HUP9800467A2 - Hialuronsav alkalmazása szövetközi cisztitisz kezelésére alkalmas gyógyászati készítmények előállítására - Google Patents
Hialuronsav alkalmazása szövetközi cisztitisz kezelésére alkalmas gyógyászati készítmények előállításáraInfo
- Publication number
- HUP9800467A2 HUP9800467A2 HU9800467A HUP9800467A HUP9800467A2 HU P9800467 A2 HUP9800467 A2 HU P9800467A2 HU 9800467 A HU9800467 A HU 9800467A HU P9800467 A HUP9800467 A HU P9800467A HU P9800467 A2 HUP9800467 A2 HU P9800467A2
- Authority
- HU
- Hungary
- Prior art keywords
- hyaluronic acid
- interstitial cystitis
- treatment
- weeks
- symptoms
- Prior art date
Links
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title abstract 3
- 208000005615 Interstitial Cystitis Diseases 0.000 title abstract 3
- 229920002674 hyaluronan Polymers 0.000 title abstract 3
- 229960003160 hyaluronic acid Drugs 0.000 title abstract 3
- 208000024891 symptom Diseases 0.000 abstract 3
- 230000006698 induction Effects 0.000 abstract 1
- 238000012423 maintenance Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 210000003932 urinary bladder Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicinal Preparation (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
A találmány tárgya legalább 2x105 átlagős mőlekűlatömegű hialűrőnsavalkalmazása szövetközi hólyaggűlladás (cisztitisz) kezelésére alkalmasgyógyászati készítmények előállítására. Elővizsgálatőt, majd klinikaivizsgálatőt végeztek szövetközi cisztitiszben szenvedő betegekenegyedenként 40 mg hialűrőnsavat 50 ml nőrmál kőnyhasóőldatban(fiziőlógiás kőnyhasóőldatban) húgycsőkatéter segítségével ahúgyhúlyagba csepegtetve. A vizsgálatőt 12 hét időtartalmig végezték,amelyből 4 hétig tartőtt az indűkciós (bevezető) időszak, és tővábbi 8hétig a fenntartó időszak. Az esetek többségében a terápia előttitünetek, fájdalmas tünetek és a sürgős vizelési kényszer tüneténeklényeges javűlását érték el. ŕ
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/388,038 US5591724A (en) | 1995-02-14 | 1995-02-14 | Method for treating the urinary bladder and associated structures using hyaluronic acid |
US59101596A | 1996-02-08 | 1996-02-08 |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP9800467A2 true HUP9800467A2 (hu) | 1998-06-29 |
HUP9800467A3 HUP9800467A3 (en) | 1999-01-28 |
Family
ID=27012116
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU9800467A HUP9800467A3 (en) | 1995-02-14 | 1996-02-14 | Use of hyaluronic acid for producing pharmaceutical compns. for the treatment of interstitial cystitis |
Country Status (20)
Country | Link |
---|---|
US (1) | US5888986A (hu) |
EP (1) | EP0813417B1 (hu) |
JP (1) | JP4354528B2 (hu) |
KR (1) | KR100268660B1 (hu) |
CN (1) | CN1181016A (hu) |
AT (1) | ATE247476T1 (hu) |
AU (1) | AU705289B2 (hu) |
BR (1) | BR9607601A (hu) |
CA (1) | CA2203621C (hu) |
CZ (1) | CZ288218B6 (hu) |
DE (1) | DE69629553T2 (hu) |
DK (1) | DK0813417T3 (hu) |
ES (1) | ES2205013T3 (hu) |
HU (1) | HUP9800467A3 (hu) |
IN (1) | IN181358B (hu) |
NO (1) | NO315842B1 (hu) |
NZ (1) | NZ300903A (hu) |
PT (1) | PT813417E (hu) |
TR (1) | TR199700782T1 (hu) |
WO (1) | WO1996025168A1 (hu) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2268476A1 (en) | 1991-07-03 | 1998-04-30 | Hyal Pharmaceutical Corporation | Use of hyaluronan in gene therapy |
US6548487B2 (en) | 1996-12-27 | 2003-04-15 | Seikagaku Corporation | Agent for treatment of bladder troubles |
CA2247389C (en) | 1996-12-27 | 2009-11-24 | Seikagaku Corporation | Agent for treatment of bladder troubles |
PT1124546E (pt) * | 1998-10-22 | 2004-08-31 | Bioniche Life Sciences Inc | Um metodo para prevenir reduzir e tratar a cistite usando acido hialuronico |
US6083933A (en) * | 1999-04-19 | 2000-07-04 | Stellar International Inc. | Treatment of cystitis-like symptoms with chondroitin sulfate following administration of a challenge solution |
WO2001044465A2 (en) * | 1999-12-13 | 2001-06-21 | Bioniche Life Sciences Inc. | Therapeutically useful synthetic oligonucleotides |
JP4215429B2 (ja) * | 1999-12-28 | 2009-01-28 | バイオニケ ライフ サイエンシーズ インコーポレイテッド | 癌治療におけるヒアルロン酸 |
US7504387B2 (en) * | 2002-10-16 | 2009-03-17 | Arthrodynamic Technologies, Animal Health Division, Inc. | Glycosaminoglycan composition and method for treatment and prevention of interstitial cystitis |
US20040161476A1 (en) | 2003-02-19 | 2004-08-19 | Hahn Sungtack Samuel | Cystitis treatment with high dose chondroitin sulfate |
JP5731729B2 (ja) * | 2005-01-14 | 2015-06-10 | ウーリゲン、インコーポレイテッド | 下部尿路障害を治療するためのキット及び改良された組成物 |
DE102006060953A1 (de) | 2006-12-12 | 2008-08-07 | Farco-Pharma Gmbh | Pharmazeutische Zubereitung für die Behandlung entzündlicher Erkrankungen des Urogenitaltraktes |
US8343942B2 (en) * | 2008-04-04 | 2013-01-01 | University Of Utah Research Foundation | Methods for treating interstitial cystitis |
TWI383796B (zh) | 2009-08-14 | 2013-02-01 | Holy Stone Healthcare Co Ltd | Use of hyaluronic acid mixture for the treatment and prevention of peptic ulcer and duodenal ulcer |
TWI516269B (zh) | 2009-08-14 | 2016-01-11 | 禾伸堂生技股份有限公司 | 使用於炎症性腸疾病(ibd)治療和預防之透明質酸混合物 |
HUP0900717A3 (en) | 2009-11-18 | 2012-02-28 | Richter Gedeon Nyrt | Pharmaceutical composition for urological use containing zinc hyaluronate |
US8575130B2 (en) * | 2010-01-04 | 2013-11-05 | Holy Stone Healthcare Co., Ltd. | Mixture of hyaluronic acid for treating and preventing inflammatory bowel disease |
US20110166098A1 (en) * | 2010-01-04 | 2011-07-07 | Wu Tsung-Chung | Mixture of hyaluronic acid for treating and preventing inflammatory bowel disease |
US8722644B2 (en) | 2010-01-04 | 2014-05-13 | Holy Stone Healthcare Co., Ltd. | Mixture of hyaluronic acid for treating and preventing peptic ulcer and duodenal ulcer |
US8449512B2 (en) | 2010-04-09 | 2013-05-28 | Davinci Biomedical Research Products Inc. | Stoma stabilitating device and method |
US9029347B2 (en) | 2010-08-05 | 2015-05-12 | Holy Stone Healthcare Co., Ltd. | Method and mixture for treating and preventing inflammatory bowel disease |
ES2665254T3 (es) | 2011-07-12 | 2018-04-25 | Holy Stone Healthcare Co., Ltd. | Composiciones que comprenden ácido hialurónico para tratamiento y prevención de enfermedades relacionadas con las mucosas |
ITMI20111732A1 (it) * | 2011-09-27 | 2013-03-28 | Bsdpharma Srl | Formulazioni farmaceutiche per la riduzione della sensibilizzazione crociata tra colon-retto ed il distretto urogenitale con mezzi non-farmacologici. |
RU2519010C1 (ru) * | 2013-03-20 | 2014-06-10 | Общество с ограниченной ответственностью "КОЛЕТЕКС" | Композиция для лечения цистита |
WO2015018461A1 (fr) | 2013-08-09 | 2015-02-12 | Genbiotech | Compositions therapeutiques comprenant d'acide hyaluronique |
CN103655601B (zh) * | 2013-12-31 | 2019-10-25 | 上海建华精细生物制品有限公司 | 一种用于膀胱灌洗的组合物 |
CN103861091B (zh) * | 2014-03-20 | 2016-04-27 | 辽宁亿灵科创生物医药科技有限公司 | 治疗膀胱炎的药物组合物 |
WO2015154007A1 (en) * | 2014-04-03 | 2015-10-08 | Lipella Pharmaceuticals, Inc. | Systems and methods of detecting interstitial cystitis |
RU2557949C1 (ru) * | 2014-08-14 | 2015-07-27 | Общество с ограниченной ответственностью "КОЛЕТЕКС" | Способ лечения лучевого и интерстициального цистита |
EP3400951B1 (de) * | 2017-05-12 | 2019-12-11 | Farco-Pharma GmbH | Blaseninstillationszusammensetzung enthaltend chondoitinsulfat (4,5 mg/ml), hyaluronsäure (16 mg/ml) und phosphatpuffer (ph 6,1 bis 7,9) mit erhöhter lagerstabiliät zur behandlung von cystitis |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4141973A (en) * | 1975-10-17 | 1979-02-27 | Biotrics, Inc. | Ultrapure hyaluronic acid and the use thereof |
US4296104A (en) * | 1979-08-30 | 1981-10-20 | Herschler R J | Therapeutic dimethyl sulfoxide composition and methods of use |
US4302577A (en) * | 1979-10-05 | 1981-11-24 | Biomed Research Inc. | Process for preparing CSA or CSC |
US5180715A (en) * | 1980-11-17 | 1993-01-19 | The Regents Of The University Of California | Irrigation of internal bladder surfaces in mammals with sodium pentosanpolysulfate |
DE3118588C2 (de) * | 1981-05-11 | 1983-07-07 | Luitpold-Werk, Chemisch-Pharmazeutische Fabrik, 8000 München | Verfahren zur Herstellung eines injizierbaren hochreinen Chondroitinpolysulfates, hiernach erhältliches Produkt und pharmazeutische Zusammensetzung |
US4640912A (en) * | 1983-06-09 | 1987-02-03 | Hausman Marvin S | Administration of "active" chondroitin sulfate A and "active" chondroitin sulfate C or mixtures thereof to mammals including humans |
US4711780A (en) * | 1984-06-11 | 1987-12-08 | Fahim Mostafa S | Composition and process for promoting epithelial regeneration |
US4966890A (en) * | 1986-04-04 | 1990-10-30 | Angiogenics, Ltd. | Method and composition for arresting angiogenesis and capillary, cell or membrane leakage |
US4820693A (en) * | 1986-05-22 | 1989-04-11 | Angiogenics, Ltd. | Method and composition for arresting angiogenesis and capillary, cell or membrane leakage |
US4879282A (en) * | 1987-03-17 | 1989-11-07 | Saliba Jr Michael J | Medical application for heparin and related molecules |
US5037810A (en) * | 1987-03-17 | 1991-08-06 | Saliba Jr Michael J | Medical application for heparin and related molecules |
DE69329407T2 (de) * | 1992-06-02 | 2001-05-03 | Bard Inc C R | Verfahren und Implantatvorrichtung für Langzeitwirkstoffabgabe |
JP2995090B2 (ja) * | 1993-03-19 | 1999-12-27 | キユー・メド・アクチエボラーグ | 組織増大のための組成物および方法 |
-
1996
- 1996-02-13 IN IN262CA1996 patent/IN181358B/en unknown
- 1996-02-14 DE DE69629553T patent/DE69629553T2/de not_active Expired - Lifetime
- 1996-02-14 CN CN96192529A patent/CN1181016A/zh active Pending
- 1996-02-14 AT AT96901681T patent/ATE247476T1/de active
- 1996-02-14 HU HU9800467A patent/HUP9800467A3/hu unknown
- 1996-02-14 PT PT96901681T patent/PT813417E/pt unknown
- 1996-02-14 JP JP52454596A patent/JP4354528B2/ja not_active Expired - Lifetime
- 1996-02-14 AU AU46179/96A patent/AU705289B2/en not_active Expired
- 1996-02-14 CZ CZ19972574A patent/CZ288218B6/cs not_active IP Right Cessation
- 1996-02-14 CA CA002203621A patent/CA2203621C/en not_active Expired - Lifetime
- 1996-02-14 TR TR97/00782T patent/TR199700782T1/xx unknown
- 1996-02-14 WO PCT/CA1996/000094 patent/WO1996025168A1/en active IP Right Grant
- 1996-02-14 DK DK96901681T patent/DK0813417T3/da active
- 1996-02-14 EP EP96901681A patent/EP0813417B1/en not_active Expired - Lifetime
- 1996-02-14 KR KR1019970705648A patent/KR100268660B1/ko not_active IP Right Cessation
- 1996-02-14 BR BR9607601-1A patent/BR9607601A/pt not_active Application Discontinuation
- 1996-02-14 ES ES96901681T patent/ES2205013T3/es not_active Expired - Lifetime
- 1996-02-14 NZ NZ300903A patent/NZ300903A/xx not_active IP Right Cessation
- 1996-05-13 US US08/644,438 patent/US5888986A/en not_active Expired - Lifetime
-
1997
- 1997-08-13 NO NO19973732A patent/NO315842B1/no not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
TR199700782T1 (xx) | 1998-03-21 |
NO973732L (no) | 1997-10-10 |
HUP9800467A3 (en) | 1999-01-28 |
JP4354528B2 (ja) | 2009-10-28 |
PT813417E (pt) | 2003-12-31 |
US5888986A (en) | 1999-03-30 |
JPH10513476A (ja) | 1998-12-22 |
EP0813417B1 (en) | 2003-08-20 |
CA2203621A1 (en) | 1996-08-22 |
KR19980702251A (ko) | 1998-07-15 |
EP0813417A1 (en) | 1997-12-29 |
DK0813417T3 (da) | 2003-11-03 |
KR100268660B1 (ko) | 2000-10-16 |
MX9706182A (es) | 1998-07-31 |
DE69629553T2 (de) | 2004-06-17 |
DE69629553D1 (de) | 2003-09-25 |
CZ288218B6 (en) | 2001-05-16 |
AU4617996A (en) | 1996-09-04 |
ES2205013T3 (es) | 2004-05-01 |
AU705289B2 (en) | 1999-05-20 |
ATE247476T1 (de) | 2003-09-15 |
NZ300903A (en) | 1999-07-29 |
NO973732D0 (no) | 1997-08-13 |
IN181358B (hu) | 1998-05-30 |
BR9607601A (pt) | 1999-09-14 |
NO315842B1 (no) | 2003-11-03 |
WO1996025168A1 (en) | 1996-08-22 |
CN1181016A (zh) | 1998-05-06 |
CZ257497A3 (cs) | 1998-01-14 |
CA2203621C (en) | 1998-04-28 |
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