HUP9601857A2 - Új N-benzil-piperidin- és tetrahidropiridinszármazékok és eljárás azok előállítására - Google Patents

Új N-benzil-piperidin- és tetrahidropiridinszármazékok és eljárás azok előállítására

Info

Publication number
HUP9601857A2
HUP9601857A2 HU9601857A HUP9601857A HUP9601857A2 HU P9601857 A2 HUP9601857 A2 HU P9601857A2 HU 9601857 A HU9601857 A HU 9601857A HU P9601857 A HUP9601857 A HU P9601857A HU P9601857 A2 HUP9601857 A2 HU P9601857A2
Authority
HU
Hungary
Prior art keywords
tetrahydro
piperidine
benzyl
processes
producing
Prior art date
Application number
HU9601857A
Other languages
English (en)
Inventor
János Kreidl
László Czibula
András Nemes
Juhász Ida Deutschné
Kálmán Harsányi
László Dobay
István Hegedűs
István Borza
Bagdy Judit Nagyné
Papp Éva Werkné
Original Assignee
Richter Gedeon Vegyészeti Gyár Rt.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyészeti Gyár Rt. filed Critical Richter Gedeon Vegyészeti Gyár Rt.
Priority to HU9601857A priority Critical patent/HU221921B1/hu
Publication of HU9601857D0 publication Critical patent/HU9601857D0/hu
Priority to SI9730291T priority patent/SI0923554T1/xx
Priority to ES97932953T priority patent/ES2170403T3/es
Priority to DE69709938T priority patent/DE69709938T2/de
Priority to AT97932953T priority patent/ATE211732T1/de
Priority to US09/214,099 priority patent/US6657062B1/en
Priority to AU36311/97A priority patent/AU3631197A/en
Priority to DK97932953T priority patent/DK0923554T3/da
Priority to EP97932953A priority patent/EP0923554B1/en
Priority to PT97932953T priority patent/PT923554E/pt
Priority to PCT/HU1997/000037 priority patent/WO1998001424A1/en
Publication of HUP9601857A2 publication Critical patent/HUP9601857A2/hu
Publication of HUP9601857A3 publication Critical patent/HUP9601857A3/hu
Publication of HU221921B1 publication Critical patent/HU221921B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A találmány tárgya új, (I) általánős képletű N-benzil-piperidin - éstetrahidrőpiridinszármazékők -, ahől a képletben X jelentése hidrőxil-csőpőrt, halőgénatőm vagy R-SO3 - általánős képletű csőpőrt, ahől Rjelentése adőtt esetben szűbsztitűált alkil- vagy arilcsőpőrt, A és Bjelentése külön-külön hidrőgénatőm vagy együtt egy vegyértékkötés -valamint cisz- és transzizőmerjeik, őptikailag aktív antipódjaik,racemátjaik és ezek sói.Az (I) általánős képletű vegyületek gyógyszeripari intermedierjei aparőxerinevű antidepresszáns hatású gyógyszer hatóanyagnak.(I)ŕ
HU9601857A 1996-07-08 1996-07-08 N-benzil-piperidin- és tetrahidropiridinszármazékok és eljárás azok előállítására HU221921B1 (hu)

Priority Applications (11)

Application Number Priority Date Filing Date Title
HU9601857A HU221921B1 (hu) 1996-07-08 1996-07-08 N-benzil-piperidin- és tetrahidropiridinszármazékok és eljárás azok előállítására
PCT/HU1997/000037 WO1998001424A1 (en) 1996-07-08 1997-07-07 N-benzylpiperidine and tetrahydropyridine derivatives
ES97932953T ES2170403T3 (es) 1996-07-08 1997-07-07 Derivados de n-bencil-piperidina y tetrahidro-piridina.
SI9730291T SI0923554T1 (en) 1996-07-08 1997-07-07 N-benzylpiperidine and tetrahydropyridine derivatives
DE69709938T DE69709938T2 (de) 1996-07-08 1997-07-07 N-benzylpiperidin- und tetrahydropyridin-derivate
AT97932953T ATE211732T1 (de) 1996-07-08 1997-07-07 N-benzylpiperidin- und tetrahydropyridin-derivate
US09/214,099 US6657062B1 (en) 1996-07-08 1997-07-07 N-benzylpiperidine and tetrahydropyridine derivatives
AU36311/97A AU3631197A (en) 1996-07-08 1997-07-07 N-benzylpiperidine and tetrahydropyridine derivatives
DK97932953T DK0923554T3 (da) 1996-07-08 1997-07-07 N-Benzylpiperidin- og tetrahydropyridinderivater
EP97932953A EP0923554B1 (en) 1996-07-08 1997-07-07 N-benzylpiperidine and tetrahydropyridine derivatives
PT97932953T PT923554E (pt) 1996-07-08 1997-07-07 N-benzilpiperidina e derivados tetrahidropiridina

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU9601857A HU221921B1 (hu) 1996-07-08 1996-07-08 N-benzil-piperidin- és tetrahidropiridinszármazékok és eljárás azok előállítására

Publications (4)

Publication Number Publication Date
HU9601857D0 HU9601857D0 (en) 1996-08-28
HUP9601857A2 true HUP9601857A2 (hu) 1998-05-28
HUP9601857A3 HUP9601857A3 (en) 1998-07-28
HU221921B1 HU221921B1 (hu) 2003-02-28

Family

ID=89994099

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9601857A HU221921B1 (hu) 1996-07-08 1996-07-08 N-benzil-piperidin- és tetrahidropiridinszármazékok és eljárás azok előállítására

Country Status (10)

Country Link
US (1) US6657062B1 (hu)
EP (1) EP0923554B1 (hu)
AT (1) ATE211732T1 (hu)
AU (1) AU3631197A (hu)
DE (1) DE69709938T2 (hu)
DK (1) DK0923554T3 (hu)
ES (1) ES2170403T3 (hu)
HU (1) HU221921B1 (hu)
PT (1) PT923554E (hu)
WO (1) WO1998001424A1 (hu)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9710004D0 (en) 1997-05-17 1997-07-09 Knoll Ag Chemical process
CA2293247C (en) * 1997-06-10 2005-04-12 Synthon B.V. 4-phenylpiperidine compounds
IL137684A0 (en) * 1998-02-06 2001-10-31 Smithkline Beechmam Plc Salts of paroxetine
GB9808894D0 (en) * 1998-04-25 1998-06-24 Smithkline Beecham Plc Novel compound
GB9814316D0 (en) * 1998-07-02 1998-09-02 Smithkline Beecham Plc Novel compounds
CH689805A8 (fr) * 1998-07-02 2000-02-29 Smithkline Beecham Plc Méthanesulfonate de paroxétine, procédé pour sa préparation et compositions pharmaceutiques le contenant.
EP1102764A1 (en) * 1998-08-08 2001-05-30 Smithkline Beecham Plc Paroxetine salts
GB9826180D0 (en) * 1998-11-30 1999-01-20 Smithkline Beecham Plc Novel process
GB9826242D0 (en) * 1998-11-30 1999-01-20 Smithkline Beecham Plc Novel process
DE69913377T2 (de) * 1998-11-30 2004-12-30 Smithkline Beecham P.L.C., Brentford Gemischte Paroxetin-Propan-2-ol-Solvate
GB9826171D0 (en) * 1998-11-30 1999-01-20 Smithkline Beecham Plc Novel compounds
GB9826178D0 (en) * 1998-11-30 1999-01-20 Smithkline Beecham Plc Novel process
GB9828780D0 (en) * 1998-12-29 1999-02-17 Smithkline Beecham Plc Novel process
IT1308629B1 (it) * 1999-02-23 2002-01-09 Recordati Chem Pharm Processo per la produzione di paroxetina.
GB9916187D0 (en) * 1999-07-09 1999-09-08 Smithkline Beecham Plc Novel process
IT1313702B1 (it) * 1999-08-02 2002-09-09 Chemi Spa Processo per la preparazione di derivati 3-sostituiti di 4-fenil-piperidine.
GB9919052D0 (en) * 1999-08-12 1999-10-13 Smithkline Beecham Plc Novel compound composition and process
GB9920146D0 (en) * 1999-08-25 1999-10-27 Smithkline Beecham Plc Novel process
GB9923540D0 (en) * 1999-10-05 1999-12-08 Smithkline Beecham Plc Novel process
GB9923539D0 (en) * 1999-10-05 1999-12-08 Smithkline Beecham Plc Novel process
HU226912B1 (en) * 2000-04-07 2010-03-01 Richter Gedeon Nyrt New paroxetin salt and medicament containing it
WO2001085688A1 (en) 2000-05-12 2001-11-15 Synthon B.V. TOSYLATE SALTS OF 4-(p-FLUOROPHENYL)-PIPERIDINE-3-CARBINOLS
ATE257823T1 (de) * 2000-05-12 2004-01-15 Synthon Bv Piperidinverbindungen und verfahren zu deren herstellung
GB0021145D0 (en) * 2000-08-30 2000-10-11 Knoll Ag Chemical process
GB0021147D0 (en) * 2000-08-30 2000-10-11 Knoll Ag Chemical process
US6777554B2 (en) * 2001-02-05 2004-08-17 Teva Pharmaceutical Industries Ltd. Preparation of N-methylparoxetine and related intermediate compounds
IL159280A0 (en) * 2001-06-14 2004-06-01 Teva Pharma A process for preparing paroxetine hcl which limits formation of pink colored compounds
GB2382074A (en) 2001-11-14 2003-05-21 Basf Ag Recovery of chiral tartaric acid resolving agents
US9138430B2 (en) * 2007-12-27 2015-09-22 Mylan Specialty L.P. Formulation and method for the release of paroxetine in the large intestine

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1422263A (en) * 1973-01-30 1976-01-21 Ferrosan As 4-phenyl-piperidine compounds
CH583730A5 (hu) * 1973-09-25 1977-01-14 Wander Ag Dr A
DE3242923A1 (de) * 1982-11-20 1984-05-24 Basf Ag, 6700 Ludwigshafen 7-phenyl-7-phenoxymethyl-hexahydro-1,4-oxazepine, ihre herstellung und verwendung
US4585777A (en) * 1984-02-07 1986-04-29 A/S Ferrosan (-)-Trans-4-(4-fluorophenyl)-3-(4-methoxyphenoxy)methylpiperidine for potentiating 5-HT
EP0190496A3 (en) * 1984-12-13 1987-05-27 Beecham Group Plc Piperidine derivatives having a gastro-intestinal activity
EP0223403B1 (en) * 1985-10-25 1993-08-04 Beecham Group Plc Piperidine derivative, its preparation, and its use as medicament
DK715988D0 (da) * 1988-12-22 1988-12-22 Ferrosan As Etherifikation og dealkylering af piperidin-derivater samt intermediater
US5258517A (en) * 1992-08-06 1993-11-02 Sepracor, Inc. Method of preparing optically pure precursors of paroxetine
NZ307479A (en) * 1995-05-17 1999-08-30 Novo Nordisk As A process for preparing 4-(4-halo substituted phenyl)-3-(3,4-methylenedioxy phenoxy methyl)piperidine derivatives
CN1256326C (zh) * 1995-09-07 2006-05-17 弗·哈夫曼-拉罗切有限公司 治疗心脏和肾功能不全的新型4－(氧烷氧基苯基)－3－氧哌啶化合物
GB9526645D0 (en) * 1995-12-28 1996-02-28 Chiroscience Ltd Stereoselective synthesis
CA2293247C (en) * 1997-06-10 2005-04-12 Synthon B.V. 4-phenylpiperidine compounds

Also Published As

Publication number Publication date
HU9601857D0 (en) 1996-08-28
ES2170403T3 (es) 2002-08-01
DK0923554T3 (da) 2002-04-29
PT923554E (pt) 2002-07-31
HUP9601857A3 (en) 1998-07-28
EP0923554B1 (en) 2002-01-09
US6657062B1 (en) 2003-12-02
DE69709938D1 (de) 2002-02-28
WO1998001424A1 (en) 1998-01-15
ATE211732T1 (de) 2002-01-15
EP0923554A1 (en) 1999-06-23
AU3631197A (en) 1998-02-02
DE69709938T2 (de) 2002-08-29
HU221921B1 (hu) 2003-02-28

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Legal Events

Date Code Title Description
HFG4 Patent granted, date of granting

Effective date: 20021220

HC9A Change of name, address

Owner name: RICHTER GEDEON NYRT., HU

Free format text: FORMER OWNER(S): RICHTER GEDEON VEGYESZETI GYAR RT., HU