HUP9801382A2 - Neurokinin antagonista piperazinszármazékok és a vegyületeket tartalmazó gyógyászati készítmények - Google Patents
Neurokinin antagonista piperazinszármazékok és a vegyületeket tartalmazó gyógyászati készítményekInfo
- Publication number
- HUP9801382A2 HUP9801382A2 HU9801382A HUP9801382A HUP9801382A2 HU P9801382 A2 HUP9801382 A2 HU P9801382A2 HU 9801382 A HU9801382 A HU 9801382A HU P9801382 A HUP9801382 A HU P9801382A HU P9801382 A2 HUP9801382 A2 HU P9801382A2
- Authority
- HU
- Hungary
- Prior art keywords
- substituted phenyl
- ring
- ora
- alkyl
- atom
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 239000005557 antagonist Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000004885 piperazines Chemical class 0.000 title 1
- 229940066771 systemic antihistamines piperazine derivative Drugs 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 4
- 229910003827 NRaRb Inorganic materials 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- -1 cyano- Chemical group 0.000 abstract 3
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 3
- 239000000843 powder Substances 0.000 abstract 3
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 125000004122 cyclic group Chemical group 0.000 abstract 2
- 125000001624 naphthyl group Chemical group 0.000 abstract 2
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 2
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Ophthalmology & Optometry (AREA)
- Neurology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
A cím szerinti vegyületek (I) általánős képletében X két hidrőgénatőm,őxigén-, kénatőm vagy =NRd; n, ű és l értéke 0, 1 vagy 2 m 1, és y 1,2 vagy 3, vagy m 2, és y 0; Rc hidrőgénatőm, alkil-, -(CH2)n1-R4csőpőrt, n1 1, 2, 3, 4, 5 vagy 6; R4 cianő-, -ORa, -SRa, -NRaRb, -C(O)-NRaRb, -C(O)ORa, -C(NH2)=NH, -N(Ra)C(O)-Rb, -OC(O)Ra, -O-(O)NRaRb, -N(Rb)C(O)-ORa, adőtt esetben szűbsztitűált fenil-,imidazőlil- vagy benzpirrőlilcsőpőrt, Rc, alkil- vagy -(CH2)nORacsőpőrt, Ra és Rb hidrőgénatőm, alkil-, adőtt esetben szűbsztitűáltfenil-, benzil- vagy allilcsőpőrt, vagy Ra és Rb a nitrőgénatőmmalegyütt heterőciklűsős csőpőrtőt képez; Rd hidrőgénatőm, alkil-,cianő-, -ORa, adőtt esetben szűbsztitűált fenil-, benzil- vagyallilcsőpőrt; Ar1 adőtt esetben szűbsztitűált fenil-, naftil-, vagyadőtt esetben a gyűrűben egy őxigénatőmőt tartalmazó triciklűsősgyűrűrendszerből álló csőpőrt; Ar2 adőtt esetben szűbsztitűált fenil-,naftil- vagy heterőarilcsőpőrt; Z 4-10 tagú gyűrűben egynitrőgénatőmőt, vagy 6-tagú gyűrűben két nitrőgénatőmőt tartalmazó ésalkiléncsőpőrttal áthidalt telített heterőciklűsős gyűrűrendszerbőlálló csőpőrt. ŕ
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/432,739 US5719156A (en) | 1995-05-02 | 1995-05-02 | Piperazino derivatives as neurokinin antagonists |
US308495P | 1995-08-31 | 1995-08-31 |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP9801382A2 true HUP9801382A2 (hu) | 1999-06-28 |
HUP9801382A3 HUP9801382A3 (en) | 2000-09-28 |
Family
ID=26671291
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU9801382A HUP9801382A3 (en) | 1995-05-02 | 1996-05-01 | Piperazine derivatives as neurokinin antagonists and pharmaceutical compositions containing these compounds |
Country Status (18)
Country | Link |
---|---|
EP (1) | EP0823906B1 (hu) |
JP (1) | JP4173912B2 (hu) |
KR (1) | KR19990008230A (hu) |
CN (1) | CN1111528C (hu) |
AT (1) | ATE244712T1 (hu) |
AU (1) | AU705683B2 (hu) |
BR (1) | BR9608245A (hu) |
CA (1) | CA2218887C (hu) |
CZ (1) | CZ342397A3 (hu) |
DE (1) | DE69629023T2 (hu) |
ES (1) | ES2197238T3 (hu) |
HU (1) | HUP9801382A3 (hu) |
MX (1) | MX9708416A (hu) |
NO (1) | NO315852B1 (hu) |
NZ (1) | NZ307716A (hu) |
PL (1) | PL323235A1 (hu) |
SK (1) | SK147297A3 (hu) |
WO (1) | WO1996034864A1 (hu) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5892039A (en) * | 1995-08-31 | 1999-04-06 | Schering Corporation | Piperazino derivatives as neurokinin antagonists |
US5968929A (en) * | 1996-10-30 | 1999-10-19 | Schering Corporation | Piperazino derivatives as neurokinin antagonists |
ATE325118T1 (de) * | 1996-10-30 | 2006-06-15 | Schering Corp | Piperazinoderivate als neurokinin-antagonisten |
US5783579A (en) * | 1996-12-20 | 1998-07-21 | Schering Corporation | Spiro-substituted azacyclic-substituted piperazino derivatives as neurokinin antagonists |
KR100420616B1 (ko) * | 1996-12-26 | 2004-05-17 | 동화약품공업주식회사 | 신규테레프탈산아미드유도체 |
US6207665B1 (en) | 1997-06-12 | 2001-03-27 | Schering Aktiengesellschaft | Piperazine derivatives and their use as anti-inflammatory agents |
AUPO735997A0 (en) | 1997-06-17 | 1997-07-10 | Fujisawa Pharmaceutical Co., Ltd. | Piperazine derivatives |
DE19737334A1 (de) * | 1997-08-27 | 1999-03-04 | Solvay Pharm Gmbh | 7-Phenyl-1,4-diazepan-Derivate, sowie Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
TW591025B (en) * | 2000-06-13 | 2004-06-11 | Fujisawa Pharmaceutical Co | Production of the piperazine derivative |
AUPR237301A0 (en) * | 2001-01-02 | 2001-01-25 | Fujisawa Pharmaceutical Co., Ltd. | Benzhydryl derivatives |
MXPA02002749A (es) * | 2001-03-27 | 2002-10-28 | Warner Lambert Co | Derivados de ciclohexilamina como antagonistas del subtipo selectivo del n-metil-d-aspartato. |
UA75425C2 (en) | 2001-07-09 | 2006-04-17 | Piperazine oxime derivatives with antagonistic activity to nk-1 receptor, use thereof, a pharmaceutical composition based thereon, a method for producing and a method for producing intermediary compounds | |
AUPR970701A0 (en) * | 2001-12-21 | 2002-01-24 | Fujisawa Pharmaceutical Co., Ltd. | Benzhydryl derivatives |
CN107602317A (zh) * | 2017-08-02 | 2018-01-19 | 凯莱英医药集团(天津)股份有限公司 | 手性2‑氨基‑2‑芳基乙酸衍生物的制备方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8908587D0 (en) * | 1989-04-15 | 1989-06-01 | Scras Societe De Conseils De R | New 2-substituted n,n'-ditrimethoxybenzoyl piperazines |
WO1992020661A1 (en) * | 1991-05-22 | 1992-11-26 | Merck & Co., Inc. | N, n-diacylpiperazines |
US5344830A (en) * | 1992-12-10 | 1994-09-06 | Merck & Co., Inc. | N,N-diacylpiperazine tachykinin antagonists |
IL111730A (en) * | 1993-11-29 | 1998-12-06 | Fujisawa Pharmaceutical Co | Piperazine derivatives, processes for their preparation and pharmaceutical preparations containing them |
US5607936A (en) * | 1994-09-30 | 1997-03-04 | Merck & Co., Inc. | Substituted aryl piperazines as neurokinin antagonists |
-
1996
- 1996-05-01 WO PCT/US1996/005660 patent/WO1996034864A1/en not_active Application Discontinuation
- 1996-05-01 KR KR1019970707756A patent/KR19990008230A/ko active IP Right Grant
- 1996-05-01 DE DE69629023T patent/DE69629023T2/de not_active Expired - Lifetime
- 1996-05-01 JP JP53335596A patent/JP4173912B2/ja not_active Expired - Fee Related
- 1996-05-01 BR BR9608245A patent/BR9608245A/pt not_active Application Discontinuation
- 1996-05-01 SK SK1472-97A patent/SK147297A3/sk unknown
- 1996-05-01 AU AU57141/96A patent/AU705683B2/en not_active Ceased
- 1996-05-01 CZ CZ973423A patent/CZ342397A3/cs unknown
- 1996-05-01 HU HU9801382A patent/HUP9801382A3/hu unknown
- 1996-05-01 CN CN96195171A patent/CN1111528C/zh not_active Expired - Fee Related
- 1996-05-01 ES ES96915342T patent/ES2197238T3/es not_active Expired - Lifetime
- 1996-05-01 CA CA002218887A patent/CA2218887C/en not_active Expired - Fee Related
- 1996-05-01 MX MX9708416A patent/MX9708416A/es not_active IP Right Cessation
- 1996-05-01 EP EP96915342A patent/EP0823906B1/en not_active Expired - Lifetime
- 1996-05-01 PL PL96323235A patent/PL323235A1/xx unknown
- 1996-05-01 AT AT96915342T patent/ATE244712T1/de not_active IP Right Cessation
- 1996-05-01 NZ NZ307716A patent/NZ307716A/en unknown
-
1997
- 1997-10-31 NO NO19975028A patent/NO315852B1/no not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
PL323235A1 (en) | 1998-03-16 |
JPH11504921A (ja) | 1999-05-11 |
CA2218887A1 (en) | 1996-11-07 |
NO975028L (no) | 1997-12-30 |
ES2197238T3 (es) | 2004-01-01 |
DE69629023T2 (de) | 2004-04-22 |
BR9608245A (pt) | 1999-05-04 |
JP4173912B2 (ja) | 2008-10-29 |
CN1189829A (zh) | 1998-08-05 |
WO1996034864A1 (en) | 1996-11-07 |
NO975028D0 (no) | 1997-10-31 |
NO315852B1 (no) | 2003-11-03 |
SK147297A3 (en) | 1998-07-08 |
EP0823906B1 (en) | 2003-07-09 |
CA2218887C (en) | 2008-04-29 |
EP0823906A1 (en) | 1998-02-18 |
AU705683B2 (en) | 1999-05-27 |
KR19990008230A (ko) | 1999-01-25 |
DE69629023D1 (de) | 2003-08-14 |
CZ342397A3 (cs) | 1998-03-18 |
ATE244712T1 (de) | 2003-07-15 |
CN1111528C (zh) | 2003-06-18 |
AU5714196A (en) | 1996-11-21 |
NZ307716A (en) | 1999-10-28 |
HUP9801382A3 (en) | 2000-09-28 |
MX9708416A (es) | 1998-02-28 |
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