HUT48901A - Process for producing 5-substituted-3'-azido-2',3'-dideoxy-ribonukleozides - Google Patents

Process for producing 5-substituted-3'-azido-2',3'-dideoxy-ribonukleozides

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Publication number
HUT48901A
HUT48901A HU610187A HU610187A HUT48901A HU T48901 A HUT48901 A HU T48901A HU 610187 A HU610187 A HU 610187A HU 610187 A HU610187 A HU 610187A HU T48901 A HUT48901 A HU T48901A
Authority
HU
Hungary
Prior art keywords
cpds
azido
ribonukleozides
dideoxy
substituted
Prior art date
Application number
HU610187A
Other languages
Hungarian (hu)
Other versions
HU198949B (en
Inventor
Ottone Szabolcs
Laszlo Oetvoes
Ferencne Tuedoes
Ferenc Varnai
Lajos Gruber
Janos Sagi
Karoly Nagy
Original Assignee
Mta Koezponti Kemiai Kutato In
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mta Koezponti Kemiai Kutato In filed Critical Mta Koezponti Kemiai Kutato In
Priority to HU610187A priority Critical patent/HU198949B/en
Publication of HUT48901A publication Critical patent/HUT48901A/en
Publication of HU198949B publication Critical patent/HU198949B/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

For the prepn. of 5-substd.-3'-azido-2'.3'-di:-dezoxy- ribo-nucleosides of formula (VI) where R is a hydrogen or a halogen, atom, a 1-3C straight or branched gp.; in this case a subst. alkyl and particularly gp.,-cpds. (I) are tritylated to obtain cpds. (II), which are mesylated to cpds. (III). Mesyl-oxy gps. of cpds. are cleaved off cpds. (III) to yield cpds. (IV). These are de-trithylated at room temp. with acetic acid to cpds. (V). Cpds. (V) and alkali-metal anodes form cpds. (VI). The end product is purified by continuous ethyl-acetate extraction.
HU610187A 1987-12-30 1987-12-30 Process for producing 5-substituted-3'azido-2',3'-dideoxyribonucleosides HU198949B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
HU610187A HU198949B (en) 1987-12-30 1987-12-30 Process for producing 5-substituted-3'azido-2',3'-dideoxyribonucleosides

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU610187A HU198949B (en) 1987-12-30 1987-12-30 Process for producing 5-substituted-3'azido-2',3'-dideoxyribonucleosides

Publications (2)

Publication Number Publication Date
HUT48901A true HUT48901A (en) 1989-07-28
HU198949B HU198949B (en) 1989-12-28

Family

ID=10971207

Family Applications (1)

Application Number Title Priority Date Filing Date
HU610187A HU198949B (en) 1987-12-30 1987-12-30 Process for producing 5-substituted-3'azido-2',3'-dideoxyribonucleosides

Country Status (1)

Country Link
HU (1) HU198949B (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994026756A1 (en) * 1993-05-12 1994-11-24 Rhone-Poulenc Chemicals Limited Preparation of fluoro-compounds
WO1994026762A1 (en) * 1993-05-12 1994-11-24 Rhone-Poulenc Chemicals Limited Preparation of fluoro-nucleosides and intermediates for use therein

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994026756A1 (en) * 1993-05-12 1994-11-24 Rhone-Poulenc Chemicals Limited Preparation of fluoro-compounds
WO1994026762A1 (en) * 1993-05-12 1994-11-24 Rhone-Poulenc Chemicals Limited Preparation of fluoro-nucleosides and intermediates for use therein

Also Published As

Publication number Publication date
HU198949B (en) 1989-12-28

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Legal Events

Date Code Title Description
HU90 Patent valid on 900628
HMM4 Cancellation of final prot. due to non-payment of fee