HUP0201571A3 - Il-8 receptor antagonist phenyl urea derivatives, process for the preparation thereof and pharmaceutical compositions containing them - Google Patents

Il-8 receptor antagonist phenyl urea derivatives, process for the preparation thereof and pharmaceutical compositions containing them

Info

Publication number: HUP0201571A3
Authority: HU; Hungary
Prior art keywords: preparation; pharmaceutical compositions; compositions containing; receptor antagonist; urea derivatives
Prior art date: 1999-06-16

Application number

HU0201571A

Other languages

Hungarian (hu)

Original Assignee

Smithkline Beecham Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-06-16

Filing date

2000-06-15

Publication date

2002-11-28

2000-06-15 Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp

2002-08-28 Publication of HUP0201571A2 publication Critical patent/HUP0201571A2/en

2002-11-28 Publication of HUP0201571A3 publication Critical patent/HUP0201571A3/en

Links

LUBJCRLGQSPQNN-UHFFFAOYSA-N 1-Phenylurea Chemical class NC(=O)NC1=CC=CC=C1 LUBJCRLGQSPQNN-UHFFFAOYSA-N 0.000 title 1
102000010681 interleukin-8 receptors Human genes 0.000 title 1
108010038415 interleukin-8 receptors Proteins 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
239000002464 receptor antagonist Substances 0.000 title 1
229940044551 receptor antagonist Drugs 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Virology (AREA)
Physical Education & Sports Medicine (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Epidemiology (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Molecular Biology (AREA)
Tropical Medicine & Parasitology (AREA)
Vascular Medicine (AREA)
Diabetes (AREA)
Pulmonology (AREA)
Urology & Nephrology (AREA)
Biotechnology (AREA)
Heart & Thoracic Surgery (AREA)
Hematology (AREA)
Cardiology (AREA)
Emergency Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Quinoline Compounds (AREA)

HU0201571A 1999-06-16 2000-06-15 Il-8 receptor antagonist phenyl urea derivatives, process for the preparation thereof and pharmaceutical compositions containing them HUP0201571A3 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US13967599P	1999-06-16	1999-06-16

Publications (2)

Publication Number	Publication Date
HUP0201571A2 HUP0201571A2 (en)	2002-08-28
HUP0201571A3 true HUP0201571A3 (en)	2002-11-28

Family

ID=22487790

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HU0201571A HUP0201571A3 (en)	1999-06-16	2000-06-15	Il-8 receptor antagonist phenyl urea derivatives, process for the preparation thereof and pharmaceutical compositions containing them

Country Status (20)

Country	Link
EP (1)	EP1185261A4 (en)
JP (1)	JP2003501459A (en)
KR (1)	KR20020010709A (en)
CN (1)	CN1355697A (en)
AR (1)	AR030391A1 (en)
AU (1)	AU766083B2 (en)
BR (1)	BR0010802A (en)
CA (1)	CA2377341A1 (en)
CO (1)	CO5200760A1 (en)
CZ (1)	CZ20014471A3 (en)
HK (1)	HK1044483A1 (en)
HU (1)	HUP0201571A3 (en)
IL (1)	IL145761A0 (en)
MX (1)	MXPA01013004A (en)
NO (1)	NO20016053D0 (en)
NZ (1)	NZ514695A (en)
PL (1)	PL352232A1 (en)
TR (1)	TR200103680T2 (en)
WO (1)	WO2000076495A1 (en)
ZA (1)	ZA200109479B (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7521479B2 (en) *	2001-04-16	2009-04-21	Panacea Pharmaceuticals, Inc.	Methods of treating prion disease in mammals
GB0201882D0 (en) *	2002-01-28	2002-03-13	Novartis Ag	Organic compounds
US20060058395A1 (en) *	2002-08-01	2006-03-16	Neurosearch A/S	Compounds useful for the treatment of diseases responsive to antiangiogenetic therapy
US7550499B2 (en)	2004-05-12	2009-06-23	Bristol-Myers Squibb Company	Urea antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
AU2005245399A1 (en) *	2004-05-12	2005-12-01	Schering Corporation	CXCR1 and CXCR2 chemokine antagonists
TW200600492A (en)	2004-05-18	2006-01-01	Achillion Pharmaceuticals Inc	Substituted aryl acylthioureas and related compounds; inhibitors of viral replication
JP2008517930A (en)	2004-10-21	2008-05-29	トランステックファーマ，インコーポレイテッド	Bissulfonamide compounds, compositions, and methods of use as agonists of GalR1
EP1954696B1 (en)	2005-01-19	2011-02-23	Bristol-Myers Squibb Company	2-phenoxy-n-(1,3,4-thiadizol-2-yl)pyridin-3-amine derivatives and related compounds as p2y1 receptor inhibitors for the treatment of thromboembolic disorders
WO2006089871A2 (en) *	2005-02-23	2006-08-31	Neurosearch A/S	Diphenylurea derivatives useful as erg channel openers for the treatment of cardiac arrhythmias
US7714002B2 (en)	2005-06-27	2010-05-11	Bristol-Myers Squibb Company	Carbocycle and heterocycle antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
WO2007002584A1 (en)	2005-06-27	2007-01-04	Bristol-Myers Squibb Company	Linear urea mimics antagonists of p2y1 receptor useful in the treatment of thrombotic conditions
ES2352796T3 (en)	2005-06-27	2011-02-23	Bristol-Myers Squibb Company	CYCLIC ANTAGONISTS UNITED TO C OF THE P2Y1 RECEIVER USEFUL IN THE TREATMENT OF THROMBOTHIC AFFECTIONS.
EP1896466B1 (en)	2005-06-27	2011-04-13	Bristol-Myers Squibb Company	N-linked heterocyclic antagonists of p2y1 receptor useful in the treatment of thrombotic conditions
US7960569B2 (en)	2006-10-17	2011-06-14	Bristol-Myers Squibb Company	Indole antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
JP2008184403A (en) *	2007-01-29	2008-08-14	Japan Health Science Foundation	New hepatitis c virus inhibitor
KR100982661B1 (en) *	2008-04-22	2010-09-17	전남대학교산학협력단	Pharmaceutical composition for the prevention and treatment of malaria containing a compound that inhibits plasmincin II activity as an active ingredient and a method for treating malaria using the same
KR100970940B1 (en) *	2010-05-03	2010-07-20	전남대학교산학협력단	Pharmaceutical composition for preventing and treating malaria comprising compounds that inhibit Plasmepsin II activity and the method of treating malaria using thereof
US10093617B1 (en) *	2015-10-30	2018-10-09	Sumitomo Chemical Company, Limited	Method for producing 2-amino-4-substituted phenol

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ZA921120B (en) *	1991-02-19	1993-01-27	Smithkline Beecham Corp	Cytokine inhibitors
JPH11503110A (en) *	1995-02-17	1999-03-23	スミスクライン・ビーチャム・コーポレイション	IL-8 receptor antagonist
WO2000016768A1 (en) *	1998-09-18	2000-03-30	Smithkline Beecham Corporation	Cxcr2 inhibitors and pmn adhesion and t-cell chemotaxis

2000
- 2000-06-13 CO CO00043844A patent/CO5200760A1/en not_active Application Discontinuation
- 2000-06-14 AR ARP000102923A patent/AR030391A1/en not_active Application Discontinuation
- 2000-06-15 IL IL14576100A patent/IL145761A0/en unknown
- 2000-06-15 PL PL00352232A patent/PL352232A1/en not_active Application Discontinuation
- 2000-06-15 NZ NZ514695A patent/NZ514695A/en unknown
- 2000-06-15 CA CA002377341A patent/CA2377341A1/en not_active Abandoned
- 2000-06-15 JP JP2001502828A patent/JP2003501459A/en not_active Withdrawn
- 2000-06-15 HU HU0201571A patent/HUP0201571A3/en unknown
- 2000-06-15 WO PCT/US2000/016499 patent/WO2000076495A1/en not_active Application Discontinuation
- 2000-06-15 CN CN00809045A patent/CN1355697A/en active Pending
- 2000-06-15 AU AU57413/00A patent/AU766083B2/en not_active Ceased
- 2000-06-15 TR TR2001/03680T patent/TR200103680T2/en unknown
- 2000-06-15 EP EP00942843A patent/EP1185261A4/en not_active Withdrawn
- 2000-06-15 CZ CZ20014471A patent/CZ20014471A3/en unknown
- 2000-06-15 KR KR1020017016142A patent/KR20020010709A/en not_active Application Discontinuation
- 2000-06-15 BR BR0010802-2A patent/BR0010802A/en not_active IP Right Cessation
- 2000-06-15 MX MXPA01013004A patent/MXPA01013004A/en unknown
2001
- 2001-11-16 ZA ZA200109479A patent/ZA200109479B/en unknown
- 2001-12-11 NO NO20016053A patent/NO20016053D0/en not_active Application Discontinuation
2002
- 2002-08-22 HK HK02106188.7A patent/HK1044483A1/en unknown

Also Published As

Publication number	Publication date
CO5200760A1 (en)	2002-09-27
PL352232A1 (en)	2003-08-11
CZ20014471A3 (en)	2002-08-14
BR0010802A (en)	2002-02-19
TR200103680T2 (en)	2002-07-22
KR20020010709A (en)	2002-02-04
JP2003501459A (en)	2003-01-14
AU5741300A (en)	2001-01-02
HK1044483A1 (en)	2002-10-25
CN1355697A (en)	2002-06-26
HUP0201571A2 (en)	2002-08-28
IL145761A0 (en)	2002-07-25
CA2377341A1 (en)	2000-12-21
MXPA01013004A (en)	2002-07-30
NZ514695A (en)	2004-05-28
NO20016053L (en)	2001-12-11
WO2000076495A1 (en)	2000-12-21
NO20016053D0 (en)	2001-12-11
EP1185261A1 (en)	2002-03-13
EP1185261A4 (en)	2004-02-25
AR030391A1 (en)	2003-08-20
AU766083B2 (en)	2003-10-09
ZA200109479B (en)	2002-11-18

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Legal Events

Date	Code	Title	Description
2008-02-28	FD9A	Lapse of provisional protection due to non-payment of fees