HUP9900327A2 - Eljárás ropivakain-hidroklorid-monohidrát előállítására - Google Patents
Eljárás ropivakain-hidroklorid-monohidrát előállításáraInfo
- Publication number
- HUP9900327A2 HUP9900327A2 HU9900327A HUP9900327A HUP9900327A2 HU P9900327 A2 HUP9900327 A2 HU P9900327A2 HU 9900327 A HU9900327 A HU 9900327A HU P9900327 A HUP9900327 A HU P9900327A HU P9900327 A2 HUP9900327 A2 HU P9900327A2
- Authority
- HU
- Hungary
- Prior art keywords
- preparation
- hydrochloride monohydrate
- ropivacaine hydrochloride
- ropivacaine
- monohydrate
- Prior art date
Links
- NDNSIBYYUOEUSV-RSAXXLAASA-N (S)-ropivacaine hydrochloride (anhydrous) Chemical compound [Cl-].CCC[NH+]1CCCC[C@H]1C(=O)NC1=C(C)C=CC=C1C NDNSIBYYUOEUSV-RSAXXLAASA-N 0.000 title 1
- 229960003691 ropivacaine hydrochloride monohydrate Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B57/00—Separation of optically-active compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9501808A SE9501808D0 (sv) | 1995-05-16 | 1995-05-16 | New process |
PCT/SE1996/000563 WO1996036606A1 (en) | 1995-05-16 | 1996-04-30 | New process for the preparation of ropivacaine hydrochloride monohydrate |
Publications (3)
Publication Number | Publication Date |
---|---|
HUP9900327A2 true HUP9900327A2 (hu) | 1999-05-28 |
HUP9900327A3 HUP9900327A3 (en) | 2001-05-28 |
HU221793B1 HU221793B1 (hu) | 2003-01-28 |
Family
ID=20398325
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU9900327A HU221793B1 (hu) | 1995-05-16 | 1996-04-30 | Eljárás ropivakain-hidroklorid-monohidrát előállítására |
Country Status (34)
Country | Link |
---|---|
US (1) | US5959112A (hu) |
EP (1) | EP0828711B1 (hu) |
JP (1) | JP3079112B2 (hu) |
KR (1) | KR100425232B1 (hu) |
CN (1) | CN1121388C (hu) |
AR (1) | AR002737A1 (hu) |
AT (1) | ATE207900T1 (hu) |
AU (1) | AU696875B2 (hu) |
BR (1) | BR9608820A (hu) |
CA (1) | CA2219308C (hu) |
CZ (1) | CZ290576B6 (hu) |
DE (1) | DE69616543T2 (hu) |
DK (1) | DK0828711T3 (hu) |
EE (1) | EE03394B1 (hu) |
ES (1) | ES2166888T3 (hu) |
HK (1) | HK1009805A1 (hu) |
HU (1) | HU221793B1 (hu) |
IL (1) | IL118178A (hu) |
IN (1) | IN185146B (hu) |
IS (1) | IS1832B (hu) |
MY (1) | MY115018A (hu) |
NO (1) | NO309035B1 (hu) |
NZ (1) | NZ308249A (hu) |
PL (1) | PL184767B1 (hu) |
PT (1) | PT828711E (hu) |
RU (1) | RU2167153C2 (hu) |
SA (1) | SA96160764B1 (hu) |
SE (1) | SE9501808D0 (hu) |
SK (1) | SK281812B6 (hu) |
TR (1) | TR199701362T1 (hu) |
TW (1) | TW340841B (hu) |
UA (1) | UA46770C2 (hu) |
WO (1) | WO1996036606A1 (hu) |
ZA (1) | ZA963545B (hu) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2309350C (en) | 1997-11-12 | 2007-04-03 | Mitsubishi Chemical Corporation | Purine derivatives and medicaments comprising the same as active ingredient |
ES2206227T3 (es) | 1999-05-11 | 2004-05-16 | Mitsubishi Chemical Corporation | Dihidrato de un derivado de purina, farmacos que lo contienen como ingrediente activo, e intermedio en su preparacion. |
AU1037701A (en) * | 1999-10-20 | 2001-04-30 | Smithkline Beecham Plc | Process for the preparation of 4-(fluorophenyl)piperidine esters |
BRPI0104491B8 (pt) * | 2001-10-10 | 2021-05-25 | Cristalia Produtos Quim Farmaceuticos Ltda | n-(2,6-dimetilfenil)-1-propil-2-piperidinocarboxamida; processo de obtenção dos enantiômeros; mistura não racêmica dos anantiômeros e seu processo de obtenção e composição farmacêutica. |
US20060270708A1 (en) * | 2005-05-25 | 2006-11-30 | Navinta Llc | Novel process for preparation of isotonic aqueous injection of ropivacaine |
WO2009044404A1 (en) * | 2007-10-01 | 2009-04-09 | Ramniwas Goel | Process for the preparation of (s)-ropivacaine hydrochloride monohydrate |
CN102093284B (zh) * | 2010-12-29 | 2013-05-08 | 宜昌人福药业有限责任公司 | 富集哌啶-2-甲酰苯胺类旋光化合物的方法 |
WO2014009964A1 (en) * | 2012-07-11 | 2014-01-16 | Neon Laboratories Limited | Process for enantiomeric enrichment of 2 ', 6 ' - pipecoloxylidide |
CN103086954A (zh) * | 2013-02-04 | 2013-05-08 | 山东省医药工业研究所 | 一种制备罗哌卡因的方法 |
CN104003930B (zh) * | 2014-06-13 | 2016-06-08 | 山东金诃药物研究开发有限公司 | 一种盐酸罗哌卡因的制备方法 |
CN113105386B (zh) * | 2021-04-10 | 2022-11-25 | 河北一品制药股份有限公司 | 一种盐酸罗哌卡因一水合物工业化的制备方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE341404B (hu) * | 1967-05-18 | 1971-12-27 | Sterling Drug Inc | |
EP0151110B1 (en) * | 1983-08-01 | 1989-03-01 | Astra Läkemedel Aktiebolag | L-n-n-propylpipecolic acid-2,6-xylidide and method for preparing the same |
SE451840B (sv) * | 1986-01-03 | 1987-11-02 | Astra Laekemedel Ab | Optiskt rent monohydrat av s-(-)-1-propyl-2',6'-pipekoloxylididhydroklorid, sett att framstella denna och farmaceutiska beredningar for lokalbedovning |
-
1995
- 1995-05-16 SE SE9501808A patent/SE9501808D0/xx unknown
-
1996
- 1996-04-19 IN IN837DE1996 patent/IN185146B/en unknown
- 1996-04-30 CA CA002219308A patent/CA2219308C/en not_active Expired - Fee Related
- 1996-04-30 PL PL96323461A patent/PL184767B1/pl unknown
- 1996-04-30 US US08/647,994 patent/US5959112A/en not_active Expired - Lifetime
- 1996-04-30 SK SK1512-97A patent/SK281812B6/sk not_active IP Right Cessation
- 1996-04-30 AT AT96914488T patent/ATE207900T1/de active
- 1996-04-30 ES ES96914488T patent/ES2166888T3/es not_active Expired - Lifetime
- 1996-04-30 KR KR1019970708171A patent/KR100425232B1/ko active IP Right Grant
- 1996-04-30 BR BR9608820A patent/BR9608820A/pt not_active Application Discontinuation
- 1996-04-30 JP JP08534738A patent/JP3079112B2/ja not_active Expired - Lifetime
- 1996-04-30 RU RU97120751/04A patent/RU2167153C2/ru active
- 1996-04-30 EE EE9700301A patent/EE03394B1/xx unknown
- 1996-04-30 TR TR97/01362T patent/TR199701362T1/xx unknown
- 1996-04-30 UA UA97126021A patent/UA46770C2/uk unknown
- 1996-04-30 HU HU9900327A patent/HU221793B1/hu active IP Right Grant
- 1996-04-30 CZ CZ19973452A patent/CZ290576B6/cs not_active IP Right Cessation
- 1996-04-30 NZ NZ308249A patent/NZ308249A/en not_active IP Right Cessation
- 1996-04-30 WO PCT/SE1996/000563 patent/WO1996036606A1/en active IP Right Grant
- 1996-04-30 AU AU57832/96A patent/AU696875B2/en not_active Expired
- 1996-04-30 PT PT96914488T patent/PT828711E/pt unknown
- 1996-04-30 DK DK96914488T patent/DK0828711T3/da active
- 1996-04-30 EP EP96914488A patent/EP0828711B1/en not_active Expired - Lifetime
- 1996-04-30 CN CN96195279A patent/CN1121388C/zh not_active Expired - Lifetime
- 1996-04-30 DE DE69616543T patent/DE69616543T2/de not_active Expired - Lifetime
- 1996-05-03 ZA ZA963545A patent/ZA963545B/xx unknown
- 1996-05-05 SA SA96160764A patent/SA96160764B1/ar unknown
- 1996-05-06 TW TW085105371A patent/TW340841B/zh not_active IP Right Cessation
- 1996-05-07 AR ARP960102486A patent/AR002737A1/es unknown
- 1996-05-07 IL IL11817896A patent/IL118178A/xx not_active IP Right Cessation
- 1996-05-16 MY MYPI96001857A patent/MY115018A/en unknown
-
1997
- 1997-11-04 IS IS4607A patent/IS1832B/is unknown
- 1997-11-13 NO NO975220A patent/NO309035B1/no not_active IP Right Cessation
-
1998
- 1998-09-17 HK HK98110674A patent/HK1009805A1/xx not_active IP Right Cessation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
HFG4 | Patent granted, date of granting |
Effective date: 20021128 |