IE37412B1 - Pyridine derivatives having hypoglycaemic activity - Google Patents
Pyridine derivatives having hypoglycaemic activityInfo
- Publication number
- IE37412B1 IE37412B1 IE426/73A IE42673A IE37412B1 IE 37412 B1 IE37412 B1 IE 37412B1 IE 426/73 A IE426/73 A IE 426/73A IE 42673 A IE42673 A IE 42673A IE 37412 B1 IE37412 B1 IE 37412B1
- Authority
- IE
- Ireland
- Prior art keywords
- group
- carboxylic acid
- formula
- alk
- prepared
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
1437781 Pyridine derivatives BEECHAM GROUP Ltd 18 May 1973 [4 April 1972] 15280/72 Heading C2C [Also in Division A5] Compounds (mostly novel) of Formulµ I and II in which formulµ "Py" represents a substituted or unsubstituted 2-, 3- or 4-pyridyl group, or an N-oxidized or quaternized pyridyl group; "A" represents a group of Formula (IIIa), (IIIb) or (IIIc) wherein "ALK" represents a straight or branched chain alkylene group having from 1 to 6 carbon atoms; R 1 represents a carboxylic acid group or a group which is converted in the human body to a carboxylic acid group R 2 , R 3 and R 4 each separately represent hydrogen, a carboxylic acid group, a group which is converted in the human body to a carboxylic acid group, a hydroxy group, an alkoxy group, an aralkoxy group, an aryloxy group, an esterified hydroxy group, a nitro group, a halogen group or an amine group, are prepared by reacting a compound of formula B-(ALK) n OH with a compound of formula HO-(ALK) m -Py in which m and n are 0 or 1, provided n + m#0, and B is a group of Formula Ia or IIa The known compounds are those in which Py is 2-pyridyl or 5-ethylpyrid-2-yl, A is R 1 is methyl or methoxycarbonyl and R 2 , R 3 and R 4 are H or halogen. 2-Chloromethylpyridine is prepared by reacting 2-hydroxymethylpyridine with phosphorus oxychloride. p - Ethoxycarbonylbenzyl bromide is prepared by reacting ethyl p-toluate with N-bromosuccinimide. Pharmaceutical composition having hypoglycaemic activity, for oral administration, comprise a compound I or II together with a pharmaceutical carrier.
[GB1437781A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1528072A GB1437781A (en) | 1972-04-04 | 1972-04-04 | Pyridine derivatives having hypoglycaemic activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE37412L IE37412L (en) | 1973-10-04 |
| IE37412B1 true IE37412B1 (en) | 1977-07-20 |
Family
ID=10056262
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE426/73A IE37412B1 (en) | 1972-04-04 | 1973-03-15 | Pyridine derivatives having hypoglycaemic activity |
Country Status (20)
| Country | Link |
|---|---|
| JP (1) | JPS49100091A (en) |
| AR (1) | AR208269A1 (en) |
| AT (1) | AT339301B (en) |
| BE (1) | BE797715A (en) |
| BG (1) | BG20352A3 (en) |
| CA (1) | CA999868A (en) |
| CH (1) | CH576961A5 (en) |
| CS (1) | CS183689B2 (en) |
| DD (1) | DD106834A5 (en) |
| DE (1) | DE2316881A1 (en) |
| ES (1) | ES413279A1 (en) |
| FR (1) | FR2182933B1 (en) |
| GB (1) | GB1437781A (en) |
| HU (1) | HU165731B (en) |
| IE (1) | IE37412B1 (en) |
| IL (1) | IL41825A (en) |
| NL (1) | NL7304610A (en) |
| PL (1) | PL96043B1 (en) |
| RO (2) | RO62274A (en) |
| ZA (1) | ZA731853B (en) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4409227A (en) | 1979-08-09 | 1983-10-11 | The Dow Chemical Co. | 4-(((Heterocyclo)thio)methyl)benzoic acids, esters and amides and their pharmaceutical use |
| ES2072085T3 (en) * | 1991-07-03 | 1995-07-01 | Unilever Nv | IMPROVED CHOCOLATE COMPOSITIONS. |
| DE69204231T2 (en) * | 1991-07-03 | 1996-01-25 | Unilever Nv | Chocolate filling containing an anti-greasy additive. |
| US5453433A (en) * | 1994-05-13 | 1995-09-26 | Sterling Winthrop Inc. | Thiadiazoles and antipicornaviral compositions |
| US6043247A (en) * | 1996-04-19 | 2000-03-28 | Novo Nordisk A/S | Modulators of molecules with phosphotyrosine recognition units |
| JP2000509373A (en) * | 1996-04-19 | 2000-07-25 | ノボ ノルディスク アクティーゼルスカブ | Modulators of molecules with phosphotyrosine recognition units |
| US6329372B1 (en) | 1998-01-27 | 2001-12-11 | Celltech Therapeutics Limited | Phenylalanine derivatives |
| ATE273273T1 (en) | 1998-02-26 | 2004-08-15 | Celltech Therapeutics Ltd | PHENYLALANINE DERIVATIVES AS INHIBITORS OF ALPHA4 INTEGRINS |
| GB9805655D0 (en) | 1998-03-16 | 1998-05-13 | Celltech Therapeutics Ltd | Chemical compounds |
| US6521626B1 (en) | 1998-03-24 | 2003-02-18 | Celltech R&D Limited | Thiocarboxamide derivatives |
| GB9811159D0 (en) | 1998-05-22 | 1998-07-22 | Celltech Therapeutics Ltd | Chemical compounds |
| GB9811969D0 (en) * | 1998-06-03 | 1998-07-29 | Celltech Therapeutics Ltd | Chemical compounds |
| GB9812088D0 (en) | 1998-06-05 | 1998-08-05 | Celltech Therapeutics Ltd | Chemical compounds |
| GB9814414D0 (en) * | 1998-07-03 | 1998-09-02 | Celltech Therapeutics Ltd | Chemical compounds |
| GB9821061D0 (en) | 1998-09-28 | 1998-11-18 | Celltech Therapeutics Ltd | Chemical compounds |
| GB9821222D0 (en) | 1998-09-30 | 1998-11-25 | Celltech Therapeutics Ltd | Chemical compounds |
| GB9825652D0 (en) | 1998-11-23 | 1999-01-13 | Celltech Therapeutics Ltd | Chemical compounds |
| GB9826174D0 (en) | 1998-11-30 | 1999-01-20 | Celltech Therapeutics Ltd | Chemical compounds |
| US6518283B1 (en) | 1999-05-28 | 2003-02-11 | Celltech R&D Limited | Squaric acid derivatives |
| US6534513B1 (en) | 1999-09-29 | 2003-03-18 | Celltech R&D Limited | Phenylalkanoic acid derivatives |
| US6455539B2 (en) | 1999-12-23 | 2002-09-24 | Celltech R&D Limited | Squaric acid derivates |
| WO2001079173A2 (en) | 2000-04-17 | 2001-10-25 | Celltech R & D Limited | Enamine derivatives as cell adhesion molecules |
| US6545013B2 (en) | 2000-05-30 | 2003-04-08 | Celltech R&D Limited | 2,7-naphthyridine derivatives |
| US6403608B1 (en) | 2000-05-30 | 2002-06-11 | Celltech R&D, Ltd. | 3-Substituted isoquinolin-1-yl derivatives |
| JP2004502762A (en) | 2000-07-07 | 2004-01-29 | セルテック アール アンド ディ リミテッド | Squaric acid derivatives as integrin antagonists containing bicyclic heteroaromatic rings |
| EP1305291A1 (en) | 2000-08-02 | 2003-05-02 | Celltech R&D Limited | 3-substituted isoquinolin-1-yl derivatives |
| ES2441874T3 (en) * | 2001-06-12 | 2014-02-06 | Wellstat Therapeutics Corporation | Compounds for the treatment of metabolic disorders |
| GB0405033D0 (en) * | 2004-03-05 | 2004-04-07 | Karobio Ab | Novel pharmaceutical compositions |
| TWI490214B (en) | 2008-05-30 | 2015-07-01 | 艾德克 上野股份有限公司 | Benzene or thiophene derivative and use thereof as vap-1 inhibitor |
| US10178875B2 (en) | 2013-07-01 | 2019-01-15 | Givaudan S.A. | Methods of modifying or imparting taste using organic compounds |
| WO2016167153A1 (en) * | 2015-04-15 | 2016-10-20 | 長谷川香料株式会社 | Flavor modulator having pyridine derivative or salt thereof as active ingredient |
| US11096909B2 (en) | 2016-04-06 | 2021-08-24 | University Of Oulu | Compounds for use in the treatment of cancer |
-
1972
- 1972-04-04 GB GB1528072A patent/GB1437781A/en not_active Expired
-
1973
- 1973-01-01 AR AR247376A patent/AR208269A1/en active
- 1973-03-15 IE IE426/73A patent/IE37412B1/en unknown
- 1973-03-16 ZA ZA731853A patent/ZA731853B/en unknown
- 1973-03-19 IL IL41825A patent/IL41825A/en unknown
- 1973-03-30 HU HURO717A patent/HU165731B/hu unknown
- 1973-04-02 AT AT286773A patent/AT339301B/en not_active IP Right Cessation
- 1973-04-03 NL NL7304610A patent/NL7304610A/xx not_active Application Discontinuation
- 1973-04-03 RO RO7300074369A patent/RO62274A/en unknown
- 1973-04-03 CA CA167,818A patent/CA999868A/en not_active Expired
- 1973-04-03 CS CS7300002387A patent/CS183689B2/en unknown
- 1973-04-03 RO RO7300083382A patent/RO63069A/en unknown
- 1973-04-03 BE BE129595A patent/BE797715A/en unknown
- 1973-04-03 ES ES413279A patent/ES413279A1/en not_active Expired
- 1973-04-03 JP JP48038610A patent/JPS49100091A/ja active Pending
- 1973-04-04 FR FR7312133A patent/FR2182933B1/fr not_active Expired
- 1973-04-04 DE DE2316881A patent/DE2316881A1/en active Pending
- 1973-04-04 PL PL1973161704A patent/PL96043B1/en unknown
- 1973-04-04 BG BG23170A patent/BG20352A3/xx unknown
- 1973-04-04 DD DD169942A patent/DD106834A5/xx unknown
- 1973-04-04 CH CH482673A patent/CH576961A5/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE2316881A1 (en) | 1973-10-11 |
| RO63069A (en) | 1978-08-15 |
| ZA731853B (en) | 1974-01-30 |
| JPS49100091A (en) | 1974-09-20 |
| CH576961A5 (en) | 1976-06-30 |
| NL7304610A (en) | 1973-10-08 |
| CA999868A (en) | 1976-11-16 |
| FR2182933A1 (en) | 1973-12-14 |
| HU165731B (en) | 1974-10-28 |
| ATA286773A (en) | 1977-02-15 |
| ES413279A1 (en) | 1976-01-01 |
| PL96043B1 (en) | 1977-11-30 |
| BE797715A (en) | 1973-10-03 |
| BG20352A3 (en) | 1975-11-05 |
| AT339301B (en) | 1977-10-10 |
| IL41825A (en) | 1977-03-31 |
| FR2182933B1 (en) | 1976-05-14 |
| IE37412L (en) | 1973-10-04 |
| IL41825A0 (en) | 1973-05-31 |
| RO62274A (en) | 1977-12-15 |
| AR208269A1 (en) | 1976-12-20 |
| DD106834A5 (en) | 1974-07-05 |
| CS183689B2 (en) | 1978-07-31 |
| GB1437781A (en) | 1976-06-03 |
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