HUP9903379A2 - Improved chemical process for preparing amide derivatives of antibiotic a 40926 - Google Patents
Improved chemical process for preparing amide derivatives of antibiotic a 40926Info
- Publication number
- HUP9903379A2 HUP9903379A2 HU9903379A HUP9903379A HUP9903379A2 HU P9903379 A2 HUP9903379 A2 HU P9903379A2 HU 9903379 A HU9903379 A HU 9903379A HU P9903379 A HUP9903379 A HU P9903379A HU P9903379 A2 HUP9903379 A2 HU P9903379A2
- Authority
- HU
- Hungary
- Prior art keywords
- alkyl
- alk1
- antibiotic
- amide derivatives
- alk3
- Prior art date
Links
- -1 amide derivatives of antibiotic a 40926 Chemical class 0.000 title abstract 4
- 238000001311 chemical methods and process Methods 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 125000003282 alkyl amino group Chemical group 0.000 abstract 3
- 125000002947 alkylene group Chemical group 0.000 abstract 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 3
- 150000001412 amines Chemical class 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000007865 diluting Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Preparation of antibiotic A 40926 amide derivatives of formula (I) comprises reacting a compound of formula (III) with an amine of formula (IV) in an inert organic solvent in the presence of a condensing agent. The initial pH of the mixture, measured after diluting a sample of the reaction mixture with 9 volumes of water, is 6.5 - 9.0. NHR3-alk1-(NR4-alk2)p-(NR5- alk3)q-W (IV). R1 = 9-12C alkyl; M = H, ~a-D-mannopyranosyl or 6-O-acetyl-~a-D-mannopyranosyl; Y = -NR2-alk1-(NR3-alk2)p- (NR4-alk3)q-W; R2 = H or 1-4C alkyl; alk1-alk3 = 2-10C alkylene; p, q = 0 or 1; R3, R4 = H or 1-4C alkyl; or R2+R3 = 2-4C alkylene provided that p = 1; or R3+R4 = 2-4C alkylene provided that p, q = 1; W = H, 1-4C alkyl, amino, mono- or di(1-4C)alkylamino or amino (substituted with one or two amino(2-4C)alkyl, (1-4C)alkylamino(2-4C)alkyl or di(1- 4C)alkylamino(2-4C)alkyl); or when p and q = 0, then W forms a piperazino or 4-methylpiperazino ring with the -NR3-alk1- moiety.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU9903379A HUP9903379A3 (en) | 1997-04-15 | 1997-04-15 | Improved chemical process for preparing amide derivatives of antibiotic a 40926 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU9903379A HUP9903379A3 (en) | 1997-04-15 | 1997-04-15 | Improved chemical process for preparing amide derivatives of antibiotic a 40926 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP9903379A2 true HUP9903379A2 (en) | 2000-02-28 |
| HUP9903379A3 HUP9903379A3 (en) | 2000-06-28 |
Family
ID=89999560
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9903379A HUP9903379A3 (en) | 1997-04-15 | 1997-04-15 | Improved chemical process for preparing amide derivatives of antibiotic a 40926 |
Country Status (1)
| Country | Link |
|---|---|
| HU (1) | HUP9903379A3 (en) |
-
1997
- 1997-04-15 HU HU9903379A patent/HUP9903379A3/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HUP9903379A3 (en) | 2000-06-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX9704433A (en) | Novel process. | |
| AU1722999A (en) | Preparation of 3-substituted adenines and imidazo pyridines | |
| CA2237470A1 (en) | Process for 6-o-alkylation of erythromycin derivatives | |
| HUP9903379A2 (en) | Improved chemical process for preparing amide derivatives of antibiotic a 40926 | |
| TW238304B (en) | A process for the preparation of 1-substituted-5(4H)-tetrazolinones | |
| HUT63395A (en) | Process for producing benzimidazole derivatives usable as thioacylating reagent | |
| AU2386197A (en) | Improved chemical process for preparing amide derivatives of antibiotic a 40926 | |
| AU683790B2 (en) | Nitric esters from derivatives of 2-(2-6-dihalophenylamino) phenylacetoxyacetic acid and their preparation process | |
| AU3934795A (en) | Bicyclic nonane and decane compounds having dopamine receptor affinity | |
| HK1054388A1 (en) | Process for preparing a substituted imidazopyridine compound. | |
| PL323033A1 (en) | Novel substituted 7,10-dioxzabenz[a]antrhracenic compounds, method of obtaining them and pharmaceutic composition containing such compounds | |
| AU681727B2 (en) | Method for the preparation of 2-perfluoroalkyl-3-oxazolin- 5-one | |
| WO2003068726A1 (en) | Amide derivative of alicyclic amine and process for producing the same | |
| JPS5758651A (en) | Preparation of diamino acid derivative | |
| EP0820993A3 (en) | Process for the production of 3-alkoxy-5-alkylpyrazin-2-amines | |
| EP1142892A4 (en) | Processes for the preparation of novel naphthyridine derivatives | |
| CA1251790A (en) | Pyrrolo[1,2-b][1,2,5]triazepines, a process and intermediates for their preparation and their use as medicaments | |
| JPS5610149A (en) | Preparation of nitrotoluene derivative | |
| JPS55120599A (en) | N-methylbleomycins, their preparation, and their intermediates | |
| JPS5690044A (en) | 2- secondary aminoacetyl aniline | |
| TW289756B (en) | Process for preparing cis-CA-cefotaxime as an antibiotic | |
| GB509891A (en) |