HUP9901208A2 - (R)-5-Bróm-n-(1-etil-4-metil-hexahidro-1H-1,4-diazepin-6-il)-2-metoxi-6-(metil-amino)-3-piridin-karboxamid, eljárás előállítására és ezt a vegyületet tartalmazó gyógyászati készítmény - Google Patents

(R)-5-Bróm-n-(1-etil-4-metil-hexahidro-1H-1,4-diazepin-6-il)-2-metoxi-6-(metil-amino)-3-piridin-karboxamid, eljárás előállítására és ezt a vegyületet tartalmazó gyógyászati készítmény

Info

Publication number
HUP9901208A2
HUP9901208A2 HU9901208A HUP9901208A HUP9901208A2 HU P9901208 A2 HUP9901208 A2 HU P9901208A2 HU 9901208 A HU9901208 A HU 9901208A HU P9901208 A HUP9901208 A HU P9901208A HU P9901208 A2 HUP9901208 A2 HU P9901208A2
Authority
HU
Hungary
Prior art keywords
same
methylhexahydro
diazepin
carboxamide
bromo
Prior art date
Application number
HU9901208A
Other languages
English (en)
Inventor
Hiroshi Harada
Yoshimi Hirokawa
Shiro Kato
Toshiya Morie
Naoyuki Yoshida
Original Assignee
Dainippon Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dainippon Pharmaceutical Co., Ltd. filed Critical Dainippon Pharmaceutical Co., Ltd.
Publication of HUP9901208A2 publication Critical patent/HUP9901208A2/hu
Publication of HUP9901208A3 publication Critical patent/HUP9901208A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/08—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

A találmány az (I) képletű vegyületre és ennek gyógyászatilagelfőgadható savaddíciós sóira vőnatkőzik. A találmány szerintivegyület kiváló antiemetikűs hatású pőtens szerőtőnin S3 és dőpamin D2receptőr antagőnista hatására tekintettel, így felhasználhatókülönböző megbetegedésekkel és hatóanyagők beadásával együttjárógasztrőintesztinális szimptómák kezelésére vagy megelőzésére. ŕ
HU9901208A 1995-07-28 1996-07-23 (r)-5-bromo-n-(1-ethyl-4-methylhexahydro-1h-1,4-diazepin-6-yl)-2-methoxy-6-methyl-amino-3-pyridine-carboxamide, process for producing the same and medicinal composition containing the same HUP9901208A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP07212495 1995-07-28
PCT/JP1996/002053 WO1997005129A1 (fr) 1995-07-28 1996-07-23 (r)-5-bromo-n-(1-ethyl-4-methylhexahydro-1h-1,4-diazepin-6-yl)-2-methoxy-6-methylamino-3-pyridine-carboxamide, son procede d'obtention et medicament le contenant

Publications (2)

Publication Number Publication Date
HUP9901208A2 true HUP9901208A2 (hu) 2000-04-28
HUP9901208A3 HUP9901208A3 (en) 2002-10-28

Family

ID=16623612

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9901208A HUP9901208A3 (en) 1995-07-28 1996-07-23 (r)-5-bromo-n-(1-ethyl-4-methylhexahydro-1h-1,4-diazepin-6-yl)-2-methoxy-6-methyl-amino-3-pyridine-carboxamide, process for producing the same and medicinal composition containing the same

Country Status (25)

Country Link
US (1) US5945415A (hu)
EP (1) EP0855397B1 (hu)
KR (1) KR19990028395A (hu)
CN (1) CN1096459C (hu)
AT (1) ATE201021T1 (hu)
AU (1) AU700635B2 (hu)
BR (1) BR9609691A (hu)
CA (1) CA2228056A1 (hu)
CZ (1) CZ290442B6 (hu)
DE (1) DE69612753T2 (hu)
DK (1) DK0855397T3 (hu)
ES (1) ES2156616T3 (hu)
GR (1) GR3036089T3 (hu)
HK (1) HK1018049A1 (hu)
HU (1) HUP9901208A3 (hu)
IL (1) IL122753A (hu)
MX (1) MX9800620A (hu)
NO (1) NO312964B1 (hu)
NZ (1) NZ312799A (hu)
PL (1) PL184073B1 (hu)
PT (1) PT855397E (hu)
RU (1) RU2156248C2 (hu)
SK (1) SK282044B6 (hu)
TR (1) TR199800165T1 (hu)
WO (1) WO1997005129A1 (hu)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19650778C2 (de) * 1996-12-06 2001-01-04 Asta Medica Ag Verwendung von Dopaminrezeptor-Antagonisten in der palliativen Tumortherapie
US20040048874A1 (en) * 2001-05-22 2004-03-11 Bardsley Hazel Judith New therapeutic use of 4-(2-fluorophenyl)-6-methyl-2-(1-piperazinyl)thieno[2,3-D]pyrimidine
GB0216027D0 (en) * 2002-07-10 2002-08-21 Arachnova Therapeutics Ltd New therapeutic use
ITBO20020198A1 (it) * 2002-04-12 2003-10-13 Univ Bologna Derivati 2 , 5 bis diammino 1 , 4 benzochenionici utili per il trattamento della malattia di alzheimer , metodo per la loro preparazione ed
ES2285407T3 (es) * 2003-01-13 2007-11-16 Dynogen Pharmaceuticals Inc. Metodo para el tratamiento de nauseas, vomitos, arcadas o cualquiera de sus combinaciones.
KR20050111318A (ko) * 2003-01-13 2005-11-24 다이노젠 파마세우티컬스, 인코포레이티드 기능성 장 질환을 치료하는 방법
US6846823B2 (en) * 2003-04-04 2005-01-25 Dynogen Pharmaceuticals, Inc. Method of treating lower urinary tract disorders
US20060293309A1 (en) * 2005-03-28 2006-12-28 Dynogen Pharmaceuticals, Inc. Method of treating disorders and conditions using peripherally-restricted antagonists and inhibitors
US20120010401A1 (en) 2009-03-31 2012-01-12 Zeria Pharmaceutical Co., Ltd. Method for manufacturing 1,5-benzodiazepine derivative
JP5858917B2 (ja) 2010-08-26 2016-02-10 興和株式会社 イソキノリン誘導体又はその塩の新規製造方法
WO2015114608A1 (en) * 2014-02-03 2015-08-06 Mylan Laboratories Ltd Processes for the preparation of intermediates of raltegravir

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5166341A (en) * 1988-07-29 1992-11-24 Dainippon Pharmaceutical Co., Ltd. 6-amino-1,4-hexahydro-1H-diazepine derivatives
US5017573A (en) * 1988-07-29 1991-05-21 Dainippon Pharmaceutical Co., Ltd. Indazole-3-carboxylic acid derivatives
JPH03223265A (ja) * 1990-01-26 1991-10-02 Dainippon Pharmaceut Co Ltd 環状ジアミン誘導体
JPH04210970A (ja) * 1990-01-26 1992-08-03 Dainippon Pharmaceut Co Ltd ベンズアミド誘導体及びその中間体
PT100990A (pt) * 1991-10-24 1994-01-31 Smithkline Beecham Plc Derivados de piridina e sua utilizacao como substancia terapeutica

Also Published As

Publication number Publication date
DE69612753D1 (de) 2001-06-13
CZ290442B6 (cs) 2002-07-17
MX9800620A (es) 1998-04-30
HUP9901208A3 (en) 2002-10-28
US5945415A (en) 1999-08-31
PL184073B1 (pl) 2002-08-30
NO980333D0 (no) 1998-01-26
PT855397E (pt) 2001-08-30
IL122753A (en) 2000-10-31
CA2228056A1 (en) 1997-02-13
DE69612753T2 (de) 2005-07-07
NO312964B1 (no) 2002-07-22
KR19990028395A (ko) 1999-04-15
EP0855397A4 (en) 1998-12-02
AU700635B2 (en) 1999-01-07
CN1192213A (zh) 1998-09-02
ATE201021T1 (de) 2001-05-15
SK282044B6 (sk) 2001-10-08
EP0855397A1 (en) 1998-07-29
IL122753A0 (en) 1998-08-16
CN1096459C (zh) 2002-12-18
SK9398A3 (en) 1998-08-05
CZ23098A3 (cs) 1998-06-17
TR199800165T1 (xx) 1998-06-22
AU6471796A (en) 1997-02-26
NZ312799A (en) 1999-04-29
EP0855397B1 (en) 2001-05-09
RU2156248C2 (ru) 2000-09-20
WO1997005129A1 (fr) 1997-02-13
BR9609691A (pt) 1999-03-23
ES2156616T3 (es) 2001-07-01
HK1018049A1 (en) 1999-12-10
NO980333L (no) 1998-03-23
PL324749A1 (en) 1998-06-08
GR3036089T3 (en) 2001-09-28
DK0855397T3 (da) 2001-06-25

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