HUP9901975A2 - Bisz(indolil)-maleinmid-csoportot tartalmazó makrociklusos vegyületek és alkalmazásuk intermedierként - Google Patents

Bisz(indolil)-maleinmid-csoportot tartalmazó makrociklusos vegyületek és alkalmazásuk intermedierként

Info

Publication number
HUP9901975A2
HUP9901975A2 HU9901975A HUP9901975A HUP9901975A2 HU P9901975 A2 HUP9901975 A2 HU P9901975A2 HU 9901975 A HU9901975 A HU 9901975A HU P9901975 A HUP9901975 A HU P9901975A HU P9901975 A2 HUP9901975 A2 HU P9901975A2
Authority
HU
Hungary
Prior art keywords
indolyl
intermediates
maleimide group
containing bis
macrocycles containing
Prior art date
Application number
HU9901975A
Other languages
English (en)
Inventor
Margaret M. Faul
Christine A. Krumrich
Leonard L. Winneroski
Original Assignee
Eli Lilly And Co.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21725638&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUP9901975(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Eli Lilly And Co. filed Critical Eli Lilly And Co.
Publication of HUP9901975A2 publication Critical patent/HUP9901975A2/hu
Publication of HUP9901975A3 publication Critical patent/HUP9901975A3/hu
Publication of HU225716B1 publication Critical patent/HU225716B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

A találmány tárgyát a (II) általánős képletű vegyületek képezik. A(II) általánős képletben R1 jelentése bróm, jódatőm vagy tőzil-őxi-csőpőrt. A találmány tárgyát képezi tővábbá a (II) általánős képletűvegyületek alkalmazása az N,N'-híddal rendelkező bisz(inidőlil)-maleinmidek előállítására. ŕ
HU9901975A 1995-11-20 1996-11-18 Novel n,n'-bridged bis-indolyl-maleimides HU225716B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US734595P 1995-11-20 1995-11-20
PCT/US1996/018518 WO1997019080A1 (en) 1995-11-20 1996-11-18 Novel intermediates and their use to prepare n,n'-bridged bisindolylmaleimides

Publications (3)

Publication Number Publication Date
HUP9901975A2 true HUP9901975A2 (hu) 1999-11-29
HUP9901975A3 HUP9901975A3 (en) 2000-01-28
HU225716B1 HU225716B1 (en) 2007-07-30

Family

ID=21725638

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9901975A HU225716B1 (en) 1995-11-20 1996-11-18 Novel n,n'-bridged bis-indolyl-maleimides

Country Status (31)

Country Link
EP (1) EP0776899B1 (hu)
JP (2) JP4100708B2 (hu)
KR (1) KR100342142B1 (hu)
CN (1) CN1066734C (hu)
AR (2) AR004719A1 (hu)
AT (1) ATE191219T1 (hu)
AU (1) AU701659B2 (hu)
BR (1) BR9611709A (hu)
CA (1) CA2237401C (hu)
CO (1) CO4750824A1 (hu)
CZ (1) CZ150398A3 (hu)
DE (1) DE69607443T2 (hu)
DK (1) DK0776899T3 (hu)
EA (1) EA000639B1 (hu)
ES (1) ES2145978T3 (hu)
GR (1) GR3033729T3 (hu)
HU (1) HU225716B1 (hu)
IL (1) IL124415A (hu)
MX (1) MX9803791A (hu)
MY (1) MY118946A (hu)
NO (1) NO310195B1 (hu)
NZ (1) NZ323282A (hu)
PE (1) PE17998A1 (hu)
PL (1) PL184728B1 (hu)
PT (1) PT776899E (hu)
TR (1) TR199800876T2 (hu)
TW (1) TW371661B (hu)
UA (1) UA56145C2 (hu)
WO (1) WO1997019080A1 (hu)
YU (1) YU49316B (hu)
ZA (1) ZA969645B (hu)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1070068B2 (en) * 1998-03-13 2007-01-17 The University Of British Columbia Granulatimide derivatives for use in cancer treatment
CA2245029A1 (en) 1998-03-13 1999-09-13 University Of British Columbia Granulatimide compounds as g2 checkpoint inhibitors
US6127401A (en) * 1998-06-05 2000-10-03 Cephalon, Inc. Bridged indenopyrrolocarbazoles
US6300106B1 (en) 2000-11-22 2001-10-09 Ppg Industries Ohio, Inc. Method of preparing 3-[2-{(Methylsulfonyl)oxy}-ethoxy ]-4-(triphenylmethoxy)-1-butanol, methane sulfonate
EP2181999A1 (en) 2008-11-03 2010-05-05 Zentiva, A.S. Method of manufacturing ruboxistarin
WO2023192984A1 (en) * 2022-03-31 2023-10-05 4M Therapeutics Inc. N-desmethyl ruboxistaurin as kinase inhibitor

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5380746A (en) * 1989-05-05 1995-01-10 Goedecke Aktiengesellschaft Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
CA2015996C (en) * 1989-05-05 2001-08-28 Hartmut Osswald Bis-(1h-indol-3-yl)-maleinimide derivatives and their use as pharmaceuticals
US5624949A (en) * 1993-12-07 1997-04-29 Eli Lilly And Company Protein kinase C inhibitors
RU2147304C1 (ru) * 1993-12-07 2000-04-10 Эли Лилли Энд Компани Бис-индолмалеимидные макроциклические производные, способ их получения (варианты) и фармацевтическая композиция
US5559228A (en) * 1995-03-30 1996-09-24 Eli Lilly And Company Synthesis of bisindolylmaleimides

Also Published As

Publication number Publication date
ATE191219T1 (de) 2000-04-15
CA2237401C (en) 2003-10-21
CA2237401A1 (en) 1997-05-29
NO982105D0 (no) 1998-05-08
YU49316B (sh) 2005-06-10
PT776899E (pt) 2000-08-31
EP0776899B1 (en) 2000-03-29
PE17998A1 (es) 1998-04-20
ES2145978T3 (es) 2000-07-16
KR19990067600A (ko) 1999-08-25
EP0776899A1 (en) 1997-06-04
NO982105L (no) 1998-05-08
HUP9901975A3 (en) 2000-01-28
IL124415A0 (en) 1998-12-06
HU225716B1 (en) 2007-07-30
EA199800368A1 (ru) 1998-12-24
GR3033729T3 (en) 2000-10-31
JP4100708B2 (ja) 2008-06-11
AR004718A1 (es) 1999-03-10
UA56145C2 (uk) 2003-05-15
CO4750824A1 (es) 1999-03-31
CN1066734C (zh) 2001-06-06
NZ323282A (en) 1999-01-28
DE69607443T2 (de) 2000-08-10
TW371661B (en) 1999-10-11
EA000639B1 (ru) 1999-12-29
DK0776899T3 (da) 2000-07-10
CN1207740A (zh) 1999-02-10
CZ150398A3 (cs) 1998-12-16
PL326753A1 (en) 1998-10-26
AR004719A1 (es) 1999-03-10
IL124415A (en) 2003-11-23
AU701659B2 (en) 1999-02-04
JP2000500496A (ja) 2000-01-18
WO1997019080A1 (en) 1997-05-29
MY118946A (en) 2005-02-28
NO310195B1 (no) 2001-06-05
MX9803791A (es) 1998-09-30
BR9611709A (pt) 1999-02-23
TR199800876T2 (xx) 1998-08-21
YU61096A (sh) 1999-03-04
AU7738896A (en) 1997-06-11
KR100342142B1 (ko) 2002-08-22
ZA969645B (en) 1998-05-18
PL184728B1 (pl) 2002-12-31
DE69607443D1 (de) 2000-05-04
JP2008138006A (ja) 2008-06-19

Similar Documents

Publication Publication Date Title
FR2421874A1 (fr) Carboxyalkylacylamino-acides utiles comme agents hypotenseurs
NO178189C (no) Tetrazolmellomprodukter
FR2434803A1 (fr) Imides et bis-imides substitues a l'azote, utilisables comme corps intermediaires
FR2371453A1 (fr) Thiadiazolotriazinediones substituees, leur preparation et leur utilisation comme herbicides et comme agents antiviraux et antimicrobiens
FR2392007A1 (fr) 3,3,3-triarylalkyl-4-phenylalkyl-4-hydroxy-piperidines, leurs derives, leur preparation et leur utilisation comme antidiarrheiques et analgesiques
FR2377402A1 (fr) 5h-imidazo(2,1-a)isoindole-2(3h),5-diones et leur utilisation comme herbicides
FR2372817A1 (fr) Derives d'acides thiazolidinecarboxyliques et d'acides apparentes, utiles comme agents anti-hypertension
FR2381762A1 (fr) Dibenzodiazepines utilisables comme antischizophreniques
HUP9901975A2 (hu) Bisz(indolil)-maleinmid-csoportot tartalmazó makrociklusos vegyületek és alkalmazásuk intermedierként
FR2375234A1 (fr) 1,2-dihydro-3h-pyrrolo(1,2-a)pyrrole-1-carboxylates et leur obtention
MX170732B (es) Composicion de derivados de succinimida y su uso
FR2369259A1 (fr) Derives de 3,3-dichloro-2-azetidinone ayant une activite anti-inflammatoire
ES8105053A1 (es) Procedimiento para la preparacion de mezclas de aclaradores opticos
ES8105054A1 (es) Procedimiento para la preparacion de mezclas de aclaradores opticos
FR2355500A1 (fr) Composition antimicrobienne a base de 1-acyloxy-2-imidazolyl-1-phenylethanes
IT8019012A0 (it) Strumento magnetico utile per curare l'impotenza.
FR2389631A1 (hu)
AU589120B2 (en) Multiply-tritiated steroidal-20,17-spirolactones and their use as tracer compounds
FR2445838A1 (fr) Nouveaux 1a,3b-dihydroxy-5-steroides
FR2359116A1 (fr) N-alkyldiphenylamines
FR2446835A1 (fr) Octahydro-2h-pyrrolo(3,4-g)quinoleines utiles comme intermediaires
FR2374311A2 (fr) Nouveaux 1-sulfonylbenzimidazoles 5(6)-substitues, et leur utilisation comme agents antiviraux
FR2397836A1 (fr) Derives de l'oxo-1-dihydro-1,2-isoquinoleine utilises comme agents anti-inflammatoires analgesiques forts
GR82272B (hu)
FR2377406A1 (fr) Composes de tetrathiapentalene et de tetraselenapentalene

Legal Events

Date Code Title Description
MM4A Lapse of definitive patent protection due to non-payment of fees