HUP9900172A2 - Idegrendszeri elváltozások kezelésére alkalmas 10-aciloxi-10,11-dihidrobenz/b,f/azepin-5-karboxamid, előállítása és ezt tartalmazó gyógyszerkészítmény - Google Patents

Idegrendszeri elváltozások kezelésére alkalmas 10-aciloxi-10,11-dihidrobenz/b,f/azepin-5-karboxamid, előállítása és ezt tartalmazó gyógyszerkészítmény

Info

Publication number
HUP9900172A2
HUP9900172A2 HU9900172A HUP9900172A HUP9900172A2 HU P9900172 A2 HUP9900172 A2 HU P9900172A2 HU 9900172 A HU9900172 A HU 9900172A HU P9900172 A HUP9900172 A HU P9900172A HU P9900172 A2 HUP9900172 A2 HU P9900172A2
Authority
HU
Hungary
Prior art keywords
pipe powder
pipe
nervous system
alkyl
powder
Prior art date
Application number
HU9900172A
Other languages
English (en)
Inventor
Jan Benes
Patríció Manuel Vieira Soares Da Silva
Original Assignee
Portela & Ca., S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=20085522&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUP9900172(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Portela & Ca., S.A. filed Critical Portela & Ca., S.A.
Publication of HUP9900172A2 publication Critical patent/HUP9900172A2/hu
Publication of HUP9900172A3 publication Critical patent/HUP9900172A3/hu
Publication of HU221382B1 publication Critical patent/HU221382B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

A találmány tárgya (I) általánős képletnek megfelelő vegyületek ésösszes lehetséges sztereőizőmerjei - a képletében R jelentése hidrőgénatőm, alkil-, aminő-alkil-, halőgén-alkil-,aralkil-, ciklőalkil-, ciklőalkil-alkil-, alkőxi-, fenil- vagyszűbsztitűált fenil- vagy piridőlcsőpőrt, amely csőpőrtőknál azalkilcsőpőrt egyenes vagy elágazó láncú 1-18 szénatőmős, a halőgénatőmjelentése flűőr-, klór-, jód- vagy brómatőm, a ciklőalkilcsőpőrt 3-6szénatőmős aliciklűsős telített csőpőrt, az aralkilcsőpőrt aril-alkil-csőpőrt, ahől az arilcsőpőrt jelentése szűbsztitűálatlan fenilcsőpőrtvagy fenilcsőpőrt, amely alkőxi-, halőgén- vagy nitrőcsőpőrttalszűbsztitűált. A találmány vőnatkőzik tővábbá a fenti (I) általánős képletűvegyületeket hatóanyagként tartalmazó gyógyszerkészítményekre, amelyekalkalmasak a közpőnti és perifériás idegrendszeri betegségekkezelésére. ŕ
HU9900172A 1995-06-30 1996-06-27 10-acyloxy-10,11-dihydrodibenz/b,f/azepine-5-carboxamide compounds useful for treating nervous system disorders, producing it and pharmaceutical compositions HU221382B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PT101732A PT101732B (pt) 1995-06-30 1995-06-30 Novas di-hidrodibenzo<b,f>azepinas substituidas processo para a sua preparacao composicoes farmaceuticas que as contem e utilizacao dos novos compostos na preparacao de composicoes farmaceuticas empregues em doencas do sistema nervoso
PCT/GB1996/001565 WO1997002250A1 (en) 1995-06-30 1996-06-27 10-ACYLOXY-10,11-DIHYDRODIBENZ/b,f/AZEPINE-5-CARBOXAMIDES USEFUL FOR TREATING NERVOUS SYSTEM DISORDERS

Publications (3)

Publication Number Publication Date
HUP9900172A2 true HUP9900172A2 (hu) 1999-04-28
HUP9900172A3 HUP9900172A3 (en) 1999-11-29
HU221382B1 HU221382B1 (en) 2002-09-28

Family

ID=20085522

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9900172A HU221382B1 (en) 1995-06-30 1996-06-27 10-acyloxy-10,11-dihydrodibenz/b,f/azepine-5-carboxamide compounds useful for treating nervous system disorders, producing it and pharmaceutical compositions

Country Status (22)

Country Link
US (1) US5753646A (hu)
EP (1) EP0751129B3 (hu)
JP (2) JP3852984B2 (hu)
KR (1) KR100376603B1 (hu)
CN (1) CN1070853C (hu)
AR (1) AR003962A1 (hu)
AT (1) ATE173468T3 (hu)
AU (1) AU705388B2 (hu)
BR (1) BRPI9602933B8 (hu)
CA (1) CA2180301C (hu)
DE (2) DE122009000049I2 (hu)
DK (1) DK0751129T6 (hu)
ES (1) ES2124612T7 (hu)
FR (1) FR09C0040I2 (hu)
HU (1) HU221382B1 (hu)
NL (1) NL300406I1 (hu)
PL (1) PL185476B1 (hu)
PT (1) PT101732B (hu)
RU (1) RU2168502C2 (hu)
SI (1) SI0751129T1 (hu)
TR (1) TR199701734T1 (hu)
WO (1) WO1997002250A1 (hu)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9930058D0 (en) 1999-12-20 2000-02-09 Novartis Ag Organic compounds
GB0111566D0 (en) 2001-05-11 2001-07-04 Portela & Ca Sa Method for preparation of (s)-(+)-and (r)-(-)-10,11-dihydro-10-hydroxy-5h-dibenz/b,f/azephine-5-carboxamide
GB0112812D0 (en) * 2001-05-25 2001-07-18 Portela & Ca Sa Mthd for preparation of 10, 11-dihydro-10-hydroxy-5H-dibenz/B,F/azepine-5-c arboxamide and 10,11-dihydro-10-oxo-5H-dibenz/B,F/azepine-5-carb oxamide therefrom
EP1446383B1 (en) * 2001-11-12 2008-09-17 Novartis AG Monohydroxycarbamazepine for use in the preparation of a medicament for the treatment of affective and attention disorder and neuropathic pain
EP1528927A1 (en) * 2002-08-06 2005-05-11 Novartis AG Use of carboxamides for the treatment of tinnitus
GB0223224D0 (en) * 2002-10-07 2002-11-13 Novartis Ag Organic compounds
GB0303613D0 (en) * 2003-02-17 2003-03-19 Novartis Ag Use of organic compounds
JP2006517941A (ja) * 2003-02-17 2006-08-03 ノバルティス アクチエンゲゼルシャフト 不安症および双極性障害の処置のための、ｓ−１０−ヒドロキシ−１０，１１−ジヒドロ−カルバマゼピンの使用
TW200501962A (en) * 2003-04-01 2005-01-16 Novartis Ag Use of carbamazepine derivatives for the treatment of agitation in dementia patients
TW200502222A (en) 2003-04-02 2005-01-16 Novartis Ag Use of 10-hydroxy-10,11-dihydrocarbamazepine derivatives for the treatment of affective disorders
GB2401605A (en) * 2003-05-12 2004-11-17 Portela & Ca Sa Method for racemisation of (S)-(+)- and (R)-(-)-10,11-dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide and optically enriched mixtures thereof
GB2416167A (en) * 2004-07-13 2006-01-18 Portela & Ca Sa Chiral inversion and esterification of (S)- and (R)-10-hydroxy-dibenzazepine carboxamides
ITMI20042230A1 (it) * 2004-11-19 2005-02-19 Farchemia Srl Procedimento per la preparazione della 10,11-diidro-10 idrossi-5h-dibenz-b,f-azepin-5carbossiammide
GB2422149A (en) * 2005-01-14 2006-07-19 Portela & Ca Sa Process for the preparation of 10,11-dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide
GB0507298D0 (en) 2005-04-11 2005-05-18 Novartis Ag Organic compounds
WO2006120501A1 (en) * 2005-05-06 2006-11-16 Portela & C.A., S.A. Methods of preparing pharmaceutical compositions comprising eslicarbazepine acetate and methods of use
US20060252745A1 (en) 2005-05-06 2006-11-09 Almeida Jose L D Methods of preparing pharmaceutical compositions comprising eslicarbazepine acetate and methods of use
PT2380575E (pt) * 2005-05-06 2015-06-17 Bial Portela & Ca Sa Acetato de eslicarbazepina e utilização
GB0515690D0 (en) * 2005-07-29 2005-09-07 Portela & Ca Sa Asymmetric catalytic reduction
GB0517740D0 (en) * 2005-08-31 2005-10-12 Novartis Ag Organic compounds
GB0603008D0 (en) * 2006-02-14 2006-03-29 Portela & Ca Sa Method
GB2437078A (en) * 2006-04-11 2007-10-17 Portela & Ca Sa 10-Acyloxy-5H-dibenzo[b,f]azepine-5-carboxamides & their asymmetric hydrogenation to the chiral 10,11-dihydro derivatives
GB0700773D0 (en) * 2007-01-15 2007-02-21 Portela & Ca Sa Drug therapies
US8372431B2 (en) 2007-10-26 2013-02-12 Bial-Portela & C.A., S.A. Pharmaceutical composition comprising licarbazepine acetate
WO2010113179A2 (en) 2009-04-02 2010-10-07 Glenmark Generics Limited A process for the purification of eslicarbazepine acetate
CA2769181C (en) * 2009-07-27 2017-11-28 Bial-Portela & Ca., S.A. Use of 5h-dibenz / b, f/ azepine-5-carboxamide derivatives for treating fibromyalgia
WO2011045648A2 (en) 2009-10-12 2011-04-21 Matrix Laboratories Limited Process for preparing (s)-(-)-10-acetoxy-10,11-dihydro-5h-dibenz[b,f]azepine-5-carboxamide and its esters thereof
WO2011091131A2 (en) * 2010-01-23 2011-07-28 Dr. Reddy's Laboratories Ltd. Eslicarbazepine acetate and its polymorphs
WO2011117885A1 (en) * 2010-03-23 2011-09-29 Intas Pharmaceuticals Limited Process for preparation of enantiomers of licarbazepine
EP2383261B1 (en) 2010-04-23 2013-09-04 Euticals GmbH Process for the asymmetric hydrogenation of ketones
WO2011138795A2 (en) * 2010-05-03 2011-11-10 Msn Laboratories Limited Process for preparing (s)-10-acetoxy-10,11-dihydro-5h-dibenz[b,f] azepine-5-carboxamide
UA115420C2 (uk) 2010-12-31 2017-11-10 Біал-Портела Енд Ка., С.А. Тверда фармацевтична композиція у формі гранул, що містить езлікарбазепіну ацетат
WO2012121701A1 (en) * 2011-03-07 2012-09-13 Watson Laboratories, Inc. Process for the resolution of racemic (±)-10,11-dihydro-10-hydroxy-5h-dibenz[b,f]azepine-5-carboxamide
WO2012120356A2 (en) 2011-03-08 2012-09-13 Jubilant Life Sciences Limited Process for the preparation of (s)-(+)-or (r)-(-)-10 hydroxy dihydrodibenz[b,f]azepines by enantioselective reduction of 10, 11-dihydro-10-oxo-5h-dibenz[b,f]azepines and polymorphs thereof
WO2012142302A2 (en) 2011-04-13 2012-10-18 Codexis, Inc. Biocatalytic process for preparing eslicarbazepine and analogs thereof
US20150065704A1 (en) 2011-07-13 2015-03-05 Ketan Hirpara Process for the preparation and purification of eslicarbazepine acetate and intermediates thereof
CA2847235C (en) 2011-08-26 2020-07-07 Bial - Portela & Ca, S.A. Treatments involving eslicarbazepine acetate or eslicarbazepine
EP2847169A4 (en) * 2012-05-07 2015-09-30 Cellix Bio Private Ltd COMPOSITIONS AND METHODS FOR TREATING NEUROLOGICAL DISORDERS
EP2900640A1 (en) 2012-09-26 2015-08-05 Ranbaxy Laboratories Limited Process for the preparation of oxcarbazepine and its use as intermediate in the preparation of eslicarbazepine acetate
CA2976314C (en) * 2014-09-26 2021-02-23 Cellix Bio Private Limited Compositions and methods for the treatment of epilepsy and neurological disorders
CN105384689B (zh) * 2014-12-24 2017-10-31 开封制药(集团)有限公司 一种改进的醋酸艾司利卡西平的合成方法
EP3064490A1 (en) 2015-03-06 2016-09-07 F.I.S.- Fabbrica Italiana Sintetici S.p.A. Improved process for the preparation of eslicarbazepine and eslicarbazepine acetate
CN105130899A (zh) * 2015-08-25 2015-12-09 安徽省新星药物开发有限责任公司 一种醋酸艾司利卡西平的合成方法
PT3402488T (pt) 2015-12-18 2022-01-25 Jubilant Generics Ltd Formas de dosagem orais sólidas de eslicarbazepina
CN106588773B (zh) * 2016-11-10 2019-09-27 北京现代药物代谢研究院 一种脑靶向艾司利卡西平酯类前药及其应用
AU2019348194A1 (en) 2018-09-28 2021-04-29 Griffith University Agents and methods for modulating pathogen activity

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH500196A (de) * 1969-03-10 1970-12-15 Ciba Geigy Ag Verfahren zur Herstellung von neuen Azepinderivaten
CH505101A (de) * 1969-03-31 1971-03-31 Ciba Geigy Ag Verfahren zur Herstellung von neuen Azepinderivaten
FI75561C (fi) * 1979-10-30 1988-07-11 Ciba Geigy Ag Foerfarande foer framstaellning av 5- karbamoyl-10-oxo-10,11-dihydro-5h-dibens/b,f/azepin och daertill noedvaendiga mellanprodukter.
CH649080A5 (de) * 1981-04-16 1985-04-30 Ciba Geigy Ag 5h-dibenz(b,f)azepin-5-carboxamide als mittel zur prophylaxe und behandlung von zerebraler leistungsinsuffizienz.
DD218889B3 (de) * 1983-11-09 1992-11-05 Dresden Arzneimittel Verfahren zur herstellung neuer 5-carbamoyl-10,11-dihydro-5h-dibenz|b,f¨azepine
US5466683A (en) * 1994-08-25 1995-11-14 Teva Pharmaceutical Industries Ltd. Water-soluble analogs of carbamazepine

Also Published As

Publication number Publication date
AU705388B2 (en) 1999-05-20
ATE173468T3 (de) 1998-12-15
JP3852984B2 (ja) 2006-12-06
HUP9900172A3 (en) 1999-11-29
DE122009000049I1 (de) 2010-01-21
KR19990028464A (ko) 1999-04-15
DE69600985D1 (de) 1998-12-24
CN1070853C (zh) 2001-09-12
DE69600985T2 (de) 1999-04-15
DK0751129T3 (da) 1999-08-02
DE69600985T3 (de) 2020-09-24
DK0751129T6 (da) 2020-05-25
CA2180301C (en) 2004-02-10
AU6310696A (en) 1997-02-05
PL185476B1 (pl) 2003-05-30
PT101732B (pt) 1997-12-31
FR09C0040I1 (hu) 2009-10-30
CA2180301A1 (en) 1996-12-31
ES2124612B5 (hu) 2019-01-28
PL324313A1 (en) 1998-05-25
CN1193965A (zh) 1998-09-23
SI0751129T1 (en) 1999-02-28
WO1997002250A1 (en) 1997-01-23
KR100376603B1 (ko) 2003-12-18
PT101732A (pt) 1997-01-31
EP0751129B1 (en) 1998-11-18
ES2124612T3 (es) 1999-02-01
EP0751129A1 (en) 1997-01-02
RU2168502C2 (ru) 2001-06-10
EP0751129B3 (en) 2020-05-13
ES2124612T7 (es) 2020-07-20
TR199701734T1 (xx) 1998-04-21
US5753646A (en) 1998-05-19
HU221382B1 (en) 2002-09-28
JP2004256516A (ja) 2004-09-16
AR003962A1 (es) 1998-09-30
FR09C0040I2 (hu) 2011-04-01
JPH09110836A (ja) 1997-04-28
BR9602933B1 (pt) 2013-06-11
NL300406I1 (nl) 2009-11-02
BRPI9602933B8 (pt) 2022-01-18
DE122009000049I2 (de) 2011-01-13
BR9602933A (pt) 1998-04-28

Similar Documents

Publication Publication Date Title
HUP9900172A2 (hu) Idegrendszeri elváltozások kezelésére alkalmas 10-aciloxi-10,11-dihidrobenz/b,f/azepin-5-karboxamid, előállítása és ezt tartalmazó gyógyszerkészítmény
HUP9600448A2 (hu) Naftilvegyületek, e vegyületeket tartalmazó gyógyszerkészítmények, eljárás előállításukra, intermedierjeik és alkalmazásuk
HUP9802637A2 (hu) A központi idegrendszerre ható szemikarbazonok és ezeket tartalmazó gyógyászati készítmények és eljárás előállításukra
HUP9800417A2 (hu) 5-Szubsztituált-3-(1,2,3,6-tetrahidro-piridin-4-il)-1H-indolok és 5-szubsztituált-3-(piridin-4-il)-1H-indolok, alkalmazásuk mint új 5-HT agonisták, a vegyületeket tartalmazó gyógyszerkészítmények
HUP0203312A2 (hu) Farmakológiailag hatékony szulfonamidszármazékok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
HUP0100702A2 (hu) Gyulladásgátló oxadiazolil-adenozin származékok, eljárás előállításukra és köztitermékeik
SE0104334D0 (sv) Therapeutic agents
NO170280C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive sulfamatderivater
HUP0401097A2 (hu) Karbociklusos hidrazinovegyületek, mint a réztartalmú aminoxidázok inhibitorai, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények
HUP0301625A2 (hu) Réztartalmú amin-oxidáz inhibitor hatású 1,3,4-oxadiazin-vegyületek, eljárás az előállításukra és alkalmazásuk gyógyszerkészítmények előállítására
HUP0004596A2 (hu) Szerotonin 1A receptorra hatással lévő arilpiperazinok és a vegyületeket tartalmazó gyógyászati készítmények valamint intermedierjeik
HUP9802937A2 (hu) Benzo[g]kinolin-származékok, e vegyületeket tartalmazó gyógyászati készítmények, eljárás előállításukra és alkalmazásuk
DE69827853D1 (de) Verwendung von ibudilast zur herstellung eines arzneimittels zur behandlung multiple sklerose
BG104983A (en) Aryl fused azapolycyclic compounds
HUP0001093A2 (hu) 5-HT2A-antagonista oxazolidinon-származékok, az ezeket tartalmazó gyógyszerkészítmények és eljárás előállításukra
DE3462894D1 (de) 3-indolecarboxamide compounds
BG103207A (en) Esters of the arylcycloalkanecarboxylic acids, their application, pharmaceutical compositions and their preparation
DE69501359D1 (de) Verwendung von Phosphatdiestern zur Behandlung von Erkrankungen der Retina
HUP0004007A2 (hu) Új policiklusos azaindolszármazékok, eljárás előállításukra és ilyen vegyületeket tartalmazó gyógyászati készítmények
KR970706826A (ko) 포스포디에스테라제 IV 억제제로서의 디아제피노-인돌(Diazepino-Indoles as Phosphodiesterase Ⅳ Inhibitors)
ATE173252T1 (de) Arylmorpholine, herstellung und verwendung
HUP0101733A2 (hu) Szulfonil dipeptideket tartalmazó gyógyszerkészítmények és alkalmazásuk
ATE245419T1 (de) Verwendung von benzofuroxanderivaten zur behandlung von angina pectoris
HUP0003127A2 (hu) Helyetesített heterogyűrűs vegyületek, eljárás előállításukra, valamint ezeket tartalmazó gyógyászati készítmények
MX9707596A (es) Benzamidas, el uso de las mismas, composiciones que las contienen, para el tratamiento del transtorno neurodegenerativo, y procedimiento para la preparacion del mismo.

Legal Events

Date Code Title Description
HC9A Change of name, address

Owner name: BIAL-PORTELA & CA, S.A., PT

Free format text: FORMER OWNER(S): PORTELA & CA., S.A., PT

AA1S Information on application for a supplementary protection certificate

Free format text: PRODUCT NAME: ESLICARBAZEPINE ACETATE; REG. NO/DATE: EU/1/09/514/001-020 20090421

Spc suppl protection certif: S0900016

Filing date: 20091012

Expiry date: 20160627

Free format text: PRODUCT NAME: ESLICARBAZEPINE ACETATE-ZEBINIX ; NATIONAL REGISTRATION NUMBER AND DATE: EU/1/09/514/001-020*2009.04.21

Spc suppl protection certif: S0900016

Filing date: 20091012

Expiry date: 20160627

FG4S Grant of supplementary protection certificate

Free format text: PRODUCT NAME: ESLICARBAZEPINE ACETATE; REG. NO/DATE: EU/1/09/514/001-020 20090421

Spc suppl protection certif: S0900016

Filing date: 20091012

Expiry date: 20160627

Extension date: 20210627