ES8200661A1 - Un procedimiento para la preparacion de nuevos derivados de dihidropiridina - Google Patents

Un procedimiento para la preparacion de nuevos derivados de dihidropiridina

Info

Publication number
ES8200661A1
ES8200661A1 ES497775A ES497775A ES8200661A1 ES 8200661 A1 ES8200661 A1 ES 8200661A1 ES 497775 A ES497775 A ES 497775A ES 497775 A ES497775 A ES 497775A ES 8200661 A1 ES8200661 A1 ES 8200661A1
Authority
ES
Spain
Prior art keywords
alkyl
alkoxy
halogen
processes
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES497775A
Other languages
English (en)
Other versions
ES497775A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of ES497775A0 publication Critical patent/ES497775A0/es
Publication of ES8200661A1 publication Critical patent/ES8200661A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO DE PREPARACION DE DERIVADOS DE DIHIDROPIRIDINA, DE FORMULA (I), EN QUE R1 Y R2 SON HIDROGENO, ALQUILO, HALOGENO Y OTROS; R3 HIDROGENO, ALQUILO, FENILO O BENCILO; R4 HIDROGENO O ALQUILO; R5 Y R6 ALQUILO, FENILO O BENCILO. SE BASA EN LA REACCION DE UN COMPUESTO DE FORMULA (II), EN QUE R10 ES UN GRUPO ALQUILO, O DE UNA SAL DEL MISMO CON UNA AMINA DE FORMULA (III), EN UN DISOLVENTE ORGANICO POLAR E INERTE FRENTE A LOS PRODUCTOS EN REACCION A LA TEMPERATURA DE REFLUJO DEL DISOLVENTE. EL PRODUCTO FINAL SE OBTIENE EN FORMA DE BASE LIBRE. EVENTUALMENTE, SE PREPARA LA SAL DE ADICION DE ACIDO DEL COMPUESTO POR REACCION CON UN ACIDO ADECUADO. DE APLICACION COMO AGENTES HIPOGLICEMICOS EN EL TRATAMIENTO DE LA DIABETES.
ES497775A 1979-04-21 1980-12-15 Un procedimiento para la preparacion de nuevos derivados de dihidropiridina Expired ES8200661A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7913950 1979-04-21

Publications (2)

Publication Number Publication Date
ES497775A0 ES497775A0 (es) 1981-11-16
ES8200661A1 true ES8200661A1 (es) 1981-11-16

Family

ID=10504698

Family Applications (2)

Application Number Title Priority Date Filing Date
ES490753A Expired ES8105286A1 (es) 1979-04-21 1980-04-21 Un procedimiento para la preparacion de nuevos derivados de dihidropiridina.
ES497775A Expired ES8200661A1 (es) 1979-04-21 1980-12-15 Un procedimiento para la preparacion de nuevos derivados de dihidropiridina

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES490753A Expired ES8105286A1 (es) 1979-04-21 1980-04-21 Un procedimiento para la preparacion de nuevos derivados de dihidropiridina.

Country Status (11)

Country Link
EP (1) EP0018134B1 (es)
JP (1) JPS55143968A (es)
AU (1) AU5759080A (es)
DE (1) DE3066911D1 (es)
DK (1) DK167680A (es)
ES (2) ES8105286A1 (es)
FI (1) FI801223A (es)
GR (1) GR67302B (es)
IL (1) IL59824A0 (es)
NO (1) NO801132L (es)
ZA (1) ZA802360B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8903592D0 (en) * 1989-02-16 1989-04-05 Boots Co Plc Therapeutic agents
JP2001261652A (ja) * 2000-03-21 2001-09-26 Suntory Ltd 二置換イミノヘテロサイクリック化合物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3933836A (en) * 1974-09-26 1976-01-20 E. R. Squibb & Sons, Inc. Pyridinylidene guanidines
CS225804B2 (cs) * 1976-03-19 1984-02-13 Mcneilab Inc Způsob výroby heterocyklických derivátů guanidinu
EP0000816A1 (en) * 1977-08-06 1979-02-21 Beecham Group Plc Substituted amino-pyridine derivatives, processes for their preparation and pharmaceutical compositions containing them
CA1201119A (en) * 1978-09-18 1986-02-25 Mcneilab, Inc. Diaza-cyclic derivatives of guanidine

Also Published As

Publication number Publication date
NO801132L (no) 1980-10-21
DE3066911D1 (en) 1984-04-19
GR67302B (es) 1981-06-29
ES497775A0 (es) 1981-11-16
EP0018134A3 (en) 1981-01-07
JPS55143968A (en) 1980-11-10
IL59824A0 (en) 1980-06-30
ZA802360B (en) 1981-04-29
DK167680A (da) 1980-10-22
FI801223A (fi) 1980-10-22
ES490753A0 (es) 1981-05-16
EP0018134B1 (en) 1984-03-14
AU5759080A (en) 1980-10-30
ES8105286A1 (es) 1981-05-16
EP0018134A2 (en) 1980-10-29

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