HUP0300073A3 - Method of purifying a fermentation broth - Google Patents
Method of purifying a fermentation brothInfo
- Publication number
- HUP0300073A3 HUP0300073A3 HU0300073A HUP0300073A HUP0300073A3 HU P0300073 A3 HUP0300073 A3 HU P0300073A3 HU 0300073 A HU0300073 A HU 0300073A HU P0300073 A HUP0300073 A HU P0300073A HU P0300073 A3 HUP0300073 A3 HU P0300073A3
- Authority
- HU
- Hungary
- Prior art keywords
- purifying
- fermentation broth
- broth
- fermentation
- Prior art date
Links
- 238000000855 fermentation Methods 0.000 title 1
- 230000004151 fermentation Effects 0.000 title 1
- 238000000034 method Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Public Health (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US18452200P | 2000-02-24 | 2000-02-24 | |
PCT/US2001/002505 WO2001062949A1 (en) | 2000-02-24 | 2001-01-25 | Method of purifying a fermentation broth |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0300073A2 HUP0300073A2 (en) | 2003-05-28 |
HUP0300073A3 true HUP0300073A3 (en) | 2004-10-28 |
Family
ID=22677241
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0300073A HUP0300073A3 (en) | 2000-02-24 | 2001-01-25 | Method of purifying a fermentation broth |
Country Status (18)
Country | Link |
---|---|
US (1) | US6387258B1 (hu) |
EP (1) | EP1263979A4 (hu) |
JP (1) | JP3740062B2 (hu) |
KR (1) | KR20030013373A (hu) |
CN (1) | CN1406283A (hu) |
AU (2) | AU2001236543B2 (hu) |
CA (1) | CA2400952A1 (hu) |
CZ (1) | CZ20022779A3 (hu) |
HR (1) | HRP20020683A2 (hu) |
HU (1) | HUP0300073A3 (hu) |
IL (1) | IL151290A0 (hu) |
IS (1) | IS6521A (hu) |
PL (1) | PL357946A1 (hu) |
RU (1) | RU2265665C2 (hu) |
SK (1) | SK12012002A3 (hu) |
WO (1) | WO2001062949A1 (hu) |
YU (1) | YU63602A (hu) |
ZA (1) | ZA200206496B (hu) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7452692B2 (en) * | 2002-02-13 | 2008-11-18 | Teva Gyógyszergyár Zártkörüen Müködö Részvénytársaság | Method for extracting a macrolide from biomatter |
CN100338043C (zh) * | 2002-02-13 | 2007-09-19 | 特瓦药厂私人有限公司 | 从生物物质中提取大环内酯的方法 |
ES2204285B1 (es) * | 2002-05-20 | 2005-03-01 | Ercros Industrial, S.A. | Procedimiento para el aislamiento y purificacion de lovastatina. |
KR100540761B1 (ko) * | 2002-08-09 | 2006-01-16 | 코바이오텍 (주) | 프라바스타틴 나트륨의 제조방법 |
US7232486B2 (en) * | 2003-03-31 | 2007-06-19 | TEVA Gyógyszergyár Zártkörűen Működő Részvénytársaság | Crystallization and purification of macrolides |
US20060169199A1 (en) * | 2003-03-31 | 2006-08-03 | Vilmos Keri | Crystallization and purification of macrolides |
WO2004111255A1 (en) * | 2003-06-09 | 2004-12-23 | TEVA Gyógyszergyár Részvénytársaság | Ion-exchange filtration of fermentation broth |
DK1558622T3 (da) * | 2003-07-24 | 2008-02-25 | Teva Gyogyszergyar Zartkoeruee | Fremgangsmåde til oprensning af macrolider |
ES2239533B1 (es) * | 2004-03-01 | 2006-12-16 | Ercros Industrial, S.A. | Procedimiento para la obtencion de compactina. |
BRPI0511132A (pt) * | 2004-05-14 | 2007-11-27 | Pfizer Prod Inc | derivados de pirimidina e composição farmacêutica compreendendo os mesmos |
TW200637835A (en) * | 2004-12-22 | 2006-11-01 | Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag | Method of purifying tacrolimus |
CN101802208B (zh) * | 2007-09-27 | 2016-05-18 | Reg生命科学有限责任公司 | 通过提取式发酵减少原料中杂质的毒性作用 |
WO2009078033A2 (en) * | 2007-12-18 | 2009-06-25 | Themis Medicare Limited | Isolation and recovery of simvastatin in lactone form or in the form of an acid salt from the harvested fermentation broth |
EP2103309A3 (de) * | 2008-03-19 | 2012-09-12 | SCHWEIGERT, Florian | Verfahren zur Extraktion und zum Nachweis von fettlöslichen Inhaltsstoffen aus biologischen Materialien |
US20120156794A1 (en) * | 2008-03-19 | 2012-06-21 | Florian Schweigert | Method for the extraction and detection of fat-soluble components from biological materials |
IN2009MU00380A (hu) * | 2009-02-18 | 2010-04-02 | ||
JP5791116B2 (ja) * | 2009-04-08 | 2015-10-07 | ナンヤン ポリテクニックNanyang Polytechnic | スタチンを含む植物抽出物ならびにその調製技術および使用 |
CN102746262B (zh) * | 2011-04-22 | 2014-06-04 | 广东蓝宝制药有限公司 | 一种康百汀纯化方法 |
CN102993145B (zh) * | 2011-09-19 | 2015-06-03 | 北大方正集团有限公司 | 一种提取纯化洛伐他汀的方法 |
CN102875505B (zh) * | 2012-08-02 | 2015-08-05 | 丽珠集团新北江制药股份有限公司 | 一种美伐他汀的提取精制工艺 |
CN102827123B (zh) * | 2012-08-02 | 2015-04-22 | 丽珠集团新北江制药股份有限公司 | 美伐他汀的分离提取工艺 |
US9861962B2 (en) * | 2013-10-08 | 2018-01-09 | Industry Foundation Of Chonnam National University | Selective surface impregnation method for catalytically active materials on particulate catalyst support using mutual repulsive force and soblubility difference between hydrophilic solvent and hydrophobic solvent |
RU2585233C2 (ru) * | 2013-12-27 | 2016-05-27 | Открытое акционерное общество "Красфарма" | Промышленный способ получения компактина |
RU2585234C2 (ru) * | 2013-12-27 | 2016-05-27 | Открытое акционерное общество "Красфарма" | Способ получения компактина |
CN106083789A (zh) * | 2016-06-07 | 2016-11-09 | 山东鲁抗医药股份有限公司 | 从发酵液中沉淀分离提取洛伐他汀的方法 |
CN114133331A (zh) * | 2021-12-10 | 2022-03-04 | 广东蓝宝制药有限公司 | 一种回收获得高纯度普伐他汀酯的方法 |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4049495A (en) | 1974-06-07 | 1977-09-20 | Sankyo Company Limited | Physiologically active substances and fermentative process for producing the same |
JPS5612114B2 (hu) | 1974-06-07 | 1981-03-18 | ||
JPS5925599B2 (ja) | 1979-02-20 | 1984-06-19 | 三共株式会社 | 新生理活性物質モナコリンkおよびその製造法 |
US4294926A (en) | 1979-06-15 | 1981-10-13 | Merck & Co., Inc. | Hypocholesteremic fermentation products and process of preparation |
US4319039A (en) | 1979-06-15 | 1982-03-09 | Merck & Co., Inc. | Preparation of ammonium salt of hypocholesteremic fermentation product |
US4294846A (en) | 1979-09-21 | 1981-10-13 | Merck & Co., Inc. | Hypocholesteremic fermentation products and products of preparation |
US4342767A (en) | 1980-01-23 | 1982-08-03 | Merck & Co., Inc. | Hypocholesteremic fermentation products |
US4420491A (en) | 1980-05-28 | 1983-12-13 | Merck & Co., Inc. | Hypocholesteremic fermentation products and process of preparation |
US5202029A (en) | 1991-03-13 | 1993-04-13 | Caron Kabushiki Kaisha | Process for purification of hmg-coa reductase inhibitors |
HU208997B (en) | 1992-06-17 | 1994-02-28 | Gyogyszerkutato Intezet | Microbiological method for producing mevinoline |
HU210867B (en) * | 1992-11-04 | 1995-10-30 | Biogal Gyogyszergyar | Method for extraction and purification of mevinolin from culture medium |
SI9300047A (en) | 1993-01-29 | 1994-09-30 | Krka | Microbiological method for preparation of lovostatin and/or mevinoline acid |
SI9300303A (en) * | 1993-06-08 | 1994-12-31 | Krka Tovarna Zdravil | Process for isolation of hypolipemic effective substance |
US5409820A (en) | 1993-08-06 | 1995-04-25 | Apotex, Inc. | Process for the production of lovastatin using Coniothyrium fuckelii |
US5616595A (en) | 1995-06-07 | 1997-04-01 | Abbott Laboratories | Process for recovering water insoluble compounds from a fermentation broth |
US5989877A (en) | 1995-08-03 | 1999-11-23 | Gist-Brocades B.V. | Selective process for the deacylation of acylated compounds |
NZ280074A (en) * | 1995-09-21 | 1997-05-26 | Apotex Inc Substituted For Sco | "compactin" produced by penicillium adametzioides g smith |
SI9800046A (sl) * | 1998-02-18 | 1999-08-31 | LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. | Postopek za pridobivanje inhibitorjev HMG-CoA reduktaze visoke čistosti |
SK282679B6 (sk) * | 1999-04-16 | 2002-11-06 | Biotika, A. S. | Spôsob izolácie lovastatínu z vyfermentovanej pôdy |
-
2001
- 2001-01-25 CN CN01805551A patent/CN1406283A/zh active Pending
- 2001-01-25 YU YU63602A patent/YU63602A/sh unknown
- 2001-01-25 RU RU2002122746/13A patent/RU2265665C2/ru not_active IP Right Cessation
- 2001-01-25 US US09/769,684 patent/US6387258B1/en not_active Expired - Fee Related
- 2001-01-25 IL IL15129001A patent/IL151290A0/xx unknown
- 2001-01-25 PL PL01357946A patent/PL357946A1/xx not_active Application Discontinuation
- 2001-01-25 SK SK1201-2002A patent/SK12012002A3/sk not_active Application Discontinuation
- 2001-01-25 KR KR1020027011048A patent/KR20030013373A/ko not_active Application Discontinuation
- 2001-01-25 AU AU2001236543A patent/AU2001236543B2/en not_active Ceased
- 2001-01-25 CZ CZ20022779A patent/CZ20022779A3/cs unknown
- 2001-01-25 AU AU3654301A patent/AU3654301A/xx active Pending
- 2001-01-25 CA CA002400952A patent/CA2400952A1/en not_active Abandoned
- 2001-01-25 HU HU0300073A patent/HUP0300073A3/hu unknown
- 2001-01-25 WO PCT/US2001/002505 patent/WO2001062949A1/en not_active Application Discontinuation
- 2001-01-25 JP JP2001561759A patent/JP3740062B2/ja not_active Expired - Fee Related
- 2001-01-25 EP EP01908701A patent/EP1263979A4/en not_active Withdrawn
-
2002
- 2002-08-14 ZA ZA200206496A patent/ZA200206496B/en unknown
- 2002-08-21 HR HRP20020683 patent/HRP20020683A2/hr not_active Application Discontinuation
- 2002-08-22 IS IS6521A patent/IS6521A/is unknown
Also Published As
Publication number | Publication date |
---|---|
US6387258B1 (en) | 2002-05-14 |
AU3654301A (en) | 2001-09-03 |
EP1263979A4 (en) | 2003-05-21 |
IS6521A (is) | 2002-08-22 |
WO2001062949A1 (en) | 2001-08-30 |
HRP20020683A2 (en) | 2004-12-31 |
IL151290A0 (en) | 2003-04-10 |
YU63602A (sh) | 2006-01-16 |
CA2400952A1 (en) | 2001-08-30 |
HUP0300073A2 (en) | 2003-05-28 |
JP2003523751A (ja) | 2003-08-12 |
RU2002122746A (ru) | 2004-02-20 |
ZA200206496B (en) | 2003-09-23 |
JP3740062B2 (ja) | 2006-01-25 |
PL357946A1 (en) | 2004-08-09 |
AU2001236543B2 (en) | 2005-02-03 |
SK12012002A3 (sk) | 2003-02-04 |
KR20030013373A (ko) | 2003-02-14 |
CZ20022779A3 (cs) | 2003-02-12 |
EP1263979A1 (en) | 2002-12-11 |
CN1406283A (zh) | 2003-03-26 |
RU2265665C2 (ru) | 2005-12-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
HC9A | Change of name, address |
Owner name: TEVA GYOGYSZERGYAR ZARTKOERUEEN MUEKOEDOE RESZ, HU Free format text: FORMER OWNER(S): BIOGAL GYOGYSZERGYAR RT., HU |
|
FD9A | Lapse of provisional protection due to non-payment of fees |