HUP0004840A2 - Eljárás kolchikon vegyületeknek a megfelelő 3-glikozil származékokká történő biotranszformációjára - Google Patents

Eljárás kolchikon vegyületeknek a megfelelő 3-glikozil származékokká történő biotranszformációjára

Info

Publication number
HUP0004840A2
HUP0004840A2 HU0004840A HUP0004840A HUP0004840A2 HU P0004840 A2 HUP0004840 A2 HU P0004840A2 HU 0004840 A HU0004840 A HU 0004840A HU P0004840 A HUP0004840 A HU P0004840A HU P0004840 A2 HUP0004840 A2 HU P0004840A2
Authority
HU
Hungary
Prior art keywords
compounds
biotransformation
glycosyl derivatives
colchicone
colchicone compounds
Prior art date
Application number
HU0004840A
Other languages
English (en)
Inventor
Ezio Bombardelli
Cesare Ponzone
Original Assignee
Indena S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indena S.P.A. filed Critical Indena S.P.A.
Publication of HUP0004840A2 publication Critical patent/HUP0004840A2/hu
Publication of HUP0004840A3 publication Critical patent/HUP0004840A3/hu
Publication of HU225686B1 publication Critical patent/HU225686B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Peptides Or Proteins (AREA)

Abstract

A találmány tárgyát kolchicinszerű vegyületeknek a megfelelő 3-O-glikozil-származékokká történő biotranszformációja képezi, amelyetkiválasztott mikrobiológiai törzsek segítségével hajtanak végre. Atalálmány szerinti eljárás - az említett kolchikonvegyületekbőlkiindulva - olyan vegyületeket eredményez magas kitermeléssel és nagytisztaságban, amelyek kizárólag az A aromás gyűrű C-3 pozíciójábanvannak glikozilálva. Ó
HU0004840A 1997-10-03 1998-09-30 A process for the biotransformation of colchicone compounds into the corresponding 3-glycosyl derivatives HU225686B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT97MI002255A IT1295272B1 (it) 1997-10-03 1997-10-03 Biotrasformazione di composti colchiconici nei corrispondenti 3- glicosilderivati
PCT/EP1998/006226 WO1999018229A1 (en) 1997-10-03 1998-09-30 A process for the biotransformation of colchicone compounds into the corresponding 3-glycosyl derivatives

Publications (3)

Publication Number Publication Date
HUP0004840A2 true HUP0004840A2 (hu) 2001-04-28
HUP0004840A3 HUP0004840A3 (en) 2002-10-28
HU225686B1 HU225686B1 (en) 2007-06-28

Family

ID=11377985

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0004840A HU225686B1 (en) 1997-10-03 1998-09-30 A process for the biotransformation of colchicone compounds into the corresponding 3-glycosyl derivatives

Country Status (21)

Country Link
US (1) US6372458B1 (hu)
EP (1) EP1019521B1 (hu)
KR (1) KR100536676B1 (hu)
CN (1) CN1188527C (hu)
AT (1) ATE328106T1 (hu)
AU (1) AU745222B2 (hu)
CA (1) CA2305046C (hu)
CZ (1) CZ295749B6 (hu)
DE (1) DE69834736T2 (hu)
DK (1) DK1019521T3 (hu)
ES (1) ES2264214T3 (hu)
HK (1) HK1031896A1 (hu)
HU (1) HU225686B1 (hu)
IL (1) IL134566A (hu)
IT (1) IT1295272B1 (hu)
NO (1) NO320096B1 (hu)
PL (1) PL190865B1 (hu)
PT (1) PT1019521E (hu)
RU (1) RU2218409C2 (hu)
SK (1) SK285923B6 (hu)
WO (1) WO1999018229A1 (hu)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040175782A1 (en) * 2003-03-06 2004-09-09 Tethys Research Llc Biotransformation of compounds using non-prokaryotic microalgae
PT1745140E (pt) * 2004-05-12 2009-09-30 Indena Spa Biotransformação de compostos colchicinóides
KR20140014072A (ko) * 2010-09-22 2014-02-05 엘리시안 라이프 사이언스이즈 프라이빗 리미티드 콜키시노이드 화합물의 미생물학적 생물전환 방법
WO2015097567A1 (en) 2013-12-23 2015-07-02 Alkaloids Corporation Process for the conversion of colchicinoids to their 3-glycosylated derivatives via their respective 3-demethyl analogues
CN105861601B (zh) * 2016-04-29 2019-05-24 中国药科大学 一种生物转化制备二氢去氢双松柏醇葡萄糖单糖苷(hmzg)的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1344157A (fr) * 1959-05-22 1963-11-29 Roussel Uclaf Nouvelles colchicines et leur procédé d'obtention
JPS5233195B2 (hu) * 1971-09-30 1977-08-26
IT1285777B1 (it) * 1996-10-07 1998-06-18 Indena Spa Processo di biotrasformazione di composti colchicinoidi nei corrispondenti 3-glicosilderivati

Also Published As

Publication number Publication date
US6372458B1 (en) 2002-04-16
AU745222B2 (en) 2002-03-14
CN1188527C (zh) 2005-02-09
CN1273607A (zh) 2000-11-15
SK285923B6 (sk) 2007-11-02
KR100536676B1 (ko) 2005-12-14
WO1999018229A1 (en) 1999-04-15
HK1031896A1 (en) 2001-06-29
IL134566A (en) 2004-06-20
NO20001706L (no) 2000-06-05
EP1019521B1 (en) 2006-05-31
CZ295749B6 (cs) 2005-10-12
PT1019521E (pt) 2006-09-29
AU1028399A (en) 1999-04-27
ATE328106T1 (de) 2006-06-15
CZ20001196A3 (cs) 2000-10-11
IL134566A0 (en) 2001-04-30
RU2218409C2 (ru) 2003-12-10
CA2305046C (en) 2008-12-09
SK4832000A3 (en) 2000-09-12
CA2305046A1 (en) 1999-04-15
NO320096B1 (no) 2005-10-24
HUP0004840A3 (en) 2002-10-28
PL190865B1 (pl) 2006-02-28
PL339620A1 (en) 2001-01-02
IT1295272B1 (it) 1999-05-04
EP1019521A1 (en) 2000-07-19
KR20010030710A (ko) 2001-04-16
HU225686B1 (en) 2007-06-28
NO20001706D0 (no) 2000-04-03
ES2264214T3 (es) 2006-12-16
DE69834736D1 (de) 2006-07-06
ITMI972255A1 (it) 1999-04-03
DE69834736T2 (de) 2007-05-10
DK1019521T3 (da) 2006-10-02

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HUP0004840A2 (hu) Eljárás kolchikon vegyületeknek a megfelelő 3-glikozil származékokká történő biotranszformációjára
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Legal Events

Date Code Title Description
MM4A Lapse of definitive patent protection due to non-payment of fees