IE33946B1 - New 7-alkyl-steroids - Google Patents
New 7-alkyl-steroidsInfo
- Publication number
- IE33946B1 IE33946B1 IE6570A IE6570A IE33946B1 IE 33946 B1 IE33946 B1 IE 33946B1 IE 6570 A IE6570 A IE 6570A IE 6570 A IE6570 A IE 6570A IE 33946 B1 IE33946 B1 IE 33946B1
- Authority
- IE
- Ireland
- Prior art keywords
- steroids
- alkyl
- group
- prepared
- cyclic
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Steroid Compounds (AREA)
Abstract
1292201 3 - Unsubstituted - 7 - alkyl - androstane compounds ORGANON LABORATORIES Ltd 21 Jan 1970 [30 Jan 1969] 2895/70 Heading C2U Novel steroids of the formula wherein R 1 is C 2-4 alkyl; R 2 is an oxo group or (α-X) (#-Y) in which X is H or C 1-6 alkyl, alkenyl, alkadienyl, alkynyl or alkadiynyl and Y is free, esterified or etherified OH; R 3 is C 1-4 alkyl; and there is present a #<SP>4</SP>-, #<SP>5(10)</SP>- or #<SP>5</SP>-double bond, are prepared from the corresponding steroids containing in position-3 a cyclic or non-cyclic dithioketal group or a halogen atom or an aliphatic-, aromatic- or araliphatic-sulphonyloxy group, by reductive splitting off of the 3-substituent. Preferably, for preparation of #<SP>4</SP>- or #<SP>5(10)</SP>-compounds the 3- thioketals are treated with an alkali metal in liquid ammonia or a C 1-4 aliphatic primary amine, while for preparation of the #<SP>5</SP>-compounds the 3-halo or -sulphonyloxy steroids are treated in the same manner or with an alkali metal in an alcohol or with an alkali metal aluminium hydride. In the products the 17- substituents may be interconverted by standard procedures. Starting materials of the formula wherein R 4 is a cyclic or non-cyclic dithioketal group or (H) (Z) in which Z is a halogen atom or a sulphonyloxy group are prepared by thioketalization of the corresponding 3-keto steroids or esterification of the corresponding 3-ols. #<SP>5</SP> - 3#,17# - Dihydroxy - 7α,18 - dimethylestrene 17-benzoate is prepared by NaBH 4 reduction of #<SP>3</SP>'<SP>5</SP> - 3# - acetoxy - 17# - benzoyloxy- 7α,18 - dimethyl - estradiene, itself prepared by enol acetylation of the corresponding #<SP>4</SP>-3-one. The steroids of the invention are stated to possess progestative, anabolic, androgenic, estrogenio, ovulation-inhibiting and anti-fertilization properties. They may be made up into pharmaceutical compositions with suitable carriers.
[GB1292201A]
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NL6901532A NL6901532A (en) | 1969-01-30 | 1969-01-30 |
Publications (2)
Publication Number | Publication Date |
---|---|
IE33946L IE33946L (en) | 1970-07-30 |
IE33946B1 true IE33946B1 (en) | 1974-12-11 |
Family
ID=19806018
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IE6570A IE33946B1 (en) | 1969-01-30 | 1970-01-19 | New 7-alkyl-steroids |
Country Status (13)
Country | Link |
---|---|
JP (1) | JPS4920577B1 (en) |
BE (1) | BE745266A (en) |
CA (1) | CA933519A (en) |
CH (1) | CH540242A (en) |
DE (1) | DE2004313A1 (en) |
DK (1) | DK129702B (en) |
ES (1) | ES376027A1 (en) |
FR (1) | FR2034509B1 (en) |
GB (1) | GB1292201A (en) |
HU (1) | HU162846B (en) |
IE (1) | IE33946B1 (en) |
NL (1) | NL6901532A (en) |
SE (1) | SE357559B (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5149081U (en) * | 1974-10-09 | 1976-04-13 | ||
JPS5832447U (en) * | 1981-08-27 | 1983-03-03 | トヨタ自動車株式会社 | Automotive engine V-belt deflection measuring device |
US4701450A (en) * | 1984-03-21 | 1987-10-20 | Akzo N.V. | Steroids for use as immunomodulators |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1538958A (en) * | 1964-04-06 | 1968-09-13 | Process for the preparation of gonans | |
BE665515A (en) * | 1964-06-17 |
-
1969
- 1969-01-30 NL NL6901532A patent/NL6901532A/xx unknown
-
1970
- 1970-01-15 CA CA72200A patent/CA933519A/en not_active Expired
- 1970-01-19 IE IE6570A patent/IE33946B1/en unknown
- 1970-01-21 GB GB289570A patent/GB1292201A/en not_active Expired
- 1970-01-26 DK DK34770A patent/DK129702B/en unknown
- 1970-01-27 CH CH115870A patent/CH540242A/en not_active IP Right Cessation
- 1970-01-29 SE SE110170A patent/SE357559B/xx unknown
- 1970-01-29 ES ES376027A patent/ES376027A1/en not_active Expired
- 1970-01-30 BE BE745266D patent/BE745266A/en unknown
- 1970-01-30 HU HUOA000442 patent/HU162846B/hu unknown
- 1970-01-30 JP JP777270A patent/JPS4920577B1/ja active Pending
- 1970-01-30 FR FR7003284A patent/FR2034509B1/fr not_active Expired
- 1970-01-30 DE DE19702004313 patent/DE2004313A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
JPS4920577B1 (en) | 1974-05-25 |
CH540242A (en) | 1973-08-15 |
GB1292201A (en) | 1972-10-11 |
NL6901532A (en) | 1970-08-03 |
IE33946L (en) | 1970-07-30 |
DK129702B (en) | 1974-11-11 |
HU162846B (en) | 1973-04-28 |
CA933519A (en) | 1973-09-11 |
FR2034509B1 (en) | 1974-03-22 |
ES376027A1 (en) | 1972-03-01 |
DE2004313A1 (en) | 1970-08-13 |
BE745266A (en) | 1970-07-30 |
FR2034509A1 (en) | 1970-12-11 |
SE357559B (en) | 1973-07-02 |
DK129702C (en) | 1975-04-21 |
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