HUP9802857A2 - 4-mercaptopyrrolidine derivatives as farnesyl transferase inhibitors, process for producing them and pharmaceutical compositions containing them - Google Patents
4-mercaptopyrrolidine derivatives as farnesyl transferase inhibitors, process for producing them and pharmaceutical compositions containing themInfo
- Publication number
- HUP9802857A2 HUP9802857A2 HU9802857A HUP9802857A HUP9802857A2 HU P9802857 A2 HUP9802857 A2 HU P9802857A2 HU 9802857 A HU9802857 A HU 9802857A HU P9802857 A HUP9802857 A HU P9802857A HU P9802857 A2 HUP9802857 A2 HU P9802857A2
- Authority
- HU
- Hungary
- Prior art keywords
- compounds
- tube atomizer
- producing
- pharmaceutical compositions
- compositions containing
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 239000003528 protein farnesyltransferase inhibitor Substances 0.000 title 1
- TZVFQFLWFZUIQS-UHFFFAOYSA-N pyrrolidine-3-thiol Chemical class SC1CCNC1 TZVFQFLWFZUIQS-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 230000006126 farnesylation Effects 0.000 abstract 2
- 238000002360 preparation method Methods 0.000 abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 101710170766 Fibulin-5 Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 102000004357 Transferases Human genes 0.000 abstract 1
- 108090000992 Transferases Proteins 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 125000004030 farnesyl group Chemical group [H]C([*])([H])C([H])=C(C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrrole Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
A találmány őlyan vegyületekre vőnatkőzik, amelyek a farnezil-fehérjetranszferáz (FPT-áz) enzim működésének gátlása révén gátőlják a műtánsras géntermékek farnezileződését. A találmány tárgyát képezik avegyületek előállítására szőlgáló eljárásők is. A találmány tárgyátképezi tővábbá a vegyületeket tartalmazó gyógyászati készítmények,valamint azők felhasználása a ras farnezileződésével közvetítettbetegsgéek (elsősőrban rákős betegségek) kezelésében. A találmány szerinti gyógyászati készítmények hatóanyagai az (I)általánős képletű vegyületek - a képletben R1, R2 és R3 hidrőgénatőmőtvagy szerves csőpőrtőt jelent, p értéke 0-3, L egy kapcsőló csőpőrtőtjelent, és A fenilcsőpőrtőt, naftilcsőpőrtőt vagy mőnő- vagybiciklűsős heterőarilcsőpőrtőt képvisel. ŕThe invention is based on compounds that inhibit the farnesylation of the dance gene products by inhibiting the function of the farnesyl protein transferase (FPT-ase) enzyme. The subject of the invention is also the processes for the production of the compounds. The subject of the invention further transforms the medicinal preparations containing the compounds, as well as their use in the treatment of diseases mediated by ras farnesylation (primarily cancer diseases). The active ingredients of the medicinal preparations according to the invention are the compounds of the general formula (I) - in the formula, R1, R2 and R3 represent a hydrogen atom or an organic tube atomizer, the value of p is 0-3, L is a cleavable tube atomizer, and A represents a phenyl tube atomizer, a naphthyl tube atomizer, or a mono- or bicyclic heteroaryl tube atomizer. ŕ
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9515975.2A GB9515975D0 (en) | 1995-08-04 | 1995-08-04 | Chemical compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP9802857A2 true HUP9802857A2 (en) | 1999-04-28 |
| HUP9802857A3 HUP9802857A3 (en) | 1999-05-28 |
Family
ID=10778742
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9802857A HUP9802857A3 (en) | 1995-08-04 | 1996-07-30 | 4-mercaptopyrrolidine derivatives as farnesyl transferase inhibitors, process for producing them and pharmaceutical compositions containing them |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US6232338B1 (en) |
| EP (1) | EP0842151A1 (en) |
| JP (1) | JPH11510178A (en) |
| KR (1) | KR100502770B1 (en) |
| CN (2) | CN1101380C (en) |
| AU (1) | AU720353B2 (en) |
| BR (1) | BR9609701A (en) |
| CA (1) | CA2226671C (en) |
| CZ (1) | CZ293694B6 (en) |
| GB (1) | GB9515975D0 (en) |
| HU (1) | HUP9802857A3 (en) |
| IL (1) | IL123155A0 (en) |
| MX (1) | MX9800946A (en) |
| MY (1) | MY141457A (en) |
| NO (2) | NO316624B1 (en) |
| NZ (1) | NZ313696A (en) |
| PL (1) | PL190873B1 (en) |
| RU (1) | RU2191773C2 (en) |
| SK (1) | SK14598A3 (en) |
| TR (2) | TR199800147T1 (en) |
| TW (1) | TW345575B (en) |
| WO (1) | WO1997006138A1 (en) |
| ZA (1) | ZA966610B (en) |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6310095B1 (en) | 1995-11-06 | 2001-10-30 | University Of Pittsburgh | Inhibitors of protein isoprenyl transferases |
| US6204293B1 (en) | 1995-11-06 | 2001-03-20 | University Of Pittsburgh | Inhibitors of protein isoprenyl transferases |
| US6693123B2 (en) | 1995-11-06 | 2004-02-17 | University Of Pittsburgh | Inhibitors of protein isoprenyl transferases |
| US6221865B1 (en) | 1995-11-06 | 2001-04-24 | University Of Pittsburgh | Inhibitors of protein isoprenyl transferases |
| WO1998007692A1 (en) * | 1996-08-17 | 1998-02-26 | Zeneca Limited | 3-mercaptopyrrolidines as farnesyl protein transferase inhibitors |
| CA2288330C (en) | 1997-05-07 | 2014-02-11 | University Of Pittsburgh | Benzoyl amino acid derivatives useful as inhibitors of protein isoprenyl tranferases |
| JP2001520222A (en) | 1997-10-22 | 2001-10-30 | ゼネカ・リミテッド | Imidazole derivatives and their use as farnesyl protein transferase inhibitors |
| DK1025088T3 (en) | 1997-10-22 | 2001-11-12 | Astrazeneca Ab | Imidazole derivatives and their use as farnesyl protein transferase inhibitors |
| WO1999041235A1 (en) * | 1998-02-10 | 1999-08-19 | Astrazeneca Uk Limited | Farnesyl transferase inhibitors |
| GB9930317D0 (en) * | 1999-12-22 | 2000-02-09 | Zeneca Ltd | Novel compounds |
| GB9930318D0 (en) | 1999-12-22 | 2000-02-09 | Zeneca Ltd | Novel compounds |
| US6924276B2 (en) | 2001-09-10 | 2005-08-02 | Warner-Lambert Company | Diacid-substituted heteroaryl derivatives as matrix metalloproteinase inhibitors |
| ITRM20020016A1 (en) * | 2002-01-15 | 2003-07-15 | Sigma Tau Ind Farmaceuti | FENYL ACID DERIVATIVES (ALCHYL) CARBOXYL AND DYNIC PHENYLALKYL THEROCYCLIC DERIVATIVES, THEIR USE AS MEDICATIONS WITH HYPOGLYCEMIC ACTIVITY |
| US7132100B2 (en) | 2002-06-14 | 2006-11-07 | Medimmune, Inc. | Stabilized liquid anti-RSV antibody formulations |
| US7425618B2 (en) | 2002-06-14 | 2008-09-16 | Medimmune, Inc. | Stabilized anti-respiratory syncytial virus (RSV) antibody formulations |
| EP1539234A4 (en) * | 2002-09-05 | 2006-02-15 | Medimmune Inc | Methods of preventing or treating cell malignancies by administering cd2 antagonists |
| US8034831B2 (en) * | 2002-11-06 | 2011-10-11 | Celgene Corporation | Methods for the treatment and management of myeloproliferative diseases using 4-(amino)-2-(2,6-Dioxo(3-piperidyl)-isoindoline-1,3-dione in combination with other therapies |
| US7563810B2 (en) * | 2002-11-06 | 2009-07-21 | Celgene Corporation | Methods of using 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myeloproliferative diseases |
| EP2316487B1 (en) | 2003-04-11 | 2014-06-11 | MedImmune, LLC | Recombinant IL-9 antibodies & uses thereof |
| JP4934426B2 (en) | 2003-08-18 | 2012-05-16 | メディミューン，エルエルシー | Antibody humanization |
| US20060228350A1 (en) * | 2003-08-18 | 2006-10-12 | Medimmune, Inc. | Framework-shuffling of antibodies |
| EP1667991B1 (en) | 2003-09-16 | 2008-05-14 | Astrazeneca AB | Quinazoline derivatives as tyrosine kinase inhibitors |
| WO2005089515A2 (en) * | 2004-03-18 | 2005-09-29 | The Brigham And Women's Hospital, Inc. | Methods for the treatment of synucleinopathies |
| WO2005089502A2 (en) * | 2004-03-18 | 2005-09-29 | The Brigham And Women's Hospital, Inc. | Methods for the treatment of synucleinopathies |
| WO2005089504A2 (en) * | 2004-03-18 | 2005-09-29 | The Brigham And Women's Hospital, Inc. | Methods for the treatment of synucleinopathies |
| US20070293539A1 (en) * | 2004-03-18 | 2007-12-20 | Lansbury Peter T | Methods for the treatment of synucleinopathies |
| WO2005089496A2 (en) * | 2004-03-18 | 2005-09-29 | The Brigham And Women's Hospital, Inc. | Methods for the treatment of synucleinopathies |
| EP2422811A2 (en) | 2004-10-27 | 2012-02-29 | MedImmune, LLC | Modulation of antibody specificity by tailoring the affinity to cognate antigens |
| JP5153613B2 (en) | 2005-03-18 | 2013-02-27 | メディミューン，エルエルシー | Antibody framework shuffle |
| KR20080025174A (en) | 2005-06-23 | 2008-03-19 | 메디뮨 인코포레이티드 | Antibody formulations having optimized aggregation and fragmentation profiles |
| WO2007092285A2 (en) * | 2006-02-02 | 2007-08-16 | Link Medicine Corporation | Treatment of synucleinopathies |
| JP5209625B2 (en) | 2006-08-28 | 2013-06-12 | 協和発酵キリン株式会社 | Antagonist human LIGHT specific human monoclonal antibody |
| AU2008232902B2 (en) | 2007-03-30 | 2013-10-03 | Medlmmune, Llc | Antibody formulation |
| CN101376656A (en) * | 2007-08-30 | 2009-03-04 | 山东轩竹医药科技有限公司 | Penem derivative |
| KR101686247B1 (en) | 2007-10-31 | 2016-12-14 | 메디뮨 엘엘씨 | Protein scaffolds |
| US8232402B2 (en) * | 2008-03-12 | 2012-07-31 | Link Medicine Corporation | Quinolinone farnesyl transferase inhibitors for the treatment of synucleinopathies and other indications |
| EP2370436A1 (en) * | 2008-11-13 | 2011-10-05 | Link Medicine Corporation | Azaquinolinone derivatives and uses thereof |
| US20110060005A1 (en) * | 2008-11-13 | 2011-03-10 | Link Medicine Corporation | Treatment of mitochondrial disorders using a farnesyl transferase inhibitor |
| US20100331363A1 (en) * | 2008-11-13 | 2010-12-30 | Link Medicine Corporation | Treatment of mitochondrial disorders using a farnesyl transferase inhibitor |
| JP2012520884A (en) | 2009-03-18 | 2012-09-10 | ザ ボード オブ トラスティーズ オブ ザ リランド スタンフォード ジュニア ユニバーシティー | Methods and compositions for treating flaviviridae viral infections |
| DK2668210T3 (en) | 2011-01-26 | 2020-08-24 | Celldex Therapeutics Inc | ANTI-KIT ANTIBODIES AND USES THEREOF |
| US9250552B2 (en) * | 2011-03-30 | 2016-02-02 | Canon Kabushiki Kaisha | Polymerizable monomer, polymeric compound, charge control agent containing the polymeric compound, and developer bearing member and toner which contain the charge control agent |
| CN116574185A (en) | 2012-07-25 | 2023-08-11 | 塞尔德克斯医疗公司 | anti-KIT antibodies and uses thereof |
| CA2887129A1 (en) | 2012-10-09 | 2014-04-17 | Igenica, Inc. | Anti-c16orf54 antibodies and methods of use thereof |
| SG11201509982UA (en) | 2013-06-06 | 2016-04-28 | Igenica Biotherapeutics Inc | |
| DK3041507T3 (en) | 2013-08-26 | 2021-07-26 | Biontech Res And Development Inc | NUCLEIC ACIDS ENCOODING HUMAN ANTIBODIES TO SIALYL-LEWIS A |
| GB201403775D0 (en) | 2014-03-04 | 2014-04-16 | Kymab Ltd | Antibodies, uses & methods |
| KR102614642B1 (en) | 2014-06-04 | 2023-12-19 | 바이오엔테크 리서치 앤드 디벨롭먼트 인코포레이티드 | Human monoclonal antibodies to ganglioside gd2 |
| PT3333191T (en) | 2014-12-11 | 2020-12-15 | Pf Medicament | Anti-c10orf54 antibodies and uses thereof |
| BR112017015880A2 (en) | 2015-03-03 | 2018-07-31 | Kymab Ltd | antibodies, uses and methods |
| EP3319938B1 (en) * | 2015-07-10 | 2022-04-06 | University of Maryland, Baltimore | Small molecule inhibitors of the mcl-1 oncoprotein and uses thereof |
| EP3909983A1 (en) | 2015-12-02 | 2021-11-17 | STCube & Co. Inc. | Antibodies and molecules that immunospecifically bind to btn1a1 and the therapeutic uses thereof |
| KR20180100122A (en) | 2015-12-02 | 2018-09-07 | 주식회사 에스티사이언스 | Antibodies specific for glycated BTLA (B- and T-lymphocyte weakening factor) |
| EP3534947A1 (en) | 2016-11-03 | 2019-09-11 | Kymab Limited | Antibodies, combinations comprising antibodies, biomarkers, uses & methods |
| CN111051346A (en) | 2017-05-31 | 2020-04-21 | 斯特库伯株式会社 | Methods of treating cancer using antibodies and molecules that immunospecifically bind to BTN1a1 |
| KR20200015602A (en) | 2017-05-31 | 2020-02-12 | 주식회사 에스티큐브앤컴퍼니 | Antibodies and molecules immunospecifically binding to BTN1A1 and therapeutic uses thereof |
| EP3635007A1 (en) | 2017-06-06 | 2020-04-15 | STCube & Co., Inc. | Methods of treating cancer using antibodies and molecules that bind to btn1a1 or btn1a1-ligands |
| US11707522B2 (en) | 2017-10-13 | 2023-07-25 | Boehringer Ingelheim International Gmbh | Human antibodies to Tn antigen |
| EP3824287A1 (en) | 2018-07-20 | 2021-05-26 | Pierre Fabre Médicament | Receptor for vista |
| GB201908453D0 (en) * | 2019-06-12 | 2019-07-24 | Enterprise Therapeutics Ltd | Compounds for treating respiratory disease |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1283906C (en) | 1983-05-09 | 1991-05-07 | Makoto Sunagawa | .beta.-LACTAM COMPOUNDS AND PRODUCTION THEREOF |
| JPS60233076A (en) | 1984-05-03 | 1985-11-19 | Sumitomo Chem Co Ltd | Novel beta-lactam and its preparation |
| DE3579888D1 (en) | 1984-11-08 | 1990-10-31 | Sumitomo Pharma | CARBAPENE COMPOUNDS AND THEIR PRODUCTION. |
| KR880006244A (en) | 1986-11-24 | 1988-07-22 | 후지사와 도모 기찌 로 | 3-Pyrrolidinylthio-1-azabibischloro [3.2.0] hapt2-ene-2-carboxylic acid compound and preparation method thereof |
| GB8921635D0 (en) | 1989-09-25 | 1989-11-08 | Fujisawa Pharmaceutical Co | 3-pyrrolidinylthio-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid derivatives |
| CA2036163C (en) | 1990-02-14 | 2001-06-19 | Makoto Sunagawa | Novel beta-lactam compounds and their production |
| IE910606A1 (en) | 1990-02-23 | 1991-08-28 | Sankyo Co | Carbapenem derivatives having antibiotic activity, their¹preparation and their use |
| GB9107363D0 (en) | 1991-04-08 | 1991-05-22 | Ici Plc | Antibiotic compounds |
| US6083917A (en) * | 1990-04-18 | 2000-07-04 | Board Of Regents, The University Of Texas System | Methods and compositions for the identification, characterization and inhibition of farnesyltransferase |
| US5185248A (en) | 1990-05-08 | 1993-02-09 | E. R. Squibb & Sons, Inc. | Farnesyl-protein transferase assay for identifying compounds that block neoplastic transformation |
| JPH0578360A (en) | 1991-01-31 | 1993-03-30 | Banyu Pharmaceut Co Ltd | 2-(2-(sulfamoylallkyl)pyrrolidinylthio)carbapenem derivative |
| GB9107341D0 (en) | 1991-04-08 | 1991-05-22 | Ici Plc | Antibiotic compounds |
| GB9107342D0 (en) | 1991-04-08 | 1991-05-22 | Ici Plc | Antibiotic compounds |
| RU2093514C1 (en) | 1991-06-04 | 1997-10-20 | Санкио Компани Лимитед | 1-methylcarbapenem derivatives and method of preparation thereof |
| JPH04368386A (en) | 1991-06-18 | 1992-12-21 | Sankyo Co Ltd | Production of 1-methylcarbapenem-3-carboxylic acid |
| US5360798A (en) | 1991-07-04 | 1994-11-01 | Shionogi Seiyaku Kabushiki Kaisha | Aminooxypyrrolidinylthiocarbapenem compounds |
| DK0537007T3 (en) | 1991-10-11 | 1995-09-25 | Squibb & Sons Inc | Use of farnesyl protein transferase inhibitors to prepare a drug to block neoplastic transformation of cells induced by ras oncogenes |
| JPH05239058A (en) | 1991-12-17 | 1993-09-17 | Fujisawa Pharmaceut Co Ltd | 3-pyrrolidinylthio-1-azabicyclo(3. 2. 0)hepto-2-ene-2-carboxylic acid compound |
| GB9202298D0 (en) | 1992-02-04 | 1992-03-18 | Ici Plc | Antibiotic compounds |
| CZ290002B6 (en) | 1992-03-11 | 2002-05-15 | Sankyo Company Limited | Antimicrobial carbapenem derivatives, process of their preparation and pharmaceutical preparation in which the derivatives are comprised |
| CA2091309A1 (en) | 1992-03-26 | 1993-09-27 | Frederic H. Jung | Antibiotic compounds |
| GB9304156D0 (en) | 1992-03-26 | 1993-04-21 | Zeneca Ltd | Antibiotic compounds |
| WO1993021186A1 (en) | 1992-04-13 | 1993-10-28 | Fujisawa Pharmaceutical Co., Ltd. | Substituted 3-pyrrolidinylthio-carbapenems as antimicrobial agents |
| EP0581501B1 (en) | 1992-07-21 | 1998-09-09 | Zeneca Limited | Antibiotic carbapenem compounds |
| CA2099818A1 (en) | 1992-07-21 | 1994-01-22 | Frederic H. Jung | Antibiotic compounds |
| EP0581502B1 (en) | 1992-07-21 | 1998-10-21 | Zeneca Limited | Antibiotic carbapenem compounds |
| EP0590885B1 (en) | 1992-09-28 | 2000-03-15 | Zeneca Limited | Antibiotic carbapenem compounds |
| CA2106330A1 (en) | 1992-10-07 | 1994-04-08 | Patrice J. Siret | Antibiotic compounds |
| CA2118985A1 (en) | 1993-04-02 | 1994-10-03 | Dinesh V. Patel | Heterocyclic inhibitors of farnesyl protein transferase |
| CA2165176A1 (en) | 1993-06-18 | 1995-01-05 | Samuel L. Graham | Inhibitors of farnesyl-protein transferase |
| US5468733A (en) * | 1993-09-30 | 1995-11-21 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| US5576293A (en) * | 1993-09-30 | 1996-11-19 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| CN1151156A (en) | 1994-03-15 | 1997-06-04 | 卫材株式会社 | Isoprenyl transferase inhibitors |
| CA2155448A1 (en) * | 1994-08-11 | 1996-02-12 | Katerina Leftheris | Inhibitors of farnesyl protein transferase |
| US5571835A (en) * | 1994-09-29 | 1996-11-05 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| ES2196163T3 (en) | 1995-07-31 | 2003-12-16 | Shionogi & Co | PIRROLIDINE DERIVATIVES WITH AN INHIBITION ACTIVITY OF PHOSPHOLIPASE A2. |
| JP3115285B2 (en) | 1999-04-27 | 2000-12-04 | 徳光 中ノ瀬 | Water facilities using synthetic resin bodies |
-
1995
- 1995-08-04 GB GBGB9515975.2A patent/GB9515975D0/en active Pending
-
1996
- 1996-07-23 TW TW085108987A patent/TW345575B/en active
- 1996-07-30 PL PL324819A patent/PL190873B1/en not_active IP Right Cessation
- 1996-07-30 TR TR1998/00147T patent/TR199800147T1/en unknown
- 1996-07-30 IL IL12315596A patent/IL123155A0/en not_active IP Right Cessation
- 1996-07-30 RU RU98103393/04A patent/RU2191773C2/en not_active IP Right Cessation
- 1996-07-30 SK SK145-98A patent/SK14598A3/en unknown
- 1996-07-30 AU AU66223/96A patent/AU720353B2/en not_active Ceased
- 1996-07-30 KR KR1019980700778A patent/KR100502770B1/en not_active IP Right Cessation
- 1996-07-30 NZ NZ313696A patent/NZ313696A/en unknown
- 1996-07-30 WO PCT/GB1996/001810 patent/WO1997006138A1/en not_active Application Discontinuation
- 1996-07-30 JP JP9508201A patent/JPH11510178A/en not_active Ceased
- 1996-07-30 CA CA002226671A patent/CA2226671C/en not_active Expired - Fee Related
- 1996-07-30 CZ CZ1998309A patent/CZ293694B6/en not_active IP Right Cessation
- 1996-07-30 MX MX9800946A patent/MX9800946A/en not_active IP Right Cessation
- 1996-07-30 US US09/011,135 patent/US6232338B1/en not_active Expired - Fee Related
- 1996-07-30 BR BR9609701A patent/BR9609701A/en not_active Application Discontinuation
- 1996-07-30 TR TR2001/01884T patent/TR200101884T2/en unknown
- 1996-07-30 EP EP96925855A patent/EP0842151A1/en not_active Withdrawn
- 1996-07-30 HU HU9802857A patent/HUP9802857A3/en unknown
- 1996-07-30 CN CN96197206A patent/CN1101380C/en not_active Expired - Fee Related
- 1996-08-02 ZA ZA9606610A patent/ZA966610B/en unknown
- 1996-08-02 MY MYPI96003186A patent/MY141457A/en unknown
-
1998
- 1998-02-03 NO NO19980467A patent/NO316624B1/en unknown
-
2000
- 2000-11-30 US US09/725,964 patent/US6541491B1/en not_active Expired - Fee Related
-
2002
- 2002-03-26 CN CN02108502A patent/CN1377647A/en active Pending
- 2002-10-15 NO NO20024950A patent/NO20024950D0/en not_active Application Discontinuation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HUP9802857A2 (en) | 4-mercaptopyrrolidine derivatives as farnesyl transferase inhibitors, process for producing them and pharmaceutical compositions containing them | |
| ATE388951T1 (en) | DPP-IV INHIBITING PURINE DERIVATIVES FOR THE TREATMENT OF DIABETES | |
| HUP0300826A2 (en) | Polymorphs of an epothilone analog, process for their preparation and pharmaceutical compositions containing them | |
| HUP0302474A2 (en) | Therapeutically effective tropane derivatives, process for their preparation pharmaceutical compositions containing them and their use | |
| MY148632A (en) | Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | |
| HUP0201343A2 (en) | Hypolipidemic benzothiazepine compounds, process for their preparation and pharmaceutical compositions containing them | |
| HUP0004434A2 (en) | Adamantane derivatives and pharmaceuticals containing them | |
| HUP0204083A2 (en) | 2-amino-nicotinamide derivatives and their use as vegf-receptor tyrosine kinase inhibitors, process for their preparation and pharmaceutical compositions containing them | |
| ES2130452T3 (en) | CYCLOBUTANE DERIVATIVES USED AS INHIBITORS OF SQUALENE-SYNTHESASE AND PROTEIN FARNESYL TRANSFERASE. | |
| HUP0203312A2 (en) | Pharmaceutically active sulfonamide derivatives, process for their preparation, and pharmaceutical compositions and their use | |
| HUP0301213A2 (en) | Aminothiazole inhibitors of cyclin dependent kinases, pharmaceutical compositions, their use and process for their preparation | |
| GEP20053595B (en) | Cyclopentanoindoles, Compositions Containing Such Compounds and Methods of Treatment | |
| HUP9600211A2 (en) | Heterocyclic compounds, process for producing them and pharmaceutical compositions containing them, as an activ ingredient | |
| NO20053077L (en) | Therapeutic formulations for the treatment of beta-amyloid-related diseases. | |
| HUP9800688A2 (en) | Complex of gamma-cyclodextrin and retinol or retinol derivatives, process for their production and cosmetic an pharmaceutical compositions containing them | |
| DE60234577D1 (en) | PHARMACEUTICAL MIXTURE FOR THE TREATMENT OF CANCER CONTAINING DIOXOLANE NUCLEOSIDE ANALOGUE | |
| NO945034D0 (en) | Vitamin D series derivatives modified at 20-position, et al. for forward. of such derivatives, intermediates used in the foregoing, pharmaceutical preparations containing the derivatives and their use in the present invention. of medicines | |
| ES2171723T3 (en) | 3,4-DIARIL-2-HYDROXI-2,5-DIHYDROFURANS AS COX-2 INHIBITORS PROPHARMS. | |
| HUP9802121A2 (en) | Imidazoline derivatives, process for producing them and pharmaceutical compositions containing them | |
| DE69823229D1 (en) | CYCLICALLY IMID-SUBSTITUTED PYRIDYLALKANE, ALKEN, AND ALKIN-CARBOXAMID DERIVATIVES, USED AS CYTOSTATIC AND IMMUNOSUPPRESSIVE AGENTS | |
| HUP0402577A2 (en) | Indole derivatives as inhibitors of cytosolic phospholipase a2, process for producing them and pharmaceutical compositions containing them | |
| HUP0500478A2 (en) | Antitumor compositions containing taxane derivatives | |
| DE69019533D1 (en) | TREATMENT OF HIV INFECTIONS AND USEFUL LINKS THEREFOR. | |
| HUP9802762A2 (en) | Diphenylmethylene piperidine derivatives, pharmaceutical compositions containing them, process for producing them and their use | |
| EA200000355A2 (en) | INDUSTRIAL PRODUCTS |