GB1458049A - Process for preparing aryl-substituted pyridones - Google Patents
Process for preparing aryl-substituted pyridonesInfo
- Publication number
- GB1458049A GB1458049A GB4107475A GB4107475A GB1458049A GB 1458049 A GB1458049 A GB 1458049A GB 4107475 A GB4107475 A GB 4107475A GB 4107475 A GB4107475 A GB 4107475A GB 1458049 A GB1458049 A GB 1458049A
- Authority
- GB
- United Kingdom
- Prior art keywords
- aryl
- dec
- optionally substituted
- substituted pyridones
- preparing aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1458049 Process for aryl-substituted pyridones AFFILIATED MEDICAL RESEARCH Inc 18 Dec 1973 [18 Dec 1972 19 July 1973] 41074/75 Divided out of 1458048 Heading C2C The invention comprises a process for making compounds (I) (where A is an optionally substituted aromatic or hereroaromatic group and R3 to R 6 are H, alkyl or optionally substituted aryl) by reacting (II) or (III) with AX (X is halogen), preferably in the presence of an alkali metal carbonate and finely divided copper. Pharmaceutical preparations having uricosuric and analgesic actions contain (I) as active ingredient.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US00315836A US3839346A (en) | 1972-12-18 | 1972-12-18 | N-substituted pyridone and general method for preparing pyridones |
US38065573A | 1973-07-19 | 1973-07-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1458049A true GB1458049A (en) | 1976-12-08 |
Family
ID=26980095
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB4107475A Expired GB1458049A (en) | 1972-12-18 | 1973-12-18 | Process for preparing aryl-substituted pyridones |
GB5864273A Expired GB1458048A (en) | 1972-12-18 | 1973-12-18 | Pharmaceutical composition |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB5864273A Expired GB1458048A (en) | 1972-12-18 | 1973-12-18 | Pharmaceutical composition |
Country Status (6)
Country | Link |
---|---|
JP (1) | JPS4987677A (en) |
DE (2) | DE2366349C2 (en) |
ES (1) | ES421598A1 (en) |
FR (1) | FR2232316B1 (en) |
GB (2) | GB1458049A (en) |
NL (1) | NL7317316A (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006122154A3 (en) * | 2005-05-10 | 2007-07-26 | Intermune Inc | Pyridone derivatives for modulating stress-activated protein kinase system |
US8304413B2 (en) | 2008-06-03 | 2012-11-06 | Intermune, Inc. | Compounds and methods for treating inflammatory and fibrotic disorders |
US9359379B2 (en) | 2012-10-02 | 2016-06-07 | Intermune, Inc. | Anti-fibrotic pyridinones |
US10233195B2 (en) | 2014-04-02 | 2019-03-19 | Intermune, Inc. | Anti-fibrotic pyridinones |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1049411A (en) * | 1972-12-18 | 1979-02-27 | Affiliated Medical Research | N-substituted pyridone and general method for preparing pyridones |
JPS5350179A (en) * | 1976-10-15 | 1978-05-08 | Rikagaku Kenkyusho | Novel 2-pyridone compounds and their preparation |
JP4542743B2 (en) * | 2002-12-26 | 2010-09-15 | Kdl株式会社 | Solution pharmaceutical composition of pyridone derivatives |
MX2007009796A (en) | 2007-08-14 | 2009-02-25 | Cell Therapy And Technology S | Gel containing pirfenidone. |
DK2670242T3 (en) * | 2011-01-31 | 2022-05-02 | Avalyn Pharma Inc | Aerosol pirfenidone and pyridone analog compounds and uses thereof |
MX2011007675A (en) | 2011-07-19 | 2012-07-11 | Cell Therapy And Technology S A De C V | Process for manufacturing a pharmaceutical composition in a sustained-release tablet form containing pirfenidone and the application thereof in the regression of chronic renal failure, breast capsular contracture and liver fibrosis in humans. |
MX346763B (en) | 2012-03-28 | 2017-03-31 | Cell Therapy And Tech S A De C V | Semi-solid topical composition which contains pirfenidone and modified diallyl disulphide oxide (m-ddo) for eliminating or preventing acne. |
ITUB20154832A1 (en) * | 2015-10-29 | 2017-04-29 | Procos Spa | PROCESS FOR SYNTHESIS OF PYRPHENING |
CA3108048A1 (en) * | 2017-07-31 | 2019-02-07 | Washington University | Pirfenidone derivatives for modulation of b lymphocyte activity and organ protection |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2947755A (en) * | 1959-02-05 | 1960-08-02 | Wallace & Tiernan Inc | Substituted 1-m-aminophenyl-2-pyridones |
US3655897A (en) * | 1971-01-25 | 1972-04-11 | Merck & Co Inc | Anti-inflammatory agents |
-
1973
- 1973-12-18 FR FR7345342A patent/FR2232316B1/fr not_active Expired
- 1973-12-18 ES ES421598A patent/ES421598A1/en not_active Expired
- 1973-12-18 JP JP14179773A patent/JPS4987677A/ja active Pending
- 1973-12-18 NL NL7317316A patent/NL7317316A/xx not_active Application Discontinuation
- 1973-12-18 DE DE19732366349 patent/DE2366349C2/en not_active Expired
- 1973-12-18 GB GB4107475A patent/GB1458049A/en not_active Expired
- 1973-12-18 DE DE19732362958 patent/DE2362958C2/en not_active Expired
- 1973-12-18 GB GB5864273A patent/GB1458048A/en not_active Expired
Cited By (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9527816B2 (en) | 2005-05-10 | 2016-12-27 | Intermune, Inc. | Method of modulating stress-activated protein kinase system |
US10010536B2 (en) | 2005-05-10 | 2018-07-03 | Intermune, Inc. | Method of modulating stress-activated protein kinase system |
EA015252B1 (en) * | 2005-05-10 | 2011-06-30 | Интермьюн, Инк. | Method of modulating stress-activated protein kinase system |
US8741936B2 (en) | 2005-05-10 | 2014-06-03 | Intermune, Inc. | Method of modulating stress-activated protein kinase system |
WO2006122154A3 (en) * | 2005-05-10 | 2007-07-26 | Intermune Inc | Pyridone derivatives for modulating stress-activated protein kinase system |
US7728013B2 (en) | 2005-05-10 | 2010-06-01 | Intermune, Inc. | Method of modulating stress-activated protein kinase system |
US8969347B2 (en) | 2008-06-03 | 2015-03-03 | Intermune, Inc. | Compounds and methods for treating inflammatory and fibrotic disorders |
US9290450B2 (en) | 2008-06-03 | 2016-03-22 | Intermune, Inc. | Compounds and methods for treating inflammatory and fibrotic disorders |
US8304413B2 (en) | 2008-06-03 | 2012-11-06 | Intermune, Inc. | Compounds and methods for treating inflammatory and fibrotic disorders |
USRE47142E1 (en) | 2008-06-03 | 2018-11-27 | Intermune, Inc. | Compounds and methods for treating inflammatory and fibrotic disorders |
US9675593B2 (en) | 2012-10-02 | 2017-06-13 | Intermune, Inc. | Anti-fibrotic pyridinones |
US9359379B2 (en) | 2012-10-02 | 2016-06-07 | Intermune, Inc. | Anti-fibrotic pyridinones |
US10376497B2 (en) | 2012-10-02 | 2019-08-13 | Intermune, Inc. | Anti-fibrotic pyridinones |
US10898474B2 (en) | 2012-10-02 | 2021-01-26 | Intermune, Inc. | Anti-fibrotic pyridinones |
US10233195B2 (en) | 2014-04-02 | 2019-03-19 | Intermune, Inc. | Anti-fibrotic pyridinones |
US10544161B2 (en) | 2014-04-02 | 2020-01-28 | Intermune, Inc. | Anti-fibrotic pyridinones |
Also Published As
Publication number | Publication date |
---|---|
AU6374673A (en) | 1975-06-19 |
FR2232316A1 (en) | 1975-01-03 |
JPS4987677A (en) | 1974-08-22 |
DE2366349C2 (en) | 1986-03-27 |
FR2232316B1 (en) | 1978-03-24 |
NL7317316A (en) | 1974-06-20 |
ES421598A1 (en) | 1977-01-01 |
DE2362958A1 (en) | 1974-06-27 |
GB1458048A (en) | 1976-12-08 |
DE2362958C2 (en) | 1984-06-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed | ||
PCNP | Patent ceased through non-payment of renewal fee |