AR017072A1 - Compuestos derivados de pirrolopirrolona como inhibidores de elastasa neutrofilica, uso de dichos compuestos, metodos de tratamiento, procesos depreparacion e intermediarios utiles para su produccion - Google Patents
Compuestos derivados de pirrolopirrolona como inhibidores de elastasa neutrofilica, uso de dichos compuestos, metodos de tratamiento, procesos depreparacion e intermediarios utiles para su produccionInfo
- Publication number
- AR017072A1 AR017072A1 ARP980104458A ARP980104458A AR017072A1 AR 017072 A1 AR017072 A1 AR 017072A1 AR P980104458 A ARP980104458 A AR P980104458A AR P980104458 A ARP980104458 A AR P980104458A AR 017072 A1 AR017072 A1 AR 017072A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- carbon atoms
- compounds
- optionally substituted
- halogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
Un compuesto de la formula (I) (estereoquímica relativa indicada) donde R1 representa alquilo de 1 a 6 átomos de carbono; R2 representa alquilo de 2 a 4átomos de carbono o alquenilo de 2 a 4 átomos de carbono; X representa CO o SO2; Het representa unsistema de anillo aromático monocíclico o bicíclico de 5 a10 elementos, opcionalmente sustituido, que contiene 1 a 4 heteroátomos seleccionados de O, N y S; n representa un numero entero de 0 a 4; R3 y R4 representanindependientemente hidrogeno, alquilo de 1 a 8 átomos de carbono, -(CH2)1-4CONR5R6, COC1-4 alquilo o (CH2)0-2 Fen en donde Fen representa fenilo opcionalmentesustituido por uno o más grupos alquilo C1-4 o grupos halogeno o NR3R4 juntos representan azetidinilo, pirrolidinilo, piperidinilo,azepinilo, morfolinilo, piperazinilo opcionalmente N-sustituido por alquilo de 1 a 6 átomos de carbono, fenilo (opcionalmente sustituido por halogeno oalquilo de 1 a 4 átomos de carbono) o bencilo (opcionalmente sustituido en el anillo de benceno por halogeno o alquilo de 1 a 4 átomos de carbono) o NR3R4juntos representan un anillo como se ha descripto hasta ahora salvo que se sustituye en el carbono por uno o más grupos alquilo de 1 a 4 átomos de carbono,CONR5R6 o COOR6. R5 y R6 representan independientemente hidrogeno o alquilo de 1 a 4 átomos de carbono; y sales y solvatos de los mismos. Los compuestos de laformula (I) son utiles inter alia, en el tratamiento de desordenes inflamatorios del tracto respiratorio. Se describen tambiénel uso de dichos compuestos enla manufactura de medicamentos y métodos de tratamiento, así como procesos de preparacion de dichos compuestos e intermediarios utiles.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9719189.4A GB9719189D0 (en) | 1997-09-09 | 1997-09-09 | New therapeutic method |
GBGB9719183.7A GB9719183D0 (en) | 1997-09-09 | 1997-09-09 | Compounds |
GBGB9719290.0A GB9719290D0 (en) | 1997-09-10 | 1997-09-10 | Compounds |
GBGB9803611.4A GB9803611D0 (en) | 1998-02-21 | 1998-02-21 | Compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
AR017072A1 true AR017072A1 (es) | 2001-08-22 |
Family
ID=27451698
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP980104458A AR017072A1 (es) | 1997-09-09 | 1998-09-07 | Compuestos derivados de pirrolopirrolona como inhibidores de elastasa neutrofilica, uso de dichos compuestos, metodos de tratamiento, procesos depreparacion e intermediarios utiles para su produccion |
Country Status (24)
Country | Link |
---|---|
EP (1) | EP1003748A2 (es) |
JP (1) | JP2001515904A (es) |
KR (1) | KR20010023766A (es) |
CN (1) | CN1278820A (es) |
AP (1) | AP2000001761A0 (es) |
AR (1) | AR017072A1 (es) |
AU (1) | AU9741298A (es) |
BR (1) | BR9812062A (es) |
CA (1) | CA2303176A1 (es) |
CO (1) | CO4970719A1 (es) |
EA (1) | EA200000204A1 (es) |
EE (1) | EE200000138A (es) |
HU (1) | HUP0004644A3 (es) |
ID (1) | ID24452A (es) |
IL (1) | IL134791A0 (es) |
IS (1) | IS5391A (es) |
MA (1) | MA26543A1 (es) |
NO (1) | NO20001198L (es) |
NZ (1) | NZ503130A (es) |
PE (1) | PE107899A1 (es) |
PL (1) | PL339176A1 (es) |
SK (1) | SK3192000A3 (es) |
TR (1) | TR200000907T2 (es) |
WO (1) | WO1999012933A2 (es) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9905418D0 (en) * | 1999-03-09 | 1999-05-05 | Glaxo Group Ltd | Process |
US7429659B2 (en) | 2004-03-31 | 2008-09-30 | Janssen Pharmaceutica N.V. | Furan compounds as histamine H3 modulators |
DE102004024772A1 (de) * | 2004-05-17 | 2005-12-22 | Grünenthal GmbH | Substituierte 5-Aminomethyl-1H-pyrrol-2-carbonsäureamide |
JP4853759B2 (ja) * | 2004-05-27 | 2012-01-11 | 日本農薬株式会社 | 置換ピラジンカルボン酸アニリド誘導体又はその塩類、その中間体及び農園芸用薬剤並びにその使用方法 |
TWI355380B (en) | 2004-05-27 | 2012-01-01 | Nihon Nohyaku Co Ltd | Substituted pyrazinecarboxanilide derivatives or s |
GB2418427A (en) | 2004-09-02 | 2006-03-29 | Univ Cambridge Tech | Ligands for G-protein coupled receptors |
ATE439347T1 (de) | 2004-11-23 | 2009-08-15 | Warner Lambert Co | 7-(2h-pyrazol-3-yl)-3,5-dihydroxy-heptansäure- derivate als hmg-co-a-reductase-inhibitoren zur behandlung von lipidemia |
US8198288B2 (en) | 2006-05-04 | 2012-06-12 | Pulmagen Therapeutics (Inflammation) Limited | Tetrahydropyrrolopyrimidinediones and their use in therapy |
WO2007129060A1 (en) | 2006-05-04 | 2007-11-15 | Argenta Discovery Limited | Tetrahydropyrrolopyrimidinediones and their use as human neutrophil elastase inhibitors |
US7662967B2 (en) | 2007-08-02 | 2010-02-16 | Cambridge Enterprise Limited | Anti-inflammatory compounds and compositions |
GB2452696B (en) | 2007-08-02 | 2009-09-23 | Cambridge Entpr Ltd | 3-(2',2'-dimethylpropanoylamino)-tetrahydropyridin-2-one and its use in pharmaceutical compositions |
WO2009060206A1 (en) * | 2007-11-07 | 2009-05-14 | Argenta Discovery Limited | 3,4,6,7-tetrahydro-1h-pyrrolo[3,4-d]pyrimidine-2,5-diones and their therapeutic use |
US20110212181A1 (en) * | 2010-02-26 | 2011-09-01 | The University Of Hong Kong | Compositions and methods for treating chronic respiratory inflammation |
JP2023500182A (ja) | 2019-09-17 | 2023-01-05 | メレオ バイオファーマ 4 リミテッド | 移植片拒絶反応、閉塞性細気管支炎症候群、及び移植片対宿主病の治療に使用するためのアルベレスタット |
DK4106757T3 (da) | 2020-04-16 | 2023-10-23 | Mereo Biopharma 4 Ltd | Fremgangsmåder der involverer neutrofil elastase-inhibitor alvelestat til behandling af luftvejssygdom medieret af alpha-1-antitrypsin-mangel |
CA3234399A1 (en) | 2021-10-20 | 2023-04-27 | Mereo Biopharma 4 Limited | Neutrophil elastase inhibitors for use in the treatment of fibrosis |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9211783D0 (en) * | 1992-06-04 | 1992-07-15 | Ici Plc | Amide derivatives |
GB9402680D0 (en) * | 1994-02-11 | 1994-04-06 | Zeneca Ltd | Pyrrolidine derivatives |
PL329153A1 (en) * | 1996-03-28 | 1999-03-15 | Glaxo Group Ltd | Derivatives of pyrrolopyrolone as inhibitors of neutropil elastase |
-
1998
- 1998-09-04 PE PE1998000828A patent/PE107899A1/es not_active Application Discontinuation
- 1998-09-07 MA MA25243A patent/MA26543A1/fr unknown
- 1998-09-07 JP JP2000510740A patent/JP2001515904A/ja active Pending
- 1998-09-07 KR KR1020007002422A patent/KR20010023766A/ko not_active Application Discontinuation
- 1998-09-07 CA CA002303176A patent/CA2303176A1/en not_active Abandoned
- 1998-09-07 EP EP98951348A patent/EP1003748A2/en not_active Withdrawn
- 1998-09-07 NZ NZ503130A patent/NZ503130A/en unknown
- 1998-09-07 TR TR2000/00907T patent/TR200000907T2/xx unknown
- 1998-09-07 HU HU0004644A patent/HUP0004644A3/hu unknown
- 1998-09-07 EA EA200000204A patent/EA200000204A1/ru unknown
- 1998-09-07 IL IL13479198A patent/IL134791A0/xx unknown
- 1998-09-07 ID IDW20000445A patent/ID24452A/id unknown
- 1998-09-07 PL PL98339176A patent/PL339176A1/xx not_active Application Discontinuation
- 1998-09-07 SK SK319-2000A patent/SK3192000A3/sk unknown
- 1998-09-07 AR ARP980104458A patent/AR017072A1/es unknown
- 1998-09-07 AP APAP/P/2000/001761A patent/AP2000001761A0/en unknown
- 1998-09-07 CN CN98810954A patent/CN1278820A/zh active Pending
- 1998-09-07 BR BR9812062-0A patent/BR9812062A/pt not_active Application Discontinuation
- 1998-09-07 EE EEP200000138A patent/EE200000138A/xx unknown
- 1998-09-07 AU AU97412/98A patent/AU9741298A/en not_active Abandoned
- 1998-09-07 WO PCT/EP1998/005609 patent/WO1999012933A2/en not_active Application Discontinuation
- 1998-09-08 CO CO98051488A patent/CO4970719A1/es unknown
-
2000
- 2000-02-29 IS IS5391A patent/IS5391A/is unknown
- 2000-03-08 NO NO20001198A patent/NO20001198L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
WO1999012933A2 (en) | 1999-03-18 |
KR20010023766A (ko) | 2001-03-26 |
AU9741298A (en) | 1999-03-29 |
HUP0004644A3 (en) | 2002-01-28 |
MA26543A1 (fr) | 2004-12-20 |
AP2000001761A0 (en) | 2000-03-31 |
EA200000204A1 (ru) | 2000-10-30 |
NO20001198D0 (no) | 2000-03-08 |
BR9812062A (pt) | 2000-09-26 |
HUP0004644A2 (hu) | 2001-09-28 |
PE107899A1 (es) | 1999-11-17 |
CO4970719A1 (es) | 2000-11-07 |
ID24452A (id) | 2000-07-20 |
JP2001515904A (ja) | 2001-09-25 |
CA2303176A1 (en) | 1999-03-18 |
CN1278820A (zh) | 2001-01-03 |
NZ503130A (en) | 2001-08-31 |
NO20001198L (no) | 2000-05-08 |
SK3192000A3 (en) | 2001-03-12 |
WO1999012933A3 (en) | 1999-05-27 |
IL134791A0 (en) | 2001-04-30 |
TR200000907T2 (tr) | 2000-11-21 |
PL339176A1 (en) | 2000-12-04 |
EP1003748A2 (en) | 2000-05-31 |
IS5391A (is) | 2000-02-29 |
EE200000138A (et) | 2001-02-15 |
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