GB1282520A - 06-methyl-steroids and processes for their preparation - Google Patents
06-methyl-steroids and processes for their preparationInfo
- Publication number
- GB1282520A GB1282520A GB45060/70A GB4506070A GB1282520A GB 1282520 A GB1282520 A GB 1282520A GB 45060/70 A GB45060/70 A GB 45060/70A GB 4506070 A GB4506070 A GB 4506070A GB 1282520 A GB1282520 A GB 1282520A
- Authority
- GB
- United Kingdom
- Prior art keywords
- steroids
- novel
- influencing
- dimethyl
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Steroid Compounds (AREA)
Abstract
1282520 16-Methyl-pregnane compounds MERCK PATENT GmbH 22 Sept 1970 [15 Nov 1969] 45060/70 Heading C2U Novel steroids of the formula wherein OR is an esterified or etherified hydroxy group and R<SP>1</SP> is F, Cl, Br, CH 3 or CF 3 , and their novel #<SP>4,6</SP>-analogues, are prepared by esterification or etherification of the free 3-ols or reactive derivatives thereof or by solvolysis of corresponding steroids containing a functionally modified 20-keto group. The etherified hydroxy group is defined as one wherein R is C 1-12 alkyl, cycloalkyl, alkenyl, alkynyl, aryl or aralkyl group, optionally substituted. 6α,16α - Dimethyl - 20,20 - ethylenedioxy - 4- pregnen-3#-ol is obtained by ketalizing the hydrochloride of 3-pyrrolidino-6,16α-dimethyl- 3,5-pregnadien-20-onewithethyleneglycol, alkaline splitting to form the 3-ketone and reduction with NaBH 4 . The novel steroids, which are stated to have gestagenic, anti-ovulatory, cycle-influencing, anti-androgenic, gonadotropin-influencing, antiestrogenic and anti-fertility activities, may be made up into pharmaceutical compositions with suitable carriers.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19691957473 DE1957473A1 (en) | 1969-11-15 | 1969-11-15 | 16-methyl steroids and process for their preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1282520A true GB1282520A (en) | 1972-07-19 |
Family
ID=5751167
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB45060/70A Expired GB1282520A (en) | 1969-11-15 | 1970-09-22 | 06-methyl-steroids and processes for their preparation |
Country Status (17)
| Country | Link |
|---|---|
| JP (1) | JPS501271B1 (en) |
| AT (2) | AT324587B (en) |
| BE (1) | BE758843A (en) |
| BR (1) | BR6915400D0 (en) |
| CH (1) | CH549561A (en) |
| CS (1) | CS156510B2 (en) |
| DE (1) | DE1957473A1 (en) |
| DK (1) | DK131608C (en) |
| ES (1) | ES385557A1 (en) |
| FR (1) | FR2073362B1 (en) |
| GB (1) | GB1282520A (en) |
| HU (1) | HU162451B (en) |
| IL (1) | IL35432A (en) |
| NL (1) | NL7013989A (en) |
| PL (1) | PL81132B1 (en) |
| SE (2) | SE364707B (en) |
| ZA (1) | ZA706463B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS54114684U (en) * | 1978-01-28 | 1979-08-11 | ||
| JPH0389670U (en) * | 1989-12-29 | 1991-09-12 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1094258B (en) * | 1959-02-17 | 1960-12-08 | Merck Ag E | Process for the preparation of fluorinated 16-methyl steroids |
-
0
- BE BE758843D patent/BE758843A/en unknown
-
1969
- 1969-11-15 DE DE19691957473 patent/DE1957473A1/en active Pending
- 1969-12-19 BR BR215400/69A patent/BR6915400D0/en unknown
-
1970
- 1970-08-10 CH CH1198370A patent/CH549561A/en not_active IP Right Cessation
- 1970-09-22 ZA ZA706463A patent/ZA706463B/en unknown
- 1970-09-22 GB GB45060/70A patent/GB1282520A/en not_active Expired
- 1970-09-22 NL NL7013989A patent/NL7013989A/xx unknown
- 1970-10-08 DK DK511070A patent/DK131608C/en active
- 1970-10-12 IL IL35432A patent/IL35432A/en unknown
- 1970-10-23 CS CS717470A patent/CS156510B2/cs unknown
- 1970-11-02 PL PL1970144208A patent/PL81132B1/pl unknown
- 1970-11-10 SE SE15151/70A patent/SE364707B/xx unknown
- 1970-11-10 SE SE7305984A patent/SE378826B/xx unknown
- 1970-11-13 AT AT931072*1A patent/AT324587B/en not_active IP Right Cessation
- 1970-11-13 HU HUME1288A patent/HU162451B/hu unknown
- 1970-11-13 AT AT1025270A patent/AT313489B/en not_active IP Right Cessation
- 1970-11-13 FR FR7040683A patent/FR2073362B1/fr not_active Expired
- 1970-11-14 ES ES385557A patent/ES385557A1/en not_active Expired
- 1970-11-14 JP JP45099881A patent/JPS501271B1/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| BE758843A (en) | 1971-05-12 |
| SE364707B (en) | 1974-03-04 |
| HU162451B (en) | 1973-02-28 |
| BR6915400D0 (en) | 1973-03-13 |
| IL35432A (en) | 1974-11-29 |
| FR2073362A1 (en) | 1971-10-01 |
| DE1957473A1 (en) | 1971-05-27 |
| CS156510B2 (en) | 1974-07-24 |
| ZA706463B (en) | 1971-05-27 |
| AT313489B (en) | 1974-02-25 |
| FR2073362B1 (en) | 1974-09-27 |
| DK131608B (en) | 1975-08-11 |
| NL7013989A (en) | 1971-05-18 |
| JPS501271B1 (en) | 1975-01-16 |
| PL81132B1 (en) | 1975-08-30 |
| CH549561A (en) | 1974-05-31 |
| DK131608C (en) | 1976-01-19 |
| ES385557A1 (en) | 1973-03-16 |
| SE378826B (en) | 1975-09-15 |
| IL35432A0 (en) | 1971-04-28 |
| AT324587B (en) | 1975-09-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PLNP | Patent lapsed through nonpayment of renewal fees |