IT1300055B1 - Eterocicli con anello a 5 termini difenil-sostituiti loro procedimento di preparazione e loro impiego come farmici - Google Patents
Eterocicli con anello a 5 termini difenil-sostituiti loro procedimento di preparazione e loro impiego come farmiciInfo
- Publication number
- IT1300055B1 IT1300055B1 IT98MI000818A ITMI980818A IT1300055B1 IT 1300055 B1 IT1300055 B1 IT 1300055B1 IT 98MI000818 A IT98MI000818 A IT 98MI000818A IT MI980818 A ITMI980818 A IT MI980818A IT 1300055 B1 IT1300055 B1 IT 1300055B1
- Authority
- IT
- Italy
- Prior art keywords
- substituted
- diphenyl
- heterocycles
- drugs
- preparation procedure
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/333—Radicals substituted by oxygen or sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
- C07D231/20—One oxygen atom attached in position 3 or 5
- C07D231/22—One oxygen atom attached in position 3 or 5 with aryl radicals attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Priority Applications (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19816880A DE19816880A1 (de) | 1998-04-17 | 1998-04-17 | Neue Diphenyl-substituierte 5-Ring-Heterocyclen, Verfahren zu ihrer Herstellung sowie deren Verwendung als Arzneimittel |
IT98MI000818A IT1300055B1 (it) | 1998-04-17 | 1998-04-17 | Eterocicli con anello a 5 termini difenil-sostituiti loro procedimento di preparazione e loro impiego come farmici |
US09/290,931 US6255327B1 (en) | 1998-02-01 | 1999-04-13 | Diphenyl-substituted heterocycles, processes for preparing them and their use as pharmaceutical compositions |
ES99920661T ES2224652T3 (es) | 1998-04-17 | 1999-04-14 | Heterociclos de 5 anillos sustituidos con difenilo, procedimiento para su preparacion, asi como su empleo como medicamentos. |
EP99920661A EP1071670B1 (de) | 1998-04-17 | 1999-04-14 | Diphenyl-substituierte 5-ring-heterocyclen, verfahren zu ihrer herstellung sowie deren verwendung als arzneimittel |
CA002322195A CA2322195C (en) | 1998-04-17 | 1999-04-14 | Novel diphenyl-substituted 5-ring-heterocycles, method for producing them and their use as medicaments |
PCT/EP1999/002496 WO1999054314A1 (de) | 1998-04-17 | 1999-04-14 | Neue diphenyl-substituierte 5-ring-heterocyclen, verfahren zu ihrer herstellung sowie deren verwendung als arzneimittel |
JP2000544653A JP4589531B2 (ja) | 1998-04-17 | 1999-04-14 | 新規ジフェニル置換5員環複素環化合物、それらの製造方法及び薬物としてのそれらの使用 |
AT99920661T ATE270665T1 (de) | 1998-04-17 | 1999-04-14 | Diphenyl-substituierte 5-ring-heterocyclen, verfahren zu ihrer herstellung sowie deren verwendung als arzneimittel |
DE59909917T DE59909917D1 (de) | 1998-04-17 | 1999-04-14 | Diphenyl-substituierte 5-ring-heterocyclen, verfahren zu ihrer herstellung sowie deren verwendung als arzneimittel |
MXPA00009474A MXPA00009474A (es) | 1998-04-17 | 1999-04-14 | Nuevos heterociclos de 5 anillos sustituidos con difenilo, procedimientos para su preparacion, asi como su empleo como medicamentos. |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19816880A DE19816880A1 (de) | 1998-04-17 | 1998-04-17 | Neue Diphenyl-substituierte 5-Ring-Heterocyclen, Verfahren zu ihrer Herstellung sowie deren Verwendung als Arzneimittel |
IT98MI000818A IT1300055B1 (it) | 1998-04-17 | 1998-04-17 | Eterocicli con anello a 5 termini difenil-sostituiti loro procedimento di preparazione e loro impiego come farmici |
Publications (2)
Publication Number | Publication Date |
---|---|
ITMI980818A1 ITMI980818A1 (it) | 1999-10-17 |
IT1300055B1 true IT1300055B1 (it) | 2000-04-05 |
Family
ID=26045525
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT98MI000818A IT1300055B1 (it) | 1998-02-01 | 1998-04-17 | Eterocicli con anello a 5 termini difenil-sostituiti loro procedimento di preparazione e loro impiego come farmici |
Country Status (10)
Country | Link |
---|---|
US (1) | US6255327B1 (it) |
EP (1) | EP1071670B1 (it) |
JP (1) | JP4589531B2 (it) |
AT (1) | ATE270665T1 (it) |
CA (1) | CA2322195C (it) |
DE (2) | DE19816880A1 (it) |
ES (1) | ES2224652T3 (it) |
IT (1) | IT1300055B1 (it) |
MX (1) | MXPA00009474A (it) |
WO (1) | WO1999054314A1 (it) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE60007697T2 (de) * | 1999-07-21 | 2004-12-09 | F. Hoffmann-La Roche Ag | Triazolderivate |
US6579880B2 (en) * | 2000-06-06 | 2003-06-17 | Ortho-Mcneil Pharmaceutical, Inc. | Isoxazoles and oxadiazoles as anti-inflammatory inhibitors of IL-8 |
US6610723B2 (en) | 2001-01-29 | 2003-08-26 | Hoffmann-La Roche Inc. | Imidazole derivatives |
US8829198B2 (en) * | 2007-10-31 | 2014-09-09 | Proteotech Inc | Compounds, compositions and methods for the treatment of beta-amyloid diseases and synucleinopathies |
GB0303503D0 (en) * | 2003-02-14 | 2003-03-19 | Novartis Ag | Organic compounds |
US20090227647A1 (en) | 2008-03-05 | 2009-09-10 | Thomas Lake | Compounds, Compositions and Methods for the Treatment of Islet Amyloid Polypeptide (IAPP) Accumulation in Diabetes |
US20090074890A1 (en) * | 2003-11-10 | 2009-03-19 | Park Min K | Substituted Triazoles as Sodium Channel Blockers |
CN1938023A (zh) * | 2004-03-08 | 2007-03-28 | 惠氏公司 | 离子通道调节剂 |
DOP2005000123A (es) | 2004-07-02 | 2011-07-15 | Merck Sharp & Dohme | Inhibidores de cetp |
EP1812071A2 (en) | 2004-10-13 | 2007-08-01 | PTC Therapeutics, Inc. | Compounds for nonsense suppression, use of these compounds for the manufacture of a medicament for treating somatic mutation-related diseases |
US20110158907A1 (en) * | 2007-04-19 | 2011-06-30 | The Trustees Of The Univeristy Of Pennsylvania | Diphenyl-heteroaryl derivatives and their use for binding and imaging amyloid plaques |
CN102060798A (zh) * | 2011-01-04 | 2011-05-18 | 复旦大学 | 2-(1-氢-4-四唑)-4′- 甲基联苯及其衍生物的合成方法 |
WO2012118935A1 (en) | 2011-03-03 | 2012-09-07 | Proteotech Inc | Compounds for the treatment of neurodegenerative diseases |
KR102447094B1 (ko) * | 2014-08-13 | 2022-09-23 | 닛뽕소다 가부시키가이샤 | 디아릴이미다졸 화합물 및 유해 생물 방제제 |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR5305E (fr) * | 1905-06-17 | 1906-02-22 | Edouard Pellorce | Appareil électrique pour l'allumage des moteurs à explosion |
DE1545806A1 (de) * | 1951-01-28 | 1969-11-27 | Hoechst Ag | Verfahren zur Herstellung von heterocyclischen Verbindungen |
FR1356901A (fr) * | 1958-03-13 | 1964-04-03 | Nouveaux aminoétheroxydes, aminothioéthers et aminoesters dérivés du pyrrole, etleur procédé de préparation | |
FR2152345A1 (en) * | 1971-09-06 | 1973-04-27 | Roussel Uclaf | Alpha-(2-thiazolyl)oxyalkanoic acids and derivatives - - with analgesic,antiinflammatory and antipyretic activity |
FR2244462A1 (en) * | 1973-09-25 | 1975-04-18 | Delalande Sa | Antihypertensive, 5-hydroxy methyl 1,2,4-triazoles - prepd. from aniline and a hydroxy methyl 1,3,4-oxadiazole |
SU753084A1 (ru) * | 1979-03-23 | 1983-01-23 | Ростовский Ордена Трудового Красного Знамени Государственный Университет | Способ получени 1-[2-алкил(аралкил)аминоарил -4-арилимидазолов общей формулы |
US4379155A (en) * | 1979-06-11 | 1983-04-05 | Gruppo Lepetit S.P.A. | 3,5-Disubstituted-1H-1,2,4-triazole derivatives |
US4370336A (en) * | 1979-06-11 | 1983-01-25 | Gruppo Lepetit S.P.A. | 3,5-Disubstituted-1H-1,2,4-triazole derivatives as antifertility agents |
US4826868A (en) * | 1986-05-29 | 1989-05-02 | Ortho Pharmaceutical Corporation | 1,5-Diaryl-3-substituted pyrazoles pharmaceutical compositions and use |
JP2928307B2 (ja) * | 1989-02-03 | 1999-08-03 | エーザイ株式会社 | ピロリジン誘導体 |
CA2396738C (en) * | 1990-11-30 | 2006-08-29 | Masatoshi Chihiro | Thiazole derivatives as active superoxide radical inhibitors |
FR2678938B1 (fr) * | 1991-07-10 | 1993-10-08 | Rhone Poulenc Rorer Sa | Derives de pyrrolidine, leur preparation et les medicaments les contenant. |
IL104311A (en) * | 1992-02-05 | 1997-07-13 | Fujisawa Pharmaceutical Co | Pyrazole derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same |
US5411977A (en) * | 1993-03-31 | 1995-05-02 | The Dupont Merck Pharmaceutical Company | Substituted 2,5-diaryl-4-isothiazolin-3-ones as antiinflammatory and antithrombotic agents |
DE19528189A1 (de) * | 1995-08-01 | 1997-02-06 | Basf Ag | Benzolderivate mit einem heterocyclischen Rest |
PT971709E (pt) * | 1996-10-07 | 2003-09-30 | Lilly Co Eli | Novos compostos uteis como agentes neuro-protectores |
DE19643037A1 (de) | 1996-10-18 | 1998-04-23 | Boehringer Ingelheim Kg | Neue Oxadiazole, Verfahren zu ihrer Herstellung sowie deren Verwendung als Arzneimittel |
EP0946587A2 (en) * | 1996-12-16 | 1999-10-06 | Fujisawa Pharmaceutical Co., Ltd. | New amide compounds |
-
1998
- 1998-04-17 DE DE19816880A patent/DE19816880A1/de not_active Withdrawn
- 1998-04-17 IT IT98MI000818A patent/IT1300055B1/it active IP Right Grant
-
1999
- 1999-04-13 US US09/290,931 patent/US6255327B1/en not_active Expired - Lifetime
- 1999-04-14 DE DE59909917T patent/DE59909917D1/de not_active Expired - Lifetime
- 1999-04-14 CA CA002322195A patent/CA2322195C/en not_active Expired - Fee Related
- 1999-04-14 JP JP2000544653A patent/JP4589531B2/ja not_active Expired - Fee Related
- 1999-04-14 AT AT99920661T patent/ATE270665T1/de active
- 1999-04-14 EP EP99920661A patent/EP1071670B1/de not_active Expired - Lifetime
- 1999-04-14 MX MXPA00009474A patent/MXPA00009474A/es active IP Right Grant
- 1999-04-14 ES ES99920661T patent/ES2224652T3/es not_active Expired - Lifetime
- 1999-04-14 WO PCT/EP1999/002496 patent/WO1999054314A1/de active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
MXPA00009474A (es) | 2002-08-12 |
JP2002512235A (ja) | 2002-04-23 |
DE19816880A1 (de) | 1999-10-21 |
ATE270665T1 (de) | 2004-07-15 |
CA2322195C (en) | 2008-02-26 |
WO1999054314A1 (de) | 1999-10-28 |
ES2224652T3 (es) | 2005-03-01 |
US6255327B1 (en) | 2001-07-03 |
DE59909917D1 (de) | 2004-08-12 |
CA2322195A1 (en) | 1999-10-28 |
EP1071670A1 (de) | 2001-01-31 |
EP1071670B1 (de) | 2004-07-07 |
JP4589531B2 (ja) | 2010-12-01 |
ITMI980818A1 (it) | 1999-10-17 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
0001 | Granted |