ES416167A1 - 3-amino-pyrazolones-5, processes for their manufacture and their use as medicines - Google Patents
3-amino-pyrazolones-5, processes for their manufacture and their use as medicinesInfo
- Publication number
- ES416167A1 ES416167A1 ES416167A ES416167A ES416167A1 ES 416167 A1 ES416167 A1 ES 416167A1 ES 416167 A ES416167 A ES 416167A ES 416167 A ES416167 A ES 416167A ES 416167 A1 ES416167 A1 ES 416167A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- alkyl
- phenyl
- formula
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/44—Oxygen and nitrogen or sulfur and nitrogen atoms
- C07D231/52—Oxygen atom in position 3 and nitrogen atom in position 5, or vice versa
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Procedure for the production of 3-aminopyrazolones- (5), of the formula **(See formula)** in which R represents a phenyl radical substituted by 1 to 2 substituents equal or different from the group consisting of alkyl, phenyl, trifluoromethoxy, nitro, cyano, carbonamido, sulfonamido, alkylamino, fluorine, bromine and iodine, with two substituents on the ring being Phenyl together eventually form a 5- to 7-membered saturated or unsaturated branched or unbranched isocyclic or heterocyclic ring capable of containing oxygen and/or sulfur atoms; or a phenyl radical substituted by a SOn-alkyl group (n = 0 to 2), an alkoxy group or the group -O- (CH2) n-N- (alkyl) 2 (n = 2 to 3); or a phenyl radical substituted by two equal substituents from the group consisting of alkoxy and trifluoromethyl; or a phenyl radical substituted by two different substituents from the group consisting of alkyl, phenyl, halogen, alkoxy, trifluoromethyl, trifluoromethoxy, alkylamino, cyano, carbonamido, sulfonamido, SOn-alkyl (n = 0 to 2) and nitro; or a phenyl radical substituted by three chlorine atoms; or a naphthyl radical substituted by 1 to 2 the same or different halogen atoms and/or alkyl, or an unsubstituted β-naphthyl, anthryl or phenanthril radical; characterized in that hydrazines of formula (II) are reacted R-CH2-NH-NH2 (II) in which R has the meaning defined above, with derivatives of acetic acid of formula (III) **(See formula)** where X is a hydroxy, alkoxy, aralkoxy, amino or alkylamino radical, Y'is hydrogen and Y''is nitrile or Y' and Y'' together represent the group **(See formula)** Y representing an alkoxy, aryloxy, aralkoxy, alkylmercapto or aralkylmercapto radical or the amino group, optionally after isolation of the intermediate amidrazones formed of the formula (IV) **(See formula)** in which X and R have the meanings indicated above, possibly in the presence of inert solvents and of basic or acid catalysts, such as alkali and alkaline earth hydroxides and carbonates or such as hydrohalic acids, sulfuric acid or sulfonic acids, at temperatures between 20º and 100ºC. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2230792A DE2230792A1 (en) | 1972-06-23 | 1972-06-23 | 3-AMINO-PYRAZOLONE- (5), METHOD FOR MANUFACTURING AND USING IT AS A MEDICINAL PRODUCT |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES416167A1 true ES416167A1 (en) | 1976-03-01 |
Family
ID=5848604
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES416167A Expired ES416167A1 (en) | 1972-06-23 | 1973-06-22 | 3-amino-pyrazolones-5, processes for their manufacture and their use as medicines |
Country Status (29)
| Country | Link |
|---|---|
| JP (1) | JPS4962463A (en) |
| KR (1) | KR780000147B1 (en) |
| AR (1) | AR205329A1 (en) |
| AT (1) | AT323735B (en) |
| BE (1) | BE801228A (en) |
| BG (1) | BG22819A3 (en) |
| CA (1) | CA1017752A (en) |
| CH (1) | CH592632A5 (en) |
| DD (1) | DD109874A5 (en) |
| DE (1) | DE2230792A1 (en) |
| DK (1) | DK133468C (en) |
| EG (1) | EG11039A (en) |
| ES (1) | ES416167A1 (en) |
| FR (1) | FR2189072B1 (en) |
| GB (1) | GB1391051A (en) |
| HK (1) | HK11276A (en) |
| HU (1) | HU168358B (en) |
| IE (1) | IE37834B1 (en) |
| IL (1) | IL42560A (en) |
| LU (1) | LU67854A1 (en) |
| NL (1) | NL7308575A (en) |
| NO (1) | NO137196C (en) |
| OA (1) | OA04432A (en) |
| PH (1) | PH11606A (en) |
| PL (1) | PL87665B1 (en) |
| RO (1) | RO71819A (en) |
| SE (1) | SE401181B (en) |
| SU (1) | SU472503A3 (en) |
| ZA (1) | ZA734244B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USRE30420E (en) * | 1973-04-17 | 1980-10-21 | Bayer Aktiengesellschaft | Pyrazol-5-ones |
| DE2319278C2 (en) * | 1973-04-17 | 1986-02-20 | Bayer Ag, 5090 Leverkusen | Pharmaceutical agent |
| DE3436383A1 (en) * | 1984-10-04 | 1986-04-10 | Bayer Ag, 5090 Leverkusen | METHOD FOR PRODUCING PYRAZOLONE DERIVATIVES |
-
1972
- 1972-06-23 DE DE2230792A patent/DE2230792A1/en not_active Withdrawn
-
1973
- 1973-06-06 RO RO7375048A patent/RO71819A/en unknown
- 1973-06-19 BG BG23919A patent/BG22819A3/xx unknown
- 1973-06-20 SE SE7308721A patent/SE401181B/en unknown
- 1973-06-20 NL NL7308575A patent/NL7308575A/xx not_active Application Discontinuation
- 1973-06-20 SU SU1938995A patent/SU472503A3/en active
- 1973-06-20 IL IL42560A patent/IL42560A/en unknown
- 1973-06-20 CH CH897973A patent/CH592632A5/xx not_active IP Right Cessation
- 1973-06-20 AT AT544673A patent/AT323735B/en not_active IP Right Cessation
- 1973-06-21 LU LU67854A patent/LU67854A1/xx unknown
- 1973-06-21 DD DD171728A patent/DD109874A5/xx unknown
- 1973-06-21 EG EG235/73A patent/EG11039A/en active
- 1973-06-21 BE BE132533A patent/BE801228A/en unknown
- 1973-06-21 JP JP48069262A patent/JPS4962463A/ja active Pending
- 1973-06-22 AR AR248701A patent/AR205329A1/en active
- 1973-06-22 FR FR7322955A patent/FR2189072B1/fr not_active Expired
- 1973-06-22 DK DK349573A patent/DK133468C/en active
- 1973-06-22 IE IE1035/73A patent/IE37834B1/en unknown
- 1973-06-22 OA OA54946A patent/OA04432A/en unknown
- 1973-06-22 HU HUBA2942A patent/HU168358B/hu unknown
- 1973-06-22 NO NO2618/73A patent/NO137196C/en unknown
- 1973-06-22 ES ES416167A patent/ES416167A1/en not_active Expired
- 1973-06-22 ZA ZA734244A patent/ZA734244B/en unknown
- 1973-06-22 CA CA174,778A patent/CA1017752A/en not_active Expired
- 1973-06-22 GB GB2978573A patent/GB1391051A/en not_active Expired
- 1973-06-22 PL PL1973163511A patent/PL87665B1/pl unknown
- 1973-06-23 KR KR7301005A patent/KR780000147B1/en active
-
1975
- 1975-01-03 PH PH16674A patent/PH11606A/en unknown
-
1976
- 1976-03-04 HK HK112/76*UA patent/HK11276A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BG22819A3 (en) | 1977-04-20 |
| HU168358B (en) | 1976-04-28 |
| LU67854A1 (en) | 1973-08-30 |
| AU5705173A (en) | 1974-12-19 |
| IE37834B1 (en) | 1977-10-26 |
| IL42560A0 (en) | 1973-08-29 |
| IL42560A (en) | 1977-05-31 |
| CA1017752A (en) | 1977-09-20 |
| GB1391051A (en) | 1975-04-16 |
| DK133468C (en) | 1976-10-18 |
| PL87665B1 (en) | 1976-07-31 |
| KR780000147B1 (en) | 1978-04-19 |
| OA04432A (en) | 1980-03-15 |
| DK133468B (en) | 1976-05-24 |
| JPS4962463A (en) | 1974-06-17 |
| IE37834L (en) | 1973-12-23 |
| ZA734244B (en) | 1974-06-26 |
| FR2189072A1 (en) | 1974-01-25 |
| RO71819A (en) | 1981-01-30 |
| NO137196B (en) | 1977-10-10 |
| SU472503A3 (en) | 1975-05-30 |
| BE801228A (en) | 1973-12-21 |
| PH11606A (en) | 1978-04-12 |
| EG11039A (en) | 1977-01-31 |
| AR205329A1 (en) | 1976-04-30 |
| NO137196C (en) | 1978-01-18 |
| FR2189072B1 (en) | 1977-09-09 |
| DD109874A5 (en) | 1974-11-20 |
| NL7308575A (en) | 1973-12-27 |
| SE401181B (en) | 1978-04-24 |
| CH592632A5 (en) | 1977-10-31 |
| DE2230792A1 (en) | 1974-01-17 |
| HK11276A (en) | 1976-03-12 |
| AT323735B (en) | 1975-07-25 |
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