HUP0303241A2 - Pirazolil-pirimidin-származékok, előállításuk, alkalmazásuk és az előállításukhoz használt köztitermékek - Google Patents
Pirazolil-pirimidin-származékok, előállításuk, alkalmazásuk és az előállításukhoz használt köztitermékekInfo
- Publication number
- HUP0303241A2 HUP0303241A2 HU0303241A HUP0303241A HUP0303241A2 HU P0303241 A2 HUP0303241 A2 HU P0303241A2 HU 0303241 A HU0303241 A HU 0303241A HU P0303241 A HUP0303241 A HU P0303241A HU P0303241 A2 HUP0303241 A2 HU P0303241A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- heterocyclyl
- arylalkyl
- aryl
- integer
- Prior art date
Links
- BWIHJLOBZMKPKS-UHFFFAOYSA-N 2-(1h-pyrazol-5-yl)pyrimidine Chemical class N1C=CC(C=2N=CC=CN=2)=N1 BWIHJLOBZMKPKS-UHFFFAOYSA-N 0.000 title abstract 2
- 239000000543 intermediate Substances 0.000 title 1
- -1 cyano, hydroxyl Chemical group 0.000 abstract 3
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000000304 alkynyl group Chemical group 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000001188 haloalkyl group Chemical group 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000002843 carboxylic acid group Chemical group 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000003831 tetrazolyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/14—Ectoparasiticides, e.g. scabicides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
A találmány szerinti (I) általános képletű új pirazolil-pirimidin-származékok általános képletében a szubsztituensek főbb jelentései akövetkezők: R1 és R2 jelentése egymástól függetlenül hidrogén- vagyhalogénatom, nitrocsoport, cianocsoport, alkilcsoport, halogén-alkil-csoport, alkoxicsoport, alkenilcsoport, alkinilcsoport, arilcsoport,aril-alkil-csoport vagy heterociklil-csoport; X jelentése halogénatom,nitrocsoport, cianocsoport, hidroxilcsoport, alkilcsoport, halogén-alkil-csoport, alkoxicsoport, alkenilcsoport, alkinilcsoport,arilcsoport, aril-alkil-csoport vagy heterociklil-csoport; Y jelentéseközvetlen kötés vagy oxigénatom; Z jelentése -(CH2)r- vagy -(CH2)r-C(O)-(CH2)t- általános képletű csoport, amelyben r jelentése 1-től 6-ig terjedő egész szám és t jelentése 0-tól 4-ig terjedő egész szám; Rjelentése karboxilcsoport vagy módosított karbonsavcsoport, adottesetben szubsztituált tetrazolilcsoport, dioxoazolil- vagydioxodiazolilcsoport. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10108480A DE10108480A1 (de) | 2001-02-22 | 2001-02-22 | Pyrazolylpyrimidine |
| PCT/EP2002/001400 WO2002068413A1 (de) | 2001-02-22 | 2002-02-11 | Pyrazolylpyrimidine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUP0303241A2 true HUP0303241A2 (hu) | 2004-01-28 |
Family
ID=7675081
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0303241A HUP0303241A2 (hu) | 2001-02-22 | 2002-02-11 | Pirazolil-pirimidin-származékok, előállításuk, alkalmazásuk és az előállításukhoz használt köztitermékek |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7087616B2 (hu) |
| EP (1) | EP1363905A1 (hu) |
| JP (1) | JP2004524315A (hu) |
| KR (1) | KR100854583B1 (hu) |
| CN (1) | CN1301992C (hu) |
| BR (1) | BR0207509A (hu) |
| DE (1) | DE10108480A1 (hu) |
| HU (1) | HUP0303241A2 (hu) |
| IL (1) | IL157298A0 (hu) |
| MX (1) | MXPA03007433A (hu) |
| TW (1) | TWI236475B (hu) |
| WO (1) | WO2002068413A1 (hu) |
| ZA (1) | ZA200306468B (hu) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI372050B (en) * | 2003-07-03 | 2012-09-11 | Astex Therapeutics Ltd | (morpholin-4-ylmethyl-1h-benzimidazol-2-yl)-1h-pyrazoles |
| MX2007008008A (es) * | 2004-12-30 | 2007-11-12 | Astex Therapeutics Ltd | Compuestos de pirazol que modulan la actividad de las cinasas cdk, gsk y aurora. |
| DE102005058418A1 (de) * | 2005-12-07 | 2007-06-21 | Bayer Cropscience Gmbh | Verfahren zur Herstellung von Haloalkyl(thio)vinimidiniumsalzen und 4-(Haloalkyl(thio))-pyrazolen und deren Umsetzung zu Pflanzenschutzmitteln |
| US8399442B2 (en) * | 2005-12-30 | 2013-03-19 | Astex Therapeutics Limited | Pharmaceutical compounds |
| EP2049119A2 (en) * | 2006-06-29 | 2009-04-22 | Astex Therapeutics Limited | Pharmaceutical combinations of 1-cyclopropyl-3-[3-(5-morphoolin-4-ylmethyl-1h-benzoimidazol-2-yl)-1h-1-pyrazol-4-yl]-urea |
| EP2043635A2 (en) * | 2006-06-29 | 2009-04-08 | Astex Therapeutics Limited | Pharmaceutical combinations |
| DE102007003036A1 (de) | 2006-12-20 | 2008-06-26 | Bayer Cropscience Ag | Pyrimidinylpyrazole |
| DE102007044032A1 (de) | 2007-09-14 | 2009-03-19 | Bayer Healthcare Ag | Substituierte heterocyclische Verbindungen und ihre Verwendung |
| DE102007048447A1 (de) | 2007-10-10 | 2009-04-16 | Bayer Healthcare Ag | Substituierte Dihydropyrazolthione und ihre Verwendung |
| EP2135865A1 (de) * | 2008-06-17 | 2009-12-23 | Bayer CropScience AG | Substituierte 1-(Diazinyl) pyrazol-4-yl-essigsäuren, Verfahren zu deren Herstellung und deren Verwendung als Herbizide und Pflanzenwachstumsregulatoren |
| JP2011530548A (ja) * | 2008-08-14 | 2011-12-22 | バイエル・クロップサイエンス・アーゲー | 殺虫性４−フェニル−１ｈ−ピラゾール類 |
| KR20120027265A (ko) | 2009-04-27 | 2012-03-21 | 다우 아그로사이언시즈 엘엘씨 | 살충성 피리딘 화합물 |
| IN2012DN02679A (hu) * | 2009-10-12 | 2015-09-04 | Bayer Cropscience Ag | |
| CN102834390B (zh) * | 2009-11-11 | 2014-11-12 | 拜尔农作物科学股份公司 | 二吖嗪基吡唑基化合物 |
| JP2012116796A (ja) * | 2010-12-01 | 2012-06-21 | Sumitomo Chemical Co Ltd | ヘテロ芳香環化合物およびその有害生物防除用途 |
| EP2852586A1 (en) | 2012-03-16 | 2015-04-01 | Axikin Pharmaceuticals, Inc. | 3,5-diaminopyrazole kinase inhibitors |
| NZ631142A (en) | 2013-09-18 | 2016-03-31 | Axikin Pharmaceuticals Inc | Pharmaceutically acceptable salts of 3,5-diaminopyrazole kinase inhibitors |
| WO2016020288A1 (en) | 2014-08-04 | 2016-02-11 | Nuevolution A/S | Optionally fused heterocyclyl-substituted derivatives of pyrimidine useful for the treatment of inflammatory, metabolic, oncologic and autoimmune diseases |
| US10118890B2 (en) | 2014-10-10 | 2018-11-06 | The Research Foundation For The State University Of New York | Trifluoromethoxylation of arenes via intramolecular trifluoromethoxy group migration |
| MY191736A (en) | 2014-12-23 | 2022-07-13 | Axikin Pharmaceuticals Inc | 3,5-diaminopyrazole kinase inhibitors |
| EP4076657A1 (en) | 2019-12-20 | 2022-10-26 | Nuevolution A/S | Compounds active towards nuclear receptors |
| CA3174176A1 (en) | 2020-03-31 | 2021-10-07 | Sanne Schroder Glad | Compounds active towards nuclear receptors |
| MX2022012260A (es) | 2020-03-31 | 2022-11-30 | Nuevolution As | Compuestos activos frente a receptores nucleares. |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3910910A (en) * | 1972-03-31 | 1975-10-07 | American Home Prod | (2-Pyrimidinylthio) alkanoic acids, esters, amides and hydrazides |
| US4663327A (en) * | 1984-05-23 | 1987-05-05 | Bayer Aktiengesellschaft | 1-heteroaryl-4-aryl-pyrazolin-5-ones |
| EP0702670A1 (de) | 1993-06-07 | 1996-03-27 | Bayer Ag | Iodpropargylcarbamate und ihre verwendung als biozide im pflanzen- und materialschutz |
| CN1153779A (zh) * | 1995-09-28 | 1997-07-09 | 山道士有限公司 | 2-(4-吡唑基氧基-嘧啶-5-基)乙酸衍生物 |
| WO1998027084A1 (fr) | 1996-12-16 | 1998-06-25 | Sumitomo Chemical Company, Limited | Composes de pyrazoline et leur utilisation en tant qu'agent de lutte contre les maladies des plantes |
-
2001
- 2001-02-22 DE DE10108480A patent/DE10108480A1/de not_active Withdrawn
-
2002
- 2002-02-11 HU HU0303241A patent/HUP0303241A2/hu unknown
- 2002-02-11 MX MXPA03007433A patent/MXPA03007433A/es active IP Right Grant
- 2002-02-11 CN CNB028054326A patent/CN1301992C/zh not_active Expired - Fee Related
- 2002-02-11 KR KR1020037010576A patent/KR100854583B1/ko not_active IP Right Cessation
- 2002-02-11 IL IL15729802A patent/IL157298A0/xx unknown
- 2002-02-11 BR BR0207509-1A patent/BR0207509A/pt not_active IP Right Cessation
- 2002-02-11 WO PCT/EP2002/001400 patent/WO2002068413A1/de active Application Filing
- 2002-02-11 US US10/468,371 patent/US7087616B2/en not_active Expired - Fee Related
- 2002-02-11 EP EP02711857A patent/EP1363905A1/de not_active Withdrawn
- 2002-02-11 JP JP2002567926A patent/JP2004524315A/ja active Pending
- 2002-02-21 TW TW091102971A patent/TWI236475B/zh not_active IP Right Cessation
-
2003
- 2003-08-20 ZA ZA200306468A patent/ZA200306468B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US7087616B2 (en) | 2006-08-08 |
| CN1301992C (zh) | 2007-02-28 |
| ZA200306468B (en) | 2005-02-04 |
| JP2004524315A (ja) | 2004-08-12 |
| US20040102465A1 (en) | 2004-05-27 |
| KR20030075188A (ko) | 2003-09-22 |
| EP1363905A1 (de) | 2003-11-26 |
| MXPA03007433A (es) | 2003-11-18 |
| WO2002068413A1 (de) | 2002-09-06 |
| BR0207509A (pt) | 2004-03-09 |
| DE10108480A1 (de) | 2002-09-05 |
| IL157298A0 (en) | 2004-02-19 |
| KR100854583B1 (ko) | 2008-08-27 |
| TWI236475B (en) | 2005-07-21 |
| CN1492864A (zh) | 2004-04-28 |
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