HUP9601331A2 - Piperazine- and homopiperazine-derivatives, process for producing them and pharmaceutical compositions containing them - Google Patents
Piperazine- and homopiperazine-derivatives, process for producing them and pharmaceutical compositions containing themInfo
- Publication number
- HUP9601331A2 HUP9601331A2 HU9601331A HUP9601331A HUP9601331A2 HU P9601331 A2 HUP9601331 A2 HU P9601331A2 HU 9601331 A HU9601331 A HU 9601331A HU P9601331 A HUP9601331 A HU P9601331A HU P9601331 A2 HUP9601331 A2 HU P9601331A2
- Authority
- HU
- Hungary
- Prior art keywords
- powder
- pipe
- tube
- alkyl
- carbon
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 239000000843 powder Substances 0.000 abstract 16
- 229910052799 carbon Inorganic materials 0.000 abstract 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 2
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical group N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 208000015114 central nervous system disease Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 150000004885 piperazines Chemical class 0.000 abstract 1
- 229940066771 systemic antihistamines piperazine derivative Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/08—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A találmány tárgyát képező új, (I) általánős képletű piperazin-,illetve hőmőpiperazinszármazékők képletében R1 jelentése halőgénatőm, 1-4 szénatőmős alkilcsőpőrt, 1-4 szénatőmősalkőxicsőpőrt, trihalőgén-metil-csőpőrt, nitrőcsőpőrt vagyaminőcsőpőrt, amely 1-4 szénatőmős alkilcsőpőrttal lehethelyettesítve, és n értéke 1 vagy 2, vagy R1 jelentése cianőcsőpőrt, és n értéke 2, m értéke 0, 1, 2 vagy 3, R2, R3 és R4 jelentése, egymástól függetlenül , hidrőgénatőm,halőgénatőm, trihalőgén-metil-csőpőrt, 1-4 szénatőmős alkilcsőpőrt, 1-4 szénatőmős alkőxicsőpőrt, nitrőcsőpőrt, karbőxilcsőpőrt,főrmilcsőpőrt, hidrőxilcsőpőrt vagy aminőcsőpőrt, amely 1-4 szénatőmősalkilcsőpőrttal lehet helyettesítve. A találmány szerinti vegyületek a közpőnti idegrendszermegbetegedéseinek kezelésére alkalmasak. ŕIn the formula of the new monocyclic piperazine and thermocyclic piperazine derivatives of formula (I) which are the subject of the invention, R1 is a halogen atom, a 1-4 carbon atom alkyl tube powder, a 1-4 carbon atom oxy tube powder, a trihalogen-methyl tube powder, a nitrogen tube powder or an amino tube powder, which can be a 1-4 carbon atom alkyl tube powder substituted and n is 1 or 2, or R1 is cyanide powder, and n is 2, m is 0, 1, 2 or 3, R2, R3 and R4 are, independently of each other, a hydrogen atom, a halogen atom, a trihalogen-methyl tube powder, 1-4 carbon atoms alkyl pipe powder, 1-4 carbon atomized alkyl pipe powder, nitro pipe powder, carboxyl pipe powder, formyl pipe powder, hydroxyl pipe powder or amino pipe powder, which can be replaced by 1-4 carbon atomized alkyl pipe powder. The compounds according to the invention are suitable for the treatment of central nervous system diseases. ŕ
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU9601331A HUP9601331A3 (en) | 1996-05-17 | 1996-05-17 | Piperazine- and homopiperazine-derivatives, process for producing them and pharmaceutical compositions containing them |
PCT/HU1997/000020 WO1997044334A2 (en) | 1996-05-17 | 1997-05-15 | Novel piperazine or homopiperazine derivatives, pharmaceutical compositions containing the same and a process for their preparation |
AU29120/97A AU2912097A (en) | 1996-05-17 | 1997-05-15 | Novel piperazine or homopiperazine derivatives, pharmaceutical compositions containing the same and process for their preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU9601331A HUP9601331A3 (en) | 1996-05-17 | 1996-05-17 | Piperazine- and homopiperazine-derivatives, process for producing them and pharmaceutical compositions containing them |
Publications (3)
Publication Number | Publication Date |
---|---|
HU9601331D0 HU9601331D0 (en) | 1996-07-29 |
HUP9601331A2 true HUP9601331A2 (en) | 1998-09-28 |
HUP9601331A3 HUP9601331A3 (en) | 2000-06-28 |
Family
ID=89993978
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU9601331A HUP9601331A3 (en) | 1996-05-17 | 1996-05-17 | Piperazine- and homopiperazine-derivatives, process for producing them and pharmaceutical compositions containing them |
Country Status (3)
Country | Link |
---|---|
AU (1) | AU2912097A (en) |
HU (1) | HUP9601331A3 (en) |
WO (1) | WO1997044334A2 (en) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5859246A (en) * | 1997-01-30 | 1999-01-12 | Neurogen Corporation | 1-phenyl-4-benzylpiperazines: dopamine receptor subtype specific ligands |
CA2336089A1 (en) * | 1998-06-30 | 2000-01-06 | Neurogen Corporation | 6-(4-arylalkylpiperazin-1-yl)benzodioxane and 6-(4-arylalkylpiperazin-1-yl)chromane derivatives: dopamine receptor subtype specific ligands |
US6177566B1 (en) | 1998-06-30 | 2001-01-23 | Neurogen Corporation | 6-(4-arylalkylpiperazin-1-yl) benzodioxane and 6-(4-arylalkylpiperazin-1-yl) chromane derivatives: dopamine receptor subtype specific ligands |
AU2001279294A1 (en) | 2000-07-06 | 2002-01-21 | Neurogen Corporation | Melanin concentrating hormone receptor ligands |
DE60130771T2 (en) | 2000-07-27 | 2008-07-17 | Eli Lilly And Co., Indianapolis | SUBSTITUTED HETEROCYCLIC AMIDS |
KR20040012851A (en) | 2001-05-22 | 2004-02-11 | 뉴로젠 코포레이션 | Melanin concentrating hormone receptor ligands: substituted 1-benzyl-4-aryl piperazine analogues |
US7253168B2 (en) | 2004-04-07 | 2007-08-07 | Neurogen Corporation | Substituted 1-benzyl-4-substituted piperazine analogues |
EP2149373A1 (en) * | 2008-08-01 | 2010-02-03 | Laboratorios Del. Dr. Esteve, S.A. | 5HT7 receptor ligands and compositions comprising the same |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1554897A (en) * | 1976-12-10 | 1979-10-31 | Beecham Group Ltd | (substituted phenyl) - piperazines and their use in pharmaceutical compositions |
CH643549A5 (en) * | 1979-08-25 | 1984-06-15 | Merz & Co | N- (TRIMETHOXYBENZYL) -N'-PHENYLPIPERAZINE. |
EP0591426A4 (en) * | 1991-06-27 | 1996-08-21 | Univ Virginia Commonwealth | Sigma receptor ligands and the use thereof |
EP0556889A1 (en) * | 1992-02-18 | 1993-08-25 | Duphar International Research B.V | Method of preparing aryl(homo)piperazines |
DE69426157T2 (en) * | 1993-07-28 | 2001-05-17 | Santen Pharmaceutical Co Ltd | 1,4-DI (PHENYLALKYL) PIPERAZINE DERIVATIVES |
EP0650964A1 (en) * | 1993-11-02 | 1995-05-03 | Duphar International Research B.V | 1 2H-1-benzopyran-2-one-8-yl -piperazine derivatives |
-
1996
- 1996-05-17 HU HU9601331A patent/HUP9601331A3/en unknown
-
1997
- 1997-05-15 WO PCT/HU1997/000020 patent/WO1997044334A2/en active Application Filing
- 1997-05-15 AU AU29120/97A patent/AU2912097A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU2912097A (en) | 1997-12-09 |
HU9601331D0 (en) | 1996-07-29 |
WO1997044334A2 (en) | 1997-11-27 |
WO1997044334A3 (en) | 1998-03-12 |
HUP9601331A3 (en) | 2000-06-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HUP9700811A2 (en) | Ring fused tetrahydropyridine-n-hydroxycarboxamide derivatives, pharmaceutical compositions containing them and process for preparing them | |
HUP9802300A2 (en) | N-heteroaryl-pyridinesulfonamide derivatives, pharmaceutical compositions containing them, process for producing them and their use | |
HUT59081A (en) | Process for producing aryl- and heteroaryl-ethylene derivatives and pharmaceutical compositions containing them | |
MY117896A (en) | Quinazoline derivatives | |
NZ518542A (en) | Triphenylalkene derivatives and their use as selective estrogen receptor modulators | |
HUP9902471A2 (en) | Piperazine and piperidine compounds, process for their preparation and pharmaceutical compositions containing the same | |
ES8308312A1 (en) | Benzazepines, process for their preparation and their application as pharmaceutical preparations. | |
UA66825C2 (en) | Azapolycyclic compounds condensed with aryl | |
HUP0102466A2 (en) | Antiestrogenic novel benzopyran or thiobenzopyran derivatives, process for producing them and medicaments containing them | |
PL368409A1 (en) | Derivatives of triazolyl-imidazopyridine and of the triazolylpurines useful as ligands of the adenosine a2a? receptor and their use as medicaments | |
ES8401961A1 (en) | Substituted N-(4-indolyl-piperidino-alkyl) benzimidazolones, processes for their preparation and their use as pharmaceutical preparations. | |
HU9400250D0 (en) | Quinoline-or quinazoine derivatives process fop producing them and pharmaceutical compositions containing them | |
ES2006623A6 (en) | Amino-5,6,7,8-tetrahydro-naphtho[2,3b]furan derivatives, processes for their preparation and pharmaceutical compositions containing them. | |
HUP9901387A2 (en) | Distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents | |
HUP9601331A2 (en) | Piperazine- and homopiperazine-derivatives, process for producing them and pharmaceutical compositions containing them | |
MD1560F2 (en) | Cyclic compounds, pharmaceutical compositions on base thereof and methods of treatment of infections or diseases provoked by retroviruses. | |
ZA941963B (en) | Substituted (arylalkoxybenzyl)aminopropanamide derivatives and process for their preparation | |
TW429255B (en) | Pyrazine compounds having treatment of central nervous system diseases and disorders | |
SE7501365L (en) | ||
HUP9600914A2 (en) | 4-indolylpiperazinyl derivatives, process for producing them and their use | |
HUP9900739A2 (en) | Process for the preparation of quinoline derivatives, and the intermediates | |
HUP9900642A2 (en) | 2-substituted benzimidazole derivatives as inhibitors of smooth muscle cell proliferation, process for producing them and their use for producing pharmaceutical compositions | |
ES8401060A1 (en) | 2-Piperazinyl-4-phenyl-quinazoline derivatives with antidepressive properties, process for the preparation of these compounds and medicines containing them. | |
NO960425D0 (en) | 15,15-dialkyl-substituted derivatives of estradiol | |
ZA831477B (en) | Substituted pyridines,processes for preparing these and pharmaceutical composition thereof |