HUP0101587A2 - Antagonista vegyületek CD11/CD18 adhéziós receptor közvetítette betegségek kezelésére - Google Patents

Antagonista vegyületek CD11/CD18 adhéziós receptor közvetítette betegségek kezelésére

Info

Publication number
HUP0101587A2
HUP0101587A2 HU0101587A HUP0101587A HUP0101587A2 HU P0101587 A2 HUP0101587 A2 HU P0101587A2 HU 0101587 A HU0101587 A HU 0101587A HU P0101587 A HUP0101587 A HU P0101587A HU P0101587 A2 HUP0101587 A2 HU P0101587A2
Authority
HU
Hungary
Prior art keywords
treatment
antagonists
adhesion receptor
receptor mediated
mediated disorders
Prior art date
Application number
HU0101587A
Other languages
English (en)
Inventor
Daniel J. Burdick
Thomas R. Gadek
James C. Marsters
Robert S. Mcdowell
David Oare
Mark Reynolds
Mark S. Stenley
Kenneth J. Weese
Original Assignee
Genentech, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech, Inc. filed Critical Genentech, Inc.
Publication of HUP0101587A2 publication Critical patent/HUP0101587A2/hu
Publication of HUP0101587A3 publication Critical patent/HUP0101587A3/hu

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/559—Eicosanoids, e.g. leukotrienes or prostaglandins having heterocyclic rings containing hetero atoms other than oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4458—Non condensed piperidines, e.g. piperocaine only substituted in position 2, e.g. methylphenidate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
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    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
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    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
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  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)

Abstract

A találmány tárgyát képezik az (I) általános képletű antagonistavegyületek amelyek a CD11/CD18 adhéziós receptorcsalád antagonistái,és különösen alkalmasak CD11/CD18 receptorok (elsősorban (Mac-1 ésLFA-1 receptorok) által közvetített rendellenességek emlősökben(elsősorban emberekben) történő kezelésére. Szintén a találmánytárgyát képezi a találmány szerinti antagonista vegyületek alkalmazása- emlősökben CD11/CD18 celluláris adhéziós molekulacsalád általközvetített immun- vagy gyulladásos reakció vagy rendellenességkezelésére vagy enyhítésére alkalmas - gyógyászati készítményelőállítására. Ó
HU0101587A 1998-03-27 1999-03-24 Antagonists for treatment of cd11/cd18 adhesion receptor mediated disorders HUP0101587A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7973298P 1998-03-27 1998-03-27
PCT/US1999/006410 WO1999049856A2 (en) 1998-03-27 1999-03-24 Antagonists for treatment of cd11/cd18 adhesion receptor mediated disorders

Publications (2)

Publication Number Publication Date
HUP0101587A2 true HUP0101587A2 (hu) 2001-08-28
HUP0101587A3 HUP0101587A3 (en) 2003-03-28

Family

ID=22152446

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0101587A HUP0101587A3 (en) 1998-03-27 1999-03-24 Antagonists for treatment of cd11/cd18 adhesion receptor mediated disorders

Country Status (19)

Country Link
US (1) US20050203135A1 (hu)
EP (1) EP1063982B1 (hu)
JP (2) JP2002509881A (hu)
KR (1) KR100596109B1 (hu)
CN (1) CN1191063C (hu)
AT (1) ATE353640T1 (hu)
AU (1) AU764524B2 (hu)
BR (1) BR9909418A (hu)
CA (1) CA2325986A1 (hu)
DE (1) DE69935133T2 (hu)
EA (1) EA007852B1 (hu)
HU (1) HUP0101587A3 (hu)
IL (2) IL138297A0 (hu)
NO (1) NO20004800L (hu)
NZ (1) NZ506779A (hu)
PL (1) PL343555A1 (hu)
UA (1) UA74531C2 (hu)
WO (1) WO1999049856A2 (hu)
ZA (1) ZA200004653B (hu)

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CN1295471A (zh) 2001-05-16
CA2325986A1 (en) 1999-10-07
IL138297A0 (en) 2001-10-31
PL343555A1 (en) 2001-08-27
WO1999049856A3 (en) 1999-11-18
CN1191063C (zh) 2005-03-02
EP1063982A2 (en) 2001-01-03
AU3113799A (en) 1999-10-18
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JP2007224037A (ja) 2007-09-06
AU764524B2 (en) 2003-08-21
WO1999049856A2 (en) 1999-10-07
ATE353640T1 (de) 2007-03-15
HUP0101587A3 (en) 2003-03-28
ZA200004653B (en) 2002-02-27
EA007852B1 (ru) 2007-02-27
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NZ506779A (en) 2003-08-29
US20050203135A1 (en) 2005-09-15
JP2002509881A (ja) 2002-04-02
IL138297A (en) 2006-06-11
BR9909418A (pt) 2001-09-25
DE69935133T2 (de) 2007-11-22
UA74531C2 (en) 2006-01-16
NO20004800L (no) 2000-11-24

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