BR9907236A - Inibidores de canais de potássio - Google Patents

Inibidores de canais de potássio

Info

Publication number
BR9907236A
BR9907236A BR9907236-0A BR9907236A BR9907236A BR 9907236 A BR9907236 A BR 9907236A BR 9907236 A BR9907236 A BR 9907236A BR 9907236 A BR9907236 A BR 9907236A
Authority
BR
Brazil
Prior art keywords
optionally substituted
alkyl
carbocycloalkyl
heterocyclyl
potassium channel
Prior art date
Application number
BR9907236-0A
Other languages
English (en)
Inventor
Michael F Gross
Neil A Castle
Original Assignee
Icagen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Icagen Inc filed Critical Icagen Inc
Publication of BR9907236A publication Critical patent/BR9907236A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/12—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
    • C07C311/13—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings the carbon skeleton containing six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/20—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/28—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40—Acylated substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Magnetic Heads (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • External Artificial Organs (AREA)
  • Seasonings (AREA)
  • Sorption Type Refrigeration Machines (AREA)

Abstract

"INIBIDORES DE CANAIS DE POTáSSIO". Os compostos de fórmula geral (I), na qual t é 1 ou 2; A e B são cada um H, ou considerados juntos formam uma ligação entre os carbonos substituidos; R1 é H, alquila, ou é selecionado do grupo consistindo em uma arila opcionalmente substituída, uma heteroarila opcionalmente substituída, uma heterociclila opcionalmente substituída e uma carbocicloalquila opcionalmente substituída; Y2 é (CH2)q, HC=CH ou NH, w é 0, 1, ou 2, q é 0, 1 ou 2; X2 é C=O, C=S, ou SO2; R3 é H, alquila, uma arila opcionalmente substituída, uma aralquila opcionalmente substituída, uma heteroarila opcionalmente substituída, uma heteroalquila opcionalmente substituída; um heterociclo opcionalmente substituído, uma heterociclila opcionalmente substituída, uma carbocicloalquila opcionalmente substituída, ou um alquileno- (amino substituído) ; Z é, em particular, H ou OH; R2 é selecionado do grupo consistindo em H, alquila, uma arila opcionalmente substituída, uma aralquila opcionalmente substituída, uma heteroarila opcionalmente substituída, uma heterociclila opcionalmente substituída, uma heteroalquila opcionalmente substituída, uma carbocicloalquila opcionalmente substituída, Ra-O-, e RbRc-N-; Y1 é (CH2)p, CHR17(CH2)o, HC=CH ou etinila, p é 0, 1, 2 ou 3, o é 0, 1 ou 2; X1 é C=O, C=S, SO2 ou (CH2) n, n é 0, 1, ou 2; R4 é H, alquila, uma arila opcionalmente substituída, uma aralquila opcionalmente substituída, uma heteroarila opcionalmente substituída, uma heteroalquila opcionalmente substituída, um heterociclo opcionalmente substituído, uma heterociclila opcionalmente substituída, uma carbocicloalquila opcionalmente substituída, ou um alquileno- (amino substituído) ; ou os sais ou prodrogas farmaceuticamente aceitáveis dos mesmos são úteis como inibidores de canais de potássio e especialmente úteis para o tratamento de arritmias cardíacas e distúrbios proliferativos celulares.
BR9907236-0A 1998-01-27 1999-01-27 Inibidores de canais de potássio BR9907236A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7271998P 1998-01-27 1998-01-27
PCT/US1999/001663 WO1999037607A1 (en) 1998-01-27 1999-01-27 Potassium channel inhibitors

Publications (1)

Publication Number Publication Date
BR9907236A true BR9907236A (pt) 2002-01-22

Family

ID=22109343

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9907236-0A BR9907236A (pt) 1998-01-27 1999-01-27 Inibidores de canais de potássio

Country Status (21)

Country Link
US (1) US6333337B1 (pt)
EP (1) EP1051394B1 (pt)
JP (1) JP2002501041A (pt)
KR (1) KR20010034377A (pt)
CN (1) CN1294577A (pt)
AT (1) ATE265426T1 (pt)
AU (1) AU745845B2 (pt)
BR (1) BR9907236A (pt)
CA (1) CA2317457A1 (pt)
DE (1) DE69916792D1 (pt)
HU (1) HUP0101269A3 (pt)
ID (1) ID25853A (pt)
IL (1) IL137219A0 (pt)
NO (1) NO20003600L (pt)
NZ (1) NZ505666A (pt)
PL (1) PL341859A1 (pt)
RU (1) RU2218330C2 (pt)
TR (1) TR200002191T2 (pt)
TW (1) TW542823B (pt)
WO (1) WO1999037607A1 (pt)
ZA (1) ZA99550B (pt)

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DE10061876A1 (de) * 2000-12-12 2002-06-20 Aventis Pharma Gmbh Arylierte Furan- und Thiophencarbonsäureamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen
US6849634B2 (en) 2000-12-21 2005-02-01 Icagen Potassium channel inhibitors
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JP4511189B2 (ja) 2002-02-12 2010-07-28 セレクトリコン アーベー センサーの周囲の溶液環境を迅速に変化させるシステム及び方法
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Also Published As

Publication number Publication date
US6333337B1 (en) 2001-12-25
NO20003600L (no) 2000-09-26
ID25853A (id) 2000-11-09
CN1294577A (zh) 2001-05-09
ATE265426T1 (de) 2004-05-15
PL341859A1 (en) 2001-05-07
WO1999037607A1 (en) 1999-07-29
ZA99550B (en) 1999-07-26
EP1051394A1 (en) 2000-11-15
IL137219A0 (en) 2001-07-24
NO20003600D0 (no) 2000-07-13
CA2317457A1 (en) 1999-07-29
HUP0101269A3 (en) 2003-01-28
DE69916792D1 (de) 2004-06-03
RU2218330C2 (ru) 2003-12-10
AU2241999A (en) 1999-08-09
HUP0101269A1 (hu) 2001-10-28
JP2002501041A (ja) 2002-01-15
TW542823B (en) 2003-07-21
KR20010034377A (ko) 2001-04-25
TR200002191T2 (tr) 2000-11-21
NZ505666A (en) 2002-11-26
EP1051394B1 (en) 2004-04-28
AU745845B2 (en) 2002-04-11

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