HUP0105437A2 - Új malonsavszármazékok, előállításuk és alkalmazásuk, valamint e vegyületeket tartalmazó gyógyászati készítmények - Google Patents
Új malonsavszármazékok, előállításuk és alkalmazásuk, valamint e vegyületeket tartalmazó gyógyászati készítményekInfo
- Publication number
- HUP0105437A2 HUP0105437A2 HU0105437A HUP0105437A HUP0105437A2 HU P0105437 A2 HUP0105437 A2 HU P0105437A2 HU 0105437 A HU0105437 A HU 0105437A HU P0105437 A HUP0105437 A HU P0105437A HU P0105437 A2 HUP0105437 A2 HU P0105437A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- preparation
- processes
- pharmaceutical compositions
- compositions containing
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title abstract 3
- 150000002690 malonic acid derivatives Chemical class 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000962 organic group Chemical group 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 208000001435 Thromboembolism Diseases 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
- C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
- C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
- C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
Abstract
A találmány szerinti vegyületek (I) általános képletében R(1)jelentése hidroxilcsoport vagy szerves csoport; R(2) jelentésehidrogénatom vagy alkilcsoport; R(3) jelentése szerves csoport; R(4)jelentése hidrogénatom vagy alkilcsoport, cikloalkilcsoport,cikloalkilalkil-csoport vagy aril-alkilcsoport; R(5) jelentésehidrogénatom vagy szerves csoport; vagy R(4) és R(5) együtt adottesetben helyettesített karboaromás csoportot alkot; és R(6) jelentésehidroxilcsoport vagy szerves csoport. A találmány tárgyköréheztartoznak a fenti vegyületek előállítása és alkalmazása, valamint evegyületeket tartalmazó gyógyászati készítmények, melyektromboembóliás betegségek kezelésére alkalmazhatók. Ó
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP99100002A EP1016663A1 (en) | 1999-01-02 | 1999-01-02 | Novel malonic acid derivatives, processes for their preparation, their use and pharmaceutical compositions containing them (inhibition of factor Xa activity) |
EP99119537 | 1999-10-01 |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0105437A2 true HUP0105437A2 (hu) | 2002-05-29 |
HUP0105437A3 HUP0105437A3 (en) | 2003-03-28 |
Family
ID=26152843
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0105437A HUP0105437A3 (en) | 1999-01-02 | 1999-12-23 | Novel malonic acid derivatives, processes for their preparation, their use and pharmaceutical compositions containing them |
Country Status (17)
Country | Link |
---|---|
US (1) | US6395737B1 (hu) |
EP (1) | EP1140878A1 (hu) |
JP (1) | JP2002534420A (hu) |
KR (1) | KR20010101355A (hu) |
CN (1) | CN1332734A (hu) |
AU (1) | AU3043100A (hu) |
BR (1) | BR9916732A (hu) |
CA (1) | CA2358578A1 (hu) |
CZ (1) | CZ20012379A3 (hu) |
HK (1) | HK1041700A1 (hu) |
HU (1) | HUP0105437A3 (hu) |
ID (1) | ID29979A (hu) |
IL (1) | IL144096A0 (hu) |
NO (1) | NO20012983L (hu) |
PL (1) | PL349343A1 (hu) |
TR (1) | TR200101903T2 (hu) |
WO (1) | WO2000040571A1 (hu) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20010089753A (ko) | 1999-01-02 | 2001-10-08 | 로버트 흐라이탁, 미쉘 베스트 | 아릴알카노일 유도체, 이의 제조방법, 이의 용도 및 이를함유하는 약제학적 조성물 |
EP1127884A1 (en) * | 2000-02-26 | 2001-08-29 | Aventis Pharma Deutschland GmbH | Novel malonic acid derivatives, processes for their preparation, their use as inhibitor of factor XA activity and pharmaceutical compositions containing them |
FR2812635B1 (fr) * | 2000-08-01 | 2002-10-11 | Aventis Pharma Sa | Nouveaux composes heterocycliques, preparation et utilisation comme medicaments notamment comme anti- bacteriens |
US20050232995A1 (en) * | 2002-07-29 | 2005-10-20 | Yam Nyomi V | Methods and dosage forms for controlled delivery of paliperidone and risperidone |
US7479502B2 (en) | 2002-12-03 | 2009-01-20 | Pharmacyclics, Inc. | 2-(2-hydroxybiphenyl-3-yl)-1H-benzoimidazole-5-carboxamidine derivatives as factor VIIA inhibitors |
EP2630191A4 (en) | 2010-10-20 | 2015-05-20 | Sirrus Inc | SYNTHESIS SUBSTANTIALLY CLEANING METHYLENE MALONATES |
US10414839B2 (en) | 2010-10-20 | 2019-09-17 | Sirrus, Inc. | Polymers including a methylene beta-ketoester and products formed therefrom |
US9279022B1 (en) | 2014-09-08 | 2016-03-08 | Sirrus, Inc. | Solution polymers including one or more 1,1-disubstituted alkene compounds, solution polymerization methods, and polymer compositions |
US9828324B2 (en) | 2010-10-20 | 2017-11-28 | Sirrus, Inc. | Methylene beta-diketone monomers, methods for making methylene beta-diketone monomers, polymerizable compositions and products formed therefrom |
US9249265B1 (en) | 2014-09-08 | 2016-02-02 | Sirrus, Inc. | Emulsion polymers including one or more 1,1-disubstituted alkene compounds, emulsion methods, and polymer compositions |
US9079929B2 (en) | 2011-10-14 | 2015-07-14 | Bristol-Myers Squibb Company | Substituted tetrahydroisoquinoline compounds as factor XIa inhibitors |
CN103987697B (zh) | 2011-10-14 | 2017-04-26 | 百时美施贵宝公司 | 作为因子xia抑制剂的取代的四氢异喹啉化合物 |
SI2766346T1 (sl) | 2011-10-14 | 2017-05-31 | Bristol-Myers Squibb Company | Substituirane tetrahidroizokinolinske spojine kot faktor xia inhibitorji |
WO2013059473A2 (en) | 2011-10-19 | 2013-04-25 | Bioformix Inc. | Multifunctional monomers, methods for making multifunctional monomers, polymerizable compositions and products formed therefrom |
EP2831125B1 (en) | 2012-03-30 | 2016-10-05 | Sirrus, Inc. | Methods for activating polymerizable compositions, polymerizable systems, and products formed thereby |
EP3848402A1 (en) | 2012-03-30 | 2021-07-14 | Sirrus, Inc. | Ink and coating formulations and polymerizable systems for producing the same |
JP6553505B2 (ja) | 2012-03-30 | 2019-07-31 | シラス・インコーポレイテッド | 複合材およびラミネート物品ならびにこれらを作製するための重合系 |
WO2013181600A2 (en) | 2012-06-01 | 2013-12-05 | Bioformix Inc. | Optical material and articles formed therefrom |
WO2014059202A1 (en) | 2012-10-12 | 2014-04-17 | Bristol-Myers Squibb Company | Guanidine substituted tetrahydroisoquinoline compounds as factor xia inhibitors |
US9403774B2 (en) | 2012-10-12 | 2016-08-02 | Bristol-Myers Squibb Company | Guanidine and amine substituted tetrahydroisoquinoline compounds as factor xia inhibitors |
TR201807316T4 (tr) | 2012-10-12 | 2018-06-21 | Squibb Bristol Myers Co | Bir faktör XIa inhibitörünün kristalli formları. |
WO2014078689A1 (en) | 2012-11-16 | 2014-05-22 | Bioformix Inc. | Plastics bonding systems and methods |
JP6549038B2 (ja) | 2012-11-30 | 2019-07-24 | シラス・インコーポレイテッド | エレクトロニクス適用のための複合組成物 |
CN110204441A (zh) | 2013-01-11 | 2019-09-06 | 瑟拉斯公司 | 经过双(羟甲基)丙二酸酯的途径获得亚甲基丙二酸酯的方法 |
US9738655B2 (en) | 2013-03-25 | 2017-08-22 | Bristol-Myers Squibb Company | Tetrahydroisoquinolines containing substituted azoles as factor XIa inhibitors |
NO2760821T3 (hu) | 2014-01-31 | 2018-03-10 | ||
TWI688564B (zh) | 2014-01-31 | 2020-03-21 | 美商必治妥美雅史谷比公司 | 作為凝血因子xia抑制劑之具有雜環p2'基團之巨環化合物 |
CA2952968A1 (en) | 2014-07-01 | 2016-01-07 | Rempex Pharmaceuticals, Inc. | Boronic acid derivatives and therapeutic uses thereof |
ES2714283T3 (es) | 2014-09-04 | 2019-05-28 | Bristol Myers Squibb Co | Macrociclos de diamida que son inhibidores de FXIa |
US9315597B2 (en) | 2014-09-08 | 2016-04-19 | Sirrus, Inc. | Compositions containing 1,1-disubstituted alkene compounds for preparing polymers having enhanced glass transition temperatures |
US9416091B1 (en) | 2015-02-04 | 2016-08-16 | Sirrus, Inc. | Catalytic transesterification of ester compounds with groups reactive under transesterification conditions |
US9453018B2 (en) | 2014-10-01 | 2016-09-27 | Bristol-Myers Squibb Company | Pyrimidinones as factor XIa inhibitors |
US10501400B2 (en) | 2015-02-04 | 2019-12-10 | Sirrus, Inc. | Heterogeneous catalytic transesterification of ester compounds with groups reactive under transesterification conditions |
US9334430B1 (en) | 2015-05-29 | 2016-05-10 | Sirrus, Inc. | Encapsulated polymerization initiators, polymerization systems and methods using the same |
US9217098B1 (en) | 2015-06-01 | 2015-12-22 | Sirrus, Inc. | Electroinitiated polymerization of compositions having a 1,1-disubstituted alkene compound |
US9518001B1 (en) | 2016-05-13 | 2016-12-13 | Sirrus, Inc. | High purity 1,1-dicarbonyl substituted-1-alkenes and methods for their preparation |
US10428177B2 (en) | 2016-06-03 | 2019-10-01 | Sirrus, Inc. | Water absorbing or water soluble polymers, intermediate compounds, and methods thereof |
US9567475B1 (en) | 2016-06-03 | 2017-02-14 | Sirrus, Inc. | Coatings containing polyester macromers containing 1,1-dicarbonyl-substituted 1 alkenes |
US9617377B1 (en) | 2016-06-03 | 2017-04-11 | Sirrus, Inc. | Polyester macromers containing 1,1-dicarbonyl-substituted 1 alkenes |
US10196481B2 (en) | 2016-06-03 | 2019-02-05 | Sirrus, Inc. | Polymer and other compounds functionalized with terminal 1,1-disubstituted alkene monomer(s) and methods thereof |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE242404C (hu) | ||||
DE235866C (hu) | ||||
DE3269422D1 (en) * | 1981-09-25 | 1986-04-03 | Wellcome Found | Pharmaceutical amides, and preparation, formulations and use thereof |
US5518735A (en) | 1990-11-15 | 1996-05-21 | Pentapharm Ag | Meta-substituted phenylalanine derivatives |
IT1254883B (it) * | 1992-04-16 | 1995-10-11 | Italfarmaco Spa | Tetrapeptidi parzialmente modificati e retroinvertiti, analoghi di frammenti della proteina c-reattiva. |
EP0635008B1 (de) | 1993-02-10 | 2002-09-04 | Pentapharm A.G. | Piperazide von substituierten phenylalanin-derivativen als thrombin inhibitoren |
US5977074A (en) * | 1993-10-01 | 1999-11-02 | Merrell Pharmaceuticals, Inc. | Inhibitors of β-amyloid protein production |
WO1995029189A1 (en) * | 1994-04-26 | 1995-11-02 | Selectide Corporation | FACTOR Xa INHIBITORS |
WO1996005189A1 (de) * | 1994-08-09 | 1996-02-22 | Pentapharm Ag | Neue inhibitoren vom benzamidintyp |
GB9420763D0 (en) * | 1994-10-14 | 1994-11-30 | Glaxo Inc | Acetamide derivatives |
JP4044614B2 (ja) * | 1995-12-20 | 2008-02-06 | アベンティス・ファーマスーティカルズ・インコーポレイテッド | N―アセチル―(L)―4―シアノフェニルアラニンAc―(L)―Phe(4―CN)―OHおよびN―アセチル―(L)―p―アミジノフェニルアラニン―シクロヘキシルグリシン―β―(3―N―メチルピリジニウム)―アラニン Ac―(L)―pAph―Chg―PalMe(3)―NH2の新規な製法 |
TR199902692T2 (xx) | 1997-05-02 | 2000-07-21 | Akzo Nobel N.V. | Serin proteaz inhibit�rleri. |
CA2316172C (en) | 1997-12-24 | 2010-02-02 | Aventis Pharma Deutschland Gmbh | Indole derivatives as inhibitors of factor xa |
EP1016663A1 (en) | 1999-01-02 | 2000-07-05 | Aventis Pharma Deutschland GmbH | Novel malonic acid derivatives, processes for their preparation, their use and pharmaceutical compositions containing them (inhibition of factor Xa activity) |
-
1999
- 1999-12-23 KR KR1020017008429A patent/KR20010101355A/ko not_active Application Discontinuation
- 1999-12-23 AU AU30431/00A patent/AU3043100A/en not_active Abandoned
- 1999-12-23 HU HU0105437A patent/HUP0105437A3/hu unknown
- 1999-12-23 WO PCT/EP1999/010340 patent/WO2000040571A1/en not_active Application Discontinuation
- 1999-12-23 EP EP99964667A patent/EP1140878A1/en not_active Withdrawn
- 1999-12-23 CN CN99815372A patent/CN1332734A/zh active Pending
- 1999-12-23 ID IDW00200101430A patent/ID29979A/id unknown
- 1999-12-23 CA CA002358578A patent/CA2358578A1/en not_active Abandoned
- 1999-12-23 IL IL14409699A patent/IL144096A0/xx unknown
- 1999-12-23 CZ CZ20012379A patent/CZ20012379A3/cs unknown
- 1999-12-23 JP JP2000592279A patent/JP2002534420A/ja not_active Abandoned
- 1999-12-23 PL PL99349343A patent/PL349343A1/xx not_active Application Discontinuation
- 1999-12-23 BR BR9916732-8A patent/BR9916732A/pt not_active IP Right Cessation
- 1999-12-23 TR TR2001/01903T patent/TR200101903T2/xx unknown
- 1999-12-28 US US09/473,053 patent/US6395737B1/en not_active Expired - Lifetime
-
2001
- 2001-06-15 NO NO20012983A patent/NO20012983L/no not_active Application Discontinuation
-
2002
- 2002-05-04 HK HK02103402.4A patent/HK1041700A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
ID29979A (id) | 2001-10-25 |
CZ20012379A3 (cs) | 2001-09-12 |
AU3043100A (en) | 2000-07-24 |
NO20012983D0 (no) | 2001-06-15 |
TR200101903T2 (tr) | 2001-11-21 |
WO2000040571A1 (en) | 2000-07-13 |
CA2358578A1 (en) | 2000-07-13 |
HUP0105437A3 (en) | 2003-03-28 |
EP1140878A1 (en) | 2001-10-10 |
PL349343A1 (en) | 2002-07-15 |
BR9916732A (pt) | 2001-09-25 |
IL144096A0 (en) | 2002-05-23 |
US6395737B1 (en) | 2002-05-28 |
JP2002534420A (ja) | 2002-10-15 |
KR20010101355A (ko) | 2001-11-14 |
CN1332734A (zh) | 2002-01-23 |
NO20012983L (no) | 2001-06-15 |
HK1041700A1 (zh) | 2002-07-19 |
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