HUP0200311A2 - Aroil- vagy aralkanoil-piridazin-származékok alkalmazása gyógyszerkészítmények előállítására - Google Patents
Aroil- vagy aralkanoil-piridazin-származékok alkalmazása gyógyszerkészítmények előállításáraInfo
- Publication number
- HUP0200311A2 HUP0200311A2 HU0200311A HUP0200311A HUP0200311A2 HU P0200311 A2 HUP0200311 A2 HU P0200311A2 HU 0200311 A HU0200311 A HU 0200311A HU P0200311 A HUP0200311 A HU P0200311A HU P0200311 A2 HUP0200311 A2 HU P0200311A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- independently
- hal
- atoms
- substituted
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 208000030507 AIDS Diseases 0.000 abstract 1
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 125000004648 C2-C8 alkenyl group Chemical group 0.000 abstract 1
- 206010009900 Colitis ulcerative Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 201000006704 Ulcerative Colitis Diseases 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000006615 aromatic heterocyclic group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 201000006417 multiple sclerosis Diseases 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Virology (AREA)
- Emergency Medicine (AREA)
- Oncology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Communicable Diseases (AREA)
- Obesity (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
A találmány tárgya (I) általános képletű vegyületek - ahol B jelentéseA, OA, NH2, NHA, NAA' vagy egy aromás heterociklusos csoport, amely 1-4 N, O és/vagy S atomot tartalmaz, és amely szubsztituálatlan, vagypedig mono-, di- vagy triszubsztituált lehet Hal, A és/vagy OAáltalános képletű csoporttal; Q vagy nincs jelen, vagy pedig 1-6szénatomos alkiléncsoportot jelent; R1 és R2 jelentése egymástólfüggetlenül -OH, -OR5, -S-R5, -SO-R5, -SO2-R5, Hal, -NO2, -NH2, -NHR5vagy -NR5R6 általános képletű csoport; vagy R1 és R2 együtt -O-CH2-O-csoportot képez; R5 és R6 jelentése egymástól függetlenül A, 3-7szénatomos cikloalkilcsoport, 4-8 szénatomos metilén-cikloalkil-csoport vagy 2-8 szénatomos alkenilcsoport; A és A' jelentéseegymástól függetlenül 1-10 szénatomos alkilcsoport, amelyszubsztituálva lehet 1-5 F és/vagy C1 atommal; és Hal jelentése F, C1,Br vagy I és/vagy azok fiziológiailag elfogadható sóinak azalkalmazása oszteoporózis, tumorok, ateroszklerózis, reumatoidarthritis, szklerózis multiplex, diabetes mellitus, fekélyképződésesvastagbélgyulladás és AIDS kezelésére alkalmas gyógyászatikészítmények előállítására. Ó
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19915364A DE19915364A1 (de) | 1999-04-06 | 1999-04-06 | Verwendung von Arylalkanoylpyridazinen |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0200311A2 true HUP0200311A2 (hu) | 2002-11-28 |
HUP0200311A3 HUP0200311A3 (en) | 2002-12-28 |
Family
ID=7903583
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0200311A HUP0200311A3 (en) | 1999-04-06 | 2000-03-15 | Use of aroyl- or arylalkanoylpyridazines for preparation of pharmaceutical compositions |
Country Status (18)
Country | Link |
---|---|
EP (1) | EP1143944A3 (hu) |
JP (1) | JP2002541095A (hu) |
KR (1) | KR20020000550A (hu) |
CN (1) | CN1355702A (hu) |
AR (1) | AR023261A1 (hu) |
AU (1) | AU3811600A (hu) |
BR (1) | BR0009549A (hu) |
CA (1) | CA2367051A1 (hu) |
CZ (1) | CZ20013598A3 (hu) |
DE (1) | DE19915364A1 (hu) |
HU (1) | HUP0200311A3 (hu) |
ID (1) | ID30381A (hu) |
MX (1) | MXPA01010034A (hu) |
NO (1) | NO20014845L (hu) |
PL (1) | PL350963A1 (hu) |
RU (1) | RU2001129703A (hu) |
WO (1) | WO2000059484A2 (hu) |
ZA (1) | ZA200109120B (hu) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1281606C (zh) * | 2002-03-01 | 2006-10-25 | 安斯泰来制药有限公司 | 含氮杂环化合物 |
DE10224888A1 (de) * | 2002-06-05 | 2003-12-24 | Merck Patent Gmbh | Pyridazinderivate |
DE10225574A1 (de) * | 2002-06-10 | 2003-12-18 | Merck Patent Gmbh | Aryloxime |
WO2005002590A1 (ja) * | 2003-07-01 | 2005-01-13 | Astellas Pharma Inc. | 骨量増加誘導剤 |
CL2008001933A1 (es) | 2007-06-29 | 2009-09-25 | Millennium Pharm Inc | Compuestos derivados de pirimidina, inhibidores de la raf quinasa; compuestos intermediarios; procedimiento de preparacion; composicion farmaceutica; y su uso para tratar trastornos proliferativos, cardiacos, neurodegenerativos, inflamatorios, oseos, inmunologicos enfermedad viral, entre otros. |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19632549A1 (de) * | 1996-08-13 | 1998-02-19 | Merck Patent Gmbh | Arylalkanoylpyridazine |
DE19826841A1 (de) * | 1998-06-16 | 1999-12-23 | Merck Patent Gmbh | Arylalkanoylpyridazine |
DE19850701A1 (de) * | 1998-11-04 | 2000-05-11 | Merck Patent Gmbh | Benzoylpyridazine |
DE19915365A1 (de) * | 1999-04-06 | 2000-10-12 | Merck Patent Gmbh | Tetrahydropyridazin-Derivate |
-
1999
- 1999-04-06 DE DE19915364A patent/DE19915364A1/de not_active Withdrawn
-
2000
- 2000-03-15 BR BR0009549-4A patent/BR0009549A/pt active Pending
- 2000-03-15 HU HU0200311A patent/HUP0200311A3/hu unknown
- 2000-03-15 RU RU2001129703/15A patent/RU2001129703A/ru unknown
- 2000-03-15 CA CA002367051A patent/CA2367051A1/en not_active Abandoned
- 2000-03-15 MX MXPA01010034A patent/MXPA01010034A/es not_active Application Discontinuation
- 2000-03-15 JP JP2000609048A patent/JP2002541095A/ja active Pending
- 2000-03-15 CN CN00805648A patent/CN1355702A/zh active Pending
- 2000-03-15 ID IDW00200102346A patent/ID30381A/id unknown
- 2000-03-15 EP EP00916949A patent/EP1143944A3/de not_active Withdrawn
- 2000-03-15 PL PL00350963A patent/PL350963A1/xx unknown
- 2000-03-15 WO PCT/EP2000/002280 patent/WO2000059484A2/de not_active Application Discontinuation
- 2000-03-15 AU AU38116/00A patent/AU3811600A/en not_active Abandoned
- 2000-03-15 KR KR1020017011993A patent/KR20020000550A/ko not_active Application Discontinuation
- 2000-03-15 CZ CZ20013598A patent/CZ20013598A3/cs unknown
- 2000-04-05 AR ARP000101547A patent/AR023261A1/es unknown
-
2001
- 2001-10-05 NO NO20014845A patent/NO20014845L/no not_active Application Discontinuation
- 2001-11-05 ZA ZA200109120A patent/ZA200109120B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
ID30381A (id) | 2001-11-29 |
KR20020000550A (ko) | 2002-01-05 |
WO2000059484A2 (de) | 2000-10-12 |
WO2000059484A3 (de) | 2001-08-23 |
ZA200109120B (en) | 2003-11-13 |
EP1143944A2 (de) | 2001-10-17 |
DE19915364A1 (de) | 2000-10-12 |
AR023261A1 (es) | 2002-09-04 |
JP2002541095A (ja) | 2002-12-03 |
NO20014845D0 (no) | 2001-10-05 |
CN1355702A (zh) | 2002-06-26 |
CZ20013598A3 (cs) | 2002-01-16 |
RU2001129703A (ru) | 2004-02-20 |
EP1143944A3 (de) | 2002-09-11 |
PL350963A1 (en) | 2003-02-24 |
MXPA01010034A (es) | 2002-04-24 |
NO20014845L (no) | 2001-10-05 |
AU3811600A (en) | 2000-10-23 |
CA2367051A1 (en) | 2000-10-12 |
BR0009549A (pt) | 2002-03-26 |
HUP0200311A3 (en) | 2002-12-28 |
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