HUP0104280A3 - Tetrahydrobenzazepine derivatives useful as modulators of dopamine d3 receptors, process for their preparation, medicaments containing them - Google Patents
Tetrahydrobenzazepine derivatives useful as modulators of dopamine d3 receptors, process for their preparation, medicaments containing themInfo
- Publication number
- HUP0104280A3 HUP0104280A3 HU0104280A HUP0104280A HUP0104280A3 HU P0104280 A3 HUP0104280 A3 HU P0104280A3 HU 0104280 A HU0104280 A HU 0104280A HU P0104280 A HUP0104280 A HU P0104280A HU P0104280 A3 HUP0104280 A3 HU P0104280A3
- Authority
- HU
- Hungary
- Prior art keywords
- dopamine
- modulators
- receptors
- preparation
- derivatives useful
- Prior art date
Links
- MZBVNYACSSGXID-UHFFFAOYSA-N 2,3,4,5-tetrahydro-1h-1-benzazepine Chemical class N1CCCCC2=CC=CC=C21 MZBVNYACSSGXID-UHFFFAOYSA-N 0.000 title 1
- 102000004073 Dopamine D3 Receptors Human genes 0.000 title 1
- 108090000525 Dopamine D3 Receptors Proteins 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Otolaryngology (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9821976.9A GB9821976D0 (en) | 1998-10-08 | 1998-10-08 | Compounds |
| GBGB9824340.5A GB9824340D0 (en) | 1998-11-06 | 1998-11-06 | Compounds |
| GBGB9910711.2A GB9910711D0 (en) | 1999-05-07 | 1999-05-07 | Compounds |
| GBGB9918032.5A GB9918032D0 (en) | 1999-07-30 | 1999-07-30 | Compounds |
| PCT/EP1999/007763 WO2000021951A1 (en) | 1998-10-08 | 1999-10-06 | Tetrahydrobenzazepine derivatives useful as modulators of dopamine d3 receptors (antipsychotic agents) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0104280A2 HUP0104280A2 (hu) | 2002-03-28 |
| HUP0104280A3 true HUP0104280A3 (en) | 2002-07-29 |
Family
ID=27451837
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0104280A HUP0104280A3 (en) | 1998-10-08 | 1999-10-06 | Tetrahydrobenzazepine derivatives useful as modulators of dopamine d3 receptors, process for their preparation, medicaments containing them |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US6605607B1 (hu) |
| EP (1) | EP1119563B1 (hu) |
| JP (1) | JP2002527433A (hu) |
| KR (1) | KR20010085898A (hu) |
| CN (1) | CN1329609A (hu) |
| AP (1) | AP2001002114A0 (hu) |
| AR (1) | AR023681A1 (hu) |
| AT (1) | ATE316969T1 (hu) |
| AU (1) | AU761018B2 (hu) |
| BG (1) | BG105467A (hu) |
| BR (1) | BR9914370A (hu) |
| CA (1) | CA2346689A1 (hu) |
| CO (1) | CO5140073A1 (hu) |
| CZ (1) | CZ20011270A3 (hu) |
| DE (1) | DE69929704T2 (hu) |
| EA (1) | EA200100428A1 (hu) |
| ES (1) | ES2255311T3 (hu) |
| HK (1) | HK1038745A1 (hu) |
| HU (1) | HUP0104280A3 (hu) |
| ID (1) | ID28385A (hu) |
| IL (1) | IL142388A0 (hu) |
| MA (1) | MA26696A1 (hu) |
| NO (1) | NO20011745L (hu) |
| NZ (1) | NZ511018A (hu) |
| OA (1) | OA11663A (hu) |
| PE (1) | PE20001088A1 (hu) |
| PL (1) | PL347237A1 (hu) |
| SK (1) | SK4782001A3 (hu) |
| TR (1) | TR200101025T2 (hu) |
| WO (1) | WO2000021951A1 (hu) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9810876D0 (en) | 1998-05-20 | 1998-07-22 | Smithkline Beecham Plc | Compounds |
| ES2255311T3 (es) | 1998-10-08 | 2006-06-16 | Smithkline Beecham Plc | Derivados de tetrahidrobenzazepina utiles como moduladores de los receptores d3 de dopamina (agentes anti-psicoticos). |
| US7229986B2 (en) * | 2000-05-16 | 2007-06-12 | Takeda Pharmaceutical Company Ltd. | Melanin-concentrating hormone antagonist |
| CA2428844A1 (en) * | 2000-11-14 | 2002-05-23 | Michael Stewart Hadley | Tetrahydrobenzazepine derivatives useful as modulators of dopamine d3 receptors (antipsychotic agents) |
| WO2002051232A2 (en) * | 2000-12-27 | 2002-07-04 | Actelion Pharmaceuticals Ltd. | Novel benzazepines and related heterocyclic derivatives |
| HU227543B1 (en) * | 2001-09-28 | 2011-08-29 | Richter Gedeon Nyrt | N-[4-(2-piperazin- and 2-piperidin-1-yl-ethyl)-cyclohexyl]-sulfon- and sulfamides, process for their preparation, their use and pharmaceutical compositions containing them |
| US20050176759A1 (en) * | 2001-12-21 | 2005-08-11 | Mahmood Ahmed | 7-sulfonyl-3-benzazepine derivatives as modulators of the dopamine receptor and their use for the treatment cns disorders |
| US20050085461A1 (en) * | 2002-02-13 | 2005-04-21 | Cooper David G. | Benzenesulfonamide derivatives |
| US7538121B2 (en) | 2002-02-15 | 2009-05-26 | Glaxo Group Limited | Vanilloid receptor modulators |
| GB0224083D0 (en) * | 2002-10-16 | 2002-11-27 | Glaxo Group Ltd | Novel compounds |
| SI1572215T1 (sl) | 2002-12-20 | 2010-01-29 | Venue Glaxo Group Ltd Glaxo We | Benzo(d)azepinski derivati za zdravljenje nevroloĺ kih motenj |
| EP3345895B1 (en) | 2003-04-11 | 2019-12-04 | PTC Therapeutics, Inc. | 1,2,4-oxadiazole benzoic acid compound and its use for nonsense suppression and the treatment of disease |
| US20050137186A1 (en) | 2003-12-18 | 2005-06-23 | Abbott Gmbh & Co. Kg. | Tetrahydrobenzazepines and their use |
| JP4982184B2 (ja) | 2003-12-18 | 2012-07-25 | アボット ゲーエムベーハー ウント カンパニー カーゲー | テトラヒドロベンズアゼピンおよびドーパミンｄ３レセプターの調節におけるこれらの使用 |
| GB0330042D0 (en) | 2003-12-24 | 2004-01-28 | Pharmacia Italia Spa | Pyrrolo [2,3-b] pyridine derivatives active as kinase inhibitors process for their preparation and pharmaceutical compositions them |
| GB0330043D0 (en) | 2003-12-24 | 2004-01-28 | Pharmacia Italia Spa | Pyrrolo [2,3-b] pyridine derivatives active as kinase inhibitors process for their preparation and pharmaceutical compositions comprising them |
| US20070185088A1 (en) * | 2004-03-17 | 2007-08-09 | Jakob Busch-Petersen | M3 muscarinic acetylchoine receptor antagonists |
| EP1725240A4 (en) * | 2004-03-17 | 2009-03-25 | Glaxo Group Ltd | ANTAGONISTS OF THE ACETYLCHOLINE MUSCARINIC RECEPTOR |
| WO2005094251A2 (en) * | 2004-03-17 | 2005-10-13 | Glaxo Group Limited | M3muscarinic acetylcholine receptor antagonists |
| RU2008118422A (ru) * | 2005-10-13 | 2009-11-20 | Морфохем Акциенгезельшафт Фюр Комбинаторише Хеми (De) | Производные 5-хинолина, обладающие антибактериальной активностью |
| HUE036035T2 (hu) * | 2013-12-13 | 2018-06-28 | Pf Medicament | Kromon-származék mint dopamin-D3 receptor antagonista autizmus spektrum betegség kezelésében történõ alkalmazásra |
| TWI695717B (zh) | 2014-03-06 | 2020-06-11 | 美商 Ptc 治療公司 | １,２,４-二唑苯甲酸之鹽及醫藥組合物 |
| KR20180081516A (ko) | 2015-10-30 | 2018-07-16 | 피티씨 테라퓨틱스, 인크. | 간질 치료 방법 |
| JP7015092B2 (ja) | 2016-07-28 | 2022-02-02 | 塩野義製薬株式会社 | ドーパミンｄ３受容体拮抗作用を有する含窒素縮環化合物 |
| NZ748072A (en) | 2017-03-20 | 2020-06-26 | Forma Therapeutics Inc | Pyrrolopyrrole compositions as pyruvate kinase (pkr) activators |
| CN111433201B (zh) * | 2017-12-21 | 2022-05-27 | 江苏恒瑞医药股份有限公司 | 苯并氮杂䓬衍生物、其制备方法及其在医药上的应用 |
| KR20200112910A (ko) | 2018-01-26 | 2020-10-05 | 시오노기 앤드 컴파니, 리미티드 | 도파민 d3 수용체 길항 작용을 갖는 축환 화합물 |
| CN110498768A (zh) * | 2018-05-17 | 2019-11-26 | 上海中泽医药科技有限公司 | 庚嗪类化合物及其在制备抗精神***症药物中的应用 |
| WO2020061255A1 (en) | 2018-09-19 | 2020-03-26 | Forma Therapeutics, Inc. | Activating pyruvate kinase r |
| MA53668A (fr) | 2018-09-19 | 2021-09-15 | Forma Therapeutics Inc | Traitement de la drépanocytose avec un composé activant la pyruvate kinase r |
Family Cites Families (77)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA792785B (en) * | 1978-07-07 | 1980-08-27 | Smithkline Corp | Mercapto substituted-2,3,4,5-tetrahydro-1h-3-benzazepines |
| US4220778A (en) | 1978-10-30 | 1980-09-02 | G. D. Searle & Co. | 8-Aryl-1,2,3,4-tetrahydroisoquinoline and derivatives thereof |
| ZA816903B (en) | 1980-10-17 | 1983-02-23 | Pennwalt Corp | N-(amino(or hydroxy)-1,2,3,4,-tetrahydroisoquinolines, precursors thereof, and methods of preparation |
| IL63918A0 (en) | 1980-10-17 | 1981-12-31 | Pennwalt Corp | N-(amino(or hydroxy)phenethyl)-1,2,3,4-tetrahydroisoquinolines,their preparation and pharmaceutical compositions containing them |
| FR2618149B1 (fr) | 1987-07-16 | 1989-09-22 | Synthelabo | Derives de n-aminoalkyl n-phenyl arylamides, leur preparation et leur application en therapeutique |
| IL89156A (en) | 1988-07-12 | 1993-05-13 | Synthelabo | Derivatives of 2-((4-piperidinyl) methyl)- 1,2,3,4- tetrahydroisoquinoline, their preparation and their application in therapeutics |
| US5217977A (en) | 1989-02-28 | 1993-06-08 | Imperial Chemical Industries Plc | Heterocyclic cycloalkanes |
| US5047406A (en) | 1989-12-06 | 1991-09-10 | Warner-Lambert Co. | Substituted cyclohexanols as central nervous system agents |
| US5633376A (en) | 1990-12-28 | 1997-05-27 | Neurogen Corporation | Certain aminomethyl phenylimidazole derivatives; and 4-aryl substituted piperazinyl and piperidinylmethyl phenylimidazole derivatives; a new class of dopamine receptor subtype ligands |
| US5681956A (en) | 1990-12-28 | 1997-10-28 | Neurogen Corporation | 4-aryl substituted piperazinylmethyl phenylimidazole derivatives; a new class of dopamine receptor subtype specific ligands |
| KR100220538B1 (ko) | 1991-01-11 | 1999-09-15 | 뮈쉘 쥐르밀 | 아크리딘 유도체 |
| EP0596120A4 (en) | 1991-08-09 | 1994-07-06 | Yoshitomi Pharmaceutical | Thiophene compound. |
| EP0596125A4 (en) | 1991-12-26 | 1994-10-05 | Yoshitomi Pharmaceutical | Condensed thiophene compound and pharmaceutical use thereof. |
| US5532240A (en) | 1991-12-26 | 1996-07-02 | Yoshitomi Pharmaceutical Industries, Ltd. | Condensed thiophene compound and pharmaceutical use thereof |
| GB9206757D0 (en) | 1992-03-27 | 1992-05-13 | Ferring Bv | Novel peptide receptor ligands |
| WO1994001408A1 (en) | 1992-07-10 | 1994-01-20 | Laboratoires Glaxo S.A. | Anilide derivatives |
| KR950702962A (ko) | 1992-08-06 | 1995-08-23 | 데이비드 로버츠 | 도파민 D₃수용체 길항제인 5-(2-옥시페닐)-피롤 유도체(5-(2-Oxyphenyl)-Pyrrole Derivatives as Dopamine D₃Receptor Antagonists) |
| US5294621A (en) | 1992-10-07 | 1994-03-15 | Ortho Pharmaceutical Corporation | Thieno tetrahydropyridines useful as class III antiarrhythmic agents |
| GB9305644D0 (en) | 1993-03-18 | 1993-05-05 | Merck Sharp & Dohme | Therapeutic agents |
| GB9307400D0 (en) | 1993-04-08 | 1993-06-02 | Smithkline Beecham Plc | Compounds |
| FR2706895A1 (en) | 1993-06-22 | 1994-12-30 | Synthelabo | Tetrahydroisoquinoline derivatives, their preparation and their application in therapeutics |
| JP2959615B2 (ja) | 1993-06-24 | 1999-10-06 | 吉富製薬株式会社 | 縮合型チオフェン化合物およびその医薬用途 |
| WO1995000508A1 (en) | 1993-06-25 | 1995-01-05 | Smithkline Beecham Plc | Phenyrrole derivatives and their use as dopamine d3 antagonists |
| GB9315801D0 (en) | 1993-07-30 | 1993-09-15 | Smithkline Beecham Plc | Compounds |
| GB9315800D0 (en) | 1993-07-30 | 1993-09-15 | Smithkline Beecham Plc | Compounds |
| SK16396A3 (en) | 1993-08-12 | 1996-09-04 | Astra Ab | Amidine derivatives with nitric oxide synthetase activities |
| AU7665694A (en) | 1993-09-21 | 1995-04-10 | Yamanouchi Pharmaceutical Co., Ltd. | N-(3-pyrrolidinyl)benzamide derivative |
| GB9320855D0 (en) | 1993-10-09 | 1993-12-01 | Smithkline Beecham Plc | Compounds |
| US6756388B1 (en) | 1993-10-12 | 2004-06-29 | Pfizer Inc. | Benzothiophenes and related compounds as estrogen agonists |
| GB9325827D0 (en) | 1993-12-17 | 1994-02-23 | Smithkline Beecham Plc | Compounds |
| GB9402197D0 (en) | 1994-02-04 | 1994-03-30 | Smithkline Beecham Plc | Compounds |
| GB9402807D0 (en) | 1994-02-14 | 1994-04-06 | Xenova Ltd | Pharmaceutical compounds |
| GB9403199D0 (en) | 1994-02-19 | 1994-04-13 | Smithkline Beecham Plc | Compounds |
| AU2351895A (en) | 1994-04-28 | 1995-11-29 | Yamanouchi Pharmaceutical Co., Ltd. | N-(3-pyrrolidinyl)benzamide derivative |
| US5414010A (en) | 1994-05-10 | 1995-05-09 | Warner-Lambert Company | Dimeric benzimidazoles as central nervous system agents |
| DE4425145A1 (de) | 1994-07-15 | 1996-01-18 | Basf Ag | Verwendung von Thiazol- und Thiadiazolverbindungen |
| DE4425146A1 (de) | 1994-07-15 | 1996-01-18 | Basf Ag | Verwendung heterocyclischer Verbindungen |
| DE4425143A1 (de) | 1994-07-15 | 1996-01-18 | Basf Ag | Substituierte Pyrimidinverbindungen und deren Verwendung |
| DE4425144A1 (de) | 1994-07-15 | 1996-01-18 | Basf Ag | Triazolverbindungen und deren Verwendung |
| GB9418912D0 (en) | 1994-09-20 | 1994-11-09 | Fisons Corp | Pharmaceutically active compounds |
| NZ295546A (en) | 1994-10-05 | 1999-01-28 | Glaxo Wellcome Inc | Parenteral medicament containing n-{4-[2-1,2,3,4-tetrahydro-6,7-dimethoxy-2-isoquinolinyl)-ethyl]-phenyl}- 9,10-dihydro-5-methoxy-9-oxo-4-acridine carboxamide, surfactant, and buffer |
| JP2941950B2 (ja) | 1994-11-23 | 1999-08-30 | ニューロゲン コーポレイション | 或る種の４−アミノメチル−２−置換イミダゾール誘導体および２−アミノメチル−４−置換イミダゾール誘導体；新規な種類のドーパミン リセプタ亜型特異性リガンド |
| US5478934A (en) | 1994-11-23 | 1995-12-26 | Yuan; Jun | Certain 1-substituted aminomethyl imidazole and pyrrole derivatives: novel dopamine receptor subtype specific ligands |
| GB9426090D0 (en) | 1994-12-23 | 1995-02-22 | Xenova Ltd | Pharmaceutical compounds |
| GB9426071D0 (en) | 1994-12-23 | 1995-02-22 | Xenova Ltd | Pharmaceutical compounds |
| GB9426224D0 (en) | 1994-12-23 | 1995-02-22 | Xenova Ltd | Pharmaceutical compounds |
| US5891877A (en) | 1995-02-14 | 1999-04-06 | Xenova Limited | Pharmaceutical compounds |
| CA2213197C (en) | 1995-02-15 | 2001-08-07 | Neurogen Corporation | Certain bridged 4-phenyl-2-aminomethylimidazoles; new dopamine receptor subtype specific ligands |
| EP0817767B1 (en) | 1995-03-27 | 2000-05-24 | Smithkline Beecham Plc | Bicyclic amine derivatives and their use as anti-psychotic agents |
| GB9512129D0 (en) | 1995-06-15 | 1995-08-16 | Smithkline Beecham Plc | Compounds |
| US5977110A (en) | 1995-09-22 | 1999-11-02 | Warner-Lambert Company | Substituted cyclohexylamines as central nervous systems agents |
| FR2741074B1 (fr) | 1995-11-09 | 1997-12-19 | Adir | Nouveaux composes tetracycliques de la 1,4-oxazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| DE19600934A1 (de) | 1996-01-12 | 1997-07-17 | Basf Ag | Substituierte Aza- und Diazacycloheptan- und Cyclooctanverbindungen und deren Verwendung |
| AU1597197A (en) | 1996-02-01 | 1997-08-22 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Thienoquinolines |
| CA2245586A1 (en) | 1996-02-06 | 1997-08-14 | Japan Tobacco Inc. | Novel compounds and pharmaceutical use thereof |
| JPH09291034A (ja) | 1996-02-27 | 1997-11-11 | Yoshitomi Pharmaceut Ind Ltd | 縮合ピリジン化合物およびその医薬としての用途 |
| US5710274A (en) | 1996-02-28 | 1998-01-20 | Neurogen Corporation | N-aminoalkyldibenzofurancarboxamides; new dopamine receptor subtype specific ligands |
| US5763609A (en) | 1996-03-21 | 1998-06-09 | Neurogen Corporation | Certain pyrrolo pyridine-3-carboxamides; a new class of gaba brain receptor ligands |
| US5703237A (en) | 1996-04-18 | 1997-12-30 | Neurogen Corporation | N-Aminoalkyl-2-anthraquinonecarboxamides; new dopamine receptor subtype specific ligands |
| US5688950A (en) | 1996-04-23 | 1997-11-18 | Neurogen Corporation | Tricyclic aminoalkylcarboxamides; novel dopamine D3 receptor subtype specific ligands |
| DE69719191T2 (de) * | 1996-05-11 | 2003-11-27 | Smithkline Beecham Plc | Tetrahydroisoquinoline derivate als modulatoren von dopamine d3 rezeptoren |
| GB9612153D0 (en) | 1996-06-11 | 1996-08-14 | Smithkline Beecham Plc | Compounds |
| ES2154470T3 (es) * | 1996-08-14 | 2001-04-01 | Smithkline Beecham Plc | Derivados de tetrahidroisoquinolina y su uso farmaceutico. |
| WO1998007421A1 (fr) | 1996-08-16 | 1998-02-26 | Ishihara Sangyo Kaisha, Ltd. | Composition medicinale |
| AU716151B2 (en) | 1996-11-27 | 2000-02-17 | Pfizer Inc. | Apo B-secretion/MTP inhibitory amides |
| FR2761985B1 (fr) | 1997-04-10 | 1999-05-21 | Adir | Nouveaux composes amines du 6,7,8,9-tetrahydro-cyclopenta[a] naphtalene et du 2,3-dihydro-cyclopenta[e]indene, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| WO1998048784A2 (en) | 1997-04-28 | 1998-11-05 | The University Of British Columbia | Method and composition for modulating amyloidosis |
| GB9708694D0 (en) | 1997-04-30 | 1997-06-18 | Smithkline Beecham Plc | Compounds |
| GB9708805D0 (en) | 1997-05-01 | 1997-06-25 | Smithkline Beecham Plc | Compounds |
| IL132631A0 (en) * | 1997-05-03 | 2001-03-19 | Smithkline Beecham Plc | Tetrahydroisoquinoline derivatives as modulators of dopamine d3 receptors |
| GB9709303D0 (en) | 1997-05-09 | 1997-06-25 | Smithkline Beecham Plc | Compounds |
| GB9710612D0 (en) | 1997-05-23 | 1997-07-16 | Glaxo Group Ltd | Synthesis of acridine derivatives |
| DE19728996A1 (de) | 1997-07-07 | 1999-01-14 | Basf Ag | Triazolverbindungen und deren Verwendung |
| GB9810876D0 (en) | 1998-05-20 | 1998-07-22 | Smithkline Beecham Plc | Compounds |
| GB9821977D0 (en) | 1998-10-08 | 1998-12-02 | Smithkline Beecham Plc | Compounds |
| ES2255311T3 (es) | 1998-10-08 | 2006-06-16 | Smithkline Beecham Plc | Derivados de tetrahidrobenzazepina utiles como moduladores de los receptores d3 de dopamina (agentes anti-psicoticos). |
| TWI274750B (en) | 1999-01-12 | 2007-03-01 | Abbott Gmbh & Co Kg | Triazole compounds showing high affinity to dopamine D3 receptor and pharmaceutical composition comprising the same |
-
1999
- 1999-10-06 ES ES99953833T patent/ES2255311T3/es not_active Expired - Lifetime
- 1999-10-06 OA OA1200100090A patent/OA11663A/en unknown
- 1999-10-06 NZ NZ511018A patent/NZ511018A/en unknown
- 1999-10-06 WO PCT/EP1999/007763 patent/WO2000021951A1/en not_active Application Discontinuation
- 1999-10-06 DE DE69929704T patent/DE69929704T2/de not_active Expired - Fee Related
- 1999-10-06 EA EA200100428A patent/EA200100428A1/ru unknown
- 1999-10-06 HU HU0104280A patent/HUP0104280A3/hu unknown
- 1999-10-06 PE PE1999001015A patent/PE20001088A1/es not_active Application Discontinuation
- 1999-10-06 TR TR2001/01025T patent/TR200101025T2/xx unknown
- 1999-10-06 AR ARP990105055A patent/AR023681A1/es not_active Application Discontinuation
- 1999-10-06 AP APAP/P/2001/002114A patent/AP2001002114A0/en unknown
- 1999-10-06 PL PL99347237A patent/PL347237A1/xx not_active Application Discontinuation
- 1999-10-06 AT AT99953833T patent/ATE316969T1/de not_active IP Right Cessation
- 1999-10-06 EP EP99953833A patent/EP1119563B1/en not_active Expired - Lifetime
- 1999-10-06 AU AU10381/00A patent/AU761018B2/en not_active Ceased
- 1999-10-06 US US09/806,902 patent/US6605607B1/en not_active Expired - Fee Related
- 1999-10-06 CN CN99814062A patent/CN1329609A/zh active Pending
- 1999-10-06 IL IL14238899A patent/IL142388A0/xx unknown
- 1999-10-06 JP JP2000575857A patent/JP2002527433A/ja not_active Withdrawn
- 1999-10-06 CO CO99063348A patent/CO5140073A1/es unknown
- 1999-10-06 CZ CZ20011270A patent/CZ20011270A3/cs unknown
- 1999-10-06 KR KR1020017004442A patent/KR20010085898A/ko not_active Application Discontinuation
- 1999-10-06 CA CA002346689A patent/CA2346689A1/en not_active Abandoned
- 1999-10-06 BR BR9914370-4A patent/BR9914370A/pt not_active IP Right Cessation
- 1999-10-06 SK SK478-2001A patent/SK4782001A3/sk unknown
- 1999-10-06 MA MA25809A patent/MA26696A1/fr unknown
- 1999-10-06 ID IDW20010785A patent/ID28385A/id unknown
-
2001
- 2001-04-06 NO NO20011745A patent/NO20011745L/no not_active Application Discontinuation
- 2001-04-24 BG BG105467A patent/BG105467A/xx unknown
-
2002
- 2002-01-09 HK HK02100150.4A patent/HK1038745A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU761018B2 (en) | 2003-05-29 |
| CA2346689A1 (en) | 2000-04-20 |
| EP1119563B1 (en) | 2006-02-01 |
| NO20011745D0 (no) | 2001-04-06 |
| NZ511018A (en) | 2003-09-26 |
| TR200101025T2 (tr) | 2001-09-21 |
| IL142388A0 (en) | 2002-03-10 |
| HUP0104280A2 (hu) | 2002-03-28 |
| CO5140073A1 (es) | 2002-03-22 |
| NO20011745L (no) | 2001-06-06 |
| BR9914370A (pt) | 2001-11-27 |
| AU1038100A (en) | 2000-05-01 |
| BG105467A (en) | 2001-11-30 |
| CN1329609A (zh) | 2002-01-02 |
| JP2002527433A (ja) | 2002-08-27 |
| EA200100428A1 (ru) | 2001-10-22 |
| DE69929704D1 (de) | 2006-04-13 |
| AR023681A1 (es) | 2002-09-04 |
| DE69929704T2 (de) | 2006-07-20 |
| ID28385A (id) | 2001-05-17 |
| PE20001088A1 (es) | 2000-12-02 |
| CZ20011270A3 (cs) | 2001-09-12 |
| PL347237A1 (en) | 2002-03-25 |
| ATE316969T1 (de) | 2006-02-15 |
| US6605607B1 (en) | 2003-08-12 |
| HK1038745A1 (zh) | 2002-03-28 |
| WO2000021951A1 (en) | 2000-04-20 |
| AP2001002114A0 (en) | 2001-06-30 |
| OA11663A (en) | 2004-12-08 |
| SK4782001A3 (en) | 2001-11-06 |
| ES2255311T3 (es) | 2006-06-16 |
| MA26696A1 (fr) | 2004-12-20 |
| EP1119563A1 (en) | 2001-08-01 |
| KR20010085898A (ko) | 2001-09-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HUP0104280A3 (en) | Tetrahydrobenzazepine derivatives useful as modulators of dopamine d3 receptors, process for their preparation, medicaments containing them | |
| HUP0203142A3 (en) | Benzodiazepine derivatives, process for preparation of the compounds, pharmaceutical compositions containing them and their use | |
| HUP0203183A3 (en) | Novel heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use | |
| HUP0003844A3 (en) | Novel spiroazabicyclic heterocyclic compounds, process for their preparation, their use and pharmaceutical compositions containing them | |
| HUP0203107A3 (en) | Novel spiro compounds, process for their preparation and pharmaceutical compositions containing them | |
| HUP0201406A2 (en) | Aromatic heterocyclic compounds as antiinflammatory agents, process for their preparation and pharmaceutical compositions containing them | |
| HUP0101599A3 (en) | Heterocyclically substituted amides, process for producing them, use of them and pharmaceutical compositions containing them | |
| HUP0101434A3 (en) | Sulfonamide-containing indole compounds, use of them for producing pharmaceutical compositions and pharmaceutical compositions containing the same | |
| AU2303402A (en) | Tetrahydrobenzazepine derivatives useful as modulators of dopamine d3 receptors (antipsychotic agents) | |
| HUP0203548A3 (en) | New spirooxindole derivatives, process for their preparation, pharmaceutical compositions containing them and their use | |
| HUP0303281A3 (en) | Benzodiazepine derivatives as gaba a receptor modulators, process for their preparation and pharmaceutical compositions containing them | |
| HUP0002843A3 (en) | New betha-carboline compounds, a process for their preparation and pharmaceutical compositions containing them | |
| HUP0105108A3 (en) | Amide compounds, process for their preparation and pharmaceutical compositions containing them | |
| IL132631A0 (en) | Tetrahydroisoquinoline derivatives as modulators of dopamine d3 receptors | |
| HUP0202075A3 (en) | Substituted 2-dialkylaminoalkylbiphenyl derivatives, process for their preparation, pharmaceutical compositions containing them and their use | |
| HUP9904063A3 (en) | Pde iv inhibiting 2-(cyanoimino)imidazole derivatives, their use, process for producing them and pharmaceutical compositions containing them | |
| HUP9802121A3 (en) | Imidazoline derivatives, process for producing them and pharmaceutical compositions containing them | |
| HUP0200281A3 (en) | Heterocyclic benzenesulphonamide compounds as bradykinine antagonists, process for their preparation and pharmaceutical compositions containing them | |
| HUP0203526A3 (en) | Thienoisoxazolyl- and thienylpyrrazolyl-phenoxy substituted propyl derivatives useful as d4 antagonists, process for their preparation and pharmaceutical compositions containing them | |
| HUP0201710A2 (en) | Biphenyl derivatives as antagonists of the neurokinine-1 receptor, process for producing them and pharmaceutical compositions containing them | |
| HUP0105116A3 (en) | 2,3-0-isopropylidene derivatives of monosaccharides as cell adhesion inhibitors, pharmaceutical compositions containing them, process for preparation of the compounds | |
| HUP0202706A3 (en) | Benzisoxazolyl-, pyridoisoxazolyl- and benzthienyl-phenoxy derivatives useful as d4 antagonists, their intermediates, process for their preparation and pharmaceutical compositions containing them | |
| HUP9701921A3 (en) | Heterocyclic amino-methyl compounds, process for producing them, and pharmaceutical compositions containing them | |
| HUP9904628A3 (en) | New imidazoline compounds, process for their production and medicaments containing them | |
| HUP0202379A3 (en) | New compounds, process for producing them and pharmaceutical compositions containing them |