HUP0001437A2 - Difenilalkil-tetrahidropiridinek, eljárás előállításukra, valamint e vegyületeket tartalmazó gyógyszerkészítmények - Google Patents
Difenilalkil-tetrahidropiridinek, eljárás előállításukra, valamint e vegyületeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0001437A2 HUP0001437A2 HU0001437A HUP0001437A HUP0001437A2 HU P0001437 A2 HUP0001437 A2 HU P0001437A2 HU 0001437 A HU0001437 A HU 0001437A HU P0001437 A HUP0001437 A HU P0001437A HU P0001437 A2 HUP0001437 A2 HU P0001437A2
- Authority
- HU
- Hungary
- Prior art keywords
- tetrahydropyridines
- preparation
- pharmaceutical compositions
- alkyl
- compositions containing
- Prior art date
Links
- 235000010290 biphenyl Nutrition 0.000 title 1
- 239000004305 biphenyl Substances 0.000 title 1
- 125000006267 biphenyl group Chemical group 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N phenylbenzene Natural products C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 title 1
- 239000000428 dust Substances 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- ZCDOYSPFYFSLEW-UHFFFAOYSA-N chromate(2-) Chemical class [O-][Cr]([O-])(=O)=O ZCDOYSPFYFSLEW-UHFFFAOYSA-N 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 230000000324 neuroprotective effect Effects 0.000 abstract 1
- 230000000508 neurotrophic effect Effects 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyridine Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
A találmány tárgya- (I) általánős képletű vegyületek, valamint sóik ésszőlvátjaik, tővábbá kvaterner ammóniűmsóik, a képletben Y jelentése -CH- vagy -N- képletű csőpőrt, R1 jelentése halőgénatőm vagytriflűőrmetilcsőpőrt, 1-4 szénatőmős alkilcsőpőrt vagy 1-4 szénatőmősalkőxicsőpőrt, R2 és R3 jelentése hidrőgénatőm vagy 1-3 szénatőmősalkilcsőpőrt, n értéke 0 vagy l, és Phl és Ph2 jelentése egymástólfüggetlenül nem helyettesített, egyszeresen helyettesített vagytöbbszörösen helyettesített fenilcsőpőrt. A találmány szerintivegyületek neűrőtrőfikűs és neűrőprőtektív aktivitással rendelkeznek. ŕ
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9615336A FR2757161B1 (fr) | 1996-12-13 | 1996-12-13 | Diphenylalkyl-tetrahydropyridines |
PCT/FR1997/002289 WO1998025904A1 (fr) | 1996-12-13 | 1997-12-12 | Diphenylalkyl-tetrahydropyridines, procede pour leur preparation et composition pharmaceutique les contenant |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0001437A2 true HUP0001437A2 (hu) | 2000-09-28 |
HUP0001437A3 HUP0001437A3 (en) | 2001-12-28 |
Family
ID=9498642
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0001437A HUP0001437A3 (en) | 1996-12-13 | 1997-12-12 | Diphenyl alkyl-tetrahydropyridines, process for their preparation, and pharmaceutical compositions containing them |
Country Status (31)
Country | Link |
---|---|
US (1) | US6124318A (hu) |
EP (1) | EP0950049B1 (hu) |
JP (1) | JP2001505903A (hu) |
KR (1) | KR100549656B1 (hu) |
CN (1) | CN1144784C (hu) |
AT (1) | ATE207056T1 (hu) |
AU (1) | AU730142B2 (hu) |
BR (1) | BR9713926A (hu) |
CA (1) | CA2274946C (hu) |
CY (1) | CY2282B1 (hu) |
CZ (1) | CZ290242B6 (hu) |
DE (1) | DE69707504T2 (hu) |
DK (1) | DK0950049T3 (hu) |
EE (1) | EE03764B1 (hu) |
ES (1) | ES2167805T3 (hu) |
FR (1) | FR2757161B1 (hu) |
HK (1) | HK1024001A1 (hu) |
HU (1) | HUP0001437A3 (hu) |
IL (2) | IL130001A0 (hu) |
IS (1) | IS2001B (hu) |
NO (1) | NO313282B1 (hu) |
NZ (1) | NZ336032A (hu) |
PL (1) | PL192926B1 (hu) |
PT (1) | PT950049E (hu) |
RS (1) | RS49672B (hu) |
RU (1) | RU2198874C2 (hu) |
SI (1) | SI0950049T1 (hu) |
SK (1) | SK283332B6 (hu) |
TR (1) | TR199901290T2 (hu) |
UA (1) | UA52708C2 (hu) |
WO (1) | WO1998025904A1 (hu) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2763847B1 (fr) * | 1997-05-28 | 2003-06-06 | Sanofi Sa | Utilisation de tetrahydropyridines 4-substituees pour fabriquer des medicaments agissant sur le tgf-beta-1 |
AU2001253597A1 (en) * | 2000-04-12 | 2001-10-30 | Minerva Biotechnologies Corporation | Treatment of neurodegenerative disease |
US6699866B2 (en) | 2001-04-17 | 2004-03-02 | Sepracor Inc. | Thiazole and other heterocyclic ligands for mammalian dopamine, muscarinic and serotonin receptors and transporters, and methods of use thereof |
US20050191349A1 (en) * | 2003-12-31 | 2005-09-01 | Garth Boehm | Galantamine formulations |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1321701A (en) * | 1969-10-01 | 1973-06-27 | Continental Pharma | Amino-alcohols their salts and process for prepairing the same |
BE775611A (fr) * | 1970-11-24 | 1972-03-16 | Synthelabo | Derives de la (diphenyl-3,3 propyl-1)-1 piperidine, leur preparation etles medicaments qui en contiennent |
FR2650505B1 (fr) * | 1989-08-07 | 1994-06-03 | Midy Spa | Utilisation de trifluoromethylphenyltetrahydropyridines pour la preparation de medicaments destines a combattre les troubles de la motricite intestinale |
US5266573A (en) * | 1989-08-07 | 1993-11-30 | Elf Sanofi | Trifluoromethylphenyltetrahydropyridines for the treatment and/or prophylaxis of intestinal motility disorders |
FR2662355B1 (fr) * | 1990-05-22 | 1994-11-10 | Sanofi Sa | Utilisation de la 1-[2-(2-naphtyl)ethyl]-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine pour la preparation de medicaments destines au traitement de troubles cerebraux et neuronaux. |
US5512584A (en) * | 1991-04-16 | 1996-04-30 | Basf Aktiengesellschaft | 1,3,4-trisubstituted piperidine derivatives, the preparation and use thereof |
HU211019B (en) * | 1991-12-02 | 1995-09-28 | Richter Gedeon Vegyeszet | Process for producing new 1,2,3,6-tetrahydropyridine and piperidine derivatives substituted with n-(hydroxylalkyl) group and compositions comprising such compounds |
DK148392D0 (da) * | 1992-12-09 | 1992-12-09 | Lundbeck & Co As H | Heterocykliske forbindelser |
-
1996
- 1996-12-13 FR FR9615336A patent/FR2757161B1/fr not_active Expired - Fee Related
-
1997
- 1997-12-11 US US09/331,005 patent/US6124318A/en not_active Expired - Fee Related
- 1997-12-12 SI SI9730241T patent/SI0950049T1/xx unknown
- 1997-12-12 PL PL334073A patent/PL192926B1/pl not_active IP Right Cessation
- 1997-12-12 DE DE69707504T patent/DE69707504T2/de not_active Expired - Fee Related
- 1997-12-12 ES ES97951326T patent/ES2167805T3/es not_active Expired - Lifetime
- 1997-12-12 HU HU0001437A patent/HUP0001437A3/hu unknown
- 1997-12-12 CZ CZ19992110A patent/CZ290242B6/cs not_active IP Right Cessation
- 1997-12-12 WO PCT/FR1997/002289 patent/WO1998025904A1/fr not_active Application Discontinuation
- 1997-12-12 DK DK97951326T patent/DK0950049T3/da active
- 1997-12-12 RS YUP-263/99A patent/RS49672B/sr unknown
- 1997-12-12 CN CNB971805830A patent/CN1144784C/zh not_active Expired - Fee Related
- 1997-12-12 EP EP97951326A patent/EP0950049B1/fr not_active Expired - Lifetime
- 1997-12-12 AU AU54895/98A patent/AU730142B2/en not_active Ceased
- 1997-12-12 JP JP52632398A patent/JP2001505903A/ja not_active Ceased
- 1997-12-12 SK SK787-99A patent/SK283332B6/sk unknown
- 1997-12-12 NZ NZ336032A patent/NZ336032A/xx unknown
- 1997-12-12 RU RU99115082/04A patent/RU2198874C2/ru not_active IP Right Cessation
- 1997-12-12 EE EEP199900238A patent/EE03764B1/xx not_active IP Right Cessation
- 1997-12-12 TR TR1999/01290T patent/TR199901290T2/xx unknown
- 1997-12-12 KR KR1019997005202A patent/KR100549656B1/ko not_active IP Right Cessation
- 1997-12-12 BR BR9713926A patent/BR9713926A/pt not_active Application Discontinuation
- 1997-12-12 CA CA002274946A patent/CA2274946C/en not_active Expired - Fee Related
- 1997-12-12 AT AT97951326T patent/ATE207056T1/de not_active IP Right Cessation
- 1997-12-12 PT PT97951326T patent/PT950049E/pt unknown
- 1997-12-12 IL IL13000197A patent/IL130001A0/xx active IP Right Grant
- 1997-12-12 UA UA99063287A patent/UA52708C2/uk unknown
-
1999
- 1999-05-18 IL IL130001A patent/IL130001A/en not_active IP Right Cessation
- 1999-06-10 IS IS5074A patent/IS2001B/is unknown
- 1999-06-11 NO NO19992870A patent/NO313282B1/no unknown
-
2000
- 2000-05-31 HK HK00103246A patent/HK1024001A1/xx not_active IP Right Cessation
-
2002
- 2002-05-15 CY CY0200036A patent/CY2282B1/xx unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA9A | Lapse of provisional patent protection due to relinquishment or protection considered relinquished |