HUP0004644A3 - Pyrrolopyrrolone derivatives as inhibitors of neutrophil elastase and pharmaceutical compositions containing them - Google Patents

Pyrrolopyrrolone derivatives as inhibitors of neutrophil elastase and pharmaceutical compositions containing them

Info

Publication number: HUP0004644A3
Authority: HU; Hungary
Prior art keywords: inhibitors; pharmaceutical compositions; compositions containing; neutrophil elastase; pyrrolopyrrolone
Prior art date: 1997-09-09

Application number

HU0004644A

Other languages

English (en)

Original Assignee

Glaxo Group Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-09-09

Filing date

1998-09-07

Publication date

2002-01-28

1997-09-09 Priority claimed from GBGB9719189.4A external-priority patent/GB9719189D0/en

1997-09-09 Priority claimed from GBGB9719183.7A external-priority patent/GB9719183D0/en

1997-09-10 Priority claimed from GBGB9719290.0A external-priority patent/GB9719290D0/en

1998-02-21 Priority claimed from GBGB9803611.4A external-priority patent/GB9803611D0/en

1998-09-07 Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd

2001-09-28 Publication of HUP0004644A2 publication Critical patent/HUP0004644A2/hu

2002-01-28 Publication of HUP0004644A3 publication Critical patent/HUP0004644A3/hu

Links

ACJSMQZKXAMMRA-UHFFFAOYSA-N 1h-pyrrolo[3,2-b]pyrrol-5-one Chemical class N1C=CC2=NC(=O)C=C21 ACJSMQZKXAMMRA-UHFFFAOYSA-N 0.000 title 1
108010028275 Leukocyte Elastase Proteins 0.000 title 1
102000016799 Leukocyte elastase Human genes 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Hydrogenated Pyridines (AREA)

HU0004644A 1997-09-09 1998-09-07 Pyrrolopyrrolone derivatives as inhibitors of neutrophil elastase and pharmaceutical compositions containing them HUP0004644A3 (en)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
GBGB9719189.4A GB9719189D0 (en)	1997-09-09	1997-09-09	New therapeutic method
GBGB9719183.7A GB9719183D0 (en)	1997-09-09	1997-09-09	Compounds
GBGB9719290.0A GB9719290D0 (en)	1997-09-10	1997-09-10	Compounds
GBGB9803611.4A GB9803611D0 (en)	1998-02-21	1998-02-21	Compounds
PCT/EP1998/005609 WO1999012933A2 (en)	1997-09-09	1998-09-07	Pyrrolopyrrolone derivatives as inhibitors of neutrophil elastase

Publications (2)

Publication Number	Publication Date
HUP0004644A2 HUP0004644A2 (hu)	2001-09-28
HUP0004644A3 true HUP0004644A3 (en)	2002-01-28

Family

ID=27451698

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HU0004644A HUP0004644A3 (en)	1997-09-09	1998-09-07	Pyrrolopyrrolone derivatives as inhibitors of neutrophil elastase and pharmaceutical compositions containing them

Country Status (24)

Country	Link
EP (1)	EP1003748A2 (hu)
JP (1)	JP2001515904A (hu)
KR (1)	KR20010023766A (hu)
CN (1)	CN1278820A (hu)
AP (1)	AP2000001761A0 (hu)
AR (1)	AR017072A1 (hu)
AU (1)	AU9741298A (hu)
BR (1)	BR9812062A (hu)
CA (1)	CA2303176A1 (hu)
CO (1)	CO4970719A1 (hu)
EA (1)	EA200000204A1 (hu)
EE (1)	EE200000138A (hu)
HU (1)	HUP0004644A3 (hu)
ID (1)	ID24452A (hu)
IL (1)	IL134791A0 (hu)
IS (1)	IS5391A (hu)
MA (1)	MA26543A1 (hu)
NO (1)	NO20001198L (hu)
NZ (1)	NZ503130A (hu)
PE (1)	PE107899A1 (hu)
PL (1)	PL339176A1 (hu)
SK (1)	SK3192000A3 (hu)
TR (1)	TR200000907T2 (hu)
WO (1)	WO1999012933A2 (hu)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9905418D0 (en) *	1999-03-09	1999-05-05	Glaxo Group Ltd	Process
US7429659B2 (en)	2004-03-31	2008-09-30	Janssen Pharmaceutica N.V.	Furan compounds as histamine H3 modulators
DE102004024772A1 (de) *	2004-05-17	2005-12-22	Grünenthal GmbH	Substituierte 5-Aminomethyl-1H-pyrrol-2-carbonsäureamide
JP4853759B2 (ja) *	2004-05-27	2012-01-11	日本農薬株式会社	置換ピラジンカルボン酸アニリド誘導体又はその塩類、その中間体及び農園芸用薬剤並びにその使用方法
TWI355380B (en)	2004-05-27	2012-01-01	Nihon Nohyaku Co Ltd	Substituted pyrazinecarboxanilide derivatives or s
GB2418427A (en)	2004-09-02	2006-03-29	Univ Cambridge Tech	Ligands for G-protein coupled receptors
ATE439347T1 (de)	2004-11-23	2009-08-15	Warner Lambert Co	7-(2h-pyrazol-3-yl)-3,5-dihydroxy-heptansäure- derivate als hmg-co-a-reductase-inhibitoren zur behandlung von lipidemia
US8198288B2 (en)	2006-05-04	2012-06-12	Pulmagen Therapeutics (Inflammation) Limited	Tetrahydropyrrolopyrimidinediones and their use in therapy
WO2007129060A1 (en)	2006-05-04	2007-11-15	Argenta Discovery Limited	Tetrahydropyrrolopyrimidinediones and their use as human neutrophil elastase inhibitors
US7662967B2 (en)	2007-08-02	2010-02-16	Cambridge Enterprise Limited	Anti-inflammatory compounds and compositions
GB2452696B (en)	2007-08-02	2009-09-23	Cambridge Entpr Ltd	3-(2',2'-dimethylpropanoylamino)-tetrahydropyridin-2-one and its use in pharmaceutical compositions
WO2009060206A1 (en) *	2007-11-07	2009-05-14	Argenta Discovery Limited	3,4,6,7-tetrahydro-1h-pyrrolo[3,4-d]pyrimidine-2,5-diones and their therapeutic use
US20110212181A1 (en) *	2010-02-26	2011-09-01	The University Of Hong Kong	Compositions and methods for treating chronic respiratory inflammation
JP2023500182A (ja)	2019-09-17	2023-01-05	メレオバイオファーマ４リミテッド	移植片拒絶反応、閉塞性細気管支炎症候群、及び移植片対宿主病の治療に使用するためのアルベレスタット
DK4106757T3 (da)	2020-04-16	2023-10-23	Mereo Biopharma 4 Ltd	Fremgangsmåder der involverer neutrofil elastase-inhibitor alvelestat til behandling af luftvejssygdom medieret af alpha-1-antitrypsin-mangel
CA3234399A1 (en)	2021-10-20	2023-04-27	Mereo Biopharma 4 Limited	Neutrophil elastase inhibitors for use in the treatment of fibrosis

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9211783D0 (en) *	1992-06-04	1992-07-15	Ici Plc	Amide derivatives
GB9402680D0 (en) *	1994-02-11	1994-04-06	Zeneca Ltd	Pyrrolidine derivatives
PL329153A1 (en) *	1996-03-28	1999-03-15	Glaxo Group Ltd	Derivatives of pyrrolopyrolone as inhibitors of neutropil elastase

1998
- 1998-09-04 PE PE1998000828A patent/PE107899A1/es not_active Application Discontinuation
- 1998-09-07 MA MA25243A patent/MA26543A1/fr unknown
- 1998-09-07 JP JP2000510740A patent/JP2001515904A/ja active Pending
- 1998-09-07 KR KR1020007002422A patent/KR20010023766A/ko not_active Application Discontinuation
- 1998-09-07 CA CA002303176A patent/CA2303176A1/en not_active Abandoned
- 1998-09-07 EP EP98951348A patent/EP1003748A2/en not_active Withdrawn
- 1998-09-07 NZ NZ503130A patent/NZ503130A/en unknown
- 1998-09-07 TR TR2000/00907T patent/TR200000907T2/xx unknown
- 1998-09-07 HU HU0004644A patent/HUP0004644A3/hu unknown
- 1998-09-07 EA EA200000204A patent/EA200000204A1/ru unknown
- 1998-09-07 IL IL13479198A patent/IL134791A0/xx unknown
- 1998-09-07 ID IDW20000445A patent/ID24452A/id unknown
- 1998-09-07 PL PL98339176A patent/PL339176A1/xx not_active Application Discontinuation
- 1998-09-07 SK SK319-2000A patent/SK3192000A3/sk unknown
- 1998-09-07 AR ARP980104458A patent/AR017072A1/es unknown
- 1998-09-07 AP APAP/P/2000/001761A patent/AP2000001761A0/en unknown
- 1998-09-07 CN CN98810954A patent/CN1278820A/zh active Pending
- 1998-09-07 BR BR9812062-0A patent/BR9812062A/pt not_active Application Discontinuation
- 1998-09-07 EE EEP200000138A patent/EE200000138A/xx unknown
- 1998-09-07 AU AU97412/98A patent/AU9741298A/en not_active Abandoned
- 1998-09-07 WO PCT/EP1998/005609 patent/WO1999012933A2/en not_active Application Discontinuation
- 1998-09-08 CO CO98051488A patent/CO4970719A1/es unknown
2000
- 2000-02-29 IS IS5391A patent/IS5391A/is unknown
- 2000-03-08 NO NO20001198A patent/NO20001198L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
WO1999012933A2 (en)	1999-03-18
KR20010023766A (ko)	2001-03-26
AU9741298A (en)	1999-03-29
MA26543A1 (fr)	2004-12-20
AP2000001761A0 (en)	2000-03-31
EA200000204A1 (ru)	2000-10-30
NO20001198D0 (no)	2000-03-08
BR9812062A (pt)	2000-09-26
HUP0004644A2 (hu)	2001-09-28
PE107899A1 (es)	1999-11-17
CO4970719A1 (es)	2000-11-07
ID24452A (id)	2000-07-20
AR017072A1 (es)	2001-08-22
JP2001515904A (ja)	2001-09-25
CA2303176A1 (en)	1999-03-18
CN1278820A (zh)	2001-01-03
NZ503130A (en)	2001-08-31
NO20001198L (no)	2000-05-08
SK3192000A3 (en)	2001-03-12
WO1999012933A3 (en)	1999-05-27
IL134791A0 (en)	2001-04-30
TR200000907T2 (tr)	2000-11-21
PL339176A1 (en)	2000-12-04
EP1003748A2 (en)	2000-05-31
IS5391A (is)	2000-02-29
EE200000138A (et)	2001-02-15

Similar Documents

Publication	Publication Date	Title
HUP9702035A3 (en)	1998-12-28	Inhibitors of leukocita-adhesion- and vla-4-antagonists and pharmaceutical compositions containing them
HUP9702036A3 (en)	1998-12-28	Inhibitors of leucocita-adhesion and wla-4-antagonists and pharmaceutical compositions containing them
HUP9702034A3 (en)	1998-12-28	Inhibitors of leukocita-adhesion and vla-4-antagonists and pharmaceutical compositions containing them
HUP9900964A3 (en)	2001-02-28	Protease inhibitors and pharmaceutical compositions containing these compounds
HUP0101810A3 (en)	2002-05-28	Substituted oxoazaheterocyclyl factor xa inhibitors and pharmaceutical compositions containing them
IL133613A0 (en)	2001-04-30	Epothilone derivatives and pharmaceutical compositions containing same
HUP0100178A3 (en)	2002-12-28	Tetrahydro-naphtiridinyl-imidazolydinyl-carboxylic acid derivatives and pharmaceutical compositions thereof
IL126674A0 (en)	1999-08-17	Urea derivatives as inhibitors of impdh enzyme and pharmaceutical compositions containing the same
HUP0102514A3 (en)	2002-03-28	Pyrido-pyrimidin and pyrimido-pyrimidin derivatives as inhibitors of cellular proliferation and pharmaceutical compositions thereof
HUP9802417A3 (en)	2001-07-30	Amide derivatives containing heteroaryl group and pharmaceutical compositions containing them
HUP0102990A3 (en)	2002-09-30	Tetrahydroimidazo-naphtyridine derivatives and pharmaceutical compositions thereof
HUP0000979A3 (en)	2002-10-28	Pharmaceutical compositions containing fk-506 and derivatives thereof
IL119466A0 (en)	1997-01-10	Thrombin inhibitors their preparation and pharmaceutical compositions containing them
HUP0002510A3 (en)	2002-10-28	Tetrazole derivatives and pharmaceutical compositions containing them
HUP0105160A3 (en)	2003-01-28	Complex of ras-farnesyltransferase inhibitor and sulfobutylether-7-betha-cyclodextrin or 2-hydroxypropyl-betha-cyclodextrin and method for its preparation and pharmaceutical compositions containing them
HUP9900567A3 (en)	2001-02-28	Pyrrolopyrrolone derivatives as inhibitors of neutrophil elastase, intermediates, preparation and use thereof, pharmaceutical compositions containing these compounds
HUP0101381A3 (en)	2002-06-28	Benzofurylpyrone derivatives and pharmaceutical compositions containing them
HUP0004644A3 (en)	2002-01-28	Pyrrolopyrrolone derivatives as inhibitors of neutrophil elastase and pharmaceutical compositions containing them
HUP0002951A3 (en)	2002-10-28	Bis-aminomethylcarbonyl compounds as protease inhibitors and pharmaceutical compositions containing them
HUP0002324A3 (en)	2001-07-30	Benzimidazole derivatives and pharmaceutical compositions containing them
HUP9700005A3 (en)	1998-07-28	2-ureido-benzamide derivatives and pharmaceutical compositions containing them as active agent
HUP0103203A3 (en)	2002-10-28	Azaadamantane derivatives and pharmaceutical compositions thereof
ZA967800B (en)	1997-04-03	Heteroaryllsubstituted acryloylguanidine derivatives and pharmaceutical compositions comprising them
HUP0100085A3 (en)	2002-12-28	Biphenylamidine derivatives and pharmaceutical compositions containing them
HUP0002331A3 (en)	2001-05-28	20-aralkyl-5alpha-pregnane derivatives and pharmaceutical compositions thereof