HUP0101269A1 - Káliumcsatorna-inhibítorok - Google Patents

Káliumcsatorna-inhibítorok

Info

Publication number
HUP0101269A1
HUP0101269A1 HU0101269A HUP0101269A HUP0101269A1 HU P0101269 A1 HUP0101269 A1 HU P0101269A1 HU 0101269 A HU0101269 A HU 0101269A HU P0101269 A HUP0101269 A HU P0101269A HU P0101269 A1 HUP0101269 A1 HU P0101269A1
Authority
HU
Hungary
Prior art keywords
alkylene
alkyl
heterocyclyl
nhc
heteroaryl
Prior art date
Application number
HU0101269A
Other languages
English (en)
Inventor
Neil A. Castle
Michael F. Gross
Original Assignee
Icagen, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Icagen, Inc. filed Critical Icagen, Inc.
Publication of HUP0101269A1 publication Critical patent/HUP0101269A1/hu
Publication of HUP0101269A3 publication Critical patent/HUP0101269A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/20—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/12—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
    • C07C311/13—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings the carbon skeleton containing six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/28—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40—Acylated substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Magnetic Heads (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • External Artificial Organs (AREA)
  • Seasonings (AREA)
  • Sorption Type Refrigeration Machines (AREA)

Abstract

Az (I) általános képletű vegyületek - a képletben t értéke 1 vagy 2; Aés B jelentése külön-külön H, vagy együtt kötést képeznek aszubsztituált szénatomok között; R1 jelentése H, alkil-, vagy adottesetben szubsztituált aril-, heteroaril-, heterociklil- vagykarbocikloalkilcsoport; Y2 jelentése (CH2)q, (CH2)WO, HC=CH vagyetinilcsoport; X2 jelentése C=O, C=S vagy SO2; R3 és R4 jelentéseegymástól függetlenül H, alkil- vagy adott esetben szubsztituáltaril-, aralkil-, heteroaril-, hetero-aralkil-, heterociklil-,karbocikloalkilcsoport vagy alki-lén-(szubsztituált amino)-csoport; Zjelentése H, alkil-, alkienil-, alkilén(heterociklil)-, alkilén--(heteroaril)-, alkilén-NHC(O)(alkil)--, alkilén-NH-C(O)(aril)-,alkilén-NHC(O)(heterociklil)-, alkilén-NHC(O)(heteroaril)-, alkilén-NHC(O)(alkilén-heterociklil)-, alkilén-NHC(O)-(heteroaralkil)-,alkilén-C(O)-(alkil)-, alkilén-C(O)O(alkil)-, OR14, SR14 vagy NR15R16csoport; R2 jelentése H, alkil-, adott esetben szubsztituált aril-,aralkil-, heteroaril-, heterociklil-, heteroaralkil-,karbocikloalkilcsoport, Ra-O- vagy RbRc-N- csoport; Y1 jelentése(CH2)p, CHR17(CH2)o, HC=CH vagy etinilcsoport; X1 jelentése C=O, C=S,SO2 vagy (CH2)n - és gyógyászatilag elfogadható sóik vagy prodrogjaikkáliumcsatorna inhibitor aktivitásuk következtében szívaritmiák éssejtproliferatív rendellenességek kezelésére alkalmazhatók. Ó
HU0101269A 1998-01-27 1999-01-27 Potassium channel inhibitors HUP0101269A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7271998P 1998-01-27 1998-01-27
PCT/US1999/001663 WO1999037607A1 (en) 1998-01-27 1999-01-27 Potassium channel inhibitors

Publications (2)

Publication Number Publication Date
HUP0101269A1 true HUP0101269A1 (hu) 2001-10-28
HUP0101269A3 HUP0101269A3 (en) 2003-01-28

Family

ID=22109343

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0101269A HUP0101269A3 (en) 1998-01-27 1999-01-27 Potassium channel inhibitors

Country Status (21)

Country Link
US (1) US6333337B1 (hu)
EP (1) EP1051394B1 (hu)
JP (1) JP2002501041A (hu)
KR (1) KR20010034377A (hu)
CN (1) CN1294577A (hu)
AT (1) ATE265426T1 (hu)
AU (1) AU745845B2 (hu)
BR (1) BR9907236A (hu)
CA (1) CA2317457A1 (hu)
DE (1) DE69916792D1 (hu)
HU (1) HUP0101269A3 (hu)
ID (1) ID25853A (hu)
IL (1) IL137219A0 (hu)
NO (1) NO20003600L (hu)
NZ (1) NZ505666A (hu)
PL (1) PL341859A1 (hu)
RU (1) RU2218330C2 (hu)
TR (1) TR200002191T2 (hu)
TW (1) TW542823B (hu)
WO (1) WO1999037607A1 (hu)
ZA (1) ZA99550B (hu)

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WO2000012077A1 (en) 1998-09-01 2000-03-09 Bristol-Myers Squibb Company Potassium channel inhibitors and method
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AU781365B2 (en) * 1999-12-21 2005-05-19 Icagen, Inc. Potassium channel inhibitors
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US6620849B2 (en) * 2000-07-26 2003-09-16 Icafen, Inc. Potassium channel inhibitors
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DE10060807A1 (de) 2000-12-07 2002-06-20 Aventis Pharma Gmbh Ortho, ortho-substituierte stickstoffhaltige Bisarylverbindungen, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen
DE10061876A1 (de) * 2000-12-12 2002-06-20 Aventis Pharma Gmbh Arylierte Furan- und Thiophencarbonsäureamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen
US6849634B2 (en) 2000-12-21 2005-02-01 Icagen Potassium channel inhibitors
DE10121003A1 (de) 2001-04-28 2002-12-19 Aventis Pharma Gmbh Anthranilsäureamide, Verfahren zur Herstellung, ihrer Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen
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GB0412986D0 (en) 2004-06-10 2004-07-14 Xention Discovery Ltd Compounds
US7576212B2 (en) 2004-12-09 2009-08-18 Xention Limited Thieno[2,3-B] pyridines as potassium channel inhibitors
DE102005017316A1 (de) * 2005-04-14 2006-10-19 Schering Ag Tetrahydronaphthalinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer
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CA2648196A1 (en) * 2006-04-14 2007-10-25 Novartis Ag Use of biarylcarboxamides in the treatment of hedgehog pathway-related disorders
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SG174095A1 (en) * 2006-08-23 2011-09-29 Valeant Pharmaceuticals Int Derivatives of 4-(n-azacycloalkyl) anilides as potassium channel modulators
BRPI0719590A2 (pt) * 2006-11-28 2014-01-21 Valeant Pharmaceuticals Int Análogos de retigabina 1,4 diamino bicíclica como modulares de canal de potássio
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Also Published As

Publication number Publication date
BR9907236A (pt) 2002-01-22
US6333337B1 (en) 2001-12-25
NO20003600L (no) 2000-09-26
ID25853A (id) 2000-11-09
CN1294577A (zh) 2001-05-09
ATE265426T1 (de) 2004-05-15
PL341859A1 (en) 2001-05-07
WO1999037607A1 (en) 1999-07-29
ZA99550B (en) 1999-07-26
EP1051394A1 (en) 2000-11-15
IL137219A0 (en) 2001-07-24
NO20003600D0 (no) 2000-07-13
CA2317457A1 (en) 1999-07-29
HUP0101269A3 (en) 2003-01-28
DE69916792D1 (de) 2004-06-03
RU2218330C2 (ru) 2003-12-10
AU2241999A (en) 1999-08-09
JP2002501041A (ja) 2002-01-15
TW542823B (en) 2003-07-21
KR20010034377A (ko) 2001-04-25
TR200002191T2 (tr) 2000-11-21
NZ505666A (en) 2002-11-26
EP1051394B1 (en) 2004-04-28
AU745845B2 (en) 2002-04-11

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