244B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USRE30420E (en) * | 1973-04-17 | 1980-10-21 | Bayer Aktiengesellschaft | Pyrazol-5-ones |
| DE2319278C2 (en) * | 1973-04-17 | 1986-02-20 | Bayer Ag, 5090 Leverkusen | Pharmaceutical agent |
| DE3436383A1 (en) * | 1984-10-04 | 1986-04-10 | Bayer Ag, 5090 Leverkusen | METHOD FOR PRODUCING PYRAZOLONE DERIVATIVES |
-
1972
- 1972-06-23 DE DE2230792A patent/DE2230792A1/en not_active Withdrawn
-
1973
- 1973-06-06 RO RO7375048A patent/RO71819A/en unknown
- 1973-06-19 BG BG23919A patent/BG22819A3/xx unknown
- 1973-06-20 SE SE7308721A patent/SE401181B/en unknown
- 1973-06-20 NL NL7308575A patent/NL7308575A/xx not_active Application Discontinuation
- 1973-06-20 SU SU1938995A patent/SU472503A3/en active
- 1973-06-20 IL IL42560A patent/IL42560A/en unknown
- 1973-06-20 CH CH897973A patent/CH592632A5/xx not_active IP Right Cessation
- 1973-06-20 AT AT544673A patent/AT323735B/en not_active IP Right Cessation
- 1973-06-21 LU LU67854A patent/LU67854A1/xx unknown
- 1973-06-21 DD DD171728A patent/DD109874A5/xx unknown
- 1973-06-21 EG EG235/73A patent/EG11039A/en active
- 1973-06-21 BE BE132533A patent/BE801228A/en unknown
- 1973-06-21 JP JP48069262A patent/JPS4962463A/ja active Pending
- 1973-06-22 AR AR248701A patent/AR205329A1/en active
- 1973-06-22 FR FR7322955A patent/FR2189072B1/fr not_active Expired
- 1973-06-22 DK DK349573A patent/DK133468C/en active
- 1973-06-22 IE IE1035/73A patent/IE37834B1/en unknown
- 1973-06-22 OA OA54946A patent/OA04432A/en unknown
- 1973-06-22 HU HUBA2942A patent/HU168358B/hu unknown
- 1973-06-22 NO NO2618/73A patent/NO137196C/en unknown
- 1973-06-22 ES ES416167A patent/ES416167A1/en not_active Expired
- 1973-06-22 ZA ZA734244A patent/ZA734244B/en unknown
- 1973-06-22 CA CA174,778A patent/CA1017752A/en not_active Expired
- 1973-06-22 GB GB2978573A patent/GB1391051A/en not_active Expired
- 1973-06-22 PL PL1973163511A patent/PL87665B1/pl unknown
- 1973-06-23 KR KR7301005A patent/KR780000147B1/en active
-
1975
- 1975-01-03 PH PH16674A patent/PH11606A/en unknown
-
1976
- 1976-03-04 HK HK112/76*UA patent/HK11276A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BG22819A3 (en) | 1977-04-20 |
| HU168358B (en) | 1976-04-28 |
| LU67854A1 (en) | 1973-08-30 |
| AU5705173A (en) | 1974-12-19 |
| ES416167A1 (en) | 1976-03-01 |
| IL42560A0 (en) | 1973-08-29 |
| IL42560A (en) | 1977-05-31 |
| CA1017752A (en) | 1977-09-20 |
| GB1391051A (en) | 1975-04-16 |
| DK133468C (en) | 1976-10-18 |
| PL87665B1 (en) | 1976-07-31 |
| KR780000147B1 (en) | 1978-04-19 |
| OA04432A (en) | 1980-03-15 |
| DK133468B (en) | 1976-05-24 |
| JPS4962463A (en) | 1974-06-17 |
| IE37834L (en) | 1973-12-23 |
| ZA734244B (en) | 1974-06-26 |
| FR2189072A1 (en) | 1974-01-25 |
| RO71819A (en) | 1981-01-30 |
| NO137196B (en) | 1977-10-10 |
| SU472503A3 (en) | 1975-05-30 |
| BE801228A (en) | 1973-12-21 |
| PH11606A (en) | 1978-04-12 |
| EG11039A (en) | 1977-01-31 |
| AR205329A1 (en) | 1976-04-30 |
| NO137196C (en) | 1978-01-18 |
| FR2189072B1 (en) | 1977-09-09 |
| DD109874A5 (en) | 1974-11-20 |
| NL7308575A (en) | 1973-12-27 |
| SE401181B (en) | 1978-04-24 |
| CH592632A5 (en) | 1977-10-31 |
| DE2230792A1 (en) | 1974-01-17 |
| HK11276A (en) | 1976-03-12 |
| AT323735B (en) | 1975-07-25 |
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