HUP0402616A2 - Bifenilmetil-tiazolidindionok, bifenilpropionsav-származékok, alkalmazásuk PPAR-gamma aktivátorként és az ezeket tartalmazó gyógyszerészeti és kozmetikai készítmények - Google Patents

Bifenilmetil-tiazolidindionok, bifenilpropionsav-származékok, alkalmazásuk PPAR-gamma aktivátorként és az ezeket tartalmazó gyógyszerészeti és kozmetikai készítmények

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Publication number
HUP0402616A2
HUP0402616A2 HU0402616A HUP0402616A HUP0402616A2 HU P0402616 A2 HUP0402616 A2 HU P0402616A2 HU 0402616 A HU0402616 A HU 0402616A HU P0402616 A HUP0402616 A HU P0402616A HU P0402616 A2 HUP0402616 A2 HU P0402616A2
Authority
HU
Hungary
Prior art keywords
group
pharmaceutical
thiazolidinedones
biphenylmethyl
ppar
Prior art date
Application number
HU0402616A
Other languages
English (en)
Inventor
Jean-Michel Bernardon
Laurence Clary
Eric Terranova
Original Assignee
Galderma Research & Development S.N.C.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Galderma Research & Development S.N.C. filed Critical Galderma Research & Development S.N.C.
Publication of HUP0402616A2 publication Critical patent/HUP0402616A2/hu
Publication of HUP0402616A3 publication Critical patent/HUP0402616A3/hu

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/34—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/41—Amines
    • A61K8/416—Quaternary ammonium compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4913—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4986—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with sulfur as the only hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/007—Preparations for dry skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/06—Preparations for care of the skin for countering cellulitis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/70—Biological properties of the composition as a whole

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Cosmetics (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Az (I) általános képletű vegyületek aktiválják a peroxiszómaproliferátor aktuális receptor gamma altípusát (PPARg) humán ésállatgyógyászatban (dermatológiában, továbbá szív-érrendszerimegbetegedések, immunrendszeri megbetegedések és/vagy a lipidmetabolizmussal kapcsolatos betegségek kezelésére szolgáló)gyógyszerészeti készítményekben, valamint kozmetikai készítményekbenhasználhatók. A képletben R1 jelentése (a) vagy (b) általános képletűcsoport; R2 és R3 jelentése egymástól függetlenül H, alkilcsoport,arilcsoport, halogénatom, éterkötéssel kapcsolódó csoport, poliéter-,nitro- vagy aminocsoport; X jelentése -CH2-N(R8)-CO-, -N(R8)-CO-N(R9)-, -N(R8)-CO-CH2- vagy N(R8)-CO2-CO-; R4 jelentése változatosaril-, hetaril-, karbociklusos és heterociklusos csoportok valamint aleírásban részletezett egyéb csoportok; R5 jelentése OH- vagy 1-9szénatomos alkoxicsoport; R6 jelentése 1-6 szénatomos alkilcsoport,éter- vagy tioéter kötésű csoportok; R8 és R9 jelentése egymástólfüggetlenül H vagy 1-6 szénatomos alkilcsoport. Ó
HU0402616A 2001-12-21 2002-12-09 Biphenylmethyl-thiazolidinedones, biphenyl-propionic acid derivatives, their use as ppar-gamma activators and pharmaceutical and cosmetic compositions containing them HUP0402616A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0116750A FR2833949B1 (fr) 2001-12-21 2001-12-21 NOUVEAUX LIGANDS ACTIVATEURS DES RECEPTEURS PPARy, LEUR PROCEDE DE PREPARATION ET LEUR UTILISATION EN MEDECINE HUMAINE AINSI QU'EN COSMETIQUE
PCT/FR2002/004232 WO2003055867A1 (fr) 2001-12-21 2002-12-09 Biphenylmethyl-thiazolidinediones et analogues et leur utilisation comme activateur ppar-gamma

Publications (2)

Publication Number Publication Date
HUP0402616A2 true HUP0402616A2 (hu) 2005-03-29
HUP0402616A3 HUP0402616A3 (en) 2009-01-28

Family

ID=8870902

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0402616A HUP0402616A3 (en) 2001-12-21 2002-12-09 Biphenylmethyl-thiazolidinedones, biphenyl-propionic acid derivatives, their use as ppar-gamma activators and pharmaceutical and cosmetic compositions containing them

Country Status (20)

Country Link
EP (1) EP1458697B1 (hu)
JP (1) JP2005518394A (hu)
KR (1) KR20040072676A (hu)
CN (1) CN100360512C (hu)
AT (1) ATE338753T1 (hu)
AU (1) AU2002364985A1 (hu)
BR (1) BR0214239A (hu)
CA (1) CA2468796C (hu)
CY (1) CY1106255T1 (hu)
DE (1) DE60214595T2 (hu)
DK (1) DK1458697T3 (hu)
ES (1) ES2272820T3 (hu)
FR (1) FR2833949B1 (hu)
HU (1) HUP0402616A3 (hu)
MX (1) MXPA04006051A (hu)
PL (1) PL372881A1 (hu)
PT (1) PT1458697E (hu)
RU (1) RU2323212C2 (hu)
WO (1) WO2003055867A1 (hu)
ZA (1) ZA200403797B (hu)

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US7687664B2 (en) 2001-06-04 2010-03-30 Eisai R&D Management Co., Ltd. Carboxylic acid derivative, a salt thereof or an ester of them, and medicament comprising it
MXPA05005334A (es) * 2002-11-25 2005-11-17 Galderma Res & Dev Compuestos bifenilo activadores de los receptores de tipo receptores activados de la proliferacion de peroxisoma gamma y su uso en composiciones cosmeticas o farmaceuticas.
WO2005007141A2 (en) 2003-07-11 2005-01-27 Proteologics, Inc. Ubiquitin ligase inhibitors and methods related thereto
FR2862870A1 (fr) * 2003-12-01 2005-06-03 Galderma Res & Dev Utilisation d'activateurs de recepteurs ppar en cosmetique et dermatologie.
EP1734963A4 (en) 2004-04-02 2008-06-18 Merck & Co Inc METHOD FOR TREATING PEOPLE WITH METABOLIC AND ANTHROPOMETRIC DISORDER
BRPI0515015A (pt) * 2004-08-11 2008-07-01 Kyorin Seiyaku Kk derivado cìclico de ácido aminobenzóico; medicamento; agonista ppar(alpha); agonista duplo ppar(alpha), y; agonista duplo ppar(alpha), (delta); modulador ppar; agente lipìdeo; agente profilático ou terapêutico compreendendo pelo menos um dos derivados cìclicos de ácido aminobenzóico ou sal do mesmo farmacêuticamente aceitável
FR2874379B1 (fr) * 2004-08-17 2006-10-27 Galderma Res & Dev Nouveaux composes bi-aromatiques activateurs des recepteurs de type ppar et leur utilisation dans des compositions cosmetiques ou pharmaceutiques
FR2874378B1 (fr) * 2004-08-17 2006-10-27 Galderma Res & Dev Nouveaux composes bi-aromatiques activateurs des recepteurs de type ppar et leur utilisation dans des compositions cosmetiques ou pharmaceutiques
DE602005010444D1 (de) * 2004-08-17 2008-11-27 Galderma Res & Dev Neuartige biaromatische ppar-rezeptoren aktivierende zusammensetzungen und ihre verwendung in kosmetischen oder pharmazeutischen zusammensetzungen
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FR2878247B1 (fr) 2004-11-19 2008-10-03 Galderma Res & Dev Nouveaux composes modulateurs des recepteurs de type ppary et leur utilisation dans des compositions cosmetiques ou pharmaceutiques
EP1814871B1 (en) * 2004-11-19 2011-03-02 Galderma Research & Development Compounds that modulate ppary type receptors, and use thereof in cosmetic or pharmaceutical compositions
FR2887444A1 (fr) * 2005-06-28 2006-12-29 Oreal Composes benzylidene-1,3-thiazolidine-2,4-diones, leurs utilisations et compositions pour stimuler ou induire la pousse des fibres keratiniques et/ou freiner leur chute et/ou augmenter leur densite.
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FR2917086B1 (fr) * 2007-06-05 2009-07-17 Galderma Res & Dev Nouveaux derives d'acide 3-phenyl acrylique activateurs des recepteurs de type ppar, leur methode de preparation et leur utilisation dans des compositions cosmetiques ou pharmaceutiques.
IE20070928A1 (en) * 2007-12-21 2009-09-30 Giuliani Int Ltd Multi target ligands
EP3239170B1 (en) 2008-06-04 2019-03-20 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
EP3241839B1 (en) 2008-07-16 2019-09-04 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
CN101774941A (zh) 2009-01-13 2010-07-14 浙江九洲药业股份有限公司 2-酰基氨基-3-联苯基丙酸的制备及拆分方法
US20130156720A1 (en) 2010-08-27 2013-06-20 Ironwood Pharmaceuticals, Inc. Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders
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JP2016514671A (ja) 2013-03-15 2016-05-23 シナジー ファーマシューティカルズ インコーポレイテッド グアニル酸シクラーゼのアゴニストおよびその使用
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CN116217511B (zh) * 2023-03-22 2024-04-19 沈阳药科大学 一种双靶点化合物及其制备方法和在制备sEH抑制剂与PPARs激动剂中的应用

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FR2767525B1 (fr) * 1997-08-21 1999-11-12 Cird Galderma Derives biphenyliques substitues par un radical aromatique ou heteroaromatique et compositions pharmaceutiques et cosmetiques les contenant
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Also Published As

Publication number Publication date
EP1458697B1 (fr) 2006-09-06
RU2323212C2 (ru) 2008-04-27
WO2003055867A1 (fr) 2003-07-10
FR2833949B1 (fr) 2005-08-05
ATE338753T1 (de) 2006-09-15
FR2833949A1 (fr) 2003-06-27
DK1458697T3 (da) 2007-01-15
MXPA04006051A (es) 2004-09-27
ZA200403797B (en) 2004-12-22
CN100360512C (zh) 2008-01-09
PT1458697E (pt) 2007-01-31
CA2468796A1 (fr) 2003-07-10
DE60214595D1 (de) 2006-10-19
ES2272820T3 (es) 2007-05-01
PL372881A1 (en) 2005-08-08
AU2002364985A1 (en) 2003-07-15
BR0214239A (pt) 2004-09-21
CY1106255T1 (el) 2011-06-08
CN1639138A (zh) 2005-07-13
RU2004122394A (ru) 2005-03-27
CA2468796C (fr) 2012-07-17
JP2005518394A (ja) 2005-06-23
KR20040072676A (ko) 2004-08-18
HUP0402616A3 (en) 2009-01-28
DE60214595T2 (de) 2007-09-13
EP1458697A1 (fr) 2004-09-22

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