HUP9802634A2 - Use of benzimidazoles for the manufacture of pharmaceutical compositions for the treatment of leukemia - Google Patents
Use of benzimidazoles for the manufacture of pharmaceutical compositions for the treatment of leukemiaInfo
- Publication number
- HUP9802634A2 HUP9802634A2 HU9802634A HUP9802634A HUP9802634A2 HU P9802634 A2 HUP9802634 A2 HU P9802634A2 HU 9802634 A HU9802634 A HU 9802634A HU P9802634 A HUP9802634 A HU P9802634A HU P9802634 A2 HUP9802634 A2 HU P9802634A2
- Authority
- HU
- Hungary
- Prior art keywords
- powder
- treatment
- carbon atoms
- benzimidazoles
- leukemia
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 150000001556 benzimidazoles Chemical class 0.000 title 1
- 208000032839 leukemia Diseases 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 239000000843 powder Substances 0.000 abstract 6
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- KDDQRKBRJSGMQE-UHFFFAOYSA-N 4-thiazolyl Chemical group [C]1=CSC=N1 KDDQRKBRJSGMQE-UHFFFAOYSA-N 0.000 abstract 1
- 206010024229 Leprosy Diseases 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 239000003513 alkali Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- -1 nitro, methyl Chemical group 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
A találmány tárgyát (I) általánős képletű vegyületek - ahől X hidrőgén-, halőgénatőm, legfeljebb 7 szénatőmős alkil- vagyalkőxicsőpőrt; n legfeljebb 4-ig terjedő pőzitív egész szám; Y hidrőgén-, klóratőm, nitrő-, metil- vagy etilcsőpőrt; R hidrőgénatőm vagy legfeljebb 8 szénatőmős alkilcsőpőrt; és R2 4-tiazőlil-csőpőrt vagy -NHCOOR1 általánős képletű csőpőrt, amelybenR1 legfeljebb 7 szénatőmős alifás szénhidrőgén-csőpőrt - vagy sóik alkalmazása képezi gyógyszerészeti hőrdőzót tartalmazó,leűkémia kezelésére szőlgáló készítmények előállítására. ŕThe subject of the invention is compounds of the general formula (I) - of which X is a hydrogen atom, a halogen atom, or an alkyl or alkali tube powder with up to 7 carbon atoms; n is a positive integer up to 4; Y hydrogen, chlorine atom, nitro, methyl or ethyl tube powder; R is a hydrogen atom or an alkyl pipe powder with up to 8 carbon atoms; and R2 4-thiazolyl pipe powder or pipe powder with the general formula -NHCOOR1, in which R1 is an aliphatic hydrocarbon pipe powder with a maximum of 7 carbon atoms - or the use of their salts for the production of preparations containing a pharmaceutical heat-treating agent and intended for the treatment of leprosy. ŕ
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47381795A | 1995-06-07 | 1995-06-07 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP9802634A2 true HUP9802634A2 (en) | 1999-03-29 |
| HUP9802634A3 HUP9802634A3 (en) | 1999-05-28 |
Family
ID=23881113
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9802634A HUP9802634A3 (en) | 1995-06-07 | 1996-05-22 | Use of benzimidazoles for the manufacture of pharmaceutical compositions for the treatment of leukemia |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0831816A1 (en) |
| JP (1) | JPH11506732A (en) |
| KR (1) | KR19990022617A (en) |
| CN (1) | CN1186433A (en) |
| AR (1) | AR003137A1 (en) |
| AU (1) | AU717382B2 (en) |
| BR (1) | BR9608730A (en) |
| CA (1) | CA2223435A1 (en) |
| CZ (1) | CZ391197A3 (en) |
| HU (1) | HUP9802634A3 (en) |
| IL (1) | IL118424A0 (en) |
| NO (1) | NO975660L (en) |
| PL (1) | PL324026A1 (en) |
| SK (1) | SK168697A3 (en) |
| TR (1) | TR199701536T1 (en) |
| WO (1) | WO1996040122A1 (en) |
| ZA (1) | ZA964373B (en) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6177460B1 (en) | 1995-04-12 | 2001-01-23 | The Procter & Gamble Company | Method of treatment for cancer or viral infections |
| US6262093B1 (en) | 1995-04-12 | 2001-07-17 | The Proctor & Gamble Company | Methods of treating cancer with benzimidazoles |
| US6479526B1 (en) | 1995-04-12 | 2002-11-12 | The Procter & Gamble Company | Pharmaceutical composition for inhibiting the growth of viruses and cancers |
| US5770616A (en) | 1995-06-07 | 1998-06-23 | The Procter & Gamble Company | Pharmaceutical composition for inhibiting the growth of cancers |
| US6265427B1 (en) | 1995-06-07 | 2001-07-24 | The Proctor & Gamble Company | Pharmaceutical composition for the method of treating leukemia |
| US6686391B2 (en) | 1995-08-04 | 2004-02-03 | University Of Arizona Foundation | N-chlorophenylcarbamate and N-chlorophenylthiocarbamate compositions |
| US5900429A (en) | 1997-01-28 | 1999-05-04 | The Procter & Gamble Company | Method for inhibiting the growth of cancers |
| US6506783B1 (en) | 1997-05-16 | 2003-01-14 | The Procter & Gamble Company | Cancer treatments and pharmaceutical compositions therefor |
| US6245789B1 (en) | 1998-05-19 | 2001-06-12 | The Procter & Gamble Company | HIV and viral treatment |
| US6423734B1 (en) | 1999-08-13 | 2002-07-23 | The Procter & Gamble Company | Method of preventing cancer |
| US6608096B1 (en) | 2000-09-26 | 2003-08-19 | University Of Arizona Foundation | Compounds and methods for use thereof in the treatment of cancer or viral infections |
| US6380232B1 (en) | 2000-09-26 | 2002-04-30 | The Procter & Gamble Company | Benzimidazole urea derivatives, and pharmaceutical compositions and unit dosages thereof |
| US6407105B1 (en) | 2000-09-26 | 2002-06-18 | The Procter & Gamble Company | Compounds and methods for use thereof in the treatment of cancer or viral infections |
| US6462062B1 (en) | 2000-09-26 | 2002-10-08 | The Procter & Gamble Company | Compounds and methods for use thereof in the treatment of cancer or viral infections |
| EP2251010A1 (en) | 2009-05-08 | 2010-11-17 | Sygnis Bioscience GmbH & Co. KG | Use of thiabendazole and derivatives thereof for the therapy of neurological conditions |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL134354C (en) * | 1963-05-23 | |||
| FR2155888A1 (en) * | 1971-10-13 | 1973-05-25 | Agot Aime | Solid anthelmintic composn - for more economical treatment of ruminants |
-
1996
- 1996-05-22 TR TR97/01536T patent/TR199701536T1/en unknown
- 1996-05-22 AU AU58020/96A patent/AU717382B2/en not_active Ceased
- 1996-05-22 CN CN96194465A patent/CN1186433A/en active Pending
- 1996-05-22 KR KR1019970709098A patent/KR19990022617A/en not_active Application Discontinuation
- 1996-05-22 EP EP96914749A patent/EP0831816A1/en not_active Withdrawn
- 1996-05-22 WO PCT/US1996/007445 patent/WO1996040122A1/en not_active Application Discontinuation
- 1996-05-22 BR BR9608730A patent/BR9608730A/en not_active Application Discontinuation
- 1996-05-22 PL PL96324026A patent/PL324026A1/en unknown
- 1996-05-22 SK SK1686-97A patent/SK168697A3/en unknown
- 1996-05-22 JP JP9500667A patent/JPH11506732A/en active Pending
- 1996-05-22 CZ CZ973911A patent/CZ391197A3/en unknown
- 1996-05-22 HU HU9802634A patent/HUP9802634A3/en unknown
- 1996-05-22 CA CA002223435A patent/CA2223435A1/en not_active Abandoned
- 1996-05-27 IL IL11842496A patent/IL118424A0/en unknown
- 1996-05-29 ZA ZA964373A patent/ZA964373B/en unknown
- 1996-06-07 AR ARP960103043A patent/AR003137A1/en not_active Application Discontinuation
-
1997
- 1997-12-05 NO NO975660A patent/NO975660L/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| BR9608730A (en) | 1999-06-29 |
| NO975660D0 (en) | 1997-12-05 |
| CN1186433A (en) | 1998-07-01 |
| HUP9802634A3 (en) | 1999-05-28 |
| CA2223435A1 (en) | 1996-12-19 |
| TR199701536T1 (en) | 1998-02-21 |
| EP0831816A1 (en) | 1998-04-01 |
| KR19990022617A (en) | 1999-03-25 |
| JPH11506732A (en) | 1999-06-15 |
| PL324026A1 (en) | 1998-05-11 |
| WO1996040122A1 (en) | 1996-12-19 |
| AU717382B2 (en) | 2000-03-23 |
| CZ391197A3 (en) | 1998-05-13 |
| IL118424A0 (en) | 1996-09-12 |
| AU5802096A (en) | 1996-12-30 |
| ZA964373B (en) | 1996-09-02 |
| AR003137A1 (en) | 1998-07-08 |
| SK168697A3 (en) | 1998-12-02 |
| NO975660L (en) | 1998-02-09 |
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