HUP1900112A1 - Immunglobulinok affinitás kromatográfiájának fejlesztése kötést megelõzõ flokkulálás alkalmazásával - Google Patents

Immunglobulinok affinitás kromatográfiájának fejlesztése kötést megelõzõ flokkulálás alkalmazásával

Info

Publication number
HUP1900112A1
HUP1900112A1 HU1900112A HUP1900112A HUP1900112A1 HU P1900112 A1 HUP1900112 A1 HU P1900112A1 HU 1900112 A HU1900112 A HU 1900112A HU P1900112 A HUP1900112 A HU P1900112A HU P1900112 A1 HUP1900112 A1 HU P1900112A1
Authority
HU
Hungary
Prior art keywords
flocculation
immunoglobulins
capture
improvement
affinity chromatography
Prior art date
Application number
HU1900112A
Other languages
English (en)
Inventor
Zsuzsanna Keszey
Zoltan Suetoe
Original Assignee
Richter Gedeon Nyrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Nyrt filed Critical Richter Gedeon Nyrt
Priority to HU1900112A priority Critical patent/HUP1900112A1/hu
Priority to US17/601,197 priority patent/US20220194981A1/en
Priority to CA3130629A priority patent/CA3130629A1/en
Priority to KR1020217034512A priority patent/KR20210149089A/ko
Priority to MA055503A priority patent/MA55503A/fr
Priority to JP2021558539A priority patent/JP7333412B2/ja
Priority to CN202080026805.7A priority patent/CN113710685A/zh
Priority to AU2020252054A priority patent/AU2020252054A1/en
Priority to PCT/EP2020/058439 priority patent/WO2020200980A1/en
Priority to EP20716409.6A priority patent/EP3947414A1/en
Publication of HUP1900112A1 publication Critical patent/HUP1900112A1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/12—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the preparation of the feed
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
    • B01D15/3804—Affinity chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
    • B01D15/3804—Affinity chromatography
    • B01D15/3809—Affinity chromatography of the antigen-antibody type, e.g. protein A, G, L chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
HU1900112A 2019-04-04 2019-04-04 Immunglobulinok affinitás kromatográfiájának fejlesztése kötést megelõzõ flokkulálás alkalmazásával HUP1900112A1 (hu)

Priority Applications (10)

Application Number Priority Date Filing Date Title
HU1900112A HUP1900112A1 (hu) 2019-04-04 2019-04-04 Immunglobulinok affinitás kromatográfiájának fejlesztése kötést megelõzõ flokkulálás alkalmazásával
US17/601,197 US20220194981A1 (en) 2019-04-04 2020-03-25 Improvement of affinity chromatography of immunoglobulins by using pre-capture flocculation
CA3130629A CA3130629A1 (en) 2019-04-04 2020-03-25 Improvement of affinity chromatography of immunoglobulins by using pre-capture flocculation
KR1020217034512A KR20210149089A (ko) 2019-04-04 2020-03-25 사전 포획 응집을 이용하는 것에 의한 면역글로불린의 친화성 크로마토그래피 개선
MA055503A MA55503A (fr) 2019-04-04 2020-03-25 Amélioration de la chromatographie d'affinité d'immunoglobulines au moyen d'une floculation de pré-capture
JP2021558539A JP7333412B2 (ja) 2019-04-04 2020-03-25 キャプチャー前の凝集の使用による免疫グロブリンのアフィニティークロマトグラフィーの改善
CN202080026805.7A CN113710685A (zh) 2019-04-04 2020-03-25 通过使用捕获前的絮凝改善免疫球蛋白的亲和色谱
AU2020252054A AU2020252054A1 (en) 2019-04-04 2020-03-25 Improvement of affinity chromatography of immunoglobulins by using pre-capture flocculation
PCT/EP2020/058439 WO2020200980A1 (en) 2019-04-04 2020-03-25 Improvement of affinity chromatography of immunoglobulins by using pre-capture flocculation
EP20716409.6A EP3947414A1 (en) 2019-04-04 2020-03-25 Improvement of affinity chromatography of immunoglobulins by using pre-capture flocculation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU1900112A HUP1900112A1 (hu) 2019-04-04 2019-04-04 Immunglobulinok affinitás kromatográfiájának fejlesztése kötést megelõzõ flokkulálás alkalmazásával

Publications (1)

Publication Number Publication Date
HUP1900112A1 true HUP1900112A1 (hu) 2020-10-28

Family

ID=89992878

Family Applications (1)

Application Number Title Priority Date Filing Date
HU1900112A HUP1900112A1 (hu) 2019-04-04 2019-04-04 Immunglobulinok affinitás kromatográfiájának fejlesztése kötést megelõzõ flokkulálás alkalmazásával

Country Status (10)

Country Link
US (1) US20220194981A1 (hu)
EP (1) EP3947414A1 (hu)
JP (1) JP7333412B2 (hu)
KR (1) KR20210149089A (hu)
CN (1) CN113710685A (hu)
AU (1) AU2020252054A1 (hu)
CA (1) CA3130629A1 (hu)
HU (1) HUP1900112A1 (hu)
MA (1) MA55503A (hu)
WO (1) WO2020200980A1 (hu)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11964998B2 (en) * 2017-08-30 2024-04-23 Fresenius Kabi Deutschland Gmbh Method for purifying anti-IL-6 receptor antibodies
AU2021371309A1 (en) * 2020-10-30 2023-05-18 Genentech, Inc. Purification platforms for obtaining pharmaceutical compositions having a reduced hydrolytic enzyme activity rate
MX2023007131A (es) * 2020-12-18 2023-06-27 Richter Gedeon Nyrt Metodos para la purificacion de proteina de fusion fc-peptido replegada.
WO2023167850A1 (en) * 2022-03-02 2023-09-07 Regeneron Pharmaceuticals, Inc. Manufacturing process for high titer antibody
CN115430198A (zh) * 2022-09-21 2022-12-06 英脉生物医药(杭州)有限公司 一种蛋白纯化方法和蛋白纯化***

Family Cites Families (21)

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ES2289997T3 (es) 1991-03-18 2008-02-16 New York University Anticuerpos monoclonales y quimericos especificos para el factor de necrosis tumoral humano.
LU91067I2 (fr) 1991-06-14 2004-04-02 Genentech Inc Trastuzumab et ses variantes et dérivés immuno chimiques y compris les immotoxines
WO1994011026A2 (en) 1992-11-13 1994-05-26 Idec Pharmaceuticals Corporation Therapeutic application of chimeric and radiolabeled antibodies to human b lymphocyte restricted differentiation antigen for treatment of b cell lymphoma
US5429746A (en) 1994-02-22 1995-07-04 Smith Kline Beecham Corporation Antibody purification
HU228630B1 (en) 1996-02-09 2013-04-29 Abbott Biotech Ltd Use of human anti bodies that bind human tnf-alpha and process for inhibiting of human tnf-alpha activity
TR199903123T2 (xx) 1997-04-07 2000-05-22 Genentech, Inc. Anti-Vegf antikorlar�.
JP2001194306A (ja) 2000-01-06 2001-07-19 Advantest Corp 化学物質検出方法及び装置
TR201809008T4 (tr) 2001-06-26 2018-07-23 Amgen Fremont Inc Opgl ye karşi antikorlar.
AU2006292739A1 (en) 2005-09-15 2007-03-29 Wyeth Protein floculation using salts
CN101534920B (zh) 2006-11-01 2013-10-16 比奥根艾迪克Ma公司 通过低ph和二价阳离子分离生物大分子的方法
ES2426158T3 (es) 2007-01-22 2013-10-21 Genentech, Inc. Precipitación con polielectrolito y purificación de anticuerpos
EP2445925A1 (en) 2009-06-25 2012-05-02 Bristol-Myers Squibb Company Protein purification by caprylic acid (octanoic acid) precipitation
SG10201804385YA (en) 2010-05-17 2018-06-28 Emd Millipore Corp Stimulus responsive polymers for the purification of biomolecules
AR089231A1 (es) 2011-12-15 2014-08-06 Amgen Inc Metodo de floculacion
EP2682168A1 (en) 2012-07-02 2014-01-08 Millipore Corporation Purification of biological molecules
SG11201505192RA (en) 2013-02-28 2015-08-28 Agency Science Tech & Res Chromatographic purification of antibodies from chromatin-deficient cell culture harvests
JP2016520655A (ja) 2013-06-04 2016-07-14 エイジェンシー・フォー・サイエンス，テクノロジー・アンド・リサーチ タンパク質精製プロセス
WO2015130222A1 (en) 2014-02-27 2015-09-03 Agency For Science, Technology And Research Antibody purification process
JP6293907B2 (ja) 2014-03-10 2018-03-14 リヒター ゲデオン エヌワイアールティー． プレクリーニング工程を用いた免疫グロブリンの精製
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US10927145B2 (en) 2016-06-15 2021-02-23 Agency For Science, Technology And Research Method of enhancing the performance of chromatography methods for purification of proteins

Also Published As

Publication number Publication date
AU2020252054A1 (en) 2021-09-16
CA3130629A1 (en) 2020-10-08
WO2020200980A1 (en) 2020-10-08
KR20210149089A (ko) 2021-12-08
JP7333412B2 (ja) 2023-08-24
US20220194981A1 (en) 2022-06-23
MA55503A (fr) 2022-02-09
JP2022526965A (ja) 2022-05-27
EP3947414A1 (en) 2022-02-09
CN113710685A (zh) 2021-11-26

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