ID30129A - Turunan-turunan tioamida - Google Patents

Turunan-turunan tioamida

Info

Publication number
ID30129A
ID30129A IDW00200101770A ID20011770A ID30129A ID 30129 A ID30129 A ID 30129A ID W00200101770 A IDW00200101770 A ID W00200101770A ID 20011770 A ID20011770 A ID 20011770A ID 30129 A ID30129 A ID 30129A
Authority
ID
Indonesia
Prior art keywords
tioamida
decreases
vcam
vla
asthma
Prior art date
Application number
IDW00200101770A
Other languages
English (en)
Inventor
Kenneth Gregory Hull
Achytharao Sidduri
Jefferson Wright Tilley
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of ID30129A publication Critical patent/ID30129A/id

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/38—Amides of thiocarboxylic acids
    • C07C327/46—Amides of thiocarboxylic acids having carbon atoms of thiocarboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/38—Amides of thiocarboxylic acids
    • C07C327/48—Amides of thiocarboxylic acids having carbon atoms of thiocarboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/56—Amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/30—Oxygen or sulfur atoms
    • C07D233/32—One oxygen atom
    • C07D233/38—One oxygen atom with acyl radicals or hetero atoms directly attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
IDW00200101770A 1999-02-18 2000-02-10 Turunan-turunan tioamida ID30129A (id)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12047599P 1999-02-18 1999-02-18

Publications (1)

Publication Number Publication Date
ID30129A true ID30129A (id) 2001-11-08

Family

ID=22390545

Family Applications (1)

Application Number Title Priority Date Filing Date
IDW00200101770A ID30129A (id) 1999-02-18 2000-02-10 Turunan-turunan tioamida

Country Status (29)

Country Link
US (6) US6288267B1 (id)
EP (1) EP1154993B1 (id)
JP (1) JP2002537286A (id)
KR (1) KR100649819B1 (id)
CN (1) CN1213025C (id)
AT (1) ATE278664T1 (id)
AU (1) AU773388B2 (id)
BR (1) BR0008280A (id)
CA (1) CA2362831C (id)
CZ (1) CZ20012980A3 (id)
DE (1) DE60014588T2 (id)
DK (1) DK1154993T3 (id)
ES (1) ES2228458T3 (id)
HK (1) HK1044330A1 (id)
HR (1) HRP20010595B1 (id)
HU (1) HUP0200155A3 (id)
ID (1) ID30129A (id)
IL (2) IL144636A0 (id)
MA (1) MA26769A1 (id)
NO (1) NO20014018L (id)
NZ (1) NZ513254A (id)
PL (1) PL349461A1 (id)
PT (1) PT1154993E (id)
RU (1) RU2245874C2 (id)
SI (1) SI1154993T1 (id)
TR (1) TR200102399T2 (id)
WO (1) WO2000048994A1 (id)
YU (1) YU58701A (id)
ZA (1) ZA200106180B (id)

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US20090297611A1 (en) * 2003-07-31 2009-12-03 Robinson Cynthia B Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a tyrosine kinase inhibitor, delta opioid receptor antagonist, neurokinin receptor antagonist, or vcam inhibitor for treatment of asthma or chronic obstructive pulmonary disease
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US20050069227A1 (en) * 2003-09-29 2005-03-31 Mark Steele Flexible package having integrated slit member
US20050176755A1 (en) * 2003-10-31 2005-08-11 Dyatkin Alexey B. Aza-bridged-bicyclic amino acid derivatives as alpha4 integrin antagonists
MXPA06009100A (es) * 2004-02-10 2007-02-02 Johnson & Johnson Piridazinonas como antagonistas de integrinas a4.
DE602005002251D1 (de) * 2004-02-10 2007-10-11 Janssen Pharmaceutica Nv Pyridazinonharnstoffe als antagonisten von a4-integrinen
EP1725542A1 (en) * 2004-03-10 2006-11-29 Merck & Co., Inc. Vla-4 antagonists
MX2007001876A (es) * 2004-08-16 2007-05-09 Merck & Co Inc Antagonistas de antigeno muy tardio-4.
US7641325B2 (en) * 2004-10-04 2010-01-05 Kodak Graphic Communications Group Canada Non-conductive fluid droplet characterizing apparatus and method
WO2006081986A1 (en) * 2005-02-07 2006-08-10 F.Hoffmann-La Roche Ag Bambuterol and integrin inhibitor combination
WO2006094640A2 (en) * 2005-03-04 2006-09-14 F.Hoffmann-La Roche Ag Roflumilast and integrin inhibitor combination and method of treatment
CZ2005337A3 (cs) * 2005-05-26 2007-01-10 Universita Karlova v Praze, Farmaceutická fakulta v Hradci Králové Antimykotické a antimykobakteriální thiosalicylanilidy a způsob jejich přípravy
EP1984344B1 (en) * 2005-12-29 2012-09-26 Lexicon Pharmaceuticals, Inc. Multicyclic amino acid derivatives and methods of their use
AU2008219007A1 (en) 2007-02-20 2008-08-28 Merrimack Pharmaceuticals, Inc. Methods of treating multiple sclerosis by administration of alpha-fetoprotein in combination with an integrin antagonist
WO2009061996A2 (en) * 2007-11-07 2009-05-14 Celldex Therapeutics Inc. Antibodies that bind human dendritic and epithelial cell 205 (dec-205)
AU2009234253C1 (en) 2008-04-11 2015-05-07 Merrimack Pharmaceuticals, Inc. Human serum albumin linkers and conjugates thereof
JP5677972B2 (ja) 2008-11-18 2015-02-25 メリマック ファーマシューティカルズ インコーポレーティッド ヒト血清アルブミンリンカーおよびそのコンジュゲート
US8343706B2 (en) * 2010-01-25 2013-01-01 International Business Machines Corporation Fluorine-free fused ring heteroaromatic photoacid generators and resist compositions containing the same
EP2769222A1 (en) 2011-10-17 2014-08-27 Westfälische Wilhelms-Universität Münster Methods of risk assessment of pml and related apparatus
US20150202287A1 (en) 2012-08-30 2015-07-23 Merrimack Pharmaceuticals, Inc. Combination therapies comprising anti-erbb3 agents
AU2019373242B2 (en) 2018-10-30 2023-07-13 Gilead Sciences, Inc. Compounds for inhibition of alpha 4 beta 7 integrin
MX2021005050A (es) 2018-10-30 2021-06-15 Gilead Sciences Inc Derivados de quinolina como inhibidores de integrina alfa4beta7.
WO2020092401A1 (en) 2018-10-30 2020-05-07 Gilead Sciences, Inc. COMPOUNDS FOR INHIBITION OF ALPHA 4β7 INTEGRIN
JP7214882B2 (ja) 2018-10-30 2023-01-30 ギリアード サイエンシーズ， インコーポレイテッド アルファ４ベータ７インテグリン阻害剤としてのイミダゾピリジン誘導体
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Also Published As

Publication number Publication date
US20020052508A1 (en) 2002-05-02
ES2228458T3 (es) 2005-04-16
DE60014588D1 (en) 2004-11-11
US20020040148A1 (en) 2002-04-04
KR20010102243A (ko) 2001-11-15
PT1154993E (pt) 2005-01-31
BR0008280A (pt) 2001-11-06
KR100649819B1 (ko) 2007-02-28
CA2362831A1 (en) 2000-08-24
IL144636A0 (en) 2002-05-23
US6288267B1 (en) 2001-09-11
NO20014018D0 (no) 2001-08-17
HUP0200155A2 (en) 2002-06-29
TR200102399T2 (tr) 2002-01-21
US20020010338A1 (en) 2002-01-24
PL349461A1 (en) 2002-07-29
AU773388B2 (en) 2004-05-27
HRP20010595A2 (en) 2002-08-31
CN1342140A (zh) 2002-03-27
DK1154993T3 (da) 2005-02-14
NO20014018L (no) 2001-08-17
JP2002537286A (ja) 2002-11-05
NZ513254A (en) 2003-10-31
RU2245874C2 (ru) 2005-02-10
US6479666B2 (en) 2002-11-12
DE60014588T2 (de) 2006-02-23
SI1154993T1 (en) 2004-12-31
WO2000048994A1 (en) 2000-08-24
EP1154993B1 (en) 2004-10-06
YU58701A (sh) 2004-05-12
US20010041799A1 (en) 2001-11-15
HRP20010595B1 (en) 2006-02-28
HK1044330A1 (en) 2002-10-18
CZ20012980A3 (cs) 2002-04-17
CN1213025C (zh) 2005-08-03
ZA200106180B (en) 2002-10-28
HUP0200155A3 (en) 2005-04-28
IL144636A (en) 2007-06-17
EP1154993A1 (en) 2001-11-21
US6426348B1 (en) 2002-07-30
MA26769A1 (fr) 2004-12-20
AU2547500A (en) 2000-09-04
US20020028933A1 (en) 2002-03-07
ATE278664T1 (de) 2004-10-15
US6458844B2 (en) 2002-10-01
CA2362831C (en) 2008-10-07
US6423728B1 (en) 2002-07-23

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