HUP9702219A3 - 6-[4-(acylamino)benzoyl]-pyrazolo[3,4-d]thieno[3,2-b]azepine derivatives, process for their preparation and pharmaceutical compositions containing them - Google Patents

6-[4-(acylamino)benzoyl]-pyrazolo[3,4-d]thieno[3,2-b]azepine derivatives, process for their preparation and pharmaceutical compositions containing them

Info

Publication number
HUP9702219A3
HUP9702219A3 HU9702219A HUP9702219A HUP9702219A3 HU P9702219 A3 HUP9702219 A3 HU P9702219A3 HU 9702219 A HU9702219 A HU 9702219A HU P9702219 A HUP9702219 A HU P9702219A HU P9702219 A3 HUP9702219 A3 HU P9702219A3
Authority
HU
Hungary
Prior art keywords
thieno
pyrazolo
acylamino
benzoyl
preparation
Prior art date
Application number
HU9702219A
Other languages
English (en)
Original Assignee
American Cyanamid Company Madi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Company Madi filed Critical American Cyanamid Company Madi
Publication of HUP9702219A2 publication Critical patent/HUP9702219A2/hu
Publication of HUP9702219A3 publication Critical patent/HUP9702219A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
HU9702219A 1995-01-17 1996-01-16 6-[4-(acylamino)benzoyl]-pyrazolo[3,4-d]thieno[3,2-b]azepine derivatives, process for their preparation and pharmaceutical compositions containing them HUP9702219A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/373,139 US5532235A (en) 1995-01-17 1995-01-17 Tricyclic benzazepine vasopressin antagonists

Publications (2)

Publication Number Publication Date
HUP9702219A2 HUP9702219A2 (hu) 1998-07-28
HUP9702219A3 true HUP9702219A3 (en) 1999-05-28

Family

ID=23471147

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9702219A HUP9702219A3 (en) 1995-01-17 1996-01-16 6-[4-(acylamino)benzoyl]-pyrazolo[3,4-d]thieno[3,2-b]azepine derivatives, process for their preparation and pharmaceutical compositions containing them

Country Status (21)

Country Link
US (2) US5532235A (hu)
EP (1) EP0804440B1 (hu)
JP (1) JP4219978B2 (hu)
CN (1) CN1061658C (hu)
AR (1) AR002268A1 (hu)
AT (1) ATE381570T1 (hu)
AU (1) AU4775596A (hu)
BR (1) BR9607186B1 (hu)
CA (1) CA2210632A1 (hu)
CZ (1) CZ224897A3 (hu)
DE (1) DE69637369T2 (hu)
DK (1) DK0804440T3 (hu)
EA (1) EA000607B1 (hu)
ES (1) ES2297835T3 (hu)
HU (1) HUP9702219A3 (hu)
IL (1) IL116773A (hu)
MX (1) MX9705415A (hu)
NZ (1) NZ302159A (hu)
TW (1) TW426684B (hu)
WO (1) WO1996022295A1 (hu)
ZA (1) ZA96299B (hu)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5532235A (en) * 1995-01-17 1996-07-02 American Cyanamid Company Tricyclic benzazepine vasopressin antagonists
JP2791430B2 (ja) 1995-11-09 1998-08-27 日本たばこ産業株式会社 縮合ヘテロ５員環アゼピン誘導体及びその医薬用途
WO1997017349A1 (fr) * 1995-11-09 1997-05-15 Japan Tobacco Inc. Derives heterocycliques fusionnes pentagonaux d'azepine et leur emploi pharmaceutique
US5880122A (en) * 1996-11-01 1999-03-09 American Home Products Corporation 3-Carboxamide derivatives of 5H-pyrrolo 2,1-c! 1,4!-benzodiazepines
US6297234B1 (en) 1999-02-04 2001-10-02 American Home Products Corporation Arylthiophene vasopressin agonists
US6235900B1 (en) 1999-02-04 2001-05-22 American Home Products Corporation Tricyclic pyridine N-oxides vasopressin agonists
US6437006B1 (en) 1999-09-27 2002-08-20 American Cyanamid Company Pharmaceutical carrier formulation
US6977254B2 (en) * 2001-04-12 2005-12-20 Wyeth Hydroxy cyclohexenyl phenyl carboxamides tocolytic oxytocin receptor antagonists
US6900200B2 (en) 2001-04-12 2005-05-31 Wyeth Tricyclic hydroxy carboxamides and derivatives thereof tocolytic oxytocin receptor antagonists
US7326700B2 (en) * 2001-04-12 2008-02-05 Wyeth Cyclohexenyl phenyl carboxamides tocolytic oxytocin receptor antagonists
US7064120B2 (en) * 2001-04-12 2006-06-20 Wyeth Tricyclic pyridyl carboxamides and derivatives thereof tocolytic oxytocin receptor antagonists
JP2004530668A (ja) 2001-04-12 2004-10-07 ワイス バソプレッシンアゴニストとしてのｎ−ビフェニルカルボニル−およびｎ−フェニルピリジルカルボニル置換二および三環アゼピンおよびジアゼピン
US7202239B2 (en) * 2001-04-12 2007-04-10 Wyeth Cyclohexylphenyl carboxamides tocolytic oxytocin receptor antagonists
US7109193B2 (en) 2001-04-12 2006-09-19 Wyeth Tricyclic diazepines tocolytic oxytocin receptor antagonists
US7022699B2 (en) 2001-04-12 2006-04-04 Wyeth Cyclohexenyl phenyl diazepines vasopressin and oxytocin receptor modulators
CA2443870A1 (en) * 2001-04-12 2002-10-24 Wyeth Cyclohexylphenyl vasopressin agonists
SE0102299D0 (sv) 2001-06-26 2001-06-26 Astrazeneca Ab Compounds
SE0102764D0 (sv) 2001-08-17 2001-08-17 Astrazeneca Ab Compounds
US7057046B2 (en) * 2002-05-20 2006-06-06 Bristol-Myers Squibb Company Lactam glycogen phosphorylase inhibitors and method of use
US7098235B2 (en) 2002-11-14 2006-08-29 Bristol-Myers Squibb Co. Triglyceride and triglyceride-like prodrugs of glycogen phosphorylase inhibiting compounds
JP2008513140A (ja) * 2004-09-17 2008-05-01 コーディス・ニューロバスキュラー・インコーポレイテッド 血管の一時的または永続的閉塞のための薄膜器具
US9145425B2 (en) 2010-04-05 2015-09-29 Shionogi & Co., Ltd. Cephem compound having catechol group
CN109789149A (zh) * 2016-05-25 2019-05-21 阿卡纳治疗学有限公司 用于治疗疾病的稠合双环化合物
MA49566A (fr) 2017-07-11 2020-05-20 Vertex Pharma Carboxamides utilisés en tant qu'inhibiteurs des canaux sodiques
WO2024051590A1 (zh) * 2022-09-05 2024-03-14 上海济煜医药科技有限公司 苯并氮杂卓并环化合物盐型、晶型及其应用

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4766108A (en) * 1986-12-04 1988-08-23 Smith Kline Beckman Corporation Tyr-Arg-vasopressin antagonists
US5055448A (en) * 1987-06-25 1991-10-08 Medical College Of Ohio Linear derivatives of arginine vasopressin antagonists
DK0382185T3 (da) * 1989-02-10 1994-07-04 Otsuka Pharma Co Ltd Carbostyrilderivater
US5258510A (en) * 1989-10-20 1993-11-02 Otsuka Pharma Co Ltd Benzoheterocyclic compounds
DE122009000062I2 (de) * 1989-10-20 2011-01-13 Otsuka Pharma Co Ltd Benzoheterozyklische verbindungen
US5070187A (en) * 1989-11-03 1991-12-03 Trustees Of Boston University Pharmacologically effective antagonists of arginine-vasopressin
TW199153B (hu) * 1990-08-07 1993-02-01 Dtsuka Seiyaku Kk
CA2066104C (en) * 1991-04-19 2003-05-27 Hidenori Ogawa Benzazepine derivatives as vasopressin antagonists
DE69223573D1 (de) * 1991-09-16 1998-01-29 Merck & Co Inc Hydantoin und Succinimid-substituierte Spiroindanylcamphorsulfonyl als Oxytocin-Antagonisten
EP0533240A3 (en) * 1991-09-16 1993-09-29 Merck & Co. Inc. Substituted amine derivatives of piperazinylcamphorsulfonyl oxytocin antagonists
US5204349A (en) * 1991-09-16 1993-04-20 Merck & Co., Inc. Amide-substituted derivatives of spiroindanylcamphorsulfonyl oxytocin antagonists
EP0533242A3 (en) * 1991-09-16 1993-09-15 Merck & Co. Inc. Substituted derivatives of piperazinylcamphorsulfonyl oxytocin antagonists
WO1994004525A1 (en) * 1992-08-20 1994-03-03 Otsuka Pharmaceutical Company, Limited Benzoheterocyclic compounds as oxytocin and vasopressin antagonists
WO1994012476A1 (en) * 1992-11-25 1994-06-09 Yamanouchi Pharmaceutical Co., Ltd. Benzanilide derivative
AU5692094A (en) * 1992-12-21 1994-07-19 Yamanouchi Pharmaceutical Co., Ltd. Novel n-(pyridylcarbonyl)benzazepine derivative and intermediate therefor
AU6219994A (en) * 1993-03-11 1994-09-26 Yamanouchi Pharmaceutical Co., Ltd. Compound with vasopressin antagonism
GB9307527D0 (en) * 1993-04-13 1993-06-02 Fujisawa Pharmaceutical Co New venzamide derivatives,processes for the preparation thereof and pharmaceutical composition comprising the same
US5512563A (en) * 1993-07-29 1996-04-30 American Cyanamid Company Tricyclic benzazepine vasopressin antagonists
US5532235A (en) * 1995-01-17 1996-07-02 American Cyanamid Company Tricyclic benzazepine vasopressin antagonists

Also Published As

Publication number Publication date
EA000607B1 (ru) 1999-12-29
MX9705415A (es) 1997-11-29
AR002268A1 (es) 1998-03-11
DE69637369D1 (de) 2008-01-31
HUP9702219A2 (hu) 1998-07-28
IL116773A (en) 2000-12-06
TW426684B (en) 2001-03-21
JPH10512867A (ja) 1998-12-08
EA199700111A1 (ru) 1997-12-30
NZ302159A (en) 2000-01-28
CA2210632A1 (en) 1996-07-25
JP4219978B2 (ja) 2009-02-04
US5719278A (en) 1998-02-17
AU4775596A (en) 1996-08-07
ATE381570T1 (de) 2008-01-15
ES2297835T3 (es) 2008-05-01
US5532235A (en) 1996-07-02
ZA96299B (en) 1997-07-15
CZ224897A3 (cs) 1998-04-15
DK0804440T3 (da) 2008-03-31
IL116773A0 (en) 1996-05-14
EP0804440B1 (en) 2007-12-19
EP0804440A1 (en) 1997-11-05
CN1181084A (zh) 1998-05-06
WO1996022295A1 (en) 1996-07-25
BR9607186B1 (pt) 2009-01-13
DE69637369T2 (de) 2009-01-22
CN1061658C (zh) 2001-02-07
BR9607186A (pt) 1997-11-11

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