IE36010L - Antibiotic axenomycin d. - Google Patents
Antibiotic axenomycin d.Info
- Publication number
- IE36010L IE36010L IE710537A IE53771A IE36010L IE 36010 L IE36010 L IE 36010L IE 710537 A IE710537 A IE 710537A IE 53771 A IE53771 A IE 53771A IE 36010 L IE36010 L IE 36010L
- Authority
- IE
- Ireland
- Prior art keywords
- axenomycine
- antibiotic
- methanol
- isopropanol
- silica gel
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Mycology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
1285163 Antibiotic axenomycine D SOC FARMACEUTICI ITALIA 30 April 1971 [4 May 1970] 12382/71 Addition to 1219709 Heading C2A The new antibiotic axenomycine D is characterized as follows: melting-point 174 to 175 C. with decomposition; elementary analysis C=60À25%, H=7À92%, 0=30À35%; optical rotation [α] D <SP>22</SP> = + 11 degrees (C=0À5 in methanol); U.V. spectrum (in methanol) has maxima at 250, 255 (E 1cm. <SP>1%</SP> =138), 265-268 (shoulder) and 330 mÁ; I.R. absorption peaks at 3440, 2980, 2950, 2890, 1735, 1705, 1675, 1630, 1610, 1465, 1385, 1355, 1290, 1265, 1195, 1170, 1115, 1080, 1050, 1005, 995, 975, 945, 925, 895, 865, 810 and 700 cm<SP>-1</SP>; Rf=0À35 on silica gel (in ethyl acetate : isopropanol : water =100 : 35 : 5); soluble in alcohols and insoluble in water and benzene. Axenomycine D is prepared by cultivating Streptomyces lisandri or an axenomycine D-producing strain thereof in an aqueous medium containing assimilable sources of carbon, nitrogen and mineral salts, the medium containing 10% by weight or more of assimilable carbon and the cultivation being carried out with stirring corresponding to an absorbed power of 2 to 4 watts per litre and with an air flux of 0À7 to 2 litres per litre of medium per minute, and isolating axenomycin D from the cultivated medium. The usual nutrients may be used, preferably with the exception of phosphates, which are said to decrease the yield of antibiotic. The axenomycine D may be recovered from the separated mycelium by extraction with an alcohol, e.g. butanol. The extract is concentrated and the product purified by chromatography on silica gel, evaporation of the active fractions and recrystallization from methanol-isopropanol. Axenomycine D has antihelmintic, antiprotozoal and antifungal activity.
[GB1285163A]
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT24144/70A IT1044819B (en) | 1970-05-04 | 1970-05-04 | ANTIBIOTIC COMPOUND |
Publications (2)
Publication Number | Publication Date |
---|---|
IE36010L true IE36010L (en) | 1971-11-04 |
IE36010B1 IE36010B1 (en) | 1976-07-21 |
Family
ID=11212205
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IE537/71A IE36010B1 (en) | 1970-05-04 | 1971-04-29 | Antibiotic compound |
Country Status (18)
Country | Link |
---|---|
JP (1) | JPS5422520B1 (en) |
AT (1) | AT303256B (en) |
BE (1) | BE766606R (en) |
CA (1) | CA981199A (en) |
CH (1) | CH518360A (en) |
CS (1) | CS170544B2 (en) |
DE (1) | DE2121248C3 (en) |
DK (1) | DK127559B (en) |
ES (1) | ES390826A2 (en) |
FR (1) | FR2092128B2 (en) |
GB (1) | GB1285163A (en) |
IE (1) | IE36010B1 (en) |
IT (1) | IT1044819B (en) |
NL (1) | NL153272B (en) |
NO (1) | NO131549C (en) |
SU (1) | SU377991A3 (en) |
YU (1) | YU35163B (en) |
ZA (1) | ZA712820B (en) |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL153271B (en) * | 1968-06-11 | 1977-05-16 | Farmaceutici Italia | METHOD FOR PREPARING ANTIBIOTICS USING A STREPTOMYCES ORGANISM AND MEDICINAL PRODUCTS CONTAINING ANTIBIOTICS. |
-
1970
- 1970-05-04 IT IT24144/70A patent/IT1044819B/en active
-
1971
- 1971-04-20 NL NL717105286A patent/NL153272B/en unknown
- 1971-04-29 IE IE537/71A patent/IE36010B1/en unknown
- 1971-04-29 SU SU1646887A patent/SU377991A3/ru active
- 1971-04-29 YU YU1077/71A patent/YU35163B/en unknown
- 1971-04-29 CS CS3108A patent/CS170544B2/cs unknown
- 1971-04-29 DE DE2121248A patent/DE2121248C3/en not_active Expired
- 1971-04-30 GB GB02382/71A patent/GB1285163A/en not_active Expired
- 1971-04-30 AT AT373071A patent/AT303256B/en not_active IP Right Cessation
- 1971-04-30 ZA ZA712820A patent/ZA712820B/en unknown
- 1971-04-30 DK DK209371AA patent/DK127559B/en unknown
- 1971-04-30 NO NO1613/71A patent/NO131549C/no unknown
- 1971-04-30 FR FR7115543A patent/FR2092128B2/fr not_active Expired
- 1971-05-01 JP JP2937671A patent/JPS5422520B1/ja active Pending
- 1971-05-03 BE BE766606A patent/BE766606R/en active
- 1971-05-03 CH CH650871A patent/CH518360A/en not_active IP Right Cessation
- 1971-05-03 ES ES390826A patent/ES390826A2/en not_active Expired
- 1971-05-04 CA CA112,065A patent/CA981199A/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
IT1044819B (en) | 1980-04-21 |
NL7105286A (en) | 1971-11-08 |
GB1285163A (en) | 1972-08-09 |
ZA712820B (en) | 1972-01-26 |
DK127559B (en) | 1973-11-26 |
AT303256B (en) | 1972-11-27 |
IE36010B1 (en) | 1976-07-21 |
YU107771A (en) | 1980-03-15 |
JPS5422520B1 (en) | 1979-08-07 |
NO131549C (en) | 1975-06-18 |
YU35163B (en) | 1980-09-25 |
CH518360A (en) | 1972-01-31 |
DE2121248A1 (en) | 1971-11-18 |
CS170544B2 (en) | 1976-08-27 |
BE766606R (en) | 1971-11-03 |
FR2092128A2 (en) | 1972-01-21 |
ES390826A2 (en) | 1973-06-01 |
CA981199A (en) | 1976-01-06 |
SU377991A3 (en) | 1973-04-17 |
NO131549B (en) | 1975-03-10 |
FR2092128B2 (en) | 1974-10-18 |
DE2121248B2 (en) | 1978-06-22 |
DE2121248C3 (en) | 1979-03-15 |
NL153272B (en) | 1977-05-16 |
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